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A pioneering survey of deep-diving and off-shore cetaceans in the northern South China Sea

Integrative Zoology 2021年第4期16卷 440-450页

作者： Mingli LIN Mingming LIU Francesco CARUSO massimiliano ROSSO Xiaoming TANG Lijun DONG Wenzhi LIN Anna BORRONI Alessandro BOCCONCELLI Liang DAI Songhai LI Marine Mammal and Marine Bioacoustics Laboratory Institute of Deep-sea Science and EngineeringChinese Academy of SciencesSanyaHainanChina University of Chinese Academy of Sciences BeijingChina CIMA Research Foundation SavonaItaly Woods Hole Oceanographic Institution Woods HoleMassachusettsUSA

A pioneering boat-based survey was conducted in 2019,to gather baseline information regarding the presence,composition,relative abundance,and spatial distribution of deep-diving and off-shore cetaceans in the northern South China Sea(SCS).A total of 27 sightings comprising at least 8 cetacean species were recorded during the 13-day survey,including 5 deep-diving species(***’s dolphin[Grampus griseus],short-finned pilot whale[Globicephala macrorhynchus],sperm whale[Physeter macrocephalus],Cuvier’s beaked whale[Ziphius cavirostris],and an unidentified beaked whale[either the ginkgo-toothed beaked whale,Mesoplodon ginkgodens,or Deraniyagala’s beaked whale,Mesoplodon hotaula]),as well as 3 off-shore dolphins(*** spotted dolphin[Stenella attenuate],striped dolphin[Stenella coeruleoalba],and Fraser’s dolphin[Lagenodelphis hosei]).With the exception of pantropical spotted dolphins,all other species were sighted and recorded at sea in the northern SCS for the first *** pantropical spotted dolphin was the most frequently sighted species,comprising 30%of the total ***-diving cetaceans were mainly sighted in the northern Xisha Archipelago,whereas off-shore dolphins were distributed across the survey *** pantropical spotted dolphin was observed in aggregations of more than 100 individuals and nearly all encountered species included calves;these findings suggested that the survey area functions as an important feeding and calving ground for various cetacean *** pioneering survey provides fundamental information regarding cetacean fauna in the northern SCS and highlights the need to strengthen research and conservation efforts concerning these species.

关键词： cetacean diversity deep divers dolphins South China Sea whales

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A Critical Approach to the Tourism Management

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Open Journal of Applied Sciences 2019年第5期9卷 335-341页

作者： Federico De Andreis massimiliano Carioni Università degli Studi Giustino Fortunato Benevento Italy

Tourist destination and, generally, tourist activities not only represent an extraordinarily important economic factor, but also an instrument of knowledge and personal empowerment. Therefore, we can state that it is essential to ensure access to the tourism experience to all citizens, regardless of personal, social, economic conditions and any other nature which may limit the fruition of this asset. The role of tourism management is to develop effective strategic plan in order to guarantee a possible growth of a destination, without having a negative impact on the resources, either natural or civilian of the destination itself. Tourist destinations follow a life-cycle (evolution cycle) based on a price factor (a greater attractiveness of an area means a greater willingness to pay of the tourists) and a trend factor (related to the fame of the area and to the evolution of tourists’ tastes and habits). These factors mark the tourism in the contents and in the methods of production and consumption, related to the concepts of supply and demand, two dimensions that must be always connected with the principles of growth, accessibility and sustainability. This research paper aims to deepen the life-cycle approach of a tourist destination, underlining the option that the tourism management could offer to relaunch an area, however considering the principle of supportable growing.

关键词： Tourism Management Tourism Development Sustainability Sustainable Tourism Performance Analysis Life-Cycle

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Street floods in Metro Manila and possible solutions

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Journal of Environmental Sciences 2017年第9期29卷 39-47页

作者： Alfredo Mahar Lagmay Jerico Mendoza Fatima cipriano Patricia Anne Delmendo Micah Nieves Lacsamana Marc Anthony Moises Nicanor Pellejera III Kenneth Nino Punay Glenn Sabio Laurize Santos Jonathan Serrano Herbert James Taniza Neil Eneri Tingin National Institute of Geological Sciences University of the PhilippinesQuezon City 1101Philippines Nationwide Operational Assessment of Hazards PhiI-LiDAR 1Flood Modelling Component UP NIGSQuezon City 1101Philippines

Urban floods from thunderstorms cause severe problems in Metro Manila due to road traffic. Using Light Detection and Ranging（Li DAR）-derived topography, flood simulations and anecdotal reports, the root of surface flood problems in Metro Manila is *** of flood-prone areas are along the intersection of creeks and streets located in topographic lows. When creeks overflow or when rapidly accumulated street flood does not drain fast enough to the nearest stream channel, the intersecting road also gets *** solutions include the elevation of roads or construction of well-designed drainage structures leading to the creeks. Proposed solutions to the flood problem of Metro Manila may avoid paralyzing traffic problems due to short-lived rain events, which according to Japan International Cooperation Agency（JICA） cost the Philippine economy 2.4 billion pesos/day.

