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Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome-wide association and whole genome sequencing analyses

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Cancer Communications 2024年第2期44卷 287-293页

作者： Kouya Shiraishi Atsushi Takahashi Yukihide Momozawa Yataro Daigo Syuzo Kaneko Takahisa Kawaguchi Hideo Kunitoh Shingo Matsumoto Hidehito Horinouchi Akiteru Goto Takayuki Honda Kimihiro Shimizu Masahiro Torasawa Daisuke Takayanagi Motonobu Saito Akira Saito Yuichiro Ohe Shun-ichi Watanabe Koichi Goto Masahiro Tsuboi Katsuya Tsuchihara Sadaaki Takata Tomomi Aoi Atsushi Takano Masashi Kobayashi Yohei Miyagi Kazumi Tanaka Hiroyuki Suzuki Daichi Maeda Takumi Yamaura Maiko Matsuda Yoko Shimada Takaaki Mizuno Hiromi Sakamoto Teruhiko Yoshida Yasushi Goto Tatsuya Yoshida Taiki Yamaji Makoto Sonobe Shinichi Toyooka Kazue Yoneda Katsuhiro Masago Fumihiro Tanaka Megumi Hara Nobuo Fuse Satoshi S.Nishizuka Noriko Motoi Norie Sawada Yuichiro Nishida Kazuki Kumada Kenji Takeuchi Kozo Tanno Yasushi Yatabe Kuniko Sunami Tomoyuki Hishida Yasunari Miyazaki Hidemi Ito Mitsuhiro Amemiya Hirohiko Totsuka Haruhiko Nakayama Tomoyuki Yokose Kazuyoshi Ishigaki Toshiteru Nagashima Yoichi Ohtaki Kazuhiro Imai Ken Takasawa Yoshihiro Minamiya Kazuma Kobayashi Kenichi Okubo Kenji Wakai Atsushi Shimizu masayuki Yamamoto Motoki Iwasaki Koichi Matsuda Johji Inazawa Yuichi Shiraishi Hiroyoshi Nishikawa Yoshinori Murakami Michiaki Kubo Fumihiko Matsuda Yoichiro Kamatani Ryuji Hamamoto Keitaro Matsuo Takashi Kohno Division of Genome Biology National Cancer Center Research InstituteTokyoJapan Department of Clinical Genomics National Cancer Center Research InstituteTokyoJapan Laboratory for Statistical Analysis Center for Integrative Medical SciencesRIKENYokohamaJapan Department of Genomic Medicine Research InstituteNational Cerebral and Cardiovascular CenterOsakaJapan Laboratory for Genotyping Development Center for Integrative Medical SciencesRIKENYokohamaJapan Center for Antibody and Vaccine Therapy Research HospitalInstitute of Medical ScienceThe University of TokyoTokyoJapan Department of Medical Oncology and Cancer Center and Center for Advanced Medicine against CancerShiga University of Medical ScienceOtsuJapan Division of Medical AI Research and Development National Cancer Center Research InstituteTokyoJapan Center for Genomic Medicine Graduate School of MedicineKyoto UniversityKyotoJapan Department of Medical Oncology Japanese Red Cross Medical CenterTokyoJapan Department of Thoracic Oncology National Cancer Center Hospital EastJapan Department of Thoracic Oncology National Cancer Center HospitalTokyoJapan Department of Cellular and Organ Pathology Graduate School of MedicineAkita UniversityAkitaJapan Department of Respiratory Medicine Tokyo Medical and Dental UniversityBunkyo-kuTokyoJapan Division of General Thoracic Surgery Department of SurgeryShinshu University School of MedicineMatsumotoNaganoJapan Department of General Surgical Science Division of General Thoracic SurgeryGunma University Graduate School of MedicineIntegrative Center of General SurgeryGunma University HospitalGunmaJapan Department of Gastrointestinal Tract Surgery Fukushima Medical University School of MedicineFukushimaJapan StaGen Co. LtdTokyoJapan Division of Thoracic Surgery National Cancer Center HospitalTokyoJapan Department of Thoracic Surgery National Cancer Center Hospital EastChibaJapan Division of Translational Informatics Exploratory Oncology Research and Clinical Trial Center(EPOC

Dear editor,Lung carcinoma is responsible for the highest fatal-ity rate among cancer-related deaths globally,with lung adenocarcinoma(LADC)emerging as the prevailing sub-type.

