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Lid scrubbing with a gel combining natural extracts for dry eye treatment

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International Journal of Ophthalmology(English edition) 2023年第7期16卷 1053-1059页

作者： Blanca Diaz-Vega Carlos Rodriguez-Fabuel Sofia Vitores-mate.Carlos Carpena-Torres Gran Visión Oftalmología Madrid 28026Spain e-Health Vision Department of OphthalmologyMadrid 28232Spain Gran Óptica Madrid Department of Dry EyeMadrid 28026Spain Ocupharm Research Group Department of Optometry and VisionFaculty of Optics and OptometryComplutense University of MadridMadrid 28037Spain

AIM:To evaluate the effect of lid scrubbing using a gel combining different natural extracts on ocular signs and symptoms of dry eye ***:A retrospective study was performed on 19 dry eye patients(51.1±16.0y).Non-invasive tear break-up time,tear meniscus height,meibomian gland loss,lipid layer thickness,conjunctival redness,corneal staining,ocular surface disease index(OSDI),and ocular pain intensity were measured before(baseline),1wk,and 2mo after lid scrubbing with a gel containing different natural extracts(okra extract,aloe vera leaf juice,hydrolysed soy protein,caffeine,citrus unshiu peel extract,and raspberry seed oil).RESULTS:Compared with the baseline,there was a statistically significant improvement in both first(P=0.048)and average(P=0.026)non-invasive tear break-up time 2mo after treatment,as well as in corneal staining(P=0.043,0.012),OSDI(P<0.001),and ocular pain intensity(P<0.001)after 1wk and *** addition,there was no correlation between ocular signs and ***:The lid scrubbing with a gel combining different natural extracts show beneficial effects on tear film stability,corneal damage,and ocular symptoms,which is the reason why this therapeutic procedure is proposed as an alternative for dry eye ***,it is not possible to attribute this beneficial effect solely to the presence of the natural extracts in the gel,primarily due to the absence of a negative control group.

关键词： lid hygiene natural extracts okra aloe vera soy dry eye

Exploring the Implications of Patient Advocacy Outcomes among Practicing Nurses within the Hospital Context: A Qualitative Research

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Open Journal of Nursing 2023年第12期13卷 855-874页

作者： Comfort Nsiah Paul Kukye-Ayiri Ninnoni mate.Siakwa Francis Nsiah School of Nursing and Midwifery University of Cape Coast Central Region Ghana School of Physical Sciences University of Cape Coast Central Region Ghana

Background: Nurses are expected by their international code of ethics to advocate for patients to enhance safety and quality care. However, there is a limited understanding regarding the implications of specific patient advocacy outcomes experienced by nurses who advocate for patients in the hospital context. Purpose: This study explored the implications of patient advocacy outcomes experienced among practicing nurses in the hospital context. Methods: A qualitative, descriptive study design was utilized. Data was collected through purposive sampling and an in-depth semi-structured interview of 25 Registered Nurses in an acute care hospital. An inductive qualitative content analysis method was used, and the SRQR guidelines for reporting qualitative studies were followed. Results: This study revealed that nurses who succeeded in advocating for patients experienced feelings of happiness, increased confidence levels, increased work output, and job satisfaction. However, nurses who failed to succeed in advocating for patients experienced physical, emotional, and psychological consequences, which contributed negatively to the quality of patient care. Therapeutic communication and nurses’ commitment to intervene for patients emerged as vital qualities and skills required to succeed in the patient advocacy process. Conclusions: This study showed that patient advocacy has advantages. However, when nurses fail to succeed in their attempt to advocate for patients in clinical practice, the outcomes can negatively affect their own well-being and the quality of patient care delivery. These study results could promote awareness and help nurses to develop strategies for improving patient advocacy activities based on their experiences. Additionally, nurses can seek help, including psychological counseling, when necessary to enhance their optimal well-being as they care for their patients. Nursing educational institutions and hospital managers can support, train, and equip nurses wit

关键词： Implications Patient Advocacy Nurses Advocacy Outcomes Qualitative Research

Suture granuloma of the abdominal wall with intra-abdominal extension 12 years after open appendectomy