关键词： Flood modeling LiDAR Urban flooding

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Base Isolation Seismic Retrofit of a Hospital Building in Italy

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Journal of Civil Engineering and Architecture 2012年第3期6卷 308-321页

作者： massimiliano Ferraioli Alberto Maria Avossa Department of Civil Engineering Second University of Naples via Roma 29 81031 Aversa CE Italy

The paper deals on a significant retrofit project currently under construction of an existing hospital building in Avellino （Italy）. The seismic retrofit was realized by connecting together the first floors of the three existing structures and by creating a unique isolation system composed of high damping rubber bearings and sliding devices. The base isolation is achieved by gradually cutting the building from foundation and installing the isolators at the level of upper edge of the columns. The study allows the verification of the adequacy of the isolation system, showing the benefits of the application of the isolation devices, the limitations and the characteristics of their performance.

关键词： Seismic retrofit base isolation seismic response.

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鄂尔多斯盆地西南部三叠纪末抬升剥蚀事件及热年代学记录

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岩石学报 2020年第4期36卷 1199-1212页

作者：王建强刘池洋赵红格张东东 ZATTIN massimiliano 彭恒大陆动力学国家重点实验室西北大学地质学系西安710069 帕多瓦大学地球科学学院帕多瓦35131

三叠纪末期大型鄂尔多斯盆地遭受了中生代成盆以来首次较大规模的抬升剥蚀,显著改造了中晚三叠世延长期盆地面貌,并控制了侏罗纪早期沉积格局和油藏分布,对盆地演化及矿产资源分布产生了重要影响。本文利用地质及大量钻井资料揭示了该... 详细信息

三叠纪末期大型鄂尔多斯盆地遭受了中生代成盆以来首次较大规模的抬升剥蚀,显著改造了中晚三叠世延长期盆地面貌,并控制了侏罗纪早期沉积格局和油藏分布,对盆地演化及矿产资源分布产生了重要影响。本文利用地质及大量钻井资料揭示了该期构造事件对盆地的剥蚀改造特征,盆地及周邻地区磷灰石裂变径迹年代学记录并约束了此次构造抬升的时限与过程;综合周邻区域构造研究成果,探讨了其发育的动力学背景。结果表明,鄂尔多斯盆地三叠纪末期的剥蚀具西南强、东北弱的特点,西南部大范围内延长组地层残缺不全,剥蚀量最大可达1000余米;前侏罗纪沉积古地貌总体呈西南高、北东低的特点;其抬升时间始于205~190Ma,西南部稍早于盆地腹部,抬升速率大于1℃/Myr,可持续至中侏罗世(约160Ma)。该期抬升剥蚀事件范围可涉及至盆地西南缘更广阔的区域,与同期秦岭造山带内出现的快速抬升冷却事件具有较好的时空耦合关系,是对秦岭造山带区域构造环境转变的响应和纪录。该研究丰富和发展了三叠纪末期构造事件在华北克拉通的影响,对该区油气、煤炭资源的进一步勘探和评价提供了新的思路,具有一定的现实意义。

关键词：鄂尔多斯盆地西南部三叠纪末抬升剥蚀磷灰石裂变径迹秦岭造山带地质动力背景

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晚三叠世-早侏罗世祁连山东部隆升的裂变径迹年代学证据及地质意义

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地球科学 2018年第6期43卷 1983-1996页

作者：彭恒王建强 massimiliano Zattin 刘池洋韩鹏张少华西北大学大陆动力学国家重点实验室陕西西安710069 西北大学地质学系陕西西安710069 帕多瓦大学地球科学学院意大利帕多瓦35131 中国石油长庆油田公司勘探开发研究院陕西西安710018

祁连山东北部为青藏高原隆升和东扩的前锋带,新生代以来经历了快速隆升和强烈剥露改造过程,致使前新生代地层面目全非,中生代陆内构造演化事件研究仍较薄弱,缺乏年代学的约束.为揭示和分析祁连山东部中生代构造隆升时限与过程,进而探讨... 详细信息

祁连山东北部为青藏高原隆升和东扩的前锋带,新生代以来经历了快速隆升和强烈剥露改造过程,致使前新生代地层面目全非,中生代陆内构造演化事件研究仍较薄弱,缺乏年代学的约束.为揭示和分析祁连山东部中生代构造隆升时限与过程,进而探讨秦祁造山带中生代陆内构造演化特点及区域动力学环境.主要采用物源分析、碎屑沉积物及基岩磷灰石裂变径迹定年,并结合裂变径迹热史反演模拟技术开展研究.研究表明,研究区侏罗系龙凤山组为近源的断陷盆地沉积,物源主要来自其周邻前中生代地层;其碎屑磷灰石裂变径迹未发生重置,年龄、径迹长度特征表明其源区在晚三叠世(±215Ma)出现了快速冷却事件,同时东北部基岩裂变径迹热史模拟结果亦显示其较好地记录了该期事件,这与前人利用40 Ar-39 Ar年代学所揭示的西秦岭地区中晚三叠世快速抬升事件具时空统一性.分析表明研究区晚三叠世-早侏罗世发生了快速抬升事件,并认为该构造隆升事件是对中晚三叠世勉略洋闭合、秦岭最终碰撞造山过程的响应.

