Discharge heart rate and future events among Japanese patients with acute heart failure receiving beta-blocker therapy

作     者：Kazuki Oshima Shun Kohsaka Kimi Koide Yuji Nagatomo Toshiyuki Nagai Yutaka Endo Tsutomu Yoshikawa Keiichi Fukuda 

作者机构：Department of Cardiology Saitama City Hospital Saitama Japan Department of Cardiology Sakakibara Heart Institute Tokyo Japan Division of Cardiology Keio University School of Medicine Tokyo Japan Japan Red Cross Ashikaga Hospital Tochigi Japan. National Cerebral and Cardiovascular Center Osaka Japan 

出 版 物：《World Journal of Cardiovascular Diseases》 (心血管病（英文）)

年 卷 期：2013年第3卷第1期

页      面：159-167页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Heart Failure Beta-Blocker Heart Rate Pharmaceutical Preparations 

摘      要：Background: Randomized trials have demonstrated the efficacy of beta-blockers (BBs) in heart failure (HF) patients. We sought to assess the impact of BBs on long-term outcome;in particular, we assessed the association between outcome and BB dose and discharge heart rate. Methods and Results: Prescriptions for dispensed medication and outcomes were identified from a prospective, single-institution HF registry. Long-term prognosis was compared between users and non-users of BBs. BB users were further divided into 2 groups based on dose (full and non-full dose) and discharge heart rate (70 bpm was significantly associated with impaired long-term outcome (HR = 1.872, P = 0.04). Conclusions: Optimizing heart rate, rather than maximizing BB dose, appears to be an appropriate treatment strategy for the beta-sensitive Japanese population.