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studies on the electronic structures of three-dimensional topological insulators by angle resolved photoemission spectroscopy

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Frontiers of physics 2012年第2期7卷 175-192页

作者： Yulin Chen (1) (2. (3) 1. Department of Physics University of Oxford Clarendon Laboratory Parks Road Oxford OX1 3PU UK2. Stanford Institute for Materials and Energy Sciences SLAC National Accelerator Laboratory 2575 Sand Hill Road Menlo Park CA 94025 USA3. Geballe Laboratory for Advanced Materials Departments of Physics and Applied Physics Stanford University Stanford CA 94305 USA

Three-dimensional （3D） topological insulators represent a new state of quantum matter with a bulk gap and odd number of relativistic Dirac fermions on the surface. The unusual surface states of topological insulators rise from the nontrivial topology of their electronic structures as a result of strong spin-orbital coupling. In this review, we will briefly introduce the concept of topological insu- lators and the experimental method that can directly probe their unique electronic structure： angle resolved photoemission spectroscopy （ARPES）. A few examples are then presented to demonstrate the unique band structures of different families of topological insulators and the unusual properties of the topological surface states. Finally, we will briefly discuss the future development of topological quantum materials.

关键词： topological insulator (TI) photoemission ARPES

IGF-1和动态微环境对脂肪干细胞向心肌细胞分化作用的研究

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生物化学与生物物理进展 2009年第12期36卷 1553-1561页

作者：朱艳霞刘天庆宋克东马学虎崔占峰大连理工大学干细胞与组织工程研发中心大连116024 institute of Biomedical Engineering Department of Engineering ScienceOxford University

体外组织工程模型中,生物化学和机械信号对心肌再生起着很重要的促进作用,对人胰岛素样生长因子(IGF-1)和三维动态微环境对脂肪干细胞向心肌细胞分化过程中的促进作用进行了研究.带有IGF-1基因的质粒整合到胶原-壳聚糖支架中,脂肪干细... 详细信息

体外组织工程模型中,生物化学和机械信号对心肌再生起着很重要的促进作用,对人胰岛素样生长因子(IGF-1)和三维动态微环境对脂肪干细胞向心肌细胞分化过程中的促进作用进行了研究.带有IGF-1基因的质粒整合到胶原-壳聚糖支架中,脂肪干细胞接种到整合质粒的支架内,未整合质粒的支架作为对照组,心肌细胞培养基作为分化培养基,转瓶生物反应器提供动态微环境.经2.分化培养后,检测质粒在支架内释放及表达情况、细胞在支架内的活性以及心肌功能性蛋白和基因的表达.结果表明:动态微环境能促进质粒DNA的释放和转染;IGF-1可促进脂肪干细胞在胶原-壳聚糖支架内增殖以及向心肌细胞分化;动态微环境可加强IGF-1的促增殖分化作用.因此,IGF-1和动态微环境能独立或相互促进脂肪干细胞在胶原-壳聚糖支架内活性,动态微环境还可强化IGF-1对脂肪干细胞的促分化作用.对体外构建工程化心肌组织进行心肌再生研究有着重要的指导意义.

关键词：脂肪干细胞心肌细胞支架 IGF-1 反应器组织工程

High density lipoprotein 3 inhibits oxidized low density lipoprotein-induced apoptosis via promoting cholesterol efflux in RAW2.4.7 cells

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Acta Pharmacologica Sinica 2006年第2期27卷 151-157页

作者： Pei JIANG~(2.5) Peng-ke YAN~(2.5) Jian-xiong CHEN~4 Bing-yang ZHU~2.Xiao-yong LEI~2.Wei-dong YIN~(3,6) Duan-fang LIAO~(2.3,6) ~2.ivision of Pharmacoproteomics.institute of Pharmacy and Pharmacology,Nanhua University,Hengyang 42.001,China,~3School of Life Science and Technology,Nanhua University,Hengyang 42.001,China,~4Department of Pathology,Vanderbilt University Medical Center Nashville.TN 372.2.USA Division of Pharmacoproteomics Institute of Pharmacy and Pharmacology Nanhua University Hengyang China Department of Pathology Vanderbilt University Medical Center Nashville USA School of Life Science and Technology Nanhua University Hengyang China