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World Journal of Gastroenterology 2009年第32期15卷 4083-4086页

作者： Goran Augustin Dragan Korolija mate.Skegro Jasminka Jakic-Razumovic Department of Surgery Division of Abdominal SurgeryUniversity Hospital Center ZagrebKipatieva 1210000 ZagrebCroatia Department of Pathology University Hospital Center Zagreb Kipatieva 1210000 ZagrebCroatia

Most complications after appendectomy occur within ten days; however, we report the unusual case of a suture granuloma 12 years after open appendectomy. The afebrile 75-year-old woman presented with a slightly painful palpable mass in the right lower abdomen. There was no nausea or vomiting and bowel movements were normal. She lost 10 kg during the 3 mo before presentation. The patient had undergone an appendectomy 12 years previously. Physical examination revealed a tender mass, 10 cm in diameter, under the appendectomy scar. The preoperative laboratory findings, tumor markers and plain abdominal radiographs were normal. Multi-slice computed tomography scanning showed an inhomo-genous abdominal mass with minimal vascularization in the right lower abdomen 8.6cm×8cm×9 cm in size which communicated with the abdominal wall. The abdominal wall was thickened, weak and bulging. The abdominal wall mass did not communicate with the cecum or the ascending colon. Complete excision of the abdominal wall mass was performed via median laparotomy. Histopathological examination revealed a granuloma with a central abscess. This case report demonstrates that a preoperative diagnosis of abdominal wall mass after open appendectomy warrants the use of a wide spectrum of diagnostic modalities and consequently different treatment options.

关键词：肉芽肿缝合组织病理学检查腹腔诊断方法实验室检查肿瘤标志物身体检查

Insight into the antifungal mechanism of Neosartorya fischeri antifungal protein

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Protein & Cell 2015年第7期6卷 518-528页

作者： mate.Viragh Annamaria Marton Csaba Vizier Liliana Toth Csaba Vagvolgyi Florentine Marx Laszlo Galgoczy Department of Microbiology Faculty of Science and Informatics University of Szeged Szeged Hungary Institute of Biochemistry Biological Research Centre Hungarian Academy of Sciences Szeged Hungary Division of Molecular Biology Biocenter Innsbruck Medical University Innsbruck Austria

Small, cysteine-rich, highly stable antifungal proteins secreted by filamentous Ascomycetes have great po- tential for the development of novel antifungal strate- gies. However, their practical application is still limited due to their not fully clarified mode of action. The aim of this work was to provide a deep insight into the anti-fungal mechanism of Neosartorya fischeri antifungal protein （NFAP）, a novel representative of this protein group. Within a short exposure time to NFAP, reduced cellular metabolism, apoptosis induction, changes in the actin distribution and chitin deposition at the hyphal tip were observed in NFAP-sensitive Aspergillus nidulans. NFAP did show neither a direct membrane disrupting- effect nor uptake by endocytosis. Investigation of A. nidulans signalling mutants revealed that NFAP acti- vates the cAMP/protein kinase A pathway via G-protein signalling which leads to apoptosis and inhibition of polar growth. In contrast, NFAP does not have any in- fluence on the cell wall integrity pathway, but an un- known cell wall integrity pathway-independent mitogen activated protein kinase A-activated target is assumed to be involved in the cell death induction. Taken to- gether, it was concluded that NFAP shows similarities, but also differences in its mode of antifungal action compared to two most investigated NFAP-related pro-teins from Aspergillus giganteus and Penicillium chrysogenum.