关键词： adenocarcinoma lung Lung

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Design and Implementation of NAREGI SuperScheduler Based on the OGSA Architecture

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Journal of Computer Science & Technology 2006年第4期21卷 521-528页

作者： Satoshi Matsuoka masayuki Hatanaka Yasumasa Nakano Yuji Iguchi Toshio Ohno Kazushige Saga Hidemoto Nakada Global Scientific Information and Computing Center Tokyo Institute of Technology 2-12-10okayama Meguro-ku Tokyo 152-8550 Japan Center for Grid Research and Development National Institute of Informatics 1-105 Kanda-Jinbocho Chiyoda-ku Tokyo 101-0051 Japan Linux Software Development Div. Server Systems Unit. Fujitsu Limited 130 Miyamoto Numazu-shi Shizuoka410-0396 Japan Grid Technology Research Center National Institute of Advanced Industrial Science and Technology 1-18-13 Sotokanda Chiyoda-ku Tokyo 101-0021 Japan

NAREGI is a 5-year Japanese National Grid Project during 2003--2007, whose chief aim is to develop a set of grid middleware to serve as a basis for future e-Science. NAREGI also aims to lead the way in standardization of grid middleware, based on the OGSA architecture. Its super-scheduler is based on the proposed OGSA-EMS Architecture, in that it becomes the first working implementation that implements the documented component relationships within the OGSA-EMS architecture document v.l.0. Through the efforts and experience in the design and implementation, it has been confirmed that the documented OGSA-EMS architecture is quite feasible, but will require significant amount of refinement and speed improvements to finalize its detailed specifications. The super-scheduler also supports co-allocation across multiple sites to support automated execution of grid-based MPIs that execute across machines. Such a resource allocation requires sophisticated interactions between the OGSA-EMS components not covered in the current OGSA-EMS architecture, some of which are non-trivial. Overall, job scheduling with OGSA-EMS has proven to not only work, but also that its job allocation and execution time is within reasonable bounds.

关键词： grid scheduling resource management open grid services architecture OGSA

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Association between Diabetes Mellitus and Oral Health Status in Japanese Adults

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International Journal of Oral Science 2010年第2期2卷 82-89页

作者： masayuki Ueno Susumu Takeuchi Akiko Oshiro Kayoko Shinada Satoko Ohara Yoko Kawaguchi Department of Oral Health Promotion Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Department of Comprehensive Oral Health Care Faculty of Dentistry Tokyo Medical and Dental University

Aim The objective of this study was to analyze the oral health among Japanese adults, with and without diabetes mellitus. Methodology The subjects were 518 community residents aged 20 to 91 years in Japan, who participated in the ＂Akita health and nutrition survey＂ and the ＂Akita dental disease survey＂, conducted in 2006. The surveys comprised a self-administered questionnaire, along with medical and dental examinations. Results Using the community periodontal index （CPI）, the mean numbers of sextants presenting codes 0, 1 and 2 were significantly lower in diabetics than non-diabetics among the 59 years or younger age group. Although the mean numbers of sextants with codes 0, 1 and 2 among the 60 to 69 years age group were lower, and sextants with a code X among the 59 years or younger age group were higher in diabetics than non-diabetics, no statistically significant differences were detected. The tendency of lower mean numbers of natural teeth and functional tooth units in diabetics than non-diabetics was observed, however no differences were statistically significant. Conclusion The outcome of periodontal disease seemed to be influenced by the diabetic state to some degree, but a clear association between diabetes and oral health status was not found.

关键词： diabetes mellitus periodontal disease community periodontal index functional tooth units

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Hepatocellular carcinoma or interferon-based therapy history attenuates sofosbuvir/ribavirin for Japanese genotype 2 hepatitis C virus

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World Journal of Gastroenterology 2018年第13期24卷 1478-1485页

作者： Masayoshi Yada masayuki Miyazaki Kosuke Tanaka Akihide Masumoto Kenta Motomura Department of Hepatology Iizuka Hospital

AIM To investigate the real-world efficacy and safety of sofosbuvir/ribavirin(SOF/RBV) therapy for Japanese patients with genotype 2 hepatitis C virus(GT2-HCV).METHODS A total of 182 patients with GT2-HCV infection who received SOF/RBV therapy for 12 wk at our hospital were enrolled. The patients comprised 122 men and 60 women(age range: 17-84 years; mean age ± SD: 60.1 ± 12.1 years). Relationships between virological response and clinical data were examined by logistic regression analyses. RESULTS The proportions of patients with liver cirrhosis and history of hepatocellular carcinoma(HCC) were 29.0% and 17.3%, respectively. The proportion of patients with prior interferon(IFN)-based therapy was 25.6%. SOF/RBV therapy rapidly decreased HCV RNA levels. Several patients required RBV dose reduction because of anemia or fatigue. Four patients discontinued the therapy. The rates of sustained virological response at 12 wk after the end of treatment were 87.9%(intention to treat: 160/182) and 94.1%(per protocol: 159/169). Multivariate analyses showed that history of HCC or IFN-based therapy independently reduced the efficacy of SOF/RBV therapy. CONCLUSION SOF/RBV therapy for GT2-HCV is safe, highly tolerated, and effective. History of HCC or IFN-based therapy independently reduces the efficacy of this treatment.

