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Poly(ethylene glycol)hydrogel elasticity influences human mesenchymal stem cell behavior

Regenerative Biomaterials 2018年第3期5卷 167-175页

作者： Anna K.Whitehead Haley H.Barnett mary e.caldore.a-moore.jamie.j.ne.man School of Biological Sciences Department of Biomedical engineering Louisiana Tech UniversityRustonLA 71272USA

Coordinated investigations into the interactions between biologically mimicking(biomimetic)material constructs and stem cells advance the potential for the regeneration and possible direct replacement of diseased cells and *** clinically relevant therapies will require the development and optimization of methods that mass produce fully functional cells and *** advances in the design and synthesis of biomaterial scaffolds,one of the biggest obstacles facing tissue engineering is understanding how specific extracellular cues produced by biomaterial scaffolds influence the proliferation and differentiation of various cell *** elasticity is one such tailorable property of synthetic scaffolds that is known to differ between ***,we investigate the interactions between an elastically tailorable polyethylene glycol(PeG)-based hydrogel platform and human bone marrow-derived mesenchymal stem cells(hMSCs).For these studies,two different hydrogel compositions with elastic moduli in the ranges of 50-60 kPa and 8-10 kPa were *** findings demonstrate that the different elasticities in this platform can produce changes in hMSC morphology and proliferation,indicating that the platform can be implemented to produce changes in hMSC behavior and cell state for a broad range of tissue engineering and regenerative ***,we show that the platform’s different elasticities influence stem cell differentiation potential,particularly when promoting stem cell differentiation toward cell types from tissues with stiffer *** findings add to the evolving and expanding library of information on stem cell-biomaterial interactions and opens the door for continued exploration into PeG-based hydrogel scaffolds for tissue engineering and regenerative medicine applications.

关键词： biomaterial-cell interaction scaffolds stem cells

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expression of octopaminergic receptor genes in 4 nonneural tissues in female Nicrophorus vespilloides beetles

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Insect Science 2015年第4期22卷 495-502页

作者： Christopher B. Cunningham mary K. Douthit Allen j. moore Department of Genetics University of Georgia Athens GA 30602 USA

Octopamine regulates the function of many tissues and physiological processes in invertebrates. The expression of octopamine receptor genes has been examined in multiple tissue types in several different insect orders. However, little work has addressed this issue in Coleoptera. Most studies characterize individual genes in different tissue types, but here we describe the expression of 6 octopamine receptor genes in thoracic musculature, oviducts, Malpighian tubules, and fat body of female Nicrophorus vespilloides beetles to characterize both different genes and different tissues within a single study. We then compare the gene expression profiles found in this beetle to other insects to examine the extent to which expression profiles are conserved across insects. We also examine the relative involvement of octopamine verses octopamine/tyramine receptors based on receptor gene expression in each tissue to help elucidate if tyramine plays a role in the regulation of these tissues. We find a high degree of overlap in the expression profile of the 6 genes examined in the thoracic muscula^tre, a moderate amount for the oviducts, and divergent profiles for Malpighian tubules and fat body. Based on expression difference in receptor subtypes, our results also support the suggestion that tyramine is a biogenic amine with physiological actions separate from octopamine.

关键词： biogenic amines Coleoptera G-protein coupled receptors quantitative real-time PCR

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Optical properties of Weyl semimetals

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National Science Review 2019年第2期6卷 206-208页

作者： joel e.moore Department of Physics University of California Materials Science Division Lawrence Berkeley National Laboratory

The behavior of electrons in ordinary metals is dominated by physics near the Fermi surface. Indeed, many of the first successes of the quantum theory of solids, such as understanding the large specific heat of metals, followed from applications of the Fermi surface concept. Great effort has been devoted in recent years to semimetals in which the Fermi surface shrinks to a set of Dirac or Weyl points, where four

