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Evolving concepts in bone infection: redefining “biofilm”,“acute vs. chronic osteomyelitis”, “the immune proteome” and “local antibiotic therapy”

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Bone Research 2019年第3期7卷 225-242页

作者： Elysia A. Masters Ryan P. Trombetta Karen L. de Mesy Bentley Brendan F Boyce Ann Lindley Gill Steven R. Gill Kohei Nishitani masahiro ishikawa Yugo Morita Hiromu Ito Sheila N. Bello-Irizarry Mark Ninomiya James D. Brodell Jr. Charles C. Lee Stephanie P. Hao Irvin Oh Chao Xie Hani A. Awad John L. Daiss John R. Owen Stephen L. Kates Edward M. Schwarz Gowrishankar Muthukrishnan Center for Musculoskeletal Research University of Rochester Medical Center Rochester NY USA Department of Biomedical Engineering University of Rochester Medical Center Rochester NY USA Department of Pathology and Laboratory Medicine University of Rochester Medical Center Rochester NY USA Department of Orthopaedics University of Rochester Medical Center Rochester NY USA Department of Microbiology & Immunology University of Rochester Medical Center Rochester NY USA Department of Orthopaedic Surgery Kyoto University Kyoto Japan Department of Orthopaedic Surgery Virginia Commonwealth University Medical Center Richmond VA USA

Osteomyelitis is a devastating disease caused by microbial infection of bone. While the frequency of infection following elective orthopedic surgery is low, rates of reinfection are disturbingly high. Staphylococcus aureus is responsible for the majority of chronic osteomyelitis cases and is often considered to be incurable due to bacterial persistence deep within bone. Unfortunately, there is no consensus on clinical classifications of osteomyelitis and the ensuing treatment algorithm. Given the high patient morbidity,mortality, and economic burden caused by osteomyelitis, it is important to elucidate mechanisms of bone infection to inform novel strategies for prevention and curative treatment. Recent discoveries in this field have identified three distinct reservoirs of bacterial biofilm including: Staphylococcal abscess communities in the local soft tissue and bone marrow, glycocalyx formation on implant hardware and necrotic tissue, and colonization of the osteocyte-lacuno canalicular network(OLCN) of cortical bone. In contrast, *** intracellular persistence in bone cells has not been substantiated in vivo, which challenges this mode of chronic osteomyelitis. There have also been major advances in our understanding of the immune proteome against S. aureus, from clinical studies of serum antibodies and media enriched for newly synthesized antibodies(MENSA), which may provide new opportunities for osteomyelitis diagnosis, prognosis, and vaccine development. Finally, novel therapies such as antimicrobial implant coatings and antibiotic impregnated 3D-printed scaffolds represent promising strategies for preventing and managing this devastating disease. Here, we review these recent advances and highlight translational opportunities towards a cure.

关键词： disease caused by soft tissue necrotic tissuel

Triploid Wild Rice (BKK) Strain Found in Bangkok Originated from Hybridizations among Three Parental <i>Oryza</i>Species

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American Journal of Plant Sciences 2022年第1期13卷 36-49页

作者： So Makabe Htet Aung Htut Hiroko Takahashi Sayaka Shida masahiro Akimoto Hathairat Urairong Ryuji ishikawa Tadashi Sato Yo-Ichiro Sato Ikuo Nakamura BEX Co Ltd. Tokyo Japan Graduate School of Horticulture Chiba University Matsudo Japan Obihiro University of Agriculture and Veterinary Medicine Obihiro Japan Biotechnology Research and Development Office DOA Thanyaburi Thailand Faculty of Agriculture and Life Science Hirosaki University Hirosaki Japan Graduate School of Life Sciences Tohoku University Sendai Japan Kyoto Prefectural University Kyoto Japan

A wild rice (BKK) strain showing sterile spikelet and big leaves inhabited at the basin of the Chao Phraya river of Bangkok city, Thailand. The BKK strain was found as a natural triploid and thus its origin has been interested long time. Three different-sized fragments were amplified in RNA polymerase I largest subunit (PolA1) gene, which is a single-copy nuclear gene per haploid genome. Short type (0.14 kb) intron 20 sequence of BKK strain was identical to that of O. rufipogon and O. sativa. Phylogenetic analysis showed that long type (1.5 kb and 1.8 kb) intron 20 sequences of BKK strain were closely related to that of O. longistaminata and O. officinalis, respectively. We analyzed protein tag (Ptag) sequence encoded by exons 19 to 21 of PolA1 gene. Determined three Ptag sequences of BKK strain were identical to that of O. rufipogon, O. longistaminata, and O. officinalis, respectively. Relative DNA content of nuclei in O. officinalis and BKK strain was 1.5 and 1.75 times than that in O. sativa, respectively. And BKK strain contained CentO-C1 repeats, which were unique to O. officinalis. These results indicated that BKK strain comprised three genomes of O. rufipogon, O. longistaminata, and O. officinalis.

