检索结果-南通市图书馆

Pleis.ocene his.ory of Iberomys.an endangered endemic rodent from s.uthwes.ern Europe

Integrative Zoology 2014年第4期9卷 481-497页

作者： Gloria CUEnCA-BEs.Ós.Juan Manuel LÓPEZ-GARCÍA María Angeles.GALInDO-PELLICEnA Ros. GARCÍA-PEREA Julio GIs.ERT Juan ROFEs.Jacint VEnTURA Res.arch Group Aragos.urus.IUCA PaleontologyEarth Sciences DepartmentUniversity of ZaragozaZaragozaSpain Res.arch Group of Paleobiology and Prehis.ory Human Studies DepartmentUniversity of FerraraFerraraItaly Res.arch Ins.itute of Evolution and Human Behavior UCM-ISCIIIMadridSpain GALEMIA Conservation and Study of Forgotten VertebratesMadridSpain Department of s.ratigraphy and Paleontology Faculty of Sciences and TechnologyUniversity of the Basque CountryGipuzkoaGuipúzcoaSpain Department of Animal Biology Plant Biology and EcologyFaculty of BiosciencesUniversity Autonoma de BarcelonaBarcelonaSpain

The extant Cabrera’s.vole,Microtus.cabrerae,differs.in morphology and evolutionary his.ory from the other s.ecies.of *** arvicoline has.unique derived features.in the cranium,mandible and ***bly its.mos. cons.icuous.features.are its.large s.ze,the high s.ull in lateral view,the long and dis.ally broad nas.ls.and the triangle s.ape of the anteroconid complex,with a marked labio-lingual as.mmetry of the occlus.l s.rface of the firs. lower *** this.s.udy,we propos. a phylogenetic lineage that includes.Cabrera’s.vole in what until now has.been the Microtus.s.bgenus.*** information and s.veral life his.ory traits.s.pport the elevation of Iberomys.to the rank of *** Iberomys.compris.s.s.ecies.that have appeared in s.cces.ion during the Quaternary:in the Early Pleis.ocene,the extinct *** in the Middle Pleis.ocene,the extinct *** and in the Late Pleis.ocene,the extant ***,the extant s.ecies.s.ows.s.veral biological s.ngularities.s.ch as.multiple polymorphic copies.of the s.Y male-s.ecific gene in both males.and females.and the lowes. bas.l metabolic rate in relation to weight among arvicoline ***,its.habitat requirement is.unique among the Iberian ***,the biological and paleontological data that we pres.nt in this.work s.pport the elevation of its.taxonomic rank to that of ge*** s.udy als. s.gges.s.a modification of nomenclature:Microtus.Iberomys.brecciens.s.is.replaced with *** and the common name of the extant M.(I.)cabrerae changed from‘topillo’to‘iberon’to improve cons.rvation and protection actions.

关键词： Cabrera’s.vole cons.rvation Iberoccitanian endemis. Iberomys origin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Geomechanical model for a s.is.ically active geothermal field:Ins.ghts.from the Tinguiririca volcanic-hydrothermal s.s.em

引用

Geos.ience Frontiers 2019年第6期10卷 2117-2133页

作者： L.Giambiagi P.Alvarez s.s.agnotto E.Godoy A.Los.ada J.Mes.ua M.Barrionuevo J.s.riano IAnIGLA CCT MendozaCONICETParque San Martín s/n5500MendozaArgentina TEHEMA s.A. Subercaseaux 4100PirqueChile Univers.dad nacional de s.n Luis Consejo Nacional de Investigaciones Científicas y TécnicasArgentina Univers.dad de Buenos.Aires Consejo Nacional de Investigaciones Científicas y TécnicasInstituto de Estudios Andinos(IDEAN)Facultad de Ciencias Exactas y NaturalesBuenos AiresArgentina Facultad de Ciencias.Exactas.y naturales Universidad Nacional de CuyoArgentina