关键词： As Ta Optical properties of Weyl semimetals

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economic Development through Medicinal and Aromatic Plants(MAPs) Cultivation in Hindu Kush Himalaya Mountains of District Swat, Pakistan

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journal of Mountain Science 2015年第5期12卷 1292-1301页

作者： Hassan SHeR mary e. BARKWORTH Center for Plant Sciences and Biodiversity University of Swat Intermountain Herbarium Department of Biology Utah State University

Poverty is pervasive in the Swat Valley in northwestern Pakistan, and most people survive by farming small landholdings. However, many supplement their meager subsistence earnings by collecting and selling plant material for use in herbal medicine. This material is wild-harvested, but collectors seem not to fully appreciate the potential value of the plant material they collect nor the longterm impact their collection has on local plant populations. A model project supported by the International Food Policy Research Institute(IFPRI)persuaded small-scale farmers in four different villages to use some of their land for cultivating traditionally wild-harvested species of medicinal and aromatic plants(MAPs) with high market value. The farmers were provided seeds or rhizomes of five MAPs and asked to monitor their germination and growth on 25 m2 plots during a 12 month period. At the end of the study, growth and yield data from the four localities were compared and economic analyses conducted to determine the profitability of the species based on yields, prevailing market prices, and costs of production. Five of the cultivated species were subsequently marketed and their value evaluated:Sesamum indicum, Linum usitatissimum, Ocimum basilicum, Nigella sativa and Viola pilosa. The MAPs V. pilosa and O. basilicum were the most profitable,whereas Nigella sativa was the least profitable because of its low germination rate. The net income from all but Nigella was higher than that would have been earned by planting the same area with the predominant cereals or tomatoes. In addition to demonstrating the feasibility and financial benefits of cultivating MAPs as a cash crop, this model study identified a number of additional steps that would increase the benefits of MAPs cultivation in this area.A combination of specialized education, market infrastructure development and a small loans program would enable farmers to increase their agricultural income without damaging the area's pl

关键词： Biological diversity Medicinal plant Aromatic plant Agriculture productivity Traditionalcrops economic analysis Himalaya Mountains

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Amount of polyhydramnios attributable to diabetes may be less than previously reported

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World journal of Diabetes 2017年第1期8卷 7-10页

作者： Lisa e moore Department of Obstetrics and Gynecology Texas Tech Health Sciences CenterEl PasoTX 79905United States

AIM To evaluate the frequency and the quantity of polyhydramnios attributable to diabetes in *** The charts of patients with a four-quadrant amniotic fluid index(AFI) ≥ 20 cm and either a diagnosis of diabetes or a diabetes screening test during the index pregnancy were retrospectively reviewed. AFI was stratified into 5 categories and the frequency of diabetes was evaluated for each group. The frequency of polyhydramnios attributable to diabetes was compared to the frequency of polyhydramnios in the setting of fetal anomalies or no known cause. ReSULTS One thousand five hundred and forty-five patients were included in the study. eight point five percent(n = 131) had diabetes and no other cause for polyhydramnios. eleven point two percent(173) had antenatally diagnosed anomalies. For all categories of AFI except the largest(> 40.9 cm) the most common cause of polyhydramnios was idiopathic. In patients with diabetes the AFI was most likely to be between 26 cm and 35.9 *** The rate of polyhydramnios in this study is 8.5%. Patients with diabetes most commonly have mild polyhydramnios between 26 and 35.9 cm of fluid on a four-quadrant AFI.

