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Differences and similarities between mesenchymal stem cell and endothelial progenitor cell immunoregulatory properties against T cells

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World Journal of Stem Cells 2021年第8期13卷 971-984页

作者： Mehdi Razazian maryam khosravi Sheyda Bahiraii Georges Uzan Sara Shamdani Sina Naserian Institut national de la santéet de la recherche médicale(Inserm)UnitéMixte de Recherche-Inserm-Ministère de la Défense 1197 Hôpital Paul BrousseVillejuif 94800France Microenvironment&Immunity Unit Institut PasteurParis 75724France Institut national de la santéet de la recherche médicale(Inserm)Unit 1224 Paris 75724France Department of Pharmacognosy University of ViennaVienna 1090Austria Paris-Saclay University Villejuif 94800France CellMedEx Saint Maur Des Fossés 94100France

Bone-marrow-derived mesenchymal stem cells and endothelial progenitor cells have some interesting biological properties that make them unique for cell therapy of degenerative and cardiovascular disorders.Although both cell populations have been already studied and used for their regenerative potentials,recently their special immunoregulatory features have brought much more attention.Mesenchymal stem cells and endothelial progenitor cells have both proangiogenic functions and have been shown to suppress the immune response,particularly T cell proliferation,activation,and cytokine production.This makes them suitable choices for allogeneic stem cell transplantation.Nevertheless,these two cells do not have equal immunoregulatory activities.Many elements including their extraction sources,age/passage,expression of different markers,secretion of bioactive mediators,and some others could change the efficiency of their immunosuppressive function.However,to our knowledge,no publication has yet compared mesenchymal stem cells and endothelial progenitor cells for their immunological interaction with T cells.This review aims to specifically compare the immunoregulatory effect of these two populations including their T cell suppression,deactivation,cytokine production,and regulatory T cells induction capacities.Moreover,it evaluates the implications of the tumor necrosis factor alpha-tumor necrosis factor receptor 2 axis as an emerging immune checkpoint signaling pathway controlling most of their immunological properties.

关键词： Endothelial Progenitor Cells Mesenchymal Stem Cells T cells Immunosuppression Immunoregulation TNFα-TNFR2 signaling pathway

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On the Relationship between Iranian EFL Students’ Writing Strategies and Writing Ability

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Journal of Linguistics and Education Research 2019年第2期2卷 1-7页

作者： Behrooz Ghoorchaei maryam khosravi Department of English Farhangian UniversityTehranIran Islamic Azad University of Gorgan Iran

This study aimed at investigating the relationship between writing strategies,and writing ability of Iranian EFL students.The participants were 120 students learming English in the Iranian EFL context.Data were gathered by means of a writing strategies questionnaire and an IELTS writing task.The results of Pearson correlation test revealed that there was a statistically significant relationship between writing strategies,and writing abilties of the participants.The results have some implications for teaching writing in the EFL context.

关键词： Writing strategy Writing ability EFL students

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A Study of the Effect of Citrus aurantiumL. Essential Oil on Anxiety and Its Interaction with GABAergic Pathways in Male Mice

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Journal of Behavioral and Brain Science 2014年第10期4卷 470-476页

作者： maryam khosravi Shahrzad Khakpour Leila Adibi Mahsa Hadipour Jahromy Biology Department Faculty of Biological Sciences Islamic Azad University North Tehran Branch Tehran Iran Faculty of Medicine Medical Sciences Research Center Tehran Medical Branch Islamic Azad UniversityTehran Iran

Anxiety is among the most common disorders affecting a great number of people. Different neurotransmitter systems, such as GABAergic system, play an important role in emergence of anxiety-related behaviors. In this study, we have investigated the effect of Citrus aurantium L. essential oil on anxiety and its interaction with GABAergic pathways. Male mice were assigned into control, sham, and experimental groups. Intraperitoneal injection of Citrus aurantium L. essential oil was applied at doses of 0.5, 2.5, and 5 percent for 5 days. Diazepam (0.1 mg/kg) was injected on the fifth day, thirty minutes before applying Citrus aurantium L. essential oil. The anxiety-related behavior of mice was then assessed using elevated plus-maze test. In groups receiving Citrus aurantium L. essential oil at doses of 2.5 and 5 percent, the percent time spent in the open arms increased significantly (P Citrus aurantium L. essential oil resulted in increasing in the number of entries to the open arms and the percent time spent in the open arms (P Citrus aurantium L. essential oil can reduce anxiety-related behaviors in male mice thah may act via GABAergic system.