In this.work,we develop a multidis.iplinary approach to inves.igate a geothermal s.s.em located at the volcanic arc of a s.bduction-related orogen and highlight the interplay between active *** field and fluid *** us.ng res.lts.of field inves.igations.from the Tinguiririca geothermal field in the High Andes.of Chile(35°s.,empirical analys.s.and numerical models.of s.atic s.res. variations.we propos.d a geomechanical model for evaluating the dis.ribution of hydrothermal manifes.ations.in a s.is.ically-active *** pres.nt geomechanical model follows.four major s.eps.(1)development of the 3 D s.ructural model of fault pattern;(2)es.imation of the in-s.tu s.res. field;(3)calculation of the res.lved-s.ear-to-normal-s.res. ratio(s.ip tendency)on each fault with varying geomechanical parameters.coefficient of friction,pore pres.ure and cohes.on)as.inputs.and(4)es.imation of Coulomb s.atic s.res. changes.as.a cons.quence of failure in a nearby *** combination of all thes. analys.s.we characterize in detail both the active deformation in the geothermal field and its.relations.ip with hot fluid migration.

关键词： s.uthern central Andes Paleos.res. analys.s Fluid migration Coulomb s.aric s.res. change

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

s.bjective Well-Being Model for Urban Mexico and Applications

引用

Economics.World 2020年第2期8卷 37-50页

作者： Rafael G.Reyes.Morales.Alicia s.lvia Gijón-Cruz Verónica Judith Yes.as.mart.nez Gloria G.Lambarria Gopar Joel Hernández Ruiz Tecnológico nacional de México/Ins.ituto Tecnológico de Oaxaca State of OaxacaMexico Univers.dad Autónoma Benito Juárez de Oaxaca State of OaxacaMexico Univers.dad Autónoma Benito Juárez de Oaxaca Oaxaca StateMexico

The purpos. of this.article is.to contribute to the analys.s.of s.bjective well-being in the cities.of Mexico through the theoretical formalization and empirical verification of a quantitative *** variables.come from the cons.ructs.of the s.lf-reported well-being module(BIARE);and they are called:overall s.tis.action with life,s.ns. of fullnes.,affect balance,and s.tis.action *** equations.were cons.ructed us.ng ordinary leas. s.uares.regres.ion with the BIARE databas.s.of 2014 and *** analys.s.of the behavior pattern of variables.conduced to findings.of urban s.ciety’s.expectations.of well-being and concerns.in the period *** quality of life-and-s.lf-realization and overall s.tis.action with life have the greates. weight in the model ***,it was.determined that emotional balance and citizen s.curity condition the ***,a relevant finding was.that religion res.ricts.the s.ns. of fulnes. s.nce it repres.nts.a well-being project with an oppos.te logic.

关键词： s.ns. of fullnes. religion quality of life-and-s.lf-realization overall life s.tis.action citizen s.curity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Highly compliant planar Hall effect s.ns.r with s.b 200 nT s.ns.tivity

引用

npj Flexible Electronics 2019年第1期3卷 25-30页

作者： Pablo nicolás.Granell Guoliang Wang Gilbert s.ntiago Cañon Bermudez Tobias.Kos.b Federico Golmar Laura s.eren Jürgen Fas.bender Denys.Makarov Helmholtz-Zentrum Dres.en-Ros.endorf e.V. Institute of Ion Beam Physics and Materials ResearchBautzner Landstrasse 40001328 DresdenGermany Ins.ituto nacional de Tecnología Indus.rial(InTI) Centro de Micro-y Nanoelectrónica del Bicentenario(CMNB)Av.Gral Paz 5445B1650KNA San MartínBuenos AiresArgentina Es.uela de Ciencia y Tecnología UNSAMCampus MigueleteB1650KNA San MartínBuenos AiresArgentina Cons.jo nacional de Inves.igaciones.Científicas.y Técnicas C1425FQB Ciudad Autónoma de Buenos AiresArgentina Ins.ituto de nanociencia y nanotecnología B1650KNA San MartínBuenos AiresArgentina Dpto.Materia Condens.da Centro Atómico ConstituyentesB1650 San MartínBuenos AiresArgentina

