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Decreased hemoglobin after initial treatment is associated with treatment resistance in Kawasaki disease in Kobayashi risk stratification

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World Journal of Pediatrics 2020年第6期16卷 623-628页

作者： Yukari Atsumi Hiroshi Sakakibara Yoshihiko Morikawa Koichi Miyata Hiroyuki Yamagishi Masahiro Misawa masaru miura Department of General Pediatrics Tokyo Metropolitan Children's Medical Center.TokyoJapan Clinical Research Support Center.Tokyo Metropolitan Children's Medical Center TokyoJapan Department of Cardiology.Tokyo Metropolitan Children's Medical Center.Tokyo Japan Department of Pediatrics Keio University School of MedicineTokyo.Japan Department of Pediatrics Tokyo Metropolitan Bokutoh HospitalTokyoJapan National Center for Global Health and Medicine.1-21-1.Toyama Shinjuku-kuTokyo 162-8655.Japan

Background Although Kawasaki disease(KD)is known to cause anemia,the relationship between its prognosis and hemoglobin level is less well *** We herein performed a secondary analysis of data from a previous study(Post-RAISE).Children aged 6 months to 2 years at the time of KD diagnosis were *** hemoglobin was defined as a decrease>10%on post-treatment day 2 compared with the level prior to the initial *** Of 1253 KD cases,treatment resistance was observed in 209(17%)and was significantly more frequent in the decreased hemoglobin group(37/167 vs.172/1086,P=0.041).Multivariable logistic regression analysis revealed that decreased hemoglobin was associated with resistance to the initial treatment(odds ratio 1.53;95%confidence interval 1.00-2.33;P=0.048).Conclusions Decreased hemoglobin was significantly associated with resistance to initial treatment in patients with KD.

关键词： Anemia Inflammation Hepcidin Kawasaki disease

Prospective Cohort Research of Aortic Root Dilatation after Surgical Repair in Adults with Tetralogy of Fallot(TRANSIT)

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Congenital Heart Disease 2024年第4期19卷 351-362页

作者： Hiroki Nagamine masaru miura Jun Maeda Takumi Nishiki Maasa Sato Fumie Takechi Shigeru Tateno Tomoko Ishizu Yumi Shiina Ken Kato Hiroshi Ono Hiroyuki Yamagishi Koichiro Niwa Department of Cardiology Tokyo Metropolitan Children’s Medical CenterTokyo183-8561Japan Department of Pediatric Cardiology Sakakibara Heart InstituteTokyo183-0003Japan Department of Adult Congenital Heart Disease Chiba Cerebral and Cardiovascular CenterChiba305-8576Japan Department of Adult Congenital Heart Disease Chiba Kaihin Municipal HospitalChiba261-0003Japan Department of Cardiology Faculty of MedicineUniversity of TsukubaTsukuba305-8576Japan Cardiovascular Center St.Luke’s International HospitalTokyo104-8560Japan Department of Cardiology Tokyo Metropolitan Tama Medical CenterTokyo183-8524Japan Division of Cardiology National Center for Child Health and DevelopmentTokyo158-8531Japan Center for Preventive Medicine Keio University School of MedicineTokyo160-0016Japan

Background:Aortic root dilatation occurs in adults with tetralogy of Fallot(TOF)after surgical repair,but the longitudinal changes are *** main research aim is to determine the annual dilatation rate of aorta in adults with repaired ***:The present,multicentric,prospective cohort study assessed the rate of aortic diameter change in adults aged 20 years or older with TOF,including pulmonary artery atresia,who underwent surgical *** data,focusing on echocardiograms,were collected at three-year intervals from seven ***:In total,104 patients(58 males;median age:29 years)were *** actual Valsalva sinus(VS)diameter was 34.3±5.8(mean±standard deviation)and 36.1±6.0 mm at the initial andﬁnal examinations,respectively,and the annual dilatation rate was 0.64(0.07,1.33)(median,interquartile)mm/*** corrected diameter at the respective examination was 21.3±3.8 and 22.2±3.7 mm/m^(2),and the annual dilation rate was 0.28(-0.21,0.76)mm/m^(2)/*** regression analysis showed that factors signiﬁcant associated with dila-tation rate of actual VS diameter were the diastolic blood pressure(standardized coefﬁcient-0.22;p=0.04),cardiothoracic ratio(0.28;0.02),and the ratio of early mitral valve inﬂow velocity to early diastolic annular velocity(E/e′)ratio(0.31;0.004).Factors signiﬁcantly associated with corrected VS diameter were diastolic blood pressure(-0.25;0.02)and the E/e′ratio(0.34;0.001).Conclusions:In adults with repaired TOF,the rate of dilatation of the aortic diameter was associated with decreased diastolic blood pressure and left ventricular diastolic dysfunction,possibly reﬂecting decreased aortic wall elasticity.