关键词： Oryza rufipogon Triploid Flow Cytometry PolA1 CentO-C1 Repeat Sequence

Utility of linked color imaging for endoscopic diagnosis of early gastric cancer

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World Journal of Gastroenterology 2019年第10期25卷 1248-1257页

作者： Toshihisa Fujiyoshi Ryoji Miyahara Kohei Funasaka Kazuhiro Furukawa Tsunaki Sawada Keiko Maeda Takeshi Yamamura Takuya ishikawa Eizaburo Ohno Masanao Nakamura Hiroki Kawashima Masato Nakaguro masahiro Nakatochi Yoshiki Hirooka Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine Department of Endoscopy Nagoya University Hospital Department of Pathology and Laboratory Medicine Nagoya University Hospital Division of Data Science Data Coordinating CenterDepartment of Advanced MedicineNagoya University Hospital

BACKGROUND Linked color imaging(LCI) is a method of endoscopic imaging that emphasizes slight differences in red mucosal *** To evaluate LCI in diagnostic endoscopy of early gastric cancer and to compare LCI and pathological *** Endoscopic images were obtained for 39 patients(43 lesions) with early gastric cancer. Three endoscopists evaluated lesion recognition with white light imaging(WLI) and LCI. Color values in Commission Internationale de l'Eclairage(CIE)1976 L*a*b* color space were used to calculate the color difference(ΔE) between cancer lesions and non-cancer areas. After endoscopic submucosal dissection,blood vessel density in the surface layer of the gastric epithelium was evaluated pathologically. The identical region of interest was selected for analyses of endoscopic images(WLI and LCI) and pathological *** LCI was superior for lesion recognition(P < 0.0001), and ΔE between cancer and non-cancer areas was significantly greater with LCI than WLI(29.4 vs 18.6, P <0.0001). Blood vessel density was significantly higher in cancer lesions(5.96% vs4.15%, P = 0.0004). An a* cut-off of ≥ 24 in CIE 1976 L*a*b* color space identified a cancer lesion using LCI with sensitivity of 76.7%, specificity of 93.0%, and accuracy of 84.9%.CONCLUSION LCI is more effective for recognition of early gastric cancer compared to WLI as a result of improved visualization of changes in redness. Surface blood vessel density was significantly higher in cancer lesions, and this result is consistent with LCI image analysis.

关键词： Linked color imaging Early gastric cancer Endoscopic submucosal dissection Vessel density Color difference

Laparoscopic Hernioplasty Using Omega-3 Coating Mesh

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Surgical Science 2012年第8期3卷 389-392页

作者： Masahiko Kawaguchi Norihiko ishikawa Youji Nishida Hideki Moriyama masahiro Kaneki Go Watanabe Department of General and Cardiothoracic Surgery Kanazawa University Kanazawa Japan

Background: Laparoscopic hernioplasty has gained popularity with significant advances in prostheses. Omega-3 coating mesh (C-Qur) is a prosthesis that can be used in the abdominal cavity, and the coating prevents adhesion of the mesh to the viscera. We planned a prospective observational study of laparoscopic hernioplasty using C-Qur. Methods: C-Qur was used in laparoscopic hernioplasty over the course of 1 year. We considered laparoscopic approaches as our primary treatment method for abdominal wall hernias. Although only a single incision was made for the majority of the laparoscopic hernioplasties, additional incisions were made when severe adhesions were encountered. For incisional or ventral hernias, a lateral lower incision was made. For inguinal hernias, an umbilical incision was made. Sex, age, diagnosis, number of incisions, additional incisions, morbidity, and follow-up period were evaluated. Results: Twenty-four patients who underwent surgery between May 2010 and April 2011 were included in this study. The median follow-up period was 14 months. The most common early complications included wound pain and edema;however, there were no persistent complications.