Aim:To investigate the protective effect of high density lipoprotein 3（HDL3）onoxidized low density lipoprotein（ox-LDL）-induced apoptosis in RAW2.4.7 cells,Methods:RAW2.4.7 cells were exposed to 50 mg/L ox-LDL for various durationsup to 48h,and apoptosis was detected using Hoechst 332.8 staining and flowcytometric *** cholesterol levels were detected by high performanceliquid chromatography,cholesterol efflux was determined by Tritium labeling,andthe cellular lipid droplets were assayed by oil red O ***:Treatmentwith 50mg/L ox-LDL for 12.2.,and 48h increased the apoptotic rate of RAW2.4,7 cells in a time-dependent *** peak apoptotic rate（47.7%）was observedafter 48h ***3at various concentrations（50mg/L,100mg/L,and 2.0mg/L）inhibited the ox-LDL（50mg/L for 48h）-mediated apoptosis that was accom-panied by an increased rate of intracellular cholesterol efflux,and decreased totalcholesterol levels in cells in a concentration-dependent *** ofcholesterol efflux by brefeldin decreased the protective effect of HDL3on ox-LDL-induced *** of the cholesterol efflux effected by another choles-terol acceptor,β-cyclodextrin,led to a dramatic decrease in the apoptotic rate ***:HDL3antagonizes ox-LDL-induced apoptosis in RAW2.4.7cells,through reducing the accumulation of toxic cholesterol.

关键词： cholesterol efflux high density lipoprotein-3 apoptosis oxidized low density lipoprotein

PPARγ phosphorylation mediated by JNK MAPK:a potential role in mac-rophage-derived foam cell formation

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Acta Pharmacologica Sinica 2006年第9期27卷 1146-1152页

作者： Ran YIN~2.Yu-gang DONG~(2.4)Hong-liang LI~3 Z Department of Cardiology,First Affiliated Hospital,Sun Yat-sen University,Guangzhou 510080,China 3 institute of Basic Medical Sciences,Chinese Academy of Medical Sciences,Beijing 100005,China Department of Cardiology First Affiliated Hospital Sun Yat-sen University Guangzhou China institute of Basic Medical Sciences Chinese Academy of Medical Sciences Beijing China

Aim:To investigate whether oxidized low-density lipoprotein(ox-LDL)modulatesperoxisome proliferator-activated receptorγ(PPARγ)activity through phosphory-lation in macrophages,and the effect of PPARγ phosphorylation on macroph-ages-derived foam cell ***:After exposing the cultured THP-1cells to ox-LDL in the presence or absence of different mitogen-activated proteinkinase(MAPK)inhibitors,PPARγ and phosphorylated PPARγ protein levels weredetected by Western *** activity was analyzed using MAP Kinase As-say *** cholesterol accumulation was assessed by Oil red O stainingand cholesterol oxidase enzymatic *** mRNA level of PPARγtarget genewas determined by reverse transcription-polymerase chain reaction(RT-PCR).Results:ox-LDL evaluated PPARγ phosphorylation status and subsequently de-creased PPARγ target gene expression in a dose-dependent manner,ox-LDL alsoinduced MAPK *** of THP- 1 cells with c-Jun N-terminal kinase-,but not p38- or extracellular signal-regulated kinase-MAPK inhibitor,significantlysuppressed PPARγ phosphorylation induced by ox-LDL,which in turn inhibitedfoam cell ***:In addition to its ligand-dependent activation,ox-LDL modulates PPARγ activity through phosphorylation,which is mediatedby MAPK ***γ phosphorylation mediated by MAPK facilitatesfoam cell formation from macrophages exposed to ox-LDL.

关键词： peroxisome proliferator-activated receptorγ phosphorylation macrophages LDL lipoprotein

数值模拟辐射场对激光等离子体中物理过程的影响

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物理学报 2001年第8期50卷 1517-1520页

作者：王薇张杰 S.J.ROSE 中国科学院物理研究所光物理开放实验室 Rutherford Appleton Laboratory Chilton

利用研究非局域热力学平衡态下等离子体的程序包NIMP ,就辐射场对等离子体中的激发和离化过程的影响进行了数值模拟研究。

关键词：激光等离子体离化态局域热力学平衡数值模拟辐射场

Preparation and Characterization of Co_(0.3)Cr_(0.7)O_x Particles Using for Thermal Radiation Coating

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稀有金属材料与工程 2012年第S1期41卷 100-103页

作者： Luo Lijie1,2.Huang Chuanbing1,Zhu Yongping1,Zhang Weigang1 1 state Key Laboratory of Multi-phase Complex Systems,institute of Process Engineering,Chinese Academy of Sciences,Beijing 100190,China 2.Graduate University of Chinese Academy of Sciences,Beijing 100049,China Chinese Acad Sci Inst Proc Engn State Key Lab Multiphase Complex Syst Beijing 100190 Peoples R China Chinese Acad Sci Grad Univ Beijing 100049 Peoples R China