关键词： Gestational diabetes Amniotic fluid index Diabetes in pregnancy Polyhydramnios

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Iodoacetic acid exposure alters the transcriptome in mouse ovarian antral follicles

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journal of environmental Sciences 2022年第7期34卷 46-57页

作者： Andressa Gonsioroski mary Laws Vasiliki e.Mourikes Alison neff jenny Drnevich Michael j.Plewa jodi A.Flaws Department of Comparative Biosciences University of Illinois Urbana-ChampaignUrbanaIllinois 61801USA Roy j.Carver Biotechnology Center University of Illinois Urbana-ChampaignUrbanaIllinois 61801USA Department of Crop Sciences and the Safe Global Water Institute University of Illinois Urbana-ChampaignUrbanaIllinois 61801USA

Iodoacetic acid(IAA) is an unregulated water disinfection byproduct that is an ovarian toxicant. However, the mechanisms of action underlying IAA toxicity in ovarian follicles remain unclear. Thus, we determined whether IAA alters gene expression in ovarian follicles in mice. Adult female mice were dosed with water or IAA(10 or 500 mg/L) in the water for 35-40 days. Antral follicles were collected for RNA-sequencing analysis and sera were collected to measure estradiol. RNA-sequencing analysis identified 1063 differentially expressed genes(DeGs) in the 10 and 500 mg/L IAA groups(false discovery rate FDR espectively, compared to controls. Gene Ontology enrichment analysis showed that DeGs were involved with RNA processing and regulation of angiogenesis(10 mg/L) and the cell cycle and cell division(500 mg/L). Pathway enrichment analysis showed that DeGs were involved in the phosphatidylinositol 3-kinase and protein kinase B(PI3K-Akt), gonadotropin-releasing hormone(Gn RH), estrogen, and insulin signaling pathways(10 mg/L). Pathway enrichment analysis showed that DeGs were involved in the oocyte meiosis, Gn RH, and oxytocin signaling pathways(500 mg/L). RNA-sequencing analysis identified 809 DeGs when comparing the 500 and 10 mg/L IAA groups(FDR eGs were related to ribosome, translation, m RNA processing, oxidative phosphorylation, chromosome, cell cycle, cell division, protein folding, and the oxytocin signaling pathway. Moreover, IAA exposure significantly decreased estradiol levels(500 mg/L) compared to control. This study identified key candidate genes and pathways involved in IAA toxicity and can help to further understand the molecular mechanisms of IAA toxicity in ovarian follicles.

关键词： Disinfection byproducts Iodoacetic acid Ovary Ovarian follicles Steroidogenesis endocrine disruptors

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Microbiological safety of spices and their interaction with antibiotics:implications for antimicrobial resistance and their role as potential antibiotic adjuncts

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Food Quality and Safety 2019年第2期3卷 93-97页

作者： Rachel e.moore B.Cherie Millar jayachandran R.Panickar john e.moore Department of Bacteriology Northern Ireland Public Health LaboratoryBelfast City HospitalLisburn RoadBelfastNorthern IrelandBT97ADUK School of Biomedical Sciences Ulster UniversityCromore RoadColeraineBT521SANorthern IrelandUK Centre for experimental Medicine Queen’s University97 Lisburn RoadBelfast BT97BLNorthern IrelandUK Department of Paediatrics Sheikh Khalifa Medical CityAbu DhabiUnited Arab Emirates

Objectives:A study was undertaken to:*** contaminating bacteria on a variety of spices purchased at retail market;*** if spice bacterial enrichments alter the phenotype of 13 bacterial foodborne and clinical pathogens and 1 probiotic organism;and *** if spices can alter antimicrobial activity of seven clinical antibiotics against 16 bacterial foodborne/clinical *** and Methods:Microbiological examination was undertaken employing 27 spice varieties with four antibiotics and 15 bacterial ***:Bacteriological contamination levels varied amongst spice varieties,ranging from Kasmin chilli powder(7.5×10^(6)cfu/g;log10^(6).88 cfu/g)to ginger(1.5×10^(4)cfu/g;log_(10)4.18 cfu/g);mean contamination was 1.38×10^(6)cfu/g(log_(10)6.14 cfu/g).Four species within the genus Bacillus were identified(Bacillus megaterium,Bacillus subtilis,Bacillus licheniformis,and Bacillus cereus).There was no phenotypic difference with the 14 bacteria,with bacterial colony growth/proliferation,pigment production,or with adhesin and mucoid *** of the spice cultures inhibited any of the 14 bacterial species *** the case of doxycycline,amoxicillin,colistin,erythromycin,and piperacillin/tazobactam,the zone of inhibition increased with the inclusion of the 26 spice varieties,suggesting that the spices were interacting synergistically with the antibiotic,thus making the antibiotic more potent against the bacteria ***:This study demonstrates a positive interaction between spices and conventional *** the burden of antimicrobial resistance(AMR)worldwide,but particularly in South Asian countries(India and Pakistan),any food-related innovation that can help maximize the potency of existing antibiotics is to be encouraged and *** specific mechanism as to how spices increase the potency of antibiotics needs to be elucidated,as well as novel food(spice)delivery modalities including novel medicinal foo