关键词： Adults aortic dilatation prospective cohort research tetralogy of Fallot

Role of the preoperative usefulness of the pathological diagnosis of pancreatic diseases

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World Journal of Gastrointestinal Oncology 2016年第9期8卷 656-662页

作者： Kazuya Matsumoto Yohei Takeda Takumi Onoyama Soichiro Kawata Hiroki Kurumi masaru Ueki Norimasa miura Hajime Isomoto Department of Gastroenterology Tottori University Hospital Department of Next Generation Advanced Medical Promotion Center Tottori University Hospital Division of Pharmacotherapeutics Department of Pathophysiological and Therapeutic ScienceFaculty of MedicineTottori University

Pancreatic cancer is the fifth leading cause of cancer death and has the lowest survival rate of any solid *** ultrasound-guided fine-needle aspiration biopsy(EUS-FNA) is currently capable of providing a cytopathological diagnosis of pancreatic malignancies with a higher diagnostic power,with a sensitivity and specificity of 85%-89% and 98%-99%,compared to pancreatic juice cytology(PJC),whose sensitivity and specificity are only 33.3%-93% and 83.3%-100%.However,EUS-FNA is not effective in the cases of carcinoma in situ and minimally invasive carcinoma because both are undetectable by endoscopic ultrasonography,although PJC is able to detect *** for the frequency of complications such as post endoscopic retrograde cholangiopancreatography pancreatitis,EUS-FNA is safer than *** diagnose pancreatic cancer appropriately,it is necessary for us to master both procedures so that we can select the best methods of sampling tissues while considering the patient's safety and condition.

关键词： Endoscopic ultrasound-guided fine-needle aspiration biopsy Cytology Pathology Pancreatic juice cytology Pancreatic cancer

Control of Collection Efficiency for Axial Flow Cyclone Dust Collectors with Fixed Guide Vanes and with Funnel Shaped Exit Pipes

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Journal of Thermal Science 2006年第3期15卷 240-250页

作者： Akira Ogawa masaru Arakawa T-110-0011 Minowa 2-14-7Taitou-KuTokyoJapan SHINWA RULES Co. Ltd.Sanjo-ShiNiigataJapan

The experimental result of the collection efficiency of the axial flow cyclone with the fixed guide vanes is lower than that with the tangential inlet pipe to the cyclone body due to the weak angular momentum transfer given by flowing through the guide vanes. However, one of the interesting points is the control of the collection efficiency depended on the funnel shaped exit pipes. The collection efficiencies for these funnel shaped exit pipes are depended on the Froude number. Then, in this paper, the experimental results of the pressure drop and also the collection efficiency using the fly-ash particles and also the comparison of the calculated results of the collection efficiency with the experimental results are described i~ detail.

关键词： Axial flow cyclone funnel shaped exit pipe fixed guide vanes pressure drop collection efficiency,Froude number cut-Size

Mechanisms of fertilization elucidated by gene-manipulated animals

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Asian Journal of Andrology 2015年第4期17卷 646-652页

作者： masaru Okabe Center for Genetic Analysis for Biological ResponsesResearch Institute for Microbial Diseases OsakaUniversity Yamadaoka 3-1 Suita Osaka 565-0871Japan.

Capacitation and the acrosome reaction are key phenomena in mammalian fertilization. These phenomena were found more than 60 years ago. However, fundamental questions regarding the nature of capacitation and the timing of the acrosome reaction remain unsolved. Factors were postulated overtime, but as their roles were not verified by gene-disruption experiments, widely accepted notions concemingthe mechanism of fertilization are facing modifications. Today, although in vitro fertilization systems remain our central research tool, the importance of in vivo observations must be revisited. Here, primarily focusing on our own research, I summarize how in vivo observations using gene-manipulated animals have elucidated new concepts in the mechanisms of fertilization.

关键词： Mechanisms fertilization gene-manipulated

Time-space Viewpoint Planning for Guard Robot with Chance Constraint

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International Journal of Automation and computing 2019年第4期16卷 475-490页

作者： Igi Ardiyanto Jun miura Department of Electrical Engineering and Information Technology Universitas Gadjah Mada No. 2 Jl. Grafika Yogyakarta 55281 Indonesia Department of Computer Science and Engineering Toyohashi University of Technology 1-1 Hibarigaoka Tenpaku-cho Toyohashi Aichi 441-8580 Japan

This paper presents a novel movement planning algorithm for a guard robot in an indoor environment, imitating the job of human security. A movement planner is employed by the guard robot to continuously observe a certain person. This problem can be distinguished from the person following problem which continuously follows the object. Instead, the movement planner aims to reduce the movement and the energy while keeping the target person under its visibility. The proposed algorithm exploits the topological features of the environment to obtain a set of viewpoint candidates, and it is then optimized by a cost-based set covering problem. Both the robot and the target person are modeled using geodesic motion model which considers the environment shape. Subsequently, a particle model-based planner is employed, considering the chance constraints over the robot visibility, to choose an optimal action for the robot. Simulation results using 3D simulator and experiments on a real environment are provided to show the feasibility and effectiveness of our algorithm.

