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Giant Brunner's gland hyperplasia of the duodenum successfully resected en bloc by endoscopic mucosal resection: A case report

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World Journal of Gastrointestinal Endoscopy 2024年第6期16卷 368-375页

作者： Makomo Makazu Akiko Sasaki Chikamasa Ichita Chihiro Sumida Takashi Nishino Miki nagayama Shinichi Teshima Gastroenterology Medicine Center Shonan Kamakura General HospitalKamakura 247-8533Japan Department of Gastroenterology Shonan Kamakura General HospitalKanagawa 247-8533Japan Department of Pathology Shonan Kamakura General HospitalKamakura 247-8533Japan

BACKGROUND Duodenal Brunner's gland hyperplasia(BGH)is a therapeutic target when complications such as bleeding or gastrointestinal obstruction occur or when malignancy cannot be ruled ***,we present a case of large BGH treated with endoscopic mucosal resection(EMR).CASE SUMMARY An 83-year-old woman presented at our hospital with *** tests revealed severe anemia,esophagogastroduodenoscopy showed a 6.5 cm lesion protruding from the anterior wall of the duodenal bulb,and biopsy revealed the presence of glandular *** ultrasonography(EUS)demonstr-ated relatively high echogenicity with a cystic *** muscularis propria was slightly elevated at the base of the *** was performed without *** formalin-fixed lesion size was 6 cm×3.5 cm×3 cm,showing nodular proliferation of non-dysplastic Brunner's glands compartmentalized by fibrous septa,confirming the diagnosis of *** of EMR or hot snare polypectomy are rare for duodenal BGH>6 *** this case,the choice of EMR was made by obtaining information on the base of the lesion as well as on the internal characteristics through *** Large duodenal lesions with good endoscopic maneuverability and no evident muscular layer involvement on EUS may be resectable via EMR.

关键词： Duodenum Brunner’s gland hyperplasia Brunner’s gland hamartoma Brunner’s gland adenoma Endoscopic mucosal resection Case report

Autophagy and thyroid cancer

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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 81-96页

作者： Yuji nagayama Department of Molecular Medicine Atomic Bomb Disease InstituteNagasaki UniversityNagasaki 852-8523 Japan

This review provides the up-to-date physiological,pathophysiological,and carcinogenic roles of autophagy in the *** data on its physiological roles are mainly obtained with genetically engineered mice,demonstrating the importance of autophagy for the maintenance of cell homeostasis and survival as well as provision of building blocks for sufficient synthesis of proteins such as *** and negative controls of autophagic activity by thyrotropin and thyroid hormone,respectively,are now *** thyroid cancer,there is no published study on the role for autophagy in the initiation/development of thyroid cancer,and there exist many inconsistent data regarding its role in established thyroid cancer *** example,definitive conclusions remain to be elucidated regarding the level of autophagic activity in thyroid cancer cells and the effect of autophagy inducers/inhibitors on cancer cell survival/***,when autophagy is targeted in novel cancer therapeutics,some studies show its pro-survival,but others its anti-survival or context-dependent,effects on thyroid cancer *** studies are in the future necessary to further elucidate the potential of autophagy as a therapeutic target for thyroid cancer.

关键词： Thyroid cancer autophagy pro-survival anti-survival

Hydraulic model tests for propagation of flow and sediment in floods due to breaking of a natural landslide dam during a mountainous torrent

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International Journal of Sediment Research 2018年第2期33卷 107-116页

作者： Takahiro Itoh Akihiko Ikeda Takahiko nagayama Takahisa Mizuyama Research and Development Center Nippon Koei Co. Ltd Saboε Landslide Technical Center Hokuriku office Nippon Koei Co. Ltd National Graduate Institute for Policy Studies (GRIPS)

During mountain torrents, large-magnitude floods may result from heavy rainfall and cause the breakage of landslide dams naturally formed by heavy rainfall, earthquakes, and so on. The characteristics of longitudinal spreading of clear water discharge and changes in flow depth must be clarified because the changes in peak depth have not yet been examined in steep-slope torrents and because there are few data on spreading of flash floods and related sedimentation in mountainous torrents. In the present study, experimental data were collected through hydraulic model tests over a rigid bed, and the spreading of water, fine sediment, bed load, and large boulders due to flooding are discussed assuming that flash flooding/debris flows occur in the upstream reach. The effects of changes in flow width, such as expansions and contractions in the flow width, as well as changes in meandering channels, sediment transportation, and spreading flow depth resulting from bores are examined using flume data for a steepslope torrent. The data obtained in the present study reveal that fine sediment components are transported to the downstream reach if large-magnitude floods occur and that the spreading rate and peak lags of the fine sediment and water level indicate the occurrence of a flood in the upstream reach.

