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Shape of Barrett's epithelium is associated with prevalence of erosive esophagitis

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World Journal of Gastroenterology 2010年第4期16卷 484-489页

作者： Tomoyuki Akiyama Masahiko Inamori Hiroshi Iida Hiroki Endo Kunihiro Hosono Yasunari Sakamoto Koji Fujita Masato Yoneda Hirokazu Takahashi Tomoko koide Chikako Tokoro Ayumu Goto Yasunobu Abe Takeshi Shimamura Noritoshi Kobayashi Kensuke Kubota Satoru Saito Atsushi Nakajima Gastroenterology Division Yokohama City University School of Medicine3-9 FukuuraKanazawa-kuYokohama 236-0004Japan

AIM:To test the hypothesis that the shape and length of Barrett's epithelium are associated with prevalence of erosive ***:A total study population comprised 869 patients who underwent endoscopy during a health checkup at our *** presence and extent of Barrett's epithelium were diagnosed based on the Prague C & M *** originally classified cases of Barrett's epithelium into two types based on its shape,namely,flamelike and lotus-like Barrett's epithelium,and into two groups based on its length,its C extent < 2 cm,and ≥ 2 *** of shape and length of Barrett's epithelium with erosive esophagitis was ***:Barrett's epithelium was diagnosed in 374 cases(43%).Most of these were diagnosed as shortsegment Barrett's *** prevalence of erosive esophagitis was significantly higher in subjects with flame-like than lotus-like Barrett's epithelium,and in those with a C extent of ≥ 2 cm than < 2 ***:Flame-like rather than lotus-like Barrett's epithelium,and Barrett's epithelium with a longer segment were more strongly associated with erosive esophagitis.

关键词： Barrett’s epithelium Esophagitis Endoscopy

characteristics of intestinal pseudo-obstruction in patients with mitochondrial diseases

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World Journal of Gastroenterology 2012年第33期18卷 4557-4562页

作者： Yusuke Sekino Masahiko Inamori Eiji Yamada Hidenori Ohkubo Eiji Sakai Takuma Higurashi Hiroshi Iida Kunihiro Hosono Hiroki Endo Takashi Nonaka Hirokazu Takahashi Tomoko koide Yasunobu Abe Eiji Gotoh Shigeru Koyano Yoshiyuki Kuroiwa Shin Maeda Atsushi Nakajima Gastroenterology Division Yokohama City University School of Medicine Yokohama 236-0004 Japan Department of Medical Education Yokohama City University School of Medicine Yokohama 236-0004 Japan Department of Neurology Yokohama City University School of Medicine Yokohama 236-0004 Japan

AIM: To reveal the frequency, characteristics and prognosis of chronic intestinal pseudo-obstruction (CIP) in mitochondrial disease patients. METHODS: Between January 2000 and December 2010, 31 patients (13 males and 18 females) were di-agnosed with mitochondrial diseases at our hospital. We conducted a retrospective review of the patients' sex, subclass of mitochondrial disease, age at onset of mitochondrial disease, frequency of CIP and the age at its onset, and the duration of survival. The age at onset or at the first diagnosis of the disorder that led to the clinical suspicion of mitochondrial disease was also examined. RESULTS: Twenty patients were sub-classified with mitochondrial encephalopathy with lactic acidosis and stroke-like episodes (MELAS), 8 with chronic progressive external ophthalmoplegia (CPEO), and 3 with myoclonus epilepsy associated with ragged-red fibers (MERRF). Nine patients were diagnosed with CIP, 8 of the 20 (40.0%) patients with MELAS, 0 of the 8 (0.0%) patients with CPEO, and 1 of the 3 (33.3%) patients with MERRF. The median age (range) at the diagnosis and the median age at onset of mitochondrial disease were 40 (17-69) and 25 (12-63) years in patients with CIP, and 49 (17-81) and 40 (11-71) years in patients without CIP. During the survey period, 5 patients (4 patients with MELAS and 1 with CPEO) died. The cause of death was cardiomyopathy in 2 patients with MELAS, cerebral infarction in 1 patient with MELAS, epilepsy and aspiration pneumonia in 1 patient with MELAS, and multiple metastases from gastric cancer and aspiration pneumonia in 1 patient with CPEO. CONCLUSION: Patients with CIP tend to have disorders that are suspected to be related to mitochondrial diseases at younger ages than are patients without CIP.