关键词： Sofosbuvir Ribavirin Genotype 2 Hepatitis C virus Interferon-based therapy Hepatocellular carcinoma

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Gastric mixed adenoma-neuroendocrine tumor:A case report

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World Journal of Clinical Cases 2020年第22期8卷 5744-5750页

作者： Shuzo Kohno Hiroaki Aoki masayuki Kato Masaich Ogawa Kazuhiko Yoshida Department of Surgery The Jikei University Katsushika Medical CenterTokyo 125-8506Katsushika-kuJapan Department of Endoscopy The Jikei University Katsushika Medical CenterTokyo 125-8506Katsushika-kuJapan

BACKGROUND Gastric mixed adenoma-neuroendocrine tumors(NETs)are quite *** the 2019 world health organization classification of tumors of the digestive system,these were designated as a combination of grade 1 or grade 2 NETs and adenomas or tubular *** are no treatment guidelines for these tumors,and pathological and clinical studies are ***,we review previous case reports and present a case of gastric mixed *** SUMMARY A 66-year-old man underwent gastrointestinal endoscopy for the evaluation of upper abdominal *** examination of the biopsy specimen indicated the possibility of gastric cancer.A histopathological examination by endoscopic submucosal dissection showed a mixed adenoma-NET that was completely excised by endoscopic submucosal *** recurrence was observed on gastrointestinal endoscopy at the 6-mo *** Clinicians'awareness of this rare tumor is important for its timely diagnosis and treatment.

关键词： Adenoma Neuroendocrine tumor Diagnosis Pathology Stomach treatment Case report

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Production analysis of functionally distributed machines for underground mining

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International Journal of Mining Science and Technology 2016年第3期26卷 477-485页

作者： Fukui Rui Kusaka Kouhei Nakao masayuki Kodama Yuichi Uetake Masaaki Kawai Kazunari Department of Mechanical Engineering The University of Tokyo Komatsu Ltd.

Recent years, underground mining method is becoming popular because of its potentially high productivity and efficiency. In this method, a mining machinery; load haul dump(LHD), is used as both an excavator and a transporter of ore. This paper proposes a distributed system that realizes the excavation and transport functions with separated vehicles, an excavator and a transporter. In addition, this research proposes a mining map and configurations suitable for the proposed distributed system. To evaluate the productivity of the proposed system, a simulation environment has been developed. Analysis using the simulator reveals what performance factors of the excavator and the transporter have large impacts on the productivity. Simulation results also demonstrate the difference of potential between LHD system and the distributed system that can be explained based on their functions allocation.

关键词：分布式系统地下开采方法生产分析挖掘机械职能配置生产力运输车功能分离

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Enzymatic treatment of estrogens and estrogen glucuronide

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Journal of Environmental Sciences 2009年第6期21卷 731-735页

作者： Takaaki Tanaka Toshiyuki Tamura Yuuichi Ishizaki Akito Kawasaki Tomokazu Kawase Masahiro Teraguchi masayuki Taniguchi Department of Materials Science and Technology Niigata University Venture Business Laboratory Niigata University Department of Chemistry and Chemical Engineering Niigata University

Natural and synthetic estrogens from sewage treatment systems are suspected to influence the reproductive health of the animals in the rivers. In this article, we investigated the enzymatic treatment of three estrogens （estrone, 17β-estradiol, and 17α-ethynyletstradiol） by a fungal laccase which oxidize phenolic compounds with dissolved oxygen. The elimination of the estrogenic activities by enzymatic oxidation was demonstrated by medaka vitellogenin assay. In addition, we developed an enzymatic treatment system comprised of β-D-glucuronidase and the laccase for 17β-estradiol 3-（β-D-glucuronide） degradation. The two enzymes eliminated 17β-estradiol 3-（β- D-glucuronide） and the intermediate, 17β-estradiol, efficiently.