关键词： Omega-3 Coating Mesh Single Incision Laparoscopic Surgery Laparoscopic Hernioplasty Inguinal Hernia Incisional Hernia

Case series of three patients with hereditary diffuse gastric cancer in a single family:Three case reports and review of literature

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World Journal of Gastroenterology 2020年第42期26卷 6689-6697页

作者： masahiro Hirakawa Kohichi Takada Masanori Sato Chisa Fujita Naotaka Hayasaka Takayuki Nobuoka Shintaro Sugita Aki ishikawa Miyako Mizukami Hiroyuki Ohnuma Kazuyuki Murase Koji Miyanishi Masayoshi Kobune Ichiro Takemasa Tadashi Hasegawa Akihiro Sakurai Junji Kato Department of Medical Oncology Sapporo Medical University School of MedicineSapporo 060-8556HokkaidoJapan Department of Gastroenterology National Hospital Organization Hokkaido Cancer CenterSapporo 003-0804HokkaidoJapan Department of Surgery Surgical Oncology and ScienceSapporo Medical University School of MedicineSapporo 060-8556HokkaidoJapan Department of Surgical Pathology Sapporo Medical University School of MedicineSapporo 060-8556HokkaidoJapan Department of Medical Genetics Sapporo Medical University School of MedicineSapporo 060-8556HokkaidoJapan Department of Hematology Sapporo Medical University School of MedicineSapporo 060-8556HokkaidoJapan

BACKGROUND Hereditary diffuse gastric cancer(HDGC)is a familial cancer syndrome often associated with germline mutations in the CDH1 ***,the frequency of CDH1 mutations is low in patients with HDGC in East Asian ***,we report three cases of HDGC harboring a missense CDH1 variant,c.1679C>G,from a single Japanese *** SUMMARY A 26-year-old female(Case 1)and a 51-year-old male(father of Case 1),who had a strong family history of gastric cancer,were diagnosed with advanced diffuse gastric *** genetic counselling,a 25-year-old younger brother of Case 1 underwent surveillance esophagogastroduodenoscopy that detected small signet ring cell carcinoma foci as multiple pale lesions in the gastric *** analysis revealed a CDH1 c.1679C>G variant in all three *** It is important for individuals suspected of having HDGC to be actively offered genetics *** report will contribute to an increased awareness of HDGC.

关键词： Hereditary diffuse gastric cancer Signet ring cell carcinoma CDH1 Ecadherin Endoscopic findings Case report

Effectiveness and safety of chemotherapy for patients with malignant gastrointestinal obstruction:A Japanese populationbased cohort study

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World Journal of Clinical Cases 2022年第16期10卷 5253-5265页

作者： Gota Fujisawa Ryota Niikura Takuya Kawahara Tetsuro Honda Kenkei Hasatani Naohiro Yoshida Tsutomu Nishida Tetsuya Sumiyoshi Shu Kiyotoki Takashi Ikeya masahiro Arai Yoku Hayakawa Takashi Kawai Mitsuhiro Fujishiro Department of Gastroenterology Graduate school of MedicineThe University of TokyoTokyo 1138655Japan Gastroenterological Endoscopy Tokyo Medical UniversityTokyo 1600023Japan Clinical Research Support Center The University of Tokyo HospitalTokyo 1138655Japan Department of Gastroenterology Nagasaki Harbor Medical CenterNagasaki 8508555Japan Department of Gastroenterology Fukui Prefectural HospitalFukui 9108526Japan Department of Gastroenterology Ishikawa Prefectural Central HospitalIshikawa 9208530Japan Department of Gastroenterology Toyonaka Municipal HospitalOsaka 5608565Japan Department of Gastroenterology Tonan HospitalHokkaido 0600004Japan Department of Gastroenterology Shuto General HospitalYamaguchi 7420032Japan Department of Gastroenterology St.Luke's International HospitalTokyo 1048560Japan Department of Gastroenterology Nerima Hikarigaoka HospitalTokyo 1790072Japan

BACKGROUND The impacts of chemotherapy on patients with malignant gastrointestinal obstructions remain unclear,and multicenter evidence is *** To evaluate the effectiveness and safety of chemotherapy in patients with unresectable malignant gastrointestinal *** We conducted a multicenter retrospective cohort study that compared the chemotherapy group who received any chemotherapeutics after interventions,including palliative surgery or selfexpandable metal stent placement,for unresectable malignant gastrointestinal obstruction vs the best supportive care(BSC)group between 2014 and 2019 in nine *** primary outcome was overall survival,and the secondary outcomes were patency duration and adverse events,including gastrointestinal perforation and gastrointestinal *** In total,470 patients in the chemotherapy group and 652 patients in the BSC group were *** the follow-up period of 54.1 mo,the median overall survival durations were 19.3 mo in the chemotherapy group and 5.4 mo in the BSC group(log-rank test,P<0.01).The median patency durations were 9.7 mo[95% confidence interval(CI):7.7-11.5 mo]in the chemotherapy group and 2.5 mo(95%CI:2.0-2.9 mo)in the BSC group(log-rank test,P<0.01).The perforation rate was 1.3%(6/470)in the chemotherapy group and 0.9%(6/652)in the BSC group(P=0.567).The gastrointestinal bleeding rate was 1.5%(7/470)in the chemotherapy group and 0.5%(3/652)in the BSC group(P=0.105).CONCLUSION Chemotherapy after interventions for unresectable malignant gastrointestinal obstruction was associated with increased overall survival and patency duration.