关键词： Anxiety Mice Citrus aurantium L. Diazepam

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Effect of Citrus aurantiumL. Essential Oil and Haloperidol on Anxiety in Male Mice

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World Journal of Neuroscience 2014年第5期4卷 427-433页

作者： Shahrzad Khakpour maryam khosravi Zahra Mashayekhipour Mahsa Hadipour Jahromy Medical Sciences Research Center Islamic Azad University Tehran Medical Branch Tehran Iran Biology Department Faculty of Biological Sciences Islamic Azad University North Tehran Branch Tehran Iran

Relationship between sociability and the amount of brain’s dopamine is very well known. In this study, we have examined the effect of Citrus aurantium L. essential oil on anxiety and its interaction with dopaminergic pathways. 70 male mice were assigned into experimental, control, and sham groups. Essential oil of Citrus aurantium L. was injected intraperitonealy at doses of 0.5%, 2.5% and 5% for 5 days. Subcutaneous injection of haloperidol was administered on the fifth day, 30 minutes before the injection of the essential oil. The anxiety-related behavior of mice was then assessed by elevated plus-maze test. The result of this study showed that the injection of Citrus aurantium L. essential oil at doses of 2.5% and 5% increased significantly the time spent in the open arms (OAT) (p < 0.001), also there was a significant increase in the number of entries into the open arms (OAE). Injection of different doses of the essential oil along with haloperidol significantly increased OAT (p < 0.001(. The results demonstrate that the essential oil of Citrus aurantium L. along with haloperidol medication reduces anxiety-related behaviors.

关键词： Anxiety Citrus aurantium L. Essential Oil Haloperidol Mice

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Interaction of Flomazenil with Anxiolytic Effects of Citrus aurantiumL. Essential Oil on Male Mice

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Pharmacology & Pharmacy 2015年第2期6卷 41-46页

作者： Leila Adibi maryam khosravi Shahrzad Khakpour Hedayat Sahraei Mahsa Hadipour Jahromy Biology Department Faculty of Biological Sciences Islamic Azad University North Tehran Branch Tehran Iran Herbal Pharmacology Research Center Tehran Medical Sciences Branch Faculty of Medicine Islamic Azad University Tehran Iran Neuroscience Research Center Baghiatallah University of Medical Tehran Iran

Due to our previous findings about the role of GABAegic neurotransmission in anxiolytic effects of Citrus aurantium L. essential oil, we are now presenting flomazenil interaction with this herb, as an antagonist of benzodiazepines at GABA receptor. The study was performed on 84 male albino mice assigned to 14 groups of six. The animals were injected intraperitoneally with the Citrus aurantium L. essential oil for 5 days. On the fifth day, either normal saline or flomazenil (0.1 mg/kg) was injected to the experimental groups. Thirty minutes after the injection, all the groups were assessed for anxiety-related behavior by elevated plus-maze test. In groups receiving Citrus aurantium L. essential oil at doses of 2.5 and 5 percent, the time spent in the open arms increased significantly (P aurantium L. essential oil regarding the increment in the number of entries to the open arms and the time spent in the open arms (P aurantium L. essential oil induces its anxiolytic effects like benzodiazepines, in the same site at GABA receptor.

关键词： Anxiety Citrus aurantium L. Flomazenil

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Niosome-encapsulated auraptene reduced the mRNA expression of VEGF-A and PDGFs genes in human retinaderived RPE cell line

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1028-1035页

作者： Akram Vahidi Teymoor khosravi Farzad Dastaviz Mehdi Sheikh Arabi Ayyoob khosravi Morteza Oladnabi Student Research Committee Golestan University of Medical SciencesGorgan ***Iran Department of Medical Nanotechnology Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Stem Cell Research Center Golestan University of Medical SciencesGorgan ***Iran Department of Molecular Medicine Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Gorgan Congenital Malformations Research Center Golestan University of Medical SciencesGorgan ***Iran

AIM:To evaluate the effect of auraptene(AUR)treatment in forms of free and encapsulated in niosome nanoparticles by investigating the mRNA expression level of vascular endothelium growth factor(VEGF)-A and platelet-derived growth factors(PDGFs)in human retinal pigment epithelium(RPE)cell line.METHODS:Niosome nanocarriers were produced using two surfactants Span 60 and Tween 80.RPE cell line was treated with both free AUR and niosome-encapsulated.Optimum dosage of treatments was calculated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)assay.Expression of VEGF-A and PDGF-A,PDGF-B,PDGF-C,PDGF-D genes was measured after total RNA extraction and cDNA synthesis,using real-time polymerase chain reaction(RT-PCR).RESULTS:The highest entrapment efficiency(EE)was achieved by Span 60:cholesterol(1:1)with 64.3%.The half maximal inhibitory concentration(IC50)of free and niosome-encapsulated AUR were 38.5 and 27.78µg/mL,respectively.Release study revealed that niosomal AUR had more gradual delivery to the cells.RT-PCR results showed reduced expression levels of VEGF-A,PDGF-A,PDGF-B,PDGF-C,and PDGF-D after treatment with both free and niosomal AUR.CONCLUSION:Niosomal formulation of Span 60:cholesterol(1:1)is an effective drug delivery approach to transfer AUR to RPE cells.VEGF-A,PDGF-A,PDGF-B,PDGF-C,and PDGF-D are four angiogenic factors,inhibiting which by niosomal AUR may be effective in age-related macular degeneration.