关键词： enzymatic treatment laccase estrone estradiol ethynylestradiol glucuronidase glucuronide

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Inactivation of severe fever with thrombocytopenia syndrome virus for improved laboratory safety

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Journal of Biosafety and Biosecurity 2020年第1期2卷 31-35页

作者： Toshihiko Harada Shuetsu Fukushi Takeshi Kurosu Tomoki Yoshikawa masayuki Shimojima Kiyoshi Tanabayashi masayuki Saijo Division of Biosafety Control and Research National Institute of Infectious DiseasesTokyoJapan Department of Virology 1 National Institute of Infectious DiseasesTokyoJapan

Severe fever with thrombocytopenia syndrome(SFTS),a tick-borne infectious disease with high mortality,is diagnosed by the serological testing of serum samples from patients in the acute and convalescent phases and/or by direct detection of the SFTS virus(SFTSV).Conventionally,heat and UV treatments have been used to inactivate the viruses present in serum samples before performing the serological ***,we examined the inactivation conditions optimal for SFTSV-containing serum samples to ensure the safety of laboratory workers while maintaining the accuracy of serological assay results *** human serum samples spiked with SFTSV to 60C for 30 min or exposing them to UV irradiation for 30 min,reduced the infectious virus titer below the limit of *** in sera from patients in the acute phase of SFTS was completely inactivated by heating to 60C for 30 min,followed by UV irradiation for 10 *** inactivation procedure had minimal impact on the performance of SFTSV antibody detection *** data provided herein can serve as a guide for laboratory workers and researchers working with SFTS serological tests.

关键词： Biosafety Inactivation Severe fever with thrombocytopenia syndrome(SFTSV) Serology

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Magnetostratigraphy of Late Tertiary sediments from the Chinese Loess Plateau and its paleoclimatic significance

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Chinese Science Bulletin 2001年第S1期46卷 16-22页

作者： SONG Yougui FANG Xiaomin masayuki Torii NAOTO Ishikawa LI Jijun AN Zhisheng National Laboratory of Western China’s Environmental Systems&Department of Geography Lanzhou UniversityLanzhou 730000China State Key Laboratory of Loess and Quaternary Geology Institute of Earth EnvironmentChinese Academy of SciencesXi’an 710075China Faculty of Informatics Okayama University of ScienceOkayama 700-0005Japan Graduate School of Human and Environment Studies Kyoto UniversityKyoto 606-8501Japan

The Late Tertiary red clay/bed sediments underlying the Quaternary loess-paleosol in the Chinese Loess Plateau possesses high-resolution paleoclimatic changes related to the uplift of the Tibetan Plateau. Magnetostratigra-phy and susceptibility measurements are discussed in this paper. The paleomagnetic results show that the red clay/bed began to accumulate at about 8.1 Ma, which represents the oldest Late Tertiary deposit continuously in the central Loess Plateau. The magnetic susceptibility curves show stepwise increases since the initiation of red clay, superimposed on several peaks. Moreover, the magnetic susceptibility increased abruptly since 3.8 Ma, which probably indicates the inception of the modern East Asia monsoon system. Between 3.8 and 2.6 Ma, the stepwise increases of susceptibility may imply progressively intensified East Asia summer monsoon activity related with the stepwise uplift process of the Tibetan Plateau.

关键词： magnetostratigraphy Late Tertiary red clay/red bed paleoclimatic change Chinese Loess Plateau.

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Inverted Meckel's diverticulum as a cause of occult lower gastrointestinal hemorrhage

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World Journal of Gastroenterology 2012年第42期18卷 6155-6159页

作者： Omar M Rashid Joseph K Ku masayuki Nagahashi Akimitsu Yamada Kazuaki Takabe Department of Surgery Virginia Commonwealth UniversityRichmondVA 23220United States Precision Plastic Surgery RiversideCA 92506United States

Meckel's diverticulum is a common asymptomatic congenital gastrointestinal anomaly,but rarely it can present with *** the last few years inverted Meckel's diverticulum has been reported in the literature with increasing frequency as an occult source of lower gastrointestinal ***,we report a case of a 54-year-old male,who was referred for surgical evaluation with persistent anemia and occult blood per rectum after a work up which failed to localize the source over 12 mo,including upper and capsule endoscopy,colonoscopy,enteroclysis,Meckel scan,and tagged nuclear red blood cell *** abdominal computed tomography scan showed a possible mid-ileal intussusception and intraluminal *** the abdominal exploration,inverted Meckel's diverticulum was diagnosed and *** review the literature,discuss the forms in which the disease presents,the diagnostic modalities utilized,pathological findings,and *** less than 40 cases have been reported in the English literature from 1978 to 2005,19 cases have been reported in the last 6 years alone(2006-2012) due to improved diagnostic *** diagnosis and treatment of this disease requires a high index of clinical suspicion,which is becoming increasingly relevant to general gastroenterologists.

关键词：消化道出血隐匿性诊断方法原因扫描显示英文文献评价工作手术切除

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