COVID-19-induced liver injury in adult patients:A brief overview
作者机构：Department of Internal MedicineAzienda Sanitaria Friuli OccidentaleSan Vito al Tagliamento 33078Italy Department of OphthalmologyUniversity Hospital of UdineUdine 33100Italy
出 版 物：《World Journal of Virology》 (世界病毒学杂志)
年 卷 期：2022年第11卷第6期
页 面：443-452页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：COVID-19 SARS-CoV-2 Hepatotropism Hepatic injury Cirrhosis Cytokine storm Angiotensin-converting enzyme 2
摘 要：Coronavirus disease has spread worldwide since 2019,causing important pandemic issues and various social health problems to *** is known about the origin of this virus and the effects it has on extra-pulmonary *** different mechanisms of the virus and the influence it has on humans are still being studied,with hopes of finding a cure for the disease and the pathologies associated with the *** damage caused by coronavirus disease 2019(COVID-19)is sometimes underestimated and has been of important clinical interest in the past few *** dysfunctions can manifest in different forms which can sometimes be mild and without specific signs and symptoms or be severe with important clinical *** are several studies that have tried to explain the mechanism of entry(hepatotropism)of the virus into hepatocytes and the effects the virus has on this important *** clearly emerges from the current literature is that hepatic injury represents an important clinical aspect in the management of patients infected with COVID-19,especially in frail patients and those with *** aim of our brief overview is to summarize the current literature regarding the forms of hepatic damage,complications,mechanisms of pathology,clinical features of liver injury,influence of comorbidities and clinical management in patients with COVID-19 infection.
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