关键词： antibiotic resistance antimicrobial resistance Bacillus foodborne pathogen microbiology Pseudomonas aeruginosa spice

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A Standard of excellence

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中国翻译 1995年第3期 61-62页

作者： mary e. Potter

My 14-year-old son, john, and I spotted thecoat simultaneously. It was hanging on a rack ata secondhand clothing store in Northampton,Mass., crammed in with shoddy trench coats andan assortment of sad, woollen overcoats—a roseamong thorns. While the other coats drooped, this onelooked as if it were holding itself up. The thick,black wool of the double-breasted chesterfieldwas soft and unworn, as though it had been pre-served in mothballs for years in dear old

关键词：盖茨比大衣普通名词英国历史美国小说生产厂家曼哈顿纽约市外交家再生

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A Room of His Own

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中国翻译 1995年第2期 62-63页

作者： mary e.Potter

Unmistakable noises are coming throughmy bedroom wall. Now a scuffling, now abumping, a long, drawn-out scraping"john, are you moving furniture in there? A-gain?" I call. The wall muffles his "yes" butdoes not filter ... 详细信息

关键词： A Room of His Own

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单壁碳纳米管作支撑的杂化金纳米催化剂比TiO_2和炭黑具有更优氧化芳香醇的性能（英文）

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新型炭材料 2017年第3期32卷 242-251,289,290,291,292,293,294,295,296,297,298,299,300,301,302,303,304,305,306页

作者： Anne e Shanahan mary McNamara james A Sullivan Hugh j Byrne FOCAS Research Institute Dublin Institute of TechnologyCamden RowDublin 8Republic of Ireland UCD School of Chemistry and Chemical Biology BelfieldDublin4Republic of Ireland

采用原位还原技术制备出以单壁碳纳米管、炭黑(P90)和TiO_2为支撑的3种金纳米复合材料,并通过多种表征手段来探讨物理性能。再将他们作为1-苯基乙醇、2-苯基乙醇和苯甲醇的绿色需氧氧化杂化催化剂来测试稳定性。在所有反应中,与P90和Ti... 详细信息

采用原位还原技术制备出以单壁碳纳米管、炭黑(P90)和TiO_2为支撑的3种金纳米复合材料,并通过多种表征手段来探讨物理性能。再将他们作为1-苯基乙醇、2-苯基乙醇和苯甲醇的绿色需氧氧化杂化催化剂来测试稳定性。在所有反应中,与P90和TiO_2相比,以单壁碳纳米管作支撑的金纳米杂化催化剂呈现出最优的反应效率和特异性。这些金纳米杂化催化剂经多次反应循环后反应活性衰减很小,从而能被重复使用。同时探讨了金纳米杂化催化剂活性高的原因,包括颗粒形貌、尺寸和支撑体性能。可以推断,基底上功能团迁移的位置、支撑材料的性质和活性金纳米颗粒相的颗粒尺寸分布均有助于使这些催化剂在反应中显示出高的选择性。

关键词：芳香的醇金纳米催化剂选择性

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