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Conservative management of spinal pathology with autologous conditioned serum: A systematic review of the literature

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world Journal of Orthopedics 2024年第9期15卷 870-881页

作者： Christian J Rajkovic matthew L Merckling Alyssa w Lee Galadu Subah Aryan Malhotra Zachary D Thomas Sabrina L Zeller John V wainwright Merritt D Kinon Department of Neurosurgery Westchester Medical CenterValhallaNY 10595United States

BACKGROUND Chronic inflammatory pain is associated with increased expression of interleukin(IL)-1,an inflammatory cytokine,and activity on its receptor(IL-1R).In response,the body produces IL-1R antagonist(IL-1Ra)to reduce this *** conditioned serum(ACS)is the only biologic therapy for spinal pathologies that enhances the action of endogenous IL-1Ra reserves to improve *** systematic review investigates the effectiveness of ACS in treating pain and dis-ability caused by spinal *** To evaluate the use of ACS as a conservative management option for spinal *** A systematic review of PubMed/Medline was performed to identify studies inve-stigating administration of ACS for treatment of any spinal *** Six articles were included,comprising 684 patients treated with epidural(n=133)or transforaminal(n=551)ACS *** had an average age of 54.0 years with slight female predominance(53.2%).The lumbar spine was most com-monly treated,with 567 patients(82.9%)receiving injections for lumbar radicu-lopathy(n=67),degenerative disc disease(DDD)(n=372),or spinal stenosis(n=128);cervical injections were performed in 109 patients(15.9%).Mean(SD)follow-up was 21.7(4.8)weeks from first ACS *** studies investigating mecha-nical lumbar and lumbar or cervical radicular pain reported significant pain re-duction at final follow-up compared to *** achieved comparable or su-perior results to lumbar epidural steroid *** events were reported in 21 patients(3.1%),with no serious adverse *** ACS injection is a safe and effective intervention for pain reduction in many spinal pathologies,including cervical and lumbar radiculopathies.

关键词： Spine Autologous conditioned serum Orthokine Regenokine Epidural steroid injection Interleukin-1 Inter-leukin-1 receptor antagonist

Reversed charge transfer induced by nickel in Fe-Ni/Mo_(2)C@nitrogen-doped carbon nanobox for promoted reversible oxygen electrocatalysis

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Journal of Energy Chemistry 2024年第1期88卷 202-212,I0005页

作者： Zhicheng Nie Lei Zhang Qiliang Zhu Zhifan Ke Yingtang Zhou Thomas wågberg Guangzhi Hu School of Materials Science and Engineering Anhui University of Science and TechnologyHuainan 232001AnhuiChina Institute for Ecological Research and Pollution Control of Plateau Lakes School of Ecology and Environmental ScienceYunnan UniversityKunming 650504YunnanChina National Engineering Research Center for Marine Aquaculture Marine Science and Technology CollegeZhejiang Ocean UniversityZhoushan 316004ZhejiangChina Department of Physics UmeåUniversityUmeåS-90187Sweden

The interaction between metal and support is critical in oxygen catalysis as it governs the charge transfer between these two entities,influences the electronic structures of the supported metal,affects the adsorption energies of reaction intermediates,and ultimately impacts the catalytic *** this study,we discovered a unique charge transfer reversal phenomenon in a metal/carbon nanohybrid ***,electrons were transferred from the metal-based species to N-doped carbon,while the carbon support reciprocally donated electrons to the metal domain upon the introduction of *** led to the exceptional electrocatalytic performances of the resulting Ni-Fe/Mo_(2)C@nitrogen-doped carbon catalyst,with a half-wave potential of 0.91 V towards oxygen reduction reaction(ORR)and a low overpotential of 290 m V at 10 mA cm^(-2)towards oxygen evolution reaction(OER)under alkaline ***,the Fe-Ni/Mo_(2)C@carbon heterojunction catalyst demonstrated high specific capacity(794 mA h g_(Zn)~(-1))and excellent cycling stability(200 h)in a Zn-air *** calculations revealed that Mo_(2)C effectively inhibited charge transfer from Fe to the support,while secondary doping of Ni induced a charge transfer reversal,resulting in electron accumulation in the Fe-Ni alloy *** local electronic structure modulation significantly reduced energy barriers in the oxygen catalysis process,enhancing the catalytic efficiency of both ORR and ***,our findings underscore the potential of manipulating charge transfer reversal between the metal and support as a promising strategy for developing highly-active and durable bi-functional oxygen electrodes.