关键词： Neosartorya fischeri antifungal protein,Aspergillus nidulans cAMP/Pka signalling Pkc/Mpksignalling antifungal mechanism

First molecular identification of multiple tick‑borne pathogens in livestock within Kassena‑Nankana,Ghana

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Animal Diseases 2023年第1期3卷 21-34页

作者： Seth Offei Addo Ronald Essah Bentil Kevin Nii Yartey Jane Ansah‑Owusu Eric Behene Selassie Bruku Victor Asoala Suzanne mate.John Asiedu Larbi Philip Kweku Baidoo Michael David Wilson Joseph W.Diclaro II Samuel K.Dadzie Parasitology Department Noguchi Memorial Institute for Medical ResearchCollege of Health SciencesUniversity of GhanaAccraGhana Department of Theoretical and Applied Biology College of ScienceKNUSTKumasiGhana Department of Epidemiology Noguchi Memorial Institute for Medical ResearchCollege of Health SciencesUniversity of GhanaAccraGhana Navrongo Health Research Centre Upper East RegionNavrongoGhana U.S.Army Emerging Infectious Diseases Branch Walter Reed Army Institute of ResearchSilver SpringMDUSA Navy and Marine Corps Public Health Center Center for Disease Control and Prevention DetachmentAtlantaGAUSA

The risk of pathogen transmission continues to increase significantly in the presence of tick vectors due to the trade of livestock across *** Ghana,there is a lack of data on the incidence of tick-borne pathogens that are of zoonotic and veterinary *** study,therefore,aimed to determine the prevalence of such pathogens in livestock using molecular approaches.A total of 276 dry blood spots were collected from cattle(100),sheep(95)and goats(81)in the Kassena-Nankana *** samples were analyzed using Polymerase Chain Reaction(qPCR)and conventional assays and Sanger sequencing that targeted pathogens including Rickettsia,Coxiella,Babesia,Theileria,Ehrlichia and *** overall prevalence of 36.96%was recorded from the livestock DBS,with mixed infections seen in 7.97%***,the prevalence of infections in livestock was recorded to be 19.21%in sheep,14.13%in cattle,and 3.62%in *** pathogens identified were Rickettsia spp.(3.26%),Babesia ***(8.70%),Theileria orientalis(2.17%),Theileria parva(0.36%),Anaplasma capra(18.48%),Anaplasma phagocytophilum(1.81%),Anaplasma marginale(3.26%)and Anaplasma ovis(7.25%).This study reports the first molecular identification of the above-mentioned pathogens in livestock in Ghana and highlights the use of dry blood spots in resource-limited *** addition,this research provides an update on tick-borne pathogens in Ghana,suggesting risks to livestock production and human *** studies will be essential to establish the distribution and epidemiology of these pathogens in Ghana.

关键词： Livestock Rickettsia Babesia Theileria Ehrlichia Anaplasma

Solid state reaction for the formation of spinel MgFe_2O_4 across perovskite oxide interface

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Science China(Physics,Mechanics & Astronomy) 2017年第9期60卷 80-84页

作者： Iftikhar Ahmed Malik XiaoXing Ke Xin Liu ChuanShou Wang XueYun Wang Rizwan ullah ChuangYe Song Jing Wang JinXing Zhang Department of Physics Beijing Normal University Institute of Microstructure and Property of Advanced mate.ials Beijing University of Technology Department of Physics University of Science and Technology Beijing

Solid state reaction is a conventional method to synthesize structurally stable inorganic solids by mixing powdered reactants together at high pressure(over 1×10~5 mbar(1 mbar=100 Pa))and high temperature(over 1300 K)[1-4].This method is effective and sophisticated to prepare solid mate.ials,especially the functional complex oxides such as high temperature superconductors,piezoelectrics,dielectrics,***,the chemical reactions cannot be intrinsically controlled and integrated at an atomic level in order to

关键词：固相反应界面形成钙钛矿型氧化物 MgFe2O4 尖晶石脉冲激光沉积高温超导体控制界面

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最值得拥有的十大数码摄像机

数字世界 2002年第6期 54-59页

作者： mate

SONY TRV15E 10倍光学变焦专业“蔡司”镜头彩色取景器超级电子防抖系统 12比特混音功能超级红外线夜摄功能数码程式编辑数码特技效果相片模式逆光补偿按钮智慧型配件适配器镁金属机身数码变焦智慧型锂电池(M)