Novel Co0.3Cr0.7ox(x=2.3)particles with spinel structure were synthesized via precipitation method through the reactions among CoSO4,Cr(NO3)3 and NaOH solutions,followed by spray-drying and sintering at 12.0 ℃for 4h in the *** particles were characterized by X-ray diffraction(XRD)and scanning electron microscopy(SEM).The XRD results revealed that the particles are composed of Co0.3Cr0.7ox phase without the presence of other *** SEM observation showed that the particles are in the shape of sphere with well *** radiation test indicated that the total infrared normal emissivity of the coating made of Co0.3Cr0.7ox can be up to 0.92.at 800℃.And the normal emissivities of the prepared Co0.3Cr0.7ox particles are always slightly larger than those of CoCr2.4 particles prepared by solid-state reaction method in the test temperature range of 50-300℃.The relatively high thermal emissivity of Co0.3Cr0.7ox is assumed to be mainly attributed to the spinel *** results indicated that Co0.3Cr0.7ox particles are a good thermal radiation material,which can be used as infrared radiation layer in thermal protection system.

关键词： Co0.3Cr0.7ox particles preparation precipitation thermal radiation coating

异丁烷选择氧化制甲基丙烯酸杂多化合物催化剂P_(1.33-d)Mo_(12.V_aCu_bSb_cAs_dK_(1.5)O_x/SiC的研究

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燃料化学学报 2004年第1期32卷 87-92页

作者：朱万春孙方龙常加贵李学福王国甲吉林大学化学学院吉林长春130023 大庆油田有限责任公司天然气利用研究所黑龙江大庆163457

采用共沉淀法制备了一系列磷钼体系多组分催化剂P1 33 dMo12.aCubSbcAsdK1 5ox/SiC(0 0≤a,b,c,d≤0 50)。利用XRD、FTIR、DSC、ESR等方法对催化剂的结构与性质进行了研究。XRD、FTIR的研究结果表明,合成的样品为具有Keggin杂多阴离子... 详细信息

采用共沉淀法制备了一系列磷钼体系多组分催化剂P1 33 dMo12.aCubSbcAsdK1 5ox/SiC(0 0≤a,b,c,d≤0 50)。利用XRD、FTIR、DSC、ESR等方法对催化剂的结构与性质进行了研究。XRD、FTIR的研究结果表明,合成的样品为具有Keggin杂多阴离子结构的磷钼杂多化合物。DSC,ESR测试结果表明催化剂具有较好的稳定性。同时考察了催化剂组分对异丁烷催化氧化性能的影响,结果表明,适量地引入V、As、Cu、Sb都能提高MAA(甲基丙烯酸)的选择性和MAA+MAL(甲基丙烯醛)的收率。催化剂P1 13Mo12.0 2.Cu0 2.Sb0 2.As0 2.1 5ox/SiC在360℃、常压、进料组成异丁烷:空气=1∶2.mol)、空速3600h-1条件下,异丁烷转化率10 7%,MAA+MAL的收率为6 8%。

关键词：异丁烷选择氧化甲基丙烯酸 Keggin结构磷钼酸盐

氧化低密度脂蛋白诱导主动脉平滑肌细胞胆固醇酯聚集和凋亡(英文)

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生物化学与生物物理进展 2002年第2期29卷 217-222页

作者：袁中华杨永宗杨小毅中南大学湘雅医学院病理生理教研室长沙410078 南华大学心血管病研究所衡阳421001

细胞内胆固醇代谢的失衡和细胞凋亡都与动脉粥样硬化的发生有关 .为了研究两者之间的关系 ,我们把猪的主动脉平滑肌细胞与 15mg/L氧化低密度脂蛋白共同孵育 72. ,发现细胞内胆固醇酯与总胆固醇的比值由 2.6 2.%增加到 6 4 1% ,并且细... 详细信息

细胞内胆固醇代谢的失衡和细胞凋亡都与动脉粥样硬化的发生有关 .为了研究两者之间的关系 ,我们把猪的主动脉平滑肌细胞与 15mg/L氧化低密度脂蛋白共同孵育 72. ,发现细胞内胆固醇酯与总胆固醇的比值由 2.6 2.%增加到 6 4 1% ,并且细胞内胆固醇酯的积聚有剂量依赖关系 ,表明细胞已经转化为平滑肌源性的泡沫细胞 .另外 ,使用荧光显微镜、激光共聚焦显微镜和流式细胞仪分别发现 ,与氧化低密度脂蛋白共孵育的细胞有典型的凋亡形态改变 .从实验可以推测 ,由氧化低密度脂蛋白诱导的平滑肌细胞凋亡 ,除了低密度脂蛋白氧化的因素外 ,也可能与细胞内胆固醇酯与总胆固醇的比值升高有关 .

关键词：主动脉氧化低密度脂蛋白胆固醇酯平滑肌细胞凋亡动脉粥样硬化

P53 a heavily dictated“dictator”of life and death

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P53 a heavily dictated“dictator”of life and death