关键词： Metal-support interaction Charge transfer reversal Oxygen reduction reaction Oxygen evolution reaction Zinc-air battery

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Out-of-Equilibrium Assembly Based on Host-Guest Interactions

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CCS Chemistry 2024年第1期6卷 27-40页

作者： Guotai Li Reece w.Lewis Rienk Eelkema School of Rehabilitation Sciences and Engineering University of Health and Rehabilitation SciencesQingdao 266071 Department of Chemical Engineering Delft University of Technology2629 HZ Delft

The field of supramolecular chemistry is rapidly progressing,transitioning from the creation of thermodynamically stable systems found in local or global minima on the free energy landscape to the development of out-of-equilibrium systems that rely on chemical reactions to establish and maintain their *** the past decade,numerous artificial out-of-equilibrium systems have been devised in various domains of supramolecular chemistry,many of which have been extensively ***,one area that has received limited attention thus far is the use of out-of-equilibrium processes to regulate host-guest *** minireview aims to address this gap by exploring the construction of out-ofequilibrium systems based on host-guest complexation,which likely employs similar strategies to those employed in analogous noncovalent *** review begins with a summary of these shared ***,it discusses representative publications that exemplify these strategies and classifies thembased onwhich component is being modulated-host,guest,or competitive *** this examination,our objective is to shed light on the design of out-of-equilibrium systems relying on host-guest interactions and provide valuable insights into the preparation strategies for various transient materials.

关键词： out-of-equilibrium host-guest chemistry self-assembly supramolecular materials chemical fuel

A harmonisation approach to traditional Chinese medicine registration in Asian countries

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Journal of Traditional Chinese Medical Sciences 2024年第2期11卷 143-147页

作者： Vivian S.w.Chan Fung Independent Scholar 2 Woodward PlaceSt IvesNSW 2075Australia

The traditional Chinese medicine(TCM)industry is critical to not only for public health but also for economic *** to the European Union(EU)directives,under the EU framework for(traditional)herbal medicinal products,herbal medicines with long history of use can be registered in ***,there is a condition in this directive in which only those that have at least 10e15 years in the EU market are accepted for registration and/or marketing *** author opinion,the condition of 10-15 years of use in EU countries set within the EU regulatory framework is with consideration of the genetic differences which can result in variation in adverse drug responses among different world *** this concept in mind,it is reasonable to project the principal of the EU directive to the Asian countries where TCM is *** like China,Singapore,Japan and South Korea that have well established drug registration framework are in best position in executing the best practice and facilitate harmonization of registration for TCM within the ***,the registration process itself allows more safety and efficacy data to be collected systemically before and after product registration/marketing *** are valuable information for future drug *** therapeutic value of TCM is limitless,it has been left out in the EU regulatory framework,and the opportunity for it to be expanded and carried forward in modern medicines is shadowed by the limited number of TCM that are qualified to be registered under the EU regulatory *** early establishment of a harmonized risk-based registration process for TCM in Asian countries is *** will strengthen the database to substantiate the history of safe use and further preserving and expanding the therapeutic values of TCM within and beyond the Asian region.

关键词： Traditional Chinese medicines Population genetic Harmonization Registration Asian countries

A hydrodynamic modelling of wave-activated bodies for wavelet marine regions

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Clean Energy 2024年第2期8卷 35-47页

作者： J.S.Peh Mohammed w.Muhieldeen N.H.Shuaib Mechanical Engineering Department Faculty of EngineeringTechnology&Built EnvironmentUCSI UniversityKuala Lumpur56000Malaysia MTC Engineer Sdn.Bhd Shah AlamSelangorMalaysia

Recently,most wave energy research has targeted sea areas with high power density under extreme wave conditions for *** trend often leads to higher energy costs for wave power ***,many marine areas with low power density,characterized by wavelet conditions and less destructive forces than extreme wave conditions,remain ***,this study aimed to propose a wave-activated body model for sea regions with wavelet *** wave-activated body design process encompassed site selection,parameter determination,geometry design,comparison and performance evaluation using the ANSYS®AQwA *** results indicated that the proposed device achieved the desired heave motion,with an amplitude range of 1.2 to-2.5 m,validating its potential for deployment in marine regions with wavelet ***,while the proposed design is optimized for wavelet conditions,it was found to have potential limitations in extreme wave *** observation emphasizes the challenge of formulating a generalized design suitable for both ***,it is pivotal for wave-activated body designs to be customized based on the specific ocean conditions they target,underscoring the need for specialized designs of wave energy converters that consider the unique wave characteristics of their deployment sites.