关键词： auraptene niosome age-related macular degeneration angiogenesis nanocarrier

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Impact of umbelliprenin-containing niosome nanoparticles on VEGF-A and CTGF genes expression in retinal pigment epithelium cells

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 7-15页

作者： Farzad Dastaviz Akram Vahidi Teymoor khosravi Ayyoob khosravi Mehdi Sheikh Arabi Abouzar Bagheri Mohsen Rashidi Morteza Oladnabi Stem Cell Research Center Golestan University of Medical SciencesGorgan ***Iran Department of Medical Genetics School of Advanced Technologies in MedicineGolestan University of Medical SciencesGorgan ***Iran Student Research Committee Golestan University of Medical SciencesGorgan ***Iran Department of Molecular Medicine Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Department of Medical Nanotechnology Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Department of Clinical Biochemistry and Genetics Faculty of MedicineMazandaran University of Medical SciencesSari ***Iran Department Pharmacology Faculty of MedicineMazandaran University of Medical SciencesSari ***Iran Gorgan Congenital Malformations Research Center Golestan University of Medical SciencesGorgan ***Iran

AIM:To investigate the impact of niosome nanoparticles carrying umbelliprenin(UMB),an anti-angiogenic and anti-inflammatory plant compound,on the expression of vascular endothelial growth factor(VEGF-A)and connective tissue growth factor(CTGF)genes in a human retinal pigment epithelium(RPE)-like retina-derived cell line.METHODS:UMB-containing niosomes were created,optimized,and characterized.RPE-like cells were treated with free UMB and UMB-containing niosomes.The IC_(50)values of the treatments were determined using an MTT assay.Gene expression of VEGF-A and CTGF was evaluated using real-time polymerase chain reaction after RNA extraction and cDNA synthesis.Niosomes’characteristics,including drug entrapment efficiency,size,dispersion index,and zeta potential were assessed.Free UMB had an IC_(50)of 96.2μg/mL,while UMB-containing niosomes had an IC_(50)of 25μg/mL.RESULTS:Treatment with UMB-containing niosomes and free UMB resulted in a significant reduction in VEGF-A expression compared to control cells(P=0.001).Additionally,UMB-containing niosomes demonstrated a significant reduction in CTGF expression compared to control cells(P=0.05).However,there was no significant reduction in the expression of both genes in cells treated with free UMB.CONCLUSION:Both free UMB and niosome-encapsulated UMB inhibits VEGF-A and CTGF genes expression.However,the latter demonstrates significantly greater efficacy,potentially due to the lower UMB dosage and gradual delivery.These findings have implications for anti-angiogenesis therapeutic approaches targeting age-related macular degeneration.

关键词： umbelliprenin niosome age-related macular degeneration vascular endothelial growth factor-A connective tissue growth factor

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Heating-Cooling Monitoring and Power Consumption Forecasting Using LSTM for Energy-Efficient Smart Management of Buildings: A Computational Intelligence Solution for Smart Homes

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Tsinghua Science and Technology 2024年第1期29卷 143-157页

作者： Omid Akbarzadeh Sahand Hamzehei Hani Attar Ayman Amer Nazanin Fasihihour Mohammad R.khosravi Ahmed A.Solyman Department of Electronics and Telecommunications Politecnico di TorinoTurin 10129Italy Department of Energy Engineering Zarqa UniversityZarqa 13110Jordan Shandong Provincial University Laboratory for Protected Horticulture Weifang University of Science and TechnologyWeifang 262799China Department of Electrical and Electronics Engineering Faculty of Engineering and ArchitectureNisantası UniversityIstanbul 25370The Republic of Turkiye

Energy management in smart homes is one of the most critical problems for the Quality of Life(QoL)and preserving energy resources.One of the relevant issues in this subject is environmental contamination,which threatens the world's future.Green computing-enabled Artificial Intelligence(Al)algorithms can provide impactful solutions to this topic.This research proposes using one of the Recurrent Neural Network(RNN)algorithms known as Long Short-Term Memory(LSTM)to comprehend how it is feasible to perform the cloud/fog/edge-enabled prediction of the building's energy.Four parameters of power electricity,power heating,power cooling,and total power in an office/home in cold-climate cities are considered as our features in the study.Based on the collected data,we evaluate the LSTM approach for forecasting parameters for the next year to predict energy consumption and online monitoring of the model's performance under various conditions.Towards implementing the Al predictive algorithm,several existing tools are studied.The results have been generated through simulations,and we find them promisingforfutureapplications.

关键词： design-builder Besos smart cities smart building neural network Long Short-Term Memory(LSTM)

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Identity, the Main Term of Contrast between ＂Globalization＂ and ＂Universalization＂ An Interpretention with a Critical Linguistic Approach

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哲学研究：英文版 2016年第3期6卷 155-161页

作者： Mohammad Tohidfam maryam khosravi Baraghani Shahab Dalili Islamic Azad University

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Commercialization Management of National Commodities for Oil and Gas Industry in Iran

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Journal of Modern Accounting and Auditing 2017年第7期13卷 320-331页

作者： maryam khosravi Saghezchi Ahmad Ramezani Saadat Abadi Ali Bonyadi Naeeni K.N. Toosi University of Technology Tehran Iran Sharif University of Technology Tehran Iran Iran University of Science and Technology Tehran Iran

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