Prospective Cohort Research of Aortic Root Dilatation after Surgical Repair in Adults with Tetralogy of Fallot(TRANSIT)

作     者：Hiroki Nagamine Masaru Miura Jun Maeda Takumi Nishiki Maasa Sato Fumie Takechi Shigeru Tateno Tomoko Ishizu Yumi Shiina Ken Kato Hiroshi Ono Hiroyuki Yamagishi Koichiro Niwa 

作者机构：Department of CardiologyTokyo Metropolitan Children’s Medical CenterTokyo183-8561Japan Department of Pediatric CardiologySakakibara Heart InstituteTokyo183-0003Japan Department of Adult Congenital Heart DiseaseChiba Cerebral and Cardiovascular CenterChiba305-8576Japan Department of Adult Congenital Heart DiseaseChiba Kaihin Municipal HospitalChiba261-0003Japan Department of CardiologyFaculty of MedicineUniversity of TsukubaTsukuba305-8576Japan Cardiovascular CenterSt.Luke’s International HospitalTokyo104-8560Japan Department of CardiologyTokyo Metropolitan Tama Medical CenterTokyo183-8524Japan Division of CardiologyNational Center for Child Health and DevelopmentTokyo158-8531Japan Center for Preventive MedicineKeio University School of MedicineTokyo160-0016Japan 

出 版 物：《Congenital Heart Disease》 (先天性心脏病（英文）)

年 卷 期：2024年第19卷第4期

页      面：351-362页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：supported by grants from the Clinical Research Fund of Tokyo Metropolitan Government Hospitals 

主　　题：Adults aortic dilatation prospective cohort research tetralogy of Fallot 

摘      要：Background:Aortic root dilatation occurs in adults with tetralogy of Fallot(TOF)after surgical repair,but the longitudinal changes are *** main research aim is to determine the annual dilatation rate of aorta in adults with repaired ***:The present,multicentric,prospective cohort study assessed the rate of aortic diameter change in adults aged 20 years or older with TOF,including pulmonary artery atresia,who underwent surgical *** data,focusing on echocardiograms,were collected at three-year intervals from seven ***:In total,104 patients(58 males;median age:29 years)were *** actual Valsalva sinus(VS)diameter was 34.3±5.8(mean±standard deviation)and 36.1±6.0 mm at the initial andfinal examinations,respectively,and the annual dilatation rate was 0.64(0.07,1.33)(median,interquartile)mm/*** corrected diameter at the respective examination was 21.3±3.8 and 22.2±3.7 mm/m^(2),and the annual dilation rate was 0.28(-0.21,0.76)mm/m^(2)/*** regression analysis showed that factors significant associated with dila-tation rate of actual VS diameter were the diastolic blood pressure(standardized coefficient-0.22;p=0.04),cardiothoracic ratio(0.28;0.02),and the ratio of early mitral valve inflow velocity to early diastolic annular velocity(E/e′)ratio(0.31;0.004).Factors significantly associated with corrected VS diameter were diastolic blood pressure(-0.25;0.02)and the E/e′ratio(0.34;0.001).Conclusions:In adults with repaired TOF,the rate of dilatation of the aortic diameter was associated with decreased diastolic blood pressure and left ventricular diastolic dysfunction,possibly reflecting decreased aortic wall elasticity.