关键词： Propagation of water and sediment Debris flow Flash flood Hydraulic model tests Flow width

Associations of body mass index and hospital-acquired disability with post-discharge mortality in older patients with acute heart failure

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Journal of Geriatric Cardiology 2022年第3期19卷 209-217页

作者： Akihiro Sakuyama Masakazu Saitoh Kentaro Hori Yuichi Adachi Keigo Iwai Masatoshi nagayama Department of Physical Therapy Faculty of Health ScienceJuntendo UniversityTokyoJapan Department of Rehabilitation Sakakibara Heart InstituteTokyoJapan Department of Cardiology Sakakibara Heart InstituteTokyoJapan

OBJECTIVES To investigate the effect of hospital-acquired disability(HAD)on all-cause mortality after discharge according to the body mass index(BMI)in older patients with acute decompensated heart *** We included 408 patients aged≥65 years who were hospitalized for acute decompensated heart failure and had undergone an acute phase of cardiac rehabilitation at the Sakakibara Heart Institute between April 2013 and September 2015(me-dian age:82 years,interquartile range(IQR):76-86;52%male).Patients were divided into three groups based on BMI at hospital admission:underweight(<18.5 kg/m^(2)),normal weight(18.5 to 25 kg/m^(2)),and overweight(≥25 kg/m^(2)).HAD was defined as a decrease of at least five points at discharge compared to before hospitalization according to the Barthel *** The median follow-up period was 475(IQR:292-730)days,and all-cause mortality during the follow-up period was 84 deaths(21%).According to multivariate Cox regression analysis,being underweight(HR:1.941,95%CI:1.134−3.321,P=0.016)or overweight(HR:0.371,95%CI:0.171−0.803,P=0.012),with normal BMI as the reference,and HAD(HR:1.857,95%CI:1.062−3.250,P=0.030)were independently associated with all-cause *** with HAD exhibited a significantly lower cumulative survival rate in the underweight group(P=0.001)and tended to have a lower cumulative survival rate in the normal weight group(P=0.072).HAD was not significantly associated with cumulative survival in the overweight group(P=0.392).CONCLUSIONS BMI and HAD independently predicted all-cause mortality after discharge in older patients with acute de-compensated heart ***,HAD was significantly associated with higher all-cause mortality after discharge,espe-cially in the underweight group.

关键词： patients acute index

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Development and installation of bedload monitoring systems with submerged load cells

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Journal of Mountain Science 2016年第2期13卷 369-376页

作者： Ken GOTO Takahiro ITOH Takahiko nagayama Rei UTSUNOMIYA Daizo TSUTSUMI Takahisa MIZUYAMA Research and Development Center Nippon Koei Co.Ltd.2304 InariharaTsukubaIbaraki 300-1259Japan Nippon Koei Co. Ltd.4-2 Koji-machiChiyodaTokyo 102-0083Japan JFE Advantech Go. Ltd.3-48 Takahata-choNishinomiyaHyogo 663-8202Japan Disaster Prevention Research Institute Kyoto University436-13 NakaoOkuhidaonsengoTakayamaGifu 506-1422Japan Graduate School of Agriculture Kyoto UniversityKitashirakawa Oiwake-choSakyoKyoto 606-8502Japan

Bedload governs riverbed channel variations and morphology, it is necessary to determine bedload discharge through an arbitrary cross section in a mountain fiver. A new system with submerged load cells has been developed to directly measure bedload discharge. The system consists of：（1） an iron box which is 1 m long, 0.5 m wide and 0.1 m in depth, （2） two submerged load cells 0.7 m apart, （3） a pressure sensor and, （4） an electromagnetic velocity meter. This system has been designed to exclude the effect of the hydraulic pressure of water on direct measurements of bedload particle weight. Initial tests in a laboratory were conducted to examine the accuracy of measurements with the system under aerial conditions. The system has been installed in the supercritical flume in Ashi-arai-dani River of the Hodaka Sedimentation Observatory of the Disaster Prevention Research Institute （DPRI） of Kyoto University to obtain bedload discharge under natural conditions. Flume tests were conducted in this channel by artificial supply of uniform sediment particles of several grain sizes. The average velocity of the sediment particles near the bed was estimated using cross-correlation functions for weight waves obtained by the two load cells, Bedload discharge calculations were based on time integration of the product of sediment velocity and sediment weight obtained by the two load cells. This study clarifies the reasons why bedload measurements are difficult, and provides some solutions using the monitoring systems with submerged load cells through the field measurements. Additionally, the applicability of bedload measurement with the submerged load cells is explained based on experimental artificial sediment supply data.