关键词：数码摄像机 SONY-TRVISE SONY-TRV30E 索尼摄像机松下佳能

Gardner's syndrome:Genetic testing and colonoscopy are indicated in adolescents and young adults with cranial osteomas:A case report

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World Journal of Gastroenterology 2007年第28期13卷 3900-3903页

作者： Dubravko Smud Goran Augustin Tihomir Kekez Emil Kinda mate.Majerovic Zeljko Jelincic Department of Surgery Division of Abdominal SurgeryClinical Hospital Center ZagrebZagrebCroatia

We present a case of a 25-year-old female with diagnosed familial adenomatous polyposis and elevated carcinoembryonic antigen with negative family history. The suspicion of Gardner's syndrome was raised because extirpation of an osteoma of the left temporo-occipital region was made 10 years ago. Restorative procto-colectomy and ileal pouch anal anastomosis was made but histology delineated adenocarcinoma of the rectum (Dukes C stage). We conclude that cranial osteomas often precede gastrointestinal manifestations of familial adenomatous polyposis or Gardner's syndrome and such patients should be evaluated with genetic testing followed by colonoscopy if results are positive to prevent the development of colorectal carcinoma. If the diagnosis is positive all family members should be evaluated for familial adenomatous polyposis.

关键词：加特纳综合征家族性腺瘤状息肉头盖骨骨瘤结肠镜检查基因测试

Perception of Local Populations of Bouba-Ndjidda National Park on Indigenous Knowledge and the Impact of Climate.Change on Biodiversity Conservation

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Open Journal of Ecology 2023年第11期13卷 865-881页

作者： Ghislain Noé Kougoum Piebeng Samuel Christian Tsakem Kalgongbe Kiebfiene Tikela Bakwo Fils Eric Moise Simon Awafor Tamungang Michel Babale Jean-Pierre mate.Mweru Isaac Diansambu Makanua Bouba Hotta Vincent Zoalang Mala Krossy Mavakala Raoul Sambieni Kouakou Baudouin Michel Department of Biological Sciences Faculty of Science University of Maroua Maroua Cameroon Garoua Wildlife School Garoua Cameroon Department of Forestry and Wildlife Management College of Technology University of Bamenda Bamenda Cameroon Regional Post-Graduate Training School on Integrated Management of Tropical Forests and Lands Kinshasa Democratic Repub-lic of the Congo Faculty of Science University of Kinshasa Kinshasa Democratic Republic of the Congo

This study deals with the perceptions of indigenous knowledge in the field of conservation and the impact of climate.change on biodiversity in the peripheral villages of the Bouba-Ndjidda National Park (PNBN), Department of Mayo-Rey, Cameroon. To this end, 23 out of 70 villages in the study area were selected, for a sample of 368 households surveyed through a questionnaire addressed to the heads of households. Data collection took place from August 27 to December 22, 2022. The results reveal that 70.7% of the population living near the PNBN practice agriculture as their main income-generating activity, followed by livestock (23.3%) and trade (6%). Knowledge in the field of the conservation of natural resources is rooted in occultism through rituals and sacrifices (99.50%) offered to the geniuses of nature and prohibitions on the felling of trees and sacred animals (13.00%). The populations perceive climate.change through the variation of the seasons (97.60%), the increase in temperature (84.80%), the reduction in the duration of the rainy seasons (54.60%), the drop in agricultural yield (84.80%) and floods (74.70%). The consequence of these changes on wildlife is the disappearance of animal species such as the Rhinoceros, the Wild Dog, the Cheetah and the Ostrich. In order to cope with climate.change, the natives have developed strategies such as the adoption of early crop varieties (maize, millet, soybeans, etc.), the reorganization of the agricultural calendar, the practice of reforestation, extension of field surfaces, the cessation of excessive deforestation and uncontrolled bush fires, the construction of fired brick houses, the practice of irrigation, seasonal migration and occultism. This indigenous knowledge is a perfect adaptation to climate.change and makes it possible to better take into account the vision of local populations in the conservation of biodiversity.

关键词： Perception Indigenous Knowledge Climate.Change Biodiversity Conservation Bouba-Ndjidda National Park