关键词： Guard robot viewpoint planning state-time space uncertainty topology chance-constraint

Effects of uniaxial compressive strain on the electronic- transport properties of zigzag carbon nanotubes

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Nano Research 2016年第5期9卷 1267-1275页

作者： Masato Ohnishi Ken Suzuki Hideo miura Fracture and Reliability Research Institute Graduate School of Engineering Tohoku University Sendai 980-8579 Japan

Recently, substantial attention has been paid to the strain sensitivity of the carbon nanotubes＇（CNTs＇） electronic properties. In this study, the relationships between the geometric structures and electronic states of zigzag CNTs under uniaxial compressive strain were investigated. We found that different factors dominate the electronic states of zigzag CNTs depending on the strain regions： the initial stage of the strain loading, which lasts until column-buckling deformation begins, and the strain regions corresponding to column- and shell-buckling deformations. Because shell-buckling deformation significantly increases the re-orbital angle, the angle between the π orbital axis vectors of adjacent atoms, strong localization of the density of states （LDOS） occurs in the buckled area. We also analyzed the current able to pass through deformed CNTs using a tight-binding-based Green＇s function approach and determined that the current can be significantly suppressed by applying uniaxial compressive strain. Our method of predicting the electronic state of a deformed CNT based on the π-orbital angle is expected to be useful for predicting the electronic properties of CNT-based electronic devices and sensors.

关键词： carbon nanotube strain buckling deformation Green's function method electronic-transport property

Photocatalytic dry reforming of methane by rhodium supported monoclinic TiO_(2)-B nanobelts

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Journal of Energy Chemistry 2022年第8期31卷 562-571,I0015页

作者： masaru Kushida Akira Yamaguchi Masahiro Miyauchi School of Materials and Chemical Technology Tokyo Institute of Technology2-12-1 OokayamaMeguro-kuTokyo 152-8552Japan

The conversion of methane and carbon dioxide into syngas(dry reforming of methane;DRM)has attracted attention owing to the potential to reuse greenhouse *** dioxide(TiO_(2))-based photocatalysts,which have been widely commercialized owing to their high efficiency,non-toxicity,and low cost,are strongly desired in ***,we report a monoclinic-phase TiO_(2)-B nanobelts-supported rhodium(Rh/TiO_(2)-B nanobelts)catalyst that efficiently promotes DRM under ultraviolet light irradiation at low *** holes in the TiO_(2)-B nanobelts were used to oxidize methane,while the electrons were trapped in rhodium to reduce carbon ***/TiO_(2)-B nanobelts exhibited considerably higher durability and activity than Rh-loaded conventional TiO_(2)(anatase and rutile),owing to the lattice and/or surface oxygen reactivity in TiO_(2)-B nanobelts,which was suggested by X-ray photoelectron spectroscopy measurements and photocatalytic performance tests under an atmosphere of methane *** study paves the path for the effective utilization of methane by constructing active TiO_(2)-based nanometal photocatalysts.

关键词： Photocatalysis Dry reforming of methane Greenhouse gas conversion Gas-phase reaction Titanium dioxide TiO_(2)-B

Last deglacial relative sea level variations in Antarctica derived from glacial isostatic adjustment modelling

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Geoscience Frontiers 2013年第6期4卷 623-632页

作者： Jun’ichi Okuno Hideki miura National Institute of Polar Research 10-3 Midori-choTachikawaTokyo 190-8518Japan Research Institute for Global Change Japan Agency for Marine-Earth Science and Technology3173-25 Showa-machiKanazawa-kuYokohama 236-0001Japan

We present relative sea level （RSL） curves in Antarctica derived from glacial isostatic adjustment （GIA）predictions based on the melting scenarios of the Antarctic ice sheet since the Last Glacial Maximum （LGM）given in previous ***,Holocene-age RSL observations obtained at the raised beaches along the coast of Antarctica are shown to be in agreement with the GIA *** differences from previously published ice-loading models regarding the spatial distribution and total mass change of the melted ice are *** models were also derived from GIA modelling; the variations can be attributed to the lack of geological and geographical evidence regarding the history of crustal movement due to ice sheet ***,we summarise the previously published ice load models and demonstrate the RSL curves based on combinations of different ice and earth *** RSL curves calculated by GIA models indicate that the model dependence of both the ice and earth models is significantly large at several sites where RSL observations were *** particular,GIA predictions based on the thin lithospheric thickness show the spatial distributions that are dependent on the melted ice thickness at each *** characteristics result from the short-wavelength deformation of the ***,our predictions strongly suggest that it is possible to find the average ice model despite the use of the different models of lithospheric *** sea level and crustal movement observations,we can deduce the geometry of the post-LGM ice sheets in detail and remove the GIA contribution from the crustal deformation and gravity change observed by space geodetic techniques,such as GPS and GRACE,for the estimation of the Antarctic ice mass change associated with recent global warming.

关键词： Antarctic ice sheet Relative sea level Glacial isostatic adjustment Melting history Lithospheric thickness