关键词：晚三叠世-早侏罗世北祁连磷灰石裂变径迹碰撞造山隆升剥蚀石油地质构造

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Gastrointestinal complications after kidney transplantation

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World Journal of Gastroenterology 2020年第38期26卷 5797-5811页

作者： Rossella Gioco Daniela Corona Burcin Ekser Lidia Puzzo Gaetano Inserra Flavia Pinto Chiara Schipa Francesca Privitera Pierfrancesco Veroux massimiliano Veroux General Surgery Unit University Hospital of CataniaCatania 95123Italy Department of Biomedical and Biotechnological Sciences University of CataniaCatania 95123Italy Department of Surgery Indiana University School of MedicineIndianapolisIN 46202United States Pathology Unit Department of Medical and Surgical Sciences and Advanced TechnologiesUniversity of CataniaCatania 95123Italy Gastroenterology Unit Department of Clinical and Experimental MedicineUniversity of CataniaCatania 95100Italy Organ Transplant Unit University Hospital of CataniaCatania 95123Italy General Surgery Unit Organ Transplant UnitUniversity Hospital of CataniaCatania 95123Italy Department of Medical and Surgical Sciences and Advanced Technologies University Hospital of CataniaCatania 95123Italy

Gastrointestinal complications are common after renal transplantation,and they have a wide clinical spectrum,varying from diarrhoea to post-transplant inflammatory bowel disease(IBD).Chronic immunosuppression may increase the risk of post-transplant infection and medication-related injury and may also be responsible for IBD in kidney transplant re-cipients despite *** the various forms of post-transplant colitis is challenging,since most have similar clinical and histological ***-related colitis are the most frequently encountered colitis after kidney transplantation,particularly those related to the chronic use of mycophenolate mofetil,while de novo IBDs are quite *** review will explore colitis after kidney transplantation,with a particular focus on different clinical and histological features,attempting to clearly identify the right treatment,thereby improving the final outcome of patients.

关键词： Inflammatory bowel disease Kidney transplantation Solid organ transplantation Crohn disease Ulcerative colitis Mycophenolate mofetil colitis Mycophenolate mofetil Colitis Cytomegalovirus

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Addition of heparin binding sites strongly increases the bone forming capabilities of BMP9 in vivo

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Bioactive Materials 2023年第11期29卷 241-250页

作者： Claudia Siverino Shorouk Fahmy-Garcia Viktoria Niklaus Nicole Kops Laura Dolcini massimiliano Maraglino Misciagna Yanto Ridwan Eric Farrell Gerjo JVMvan Osch Joachim Nickel Department of Tissue Engineering and Regenerative Medicine University Hospital WuerzburgWuerzburgGermany Department of Orthopaedics and Sports Medicine Erasmus MCUniversity Medical CenterRotterdamthe Netherlands Department of Internal Medicine Erasmus MCUniversity Medical CenterRotterdamthe Netherlands Department of Oral and Maxillofacial Surgery Erasmus MCUniversity Medical CenterRotterdamthe Netherlands Fin-Ceramica Faenza SpA Via Granarolo 177/348018FaenzaItaly AMIE Core Facility Erasmus University Medical CenterRotterdamthe Netherlands Department of Otorhinolaryngology Head and Neck SurgeryErasmus MCUniversity Medical CenterRotterdamthe Netherlands Department of Biomechanical Engineering Faculty of MechanicalMaritime and Materials EngineeringDelft University of TechnologyDelftthe Netherlands Fraunhofer ISC Translational Center RTWuerzburgGermany

