A DNA origami plasmonic sensor with environment-independent read-out

作     者：Valentina Masciotti Luca Piantanida Denys Naumenko Heinz Amenitsch Mattia Fanetti Matjaz Valant Dongsheng Lei Gang Ren Marco Lazzarino 

作者机构：CNR-IOMAREA Science ParkBasovizza TriesteI-34149Italy PhD Course in NanotechnologyUniversity of TriesteTriesteI-34127Italy Institute for Physics of SemiconductorsNational Academy of Sciences of UkraineKyiv03028Ukraine Institute of Inorganic ChemistryGraz University of TechnologyGrazA-8010Austria Materials Research LaboratoryUniversity of Nova GoricaNova GoricaSI-5000Slovenia Institute of Fundamental and Frontier SciencesUniversity of Electronic Science and Technology of ChinaChengdu610054China The Molecular FoundryLawrence Berkeley National LaboratoryBerkeleyCA94720USA School of Physical Science and TechnologyElectron Microscopy Center of LZULanzhou UniversityLanzhou730000China Micron School of Materials Science&EngineeringBoise State UniversityBoiseID 83725USA 

出 版 物：《Nano Research》 (纳米研究（英文版）)

年 卷 期：2019年第12卷第11期

页      面：2900-2907页

核心收录：

学科分类：07[理学] 070202[理学-粒子物理与原子核物理] 0702[理学-物理学] 

基　　金：V.M.acknowledges financial support from MIUR(MIUR Giovani-Ambito“Salute dell’uomo”).Work at the Molecular Foundry under the research project No.3376 was supported by the Office of Science Office of Basic Energy Sciences of the U.S.Department of Energy under Contract No.DE-AC02-05CH11231.We acknowledge the Facility of Nanofabrication(FNF)of IOM for the support in sample preparation Simone Dal Zilio and Silvio Greco for help in data analysis and stimulating discussions.We acknowledge Prof.Giuseppe Firrao for valuable comments and inspiring ideas the NanoInnovation laboratory(Elettra Sincrotrone)for suggestion provided for AFM analysis and the BioLab(Elettra Sincrotrone)for the use of lab and instrumentation 

主　　题：DNA origami plasmonic sensor molecular detection gold nanoparticle 

摘      要：DNA origami is a promising technology for its reproducibility,flexibility,scalability and *** the several potential applications,DNA origami has been proposed as a tool for drug delivery and as a contrast agent,since a conformational change upon specific target interaction may be used to release a drug or produce a physical signal,***,its conformation should be robust with respect to the properties of the medium in which either the recognition or the read-out take place,such as pressure,viscosity and any other unspecific interaction other than the desired target *** we report on the read-out robustness of a tetragonal DNA-origami/gold-nanoparticle hybrid structure able to change its configuration,which is transduced in a change of its plasmonic properties,upon interaction with a specific DNA *** investigated its response when analyzed in three different media:aqueous solution,solid support and viscous *** show that,once a conformational variation is produced,it remains unaffected by the subsequent physical interactions with the environment.