关键词： wave energy converter South China sea renewable and sustainable energy wavelet ANSYS AQwA hydrodynamic wave-activated bodies

Efficient fidelity estimation:alternative derivation and related applications

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Communications in Theoretical Physics 2024年第9期76卷 16-20页

作者： Diego S Starke Marcos L w Basso Jonas Maziero Physics Department Center for Natural and Exact SciencesFederal University of Santa MariaRoraima Avenue 1000Santa MariaRS97105-900Brazil Center for Natural and Human Sciences Federal University of ABCAvenue of the StatesSanto AndréSão Paulo09210-580Brazil

In[***.A 107012427(2023)],Baldwin and Jones prove that Uhlmann–Jozsa’s fidelity between two quantum statesρandσ,i.e.,F(ρ,σ)=(Tr√√ρσ√ρ)^(2),can be written in a simplified form as F(ρ,σ)=(Tr√ρσ)^(2).In this article,we give an alternative proof of this result,using a function power series expansion and the properties of the trace *** approach not only reinforces the validity of the simplified expression but also facilitates the exploration of novel dissimilarity functions for quantum states and more complex trace functions of density operators.

关键词： Ulhmann–Jozsa fidelity Rényi entropy efficient fidelity estimation Chebyshev polynomials

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Towards a lightweight security framework using blockchain and machine learning

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Blockchain(Research and Applications) 2024年第1期5卷 107-118页

作者： Shereen Ismail Muhammad Nouman Diana w.Dawoud Hassan Reza School of Electrical Engineering and Computer Science University of North DakotaND 58202USA Department of Computer Science COMSATS University IslamabadIslamabad 44000Pakistan College of Engineering and Information Technology University of DubaiDubaiUnited Arab Emirates

Cyber-attacks pose a significant challenge to the security of Internet of Things(IoT)sensor networks,necessitating the development of robust countermeasures tailored to their unique characteristics and *** prevention and detection techniques have been proposed to mitigate these *** this paper,we propose an integrated security framework using blockchain and Machine Learning(ML)to protect IoT sensor *** framework consists of two modules:a blockchain prevention module and an ML detection *** blockchain prevention module has two lightweight mechanisms:identity management and trust *** management employs a lightweight Smart Contract(SC)to manage node registration and authentication,ensuring that unauthorized entities are prohibited from engaging in any tasks,while trust management uses a lightweight SC that is responsible for maintaining trust and credibility between sensor nodes throughout the network’s lifetime and tracking historical node *** and transaction validation are achieved through a Verifiable Byzantine Fault Tolerance(VBFT)mechanism to ensure network reliability and *** ML detection module utilizes the Light Gradient Boosting Machine(LightGBM)algorithm to classify malicious nodes and notify the blockchain network if it must make decisions to mitigate their *** investigate the performance of several off-the-shelf ML algorithms,including Logistic Regression,Complement Naive Bayes,Nearest Centroid,and Stacking,using the wSN-DS *** is selected following a detailed comparative analysis conducted using accuracy,precision,recall,F1-score,processing time,training time,prediction time,computational complexity,and matthews Correlation Coefficient(MCC)evaluation metrics.