Bone Morphogenetic proteins(BMPs)like BMP2 and BMP7 have shown great potential in the treatment of severe bone *** recent in vitro studies,BMP9 revealed the highest osteogenic potential compared to other BMPs,possibly due to its unique signaling pathways that differs from other osteogenic ***,in vivo the bone forming capacity of BMP9-adsorbed scaffolds is not superior to BMP2 or *** silico analysis of the BMP9 protein sequence revealed that BMP9,in contrast to other osteogenic BMPs such as BMP2,completely lacks so-called heparin binding motifs that enable extracellular matrix(ECM)interactions which in general might be essential for the BMPs’osteogenic ***,we genetically engineered a new BMP9 variant by adding BMP2-derived heparin binding motifs to the N-terminal segment of BMP9′s mature *** resulting protein(BMP9 HB)showed higher heparin binding affinity than BMP2,similar osteogenic activity in vitro and comparable binding affinities to BMPR-II and ALK1 compared to ***,remarkable differences were observed when BMP9 HB was adsorbed to collagen scaffolds and implanted subcutaneously in the dorsum of rats,showing a consistent and significant increase in bone volume and density compared to BMP2 and *** at 10-fold lower BMP9 HB doses bone tissue formation was *** innovative approach of significantly enhancing the osteogenic properties of BMP9 simply by addition of ECM binding motifs,could constitute a valuable replacement to the commonly used *** possibility to use lower protein doses demonstrates BMP9 HB’s high translational potential.

关键词： Bone morphogenetic protein 9(BMP9) Heparin binding sites Bone regeneration Subcutaneous animal model

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How to reduce bacillus Calmette-Guerin discontinuation in patients with severe functional impairment

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Current Urology 2022年第3期16卷 160-167页

作者： Luca Di Gianfrancesco Mauro Ragonese massimiliano Foti Giuseppe Palermo Emilio Sacco PierFrancesco Bassi Marco Racioppi Clinica Urologica Fondazione Policlinico Universitario"Agostino Gemelli"IRCCS-Università Cattolica del Sacro Cuore di RomaRome800168Italy

Background:Severe functional impairment is often considered a contraindication to intravesical therapy for nonmuscle-invasive bladder cancer(NMIBC).A tailored intravesical bacillus Calmette-Guérin(BCG)procedure was evaluated in high-risk(HR)-NMIBC patients with severe functional *** and methods:Patients with a Katz Index score of 2 or less and an initial diagnosis of HR-NMIBC with atraumatic insertion of a Foley-type indwelling catheter,bladder emptying,and BCG instillation were prospectively treated;after 2 hours,the bladder was emptied and the catheter was removed(group A).After propensity score matching,52 patients in group A were compared with that of 52 consecutive patients in group B using a retrospective database,with similar baseline/oncological characteristics and treated with standard intermittent ***,groups A and B were compared with that of 130 consecutive patients(group C)retrospectively evaluated,with similar oncological characteristics but with a Katz Index score of 3 or greater and treated with standard intermittent ***:The discontinuation rates were 11.5%,35%,and 9%in groups A,B,and C,respectively(A vs.B,log-rank score 42.52[po0.05]).The overall adverse event rates were 38.5%,57.7%,and 39.2%,respectively(A vs.B,p=0.04;B vs.C,0.03;A vs.C,0.92).The rates of severe adverse events were 1.9%,1.9%,and 1.5%,respectively,without statistically significant *** cumulative HR disease-free survival rates were 63.4%,48%,and 69.2%,respectively(A vs.B,log-rank score 154.9[p<0.05];B vs.C,415[p<0.05];A vs.C,244[p<0.05]).Conclusions:A tailored intravesical instillation procedure may reduce BCG discontinuation and adverse effects.

关键词： Intravesical bacillus Calmette-Guérin Discontinuation rate Adverse event Tailored procedure Severe functional impairment

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COVID-19-induced liver injury in adult patients:A brief overview

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World Journal of Virology 2022年第6期11卷 443-452页

作者： Martina Grando massimiliano Balbi Marco Zeppieri Department of Internal Medicine Azienda Sanitaria Friuli OccidentaleSan Vito al Tagliamento 33078Italy Department of Ophthalmology University Hospital of UdineUdine 33100Italy

Coronavirus disease has spread worldwide since 2019,causing important pandemic issues and various social health problems to *** is known about the origin of this virus and the effects it has on extra-pulmonary *** different mechanisms of the virus and the influence it has on humans are still being studied,with hopes of finding a cure for the disease and the pathologies associated with the *** damage caused by coronavirus disease 2019(COVID-19)is sometimes underestimated and has been of important clinical interest in the past few *** dysfunctions can manifest in different forms which can sometimes be mild and without specific signs and symptoms or be severe with important clinical *** are several studies that have tried to explain the mechanism of entry(hepatotropism)of the virus into hepatocytes and the effects the virus has on this important *** clearly emerges from the current literature is that hepatic injury represents an important clinical aspect in the management of patients infected with COVID-19,especially in frail patients and those with *** aim of our brief overview is to summarize the current literature regarding the forms of hepatic damage,complications,mechanisms of pathology,clinical features of liver injury,influence of comorbidities and clinical management in patients with COVID-19 infection.

关键词： COVID-19 SARS-CoV-2 Hepatotropism Hepatic injury Cirrhosis Cytokine storm Angiotensin-converting enzyme 2

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