关键词： Bedload Submerged load cell Flume tests

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Single molecular DNA/RNA sequencing with microscopy

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Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 83-84页

作者： Masanori Kataoka Kuniaki nagayama Hidehiro Oana Oceanography Section Science Research CenterKochi UniversityKochiJapan The Graduate University for Advanced Studies KanagawaJapan Department of Mechanical Engineering The University of TokyoTokyoJapan

Ultra high-throughput DNA sequencing has been a very hot topic beyond the field of genomic *** have been various approaches to this issue ranging from direct observation of individual DNA synthesis[1],amperometric/optical detection of bases using a nanopore[2,3]and direct sequencing with a high-resolution probe microscope[4].Recently,we have developed a technique to chemically modify all nucleobases in DNA[5],so that the bases A,T,G,C can be differentiated in the sequence by using high-resolution electron microscopy(EM).

关键词： Single molecular DNA/RNA sequencing Quantum dot complex

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Adhesion Force Measurements of Polymer Particles by Detachment Field Method

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仪器仪表学报 2004年第S3期 62-66页

作者： Masashi nagayama ,Nobuyasu Sakurai,Tatsuaki Wada,Manabu Takeuchi Department of Electrical and Electronic Engineering Ibaraki University Hitachi 316-8511 Japan Department of Electrical and Electronic Engineering Ibaraki University Hitachi 316-8511 Japan Department of Electrical and Electronic Engineering Ibaraki University Hitachi 316-8511 Japan Department of Electrical and Electronic Engineering Ibaraki University Hitachi 316-8511 Japan

The adhesion force distributions of polymer particles to aluminum substrates were measured by the detachment field method. Polymer particles with conducting surface treatment were used for the measurements. Further the conventional detachment field method was modified to be applicable to the adhesion force measurements of a single particle. The adhesion force of the polymer particles increased with an increase in relative humidity. The surface roughness of the substrate influenced the adhesion forces of particles significantly. The influence of the CF4 plasma treatment of the polymer particles and thin layer coating of the substrate surface on the adhesion forces of the polymer particles was also studied, and factors affecting adhesion forces of polymer particles are discussed.

关键词： Toner Adhesion force van der Waals force

Quantitative Evaluation of Neuroplastic Biomaterial for Human Brain Rehabilitation to Stroke Subjects

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Journal of Chemistry and Chemical Engineering 2013年第11期7卷 1036-1043页

作者： Chiyuri nagayama Graduate School of Ochanomizu University Tokyo 112-0012 Japan Tokyo Metropolitan Senior High School Tokyo 156-0055 Japan

Neurorehabilitation involves training of brain activity, which influences the resistive torque and electromyogram. This quantitative evaluation is numerical modeling of biomaterial of human body. Measurement for rehabilitation and developing numerical modeling in patients are useful for information technology education with healthcare background. The resistive torque and electromyogram were measured. Electromyogram is the neuronal activity from eight lower limb muscles. Both activities are output signals for angle input signals. The resistive torque of a stroke patient shows a hysteresis curve, and this is a velocity-dependent component, particular for stroke. Differentiated angle by muscle spindle, a velocity-dependent component, is a stretch reflex （spasticity）. In an electromyogram of a stroke patient, SLR （stretch reflex via spinal cord） means a short latency reflex, and LLR （stretch reflex via cerebral cortex） means a long latency reflex. An example of some stroke electromyogram shows long latency reflex, and this is voluntary movement during the experiment. The example of some stroke resistive torque reveals that viscoelasticity is used for the intrinsic component. The example of some stroke electromyogram reveals that long latency reflex is used for the reflex component of lower limbs. Current research needs improvement. Intrinsic viscoelasticity is modeled by a second-order differential equation. The reflex component of stroke patients is modeled by a double exponential function. Open source software is in use. Information technology-based analyses by numerical modeling would be applied in future healthcare education.

关键词： Analysis programming biological tissue educational effect developmental process.

Mechanical Stress to Cell Nucleus Inhibits Proliferation and Differentiation of Vascular Smooth Muscle Cells

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Journal of Biosciences and Medicines 2020年第5期8卷 132-141页

作者： Kazuaki nagayama Micro-Nano Biomechanics Laboratory Department of Mechanical Systems Engineering Ibaraki University Ibaraki Japan

Cells sense the external environment such as a surface topography and change many cellular functions. Cell nucleus has been proposed to act as a cellular mechanosensor, and the changes in nuclear shape possibly affect the functional regulation of cells. This study demonstrated a large-scale mechanical deformation of the intracellular nucleus using polydimethylsiloxane (PDMS)-based micropillar substrates and investigated the effects of nuclear deformation on migration, proliferation, and differentiation of vascular smooth muscle cells (VSMCs). VSMCs spread completely between the fibronectin-coated pillars, leading to strong deformations of their nuclei resulted in a significant inhibition of the cell migration. The proliferation and smooth muscle differentiation of VSMCs with deformed nuclei were dramatically inhibited on the micropillars. These results indicate that the inhibition of proliferation and VSMC differentiation resulted from deformation of the nucleus with high internal stress, and this type of large-scale nuclear mechanical stress might lead the cells to a “quiescent state”.

关键词： Cell Biomechanics Mechanobiology Nuclear Mechanotransduction Microfabrication