关键词：线粒体疾病肠梗阻患者假性死亡原因 CIP 心肌病生存时间

“Magicpro-NAVI MILL/LATHE on PC for700/70”的开发

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金属加工（冷加工） 2008年第16期 80-82页

作者： Akihiko koide MITSUBISHI ELECTRIC MECHATRONICS SOFTWARE CORPORATION

“Magicpro-NAVI MILL On PC for 700／70”“Magicpro-NAVI LATHE On PC for 700／70”是使MIT-SUBISHI CNC700／70系列产品上配置的简易程序创建功能“NAVI MILL”、“NAVI LATHE”能在市售PC上进行操作的软件。通过本软件，操作员可... 详细信息

关键词： PC NAVI 开发简易程序 NC程序操作员软件

A Patient with Intravenous Immunoglobulin-Responsive Lower Motor Neuron Syndrome

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International Journal of Clinical Medicine 2012年第3期3卷 190-193页

作者： Takaomi Kessoku Takashi koide Katsunori Akiyama Sachiko Irie Tadayuki Ishihara Fumihito Yoshii 2Department of Neurology Hiratsuka City Hospital Hiratsuka Japan Department of Internal Medicine Hiratsuka City Hospital Hiratsuka Japan Department of Neurology Hiratsuka City Hospital Hiratsuka Japan Department of Neurology Kitasato University School of Medicine Sagamihara Japan Department of Neurology National Hakone Hospital Odawara Japan Department of Neurology Tokai University School of Medicine Isehara Japan

We report a 50-year-old woman who developed localized proximal muscle weakness, in addition to transient elevation of antibodies to GM-1 ganglioside, without multifocal conduction block. She was treated with intravenous immunoglobulin (IVIg) and steroid pulse therapy, which were effective for over 10 years. Her clinical course and laboratory tests were consistent with lower motor neuron syndrome (LMNS) with localized proximal muscle weakness. We suggest that some patients diagnosed as LMNS may remain responsive to IVIg or steroid pulse therapy for a long time.

关键词： Lower Motor Neuron Syndrome (LMNS) Multifocal Motor Neuropathy (MMN) Localized Proximal Muscle Weakness Intravenous Immunoglobulin (IVIg) Anti-GM1 Ganglioside Antibody

Actual Status of Healthy Lifestyle Habits of Public Health Nurses in Japan

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Health 2018年第2期10卷 189-203页

作者： Yoko Nishida Keiko koide Reiko Okamoto Saori Iwamoto Kayoko Goda Hiroko Seki Yukiko Sugimoto Department of Nursing Faculty of Health and Welfare Kawasaki University of Medical Welfare Okayama Japan Faculty of Education Shitennoji University Osaka Japan Division of Health Sciences Graduate School of Medicine Osaka University Osaka Japan Graduate School of Biomedical Sciences Tokushima University Tokushima Japan Faculty of Nursing and Rehabilitation Konan Women’s University Hyogo Japan Former Graduate School of Health Sciences Okayama University Okayama Japan

Background: The public health nurse should make efforts to keep his/her own mental and physical health good, which is the professional responsibility. However, a variety of challenging issues have been pointed out with regard to well-being of healthcare professionals. Public health nurses are likely to face some difficulties in their habits of leading healthy lifestyles. The purpose of this study was to identify how Japanese public health nurses actually live their healthy lives. Methods: This study covered 1725 public health nurses in the Chugoku/Shikoku Region. We conducted an anonymous self-completed questionnaire survey. As basic attributes, the following 6 categories were set. The health practice indices used in this research consisted of the 7 practices of Breslow’s Health Practice Index (B-HPI), the Morimoto’s 8 practices, and 6 practices related to lifestyle habits that have been developed independently by the authors of this research (Health Lifestyle Index (HLI)), that is, 16 practices in total. The study plan was approved by the Ethics Committee of Okayama University. Results: We analyzed the 960 (55.7%) valid responses. This survey has demonstrated that the healthy life-style practices of public health nurses are generally good. However, there were some practices such as eating between meals, having little physical activity, and not having a good rest/sleep, that need to be improved. None of the assessment tools correlated with the length of experience. Conclusions: This survey has clarified that the healthy lifestyle practices of public health nurses did not correlated with their length of experience, indicating that the healthy lifestyle practices are not intensified by the accumulated career experience as public health nurses.

关键词： Public Health Nursing Related Factors Health Practice Breslow’s Health Practice

Maleylated-BSA induces TNF-α production through the ERK and NF-κB signaling pathways in murine RAW264.7 macrophages

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Open Journal of Immunology 2013年第4期3卷 184-189页

作者： Rui Tada Yusuke koide Mitsuaki Yamamuro Akira Hidaka Koichiro Nagao Yoichi Negishi Yukihiko Aramaki Department of Drug Delivery and Molecular Biopharmaceutics School of Pharmacy Tokyo University of Pharmacy and Life Sciences Tokyo Japan

Ligands for macrophage scavenger receptors are reported to induce a wide range of host cell responses, including the production of inflammatory cytokines;however, the underlying mechanisms have not yet been fully understood and which remain obscure. In this study, we have examined the effect of maleylated bovine serum albumin (maleylated-BSA), a well-known ligand of the scavenger receptor, on the murine macrophage cell line RAW264.7. Maleylated-BSA strongly induced the production of tumor necrosis factor-α (TNF-α) and induced phosphorylation of extracellular signal-regulated kinase (ERK) and NF-kB p65. We also observed that maleylated-BSA-induced TNF-α production was blocked by the ERK inhibitor U0126. Together, these data demonstrates that maleylated-BSA- induced production of TNF-α requires the ERK/NF-κB signaling cascade in murine RAW- 264.7 macrophages.