关键词： Gastrointestinal cancer Chemotherapy Malignant gastrointestinal obstruction Self-expandable metal stent Palliative surgery

A new risk assessment method for evaluation of oxidative chemicals using catalase mutant mouse primary hepatocytes

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Health 2011年第5期3卷 288-291页

作者： Da-Hong Wang Yasuo ishikawa masahiro Miyazaki Hirofumi Fujita Ken Tsutsui Kuniaki Sano Noriyoshi Masuoka Keiki Ogino 不详

We examined the possibility of developing a new risk assessment method for potentially hazardous chemicals by using mouse primary hepatocytes from acatalasemic mice (Csb) and the wild-type (Csa) as predictive model. Chemical-induced cytotoxicities, such as hydrogen peroxide and lawsone, a main hair dye ingredient of henna, were examined. We observed the differences in cell survival between the Csa and Csb in a dose-dependant manner after treatment with either hydrogen peroxide or lawsone, supporting the usefulness of this newly established method for hazard identification of oxidative chemicals in a risk assessment process. More chemicals will be tested to confirm the usefulness of this method for the preliminary screening of oxidative chemicals before animal experimentation.

关键词： Catalase-Mutant Mouse Hepatocytes Reactive Oxygen Species Hydrogen Peroxide Hazard Assessment Lawsone Cytotoxicity

Kosa (yellow sand) components in precipitation collected at central Japan

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Science China Earth Sciences 2002年第Z1期45卷 71-77页

作者： Chohji Tetsuji Kitamura Moritsugu Tabata masahiro Department of Ecomaterials Engineering Toyama National College of Technology 13 Hongo-machi Toyama 939-8630 Japan ishikawa Prefectural Institute of Public Health and Environmental Science Taiyogaoka Kanazawa 920-1154 Japan

In east Asia, acidic gases derived from fossil fuel combustion have increased in the pastdecades. On the other hand, the Asian dust, also called Kosa (yellow sand) is transported follow-ing windstorms from arid lands in the Asian continent. Many researchers have been interested inthe reaction between acidic aerosols and Kosa aerosols as well as the long-range transport ofthese emissions. To investigate the characteristics of chemical components in precipitation on along-term basis over Japan, precipitation was sequentially collected from April 1984 to March 1997at Kanazawa located near the coast of the Sea of Japan. Precipitation samples were collected at 1mm intervals for the first 5 mm rainfall and all volume of rainwater after 6 mm for all precipitationevents with an automatic wet only precipitation collector. According to the analyses of precipitationincluding Kosa aerosols during Kosa periods, the reaction in the air between Kosa and acidiccomponents during the long-range transport was discussed.

关键词： Kosa aerosols, acidic gases, precipitation, chemical components, neutralization.

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应用SiC混合模块的牵引逆变器

电力电子 2012年第1期10卷 20-23,51页

作者： Kazutoshi Ogawa Katsumi ishikawa Norihumi Kameshiro Hidekatsu Onose masahiro Nagasu Hitachi J 周东海吴立成北京工业大学

研发了一种结势垒肖特基(JBS)二极管,在3kV电压下,具有低正向电压和低漏电流特性。用Si-IGBTs和SiC-JBS二极管搭建了标准3kV/200A混合模块。通过采用混合模块和高速驱动电路,我们试图降低反向恢复损耗及开通功率损耗。同时,我们估算变... 详细信息

研发了一种结势垒肖特基(JBS)二极管,在3kV电压下,具有低正向电压和低漏电流特性。用Si-IGBTs和SiC-JBS二极管搭建了标准3kV/200A混合模块。通过采用混合模块和高速驱动电路,我们试图降低反向恢复损耗及开通功率损耗。同时,我们估算变流器和逆变器的总能量损耗减小到原来的32.4%。另外,混合模块能成功地驱动了列车的感应电动机。

关键词：高速驱动电路变流器 SiC