A new risk assessment method for evaluation of oxidative chemicals using catalase mutant mouse primary hepatocytes
A new risk assessment method for evaluation of oxidative chemicals using catalase mutant mouse primary hepatocytes作者机构：不详
出 版 物：《Health》 (健康（英文）)
年 卷 期：2011年第3卷第5期
页 面：288-291页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Catalase-Mutant Mouse Hepatocytes Reactive Oxygen Species Hydrogen Peroxide Hazard Assessment Lawsone Cytotoxicity
摘 要：We examined the possibility of developing a new risk assessment method for potentially hazardous chemicals by using mouse primary hepatocytes from acatalasemic mice (Csb) and the wild-type (Csa) as predictive model. Chemical-induced cytotoxicities, such as hydrogen peroxide and lawsone, a main hair dye ingredient of henna, were examined. We observed the differences in cell survival between the Csa and Csb in a dose-dependant manner after treatment with either hydrogen peroxide or lawsone, supporting the usefulness of this newly established method for hazard identification of oxidative chemicals in a risk assessment process. More chemicals will be tested to confirm the usefulness of this method for the preliminary screening of oxidative chemicals before animal experimentation.
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