关键词： Maleylated-BSA ERK Macrophages Signaling Pathway TNF-α

Effect of sumatriptan on gastric emptying:A crossover study using the BreathID system

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World Journal of Gastroenterology 2012年第26期18卷 3415-3419页

作者： Yasunari Sakamoto Yusuke Sekino Eiji Yamada Takuma Higurashi Hidenori Ohkubo Eiji Sakai Hiroki Endo Hiroshi Iida Takashi Nonaka Koji Fujita Masato Yoneda Tomoko koide Hirokazu Takahashi Ayumu Goto Yasunobu Abe Eiji Gotoh Shin Maeda Atsushi Nakajima Masahiko Inamori Gastroenterology Division Yokohama City University Hospital3-9 FukuuraKanazawa-kuYokohamaKanagawa 236-0004Japan Department of Medical Education Yokohama City University School of Medicine3-9 FukuuraKanazawa-kuYokohamaKanagawa 236-0004Japan Office of Postgraduate Medical Education Yokohama City University Hospital3-9 FukuuraKanazawakuYokohamaKanagawa 236-0004Japan

AIM:To determine the effect of oral sumatriptan on gastric emptying using a continuous 13 C breath test(BreathID system).METHODS:Ten healthy male volunteers participated in this randomized,2-way crossover *** subjects fasted overnight and were randomly assigned to receive a test meal(200 kcal/200 mL) 30 min after pre-medication with sumatriptan 50 mg(sumatriptan condition),or the test meal alone(control condition).Gastric emptying was monitored for 4 h after administration of the test meal by the 13 C-acetic acid breath test performed continually using the BreathID ***,using Oridion Research Software(β version),the time taken for emptying of 50% of the labeled meal(T 1/2) similar to the scintigraphy lag time for 10% emptying of the labeled meal(T lag),the gastric emptying coefficient(GEC),and the regression-estimated constants(β and κ) were *** statistical significance of any differences in the parameters were analyzed using Wilcoxon's signed-rank ***:In the sumatriptan condition,significant differences compared with the control condition were found in T 1/2 [median 131.84 min(range,103.13-168.70) vs 120.27 min(89.61-138.25);P = 0.0016],T lag [median 80.085 min(59.23-125.89) vs 61.11 min(39.86-87.05);P = 0.0125],and β [median 2.3374(1.6407-3.8209) vs 2.0847(1.4755-2.9269);P = 0.0284].There were no significant differences in the GEC or κ between the 2 ***:This study showed that oral sumatriptan significantly delayed gastric emptying of a liquid meal.

关键词： ID系统胃排空监测试验滞后时间舒马普坦控制条件中位数回归估计

在JT—60U高βp放电中q=3磁面上的内输运位垒和极向等离…

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国外核聚变与等离子体应用 1995年第6期 24-28页

作者： koide,Y 高玉

在ＪＴ－６０Ｕ托卡马克的高βｐ放电中，伴随着改善约束，观测到内输运位垒的自然形成。发现输运位垒的径向位置是在ｑ＝３磁面上。定域于输运位垒的一个快磁流体动力学事件引起边缘位垒随后形成，此位垒导致约束进一步改善。在这些放... 详细信息

在ＪＴ－６０Ｕ托卡马克的高βｐ放电中，伴随着改善约束，观测到内输运位垒的自然形成。发现输运位垒的径向位置是在ｑ＝３磁面上。定域于输运位垒的一个快磁流体动力学事件引起边缘位垒随后形成，此位垒导致约束进一步改善。在这些放电中，在ｒ／ａ＝０．８处也观测到明显超过现在的新经典理论预言的高极向等离子体旋转速度。

关键词：输运位垒极向等离子体旋升托卡马克

Discharge heart rate and future events among Japanese patients with acute heart failure receiving beta-blocker therapy

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World Journal of Cardiovascular Diseases 2013年第1期3卷 159-167页

作者： Kazuki Oshima Shun Kohsaka Kimi koide Yuji Nagatomo Toshiyuki Nagai Yutaka Endo Tsutomu Yoshikawa Keiichi Fukuda Department of Cardiology Saitama City Hospital Saitama Japan Department of Cardiology Sakakibara Heart Institute Tokyo Japan Division of Cardiology Keio University School of Medicine Tokyo Japan Japan Red Cross Ashikaga Hospital Tochigi Japan. National Cerebral and Cardiovascular Center Osaka Japan

Background: Randomized trials have demonstrated the efficacy of beta-blockers (BBs) in heart failure (HF) patients. We sought to assess the impact of BBs on long-term outcome;in particular, we assessed the association between outcome and BB dose and discharge heart rate. Methods and Results: Prescriptions for dispensed medication and outcomes were identified from a prospective, single-institution HF registry. Long-term prognosis was compared between users and non-users of BBs. BB users were further divided into 2 groups based on dose (full and non-full dose) and discharge heart rate (70 bpm was significantly associated with impaired long-term outcome (HR = 1.872, P = 0.04). Conclusions: Optimizing heart rate, rather than maximizing BB dose, appears to be an appropriate treatment strategy for the beta-sensitive Japanese population.

关键词： Heart Failure Beta-Blocker Heart Rate Pharmaceutical Preparations