关键词： Blockchain Machine learning IoT Security Integration Smart contracts

Permian ridge subduction-related magmatism in the Chinese Altai: Insights from geochronology and geochemistry of the Jiangjunshan pluton

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Journal of Earth Science 2024年

作者： Shi-Heng Bai Ru-Xiong Lei matthew J.Brzozowski Zhenhua wang wei wang Chang-Zhi wu Laboratory of Mineralization and Dynamics， School of Earth Science and Resources， Chang'an University Xinjiang Natural Resources and Ecological Environment Research Center

The Chinese Altai is an important constituent of the Central Asian Orogenic Belt， a prominent Phanerozoic accretionary orogenic belt. Oceanic-continental subduction processes during the Cambrian–Carboniferous and intracontinental extension from the Triassic onwards have been well constrained in the Chinese Altai， the southwestern portion of the CAOB. Characterizing the petrogenetic evolution of the Chinese Altai during the Permian has， therefore， been considered critical to enhancing our understanding of the tectonic transformations that occurred in this region. Despite this， the tectonic environment of the Chinese Altai during this period remains equivocal. To address this deficiency， this contribution characterizes the age of formation and geochemical composition of the Jiangjunshan pluton located in the southern portion of the Chinese Altai. Zircon U-Pb geochronology demonstrates that the gabbro and two-mica alkali feldspar granite， which comprise the main body of the Jiangjunshan pluton， formed at ca. 272 ± 3.5 and 272 ± 1.6 Ma， respectively. Geochemically， the gabbro is depleted in light rare earth elements （LREE）， has low Nb/Yb （0.39–0.46） and Ti/V （23.7–25.3） ratios， exhibits trace-element characteristics resembling normal mid-ocean ridge basalts （N-MORB）， but is depleted in Nb and Ta similar to island arc basalts. The depleted Hf and Nd isotope compositions (εHf（t） = +0.60 to +4.63， εNd（t） = +6.32 to +7.80) of the gabbro， coupled with the weak correlation between εNd（t） values and SiO2contents， suggest that the magma from which it crystallized was slightly contaminated by crustal material during its evolution. Based on the Sm， Yb， and La contents， it is inferred that the melt from which the gabbro crystallized originated from approximately 8–20% partial melting of spinel lherzolite mantle. The depleted Hf and Nd isotope compositions (εHf（t） = +6.81 to +9.10， εNd（t） = +0.79 to +1.45) of the granite， combined with petrographic observations （e.g.， absent of the

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Sustained adenosine release:Revealing its impact on osteogenic signalling pathways of human mesenchymal stromal cells

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Engineered Regeneration

Engineered Regeneration 2024年第2期5卷 255-268页

作者： Hadi Hajiali Jane McLaren Cristina Gonzalez-García Salah Abdelrazig Dong-Hyun Kim matthew J.Dalby Manuel Salmerón-Sánchez Felicity R.A.J.Rose School of Pharmacy Nottingham Biodiscovery InstituteUniversity of NottinghamNottinghamUK Healthcare Technologies Institute School of Chemical EngineeringUniversity of BirminghamBirminghamUK Centre for the Cellular Microenvironment University of GlasgowGlasgowUK Centre for Analytical Bioscience Advanced Materials&Healthcare Technologies DivisionSchool of PharmacyUniversity of NottinghamNottinghamUK Marine Microbiomics Program in BiologyDivision of Science and MathematicsNew York University Abu Dhabi(NYUAD)P.O.Box 129188Abu DhabiUnited Arab Emirates

Non-healing fractures,a global health concern arising from trauma,osteoporosis,and tumours,can lead to severe ***,integral to cellular energy metabolism,gains prominence in bone regeneration via adeno-sine A2 B receptor *** study introduces a controlled-release system for localized adenosine delivery,fostering human mesenchymal stromal cell(hMSC)differentiation into functional bone *** study investi-gates how the ratio of lactic acid to glycolic acid in microparticles can influence adenosine release and explores the downstream effects on gene expression and metabolic profiles of osteogenic differentiation in hMSCs cultured in growth and osteoinductive *** into adenosine-modulated signalling pathways during MSC differenti-ation,with osteogenic factors,provide a comprehensive understanding of the pathways *** gene expression and metabolic profiles unravels adenosine’s regulatory mechanisms in MSC *** adenosine release from microparticles induces mineralization,synergizing with osteogenic media supplements,showcasing the potential of adenosine for treating critical bone defects and metabolic *** study high-lights the efficacy of a polymeric microparticle-based delivery system,offering novel strategies for bone *** adenosine’s roles and associated signalling pathways advances our comprehension of molecular mech-anisms steering bone regeneration,propelling innovative biomaterial,combined with metabolites,approaches for clinical use.

关键词： Adenosine release Osteogenic signalling pathways Human mesenchymal stromal cells Bone regeneration