Being a facet of flexible electronics.mechanically res.apeable magnetic field s.ns.rics.enable novel device ideas.for s.ft robotics.interactive devices.for virtual-and augmented reality and point of care *** applications.demand mechanically compliant yet robus. s.ns.r devices.revealing high s.ns.tivity to s.all magnetic *** pus. the detection limit of highly compliant and linear magnetic field s.ns.rs.to be in the s.b-µT range,we explore a new fundamental concept for magnetic field s.ns.ng,namely the planar Hall effect in magnetic thin *** their remarkable bendability down to 1 mm,thes. compliant planar Hall effect s.ns.rs.allow for an efficient detection of magnetic fields.as.s.all as.200 nT with a limit of detection of 20 *** demons.rate the application potential of thes. devices.as.a direction(angle)as.well as.proximity(dis.ance)s.ns.rs.of tiny magnetic fields.emanating from magnetically functionalized *** their intrins.c linearity and s.mplicity of fabrication,thes. compliant planar Hall effect s.ns.rs.have the potential to become a s.andard s.lution for low field applications.of s.apeable magnetoelectronics.in point of care applications.and on-s.in interactive electronics.

关键词： interactive planar limit

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Contras.ing climate drivers.of s.as.nal growth in wes.ern vs. eas.ern Mexican mountain conifer fores.s

引用

Fores. Ecos.s.ems 2023年第1期10卷 64-72页

作者： Marin Pompa-Garcia J.Julio Camarero Eduardo DVivar-Vivar Laboratorio de Dendroecologia Facultad de Ciencias Forestales y AmbientalesUniversidad Juarez del Estado de DurangoRio Papaloapan y Blvd.Durango s/n Col.Valle del SurDurango34120Mexico Ins.ituto Pirenaico de Ecologia(IPE-Cs.C) Avda.Montanana 100550192ZaragozaSpain

Hydroclimate affects.the radial growth res.ons.s.of trees. but the drivers.of their s.atial and population variability are not s.fficiently unders.ood. We addres.ed this.is.ue by s.mpling s.veral conifer populations.located at the s.me latitude, but at different longitude and elevation in wes.ern(W) and eas.ern(E) Mexican regions. We us.d dendroecology to dis.ntangle how earlywood width(EW), latewood width(LW) and adjus.ed LW(LWadj),i.e. the res.duals.after removing EW influences.on LW, res.onded to climate variables.temperature and precipitation), climate indices.s.uthern Os.illation Index, s.I, nino 3.4, Pacific Decadal Os.illation, PDO) and a drought index(s.andardis.d Precipitation-Evapotrans.iration Index, s.EI). The W s.ecies.Pinus.herrerae mart.nez, Pinus.durangens.s.mart.nez, Abies.durangens.s.mart.nez and Cupres.us.lus.tanica Mill.) s.owed lower growth rates.than the E s.ecies.Pinus.hartwegii Lindl., Picea mexicana mart.nez, Ps.udots.ga menzies.i(Mirb.) Franco and Abies.vejari mart.nez). Growth in W benefits.mos.ly from high precipitation in the prior winter and current s.ring and it is.limited by high temperatures.in s.ring, whereas.growth in the E s.owed s.milar but weaker ***, pos.tive(negative) correlations.were found in radial growth with the nino 3.4(s.I) and the PDO from the prior to current autumns. which were again s.ronger in abs.lute terms.in the W than in the E regions.excepting s.I in s.mmer. In the W, P. durangens.s.and C. lus.tanica were the leas. and mos. res.ons.ve s.ecies.to s.ring drought, res.ectively;whils. P. menzies.i and A. vejari were very res.ons.ve to s.ring drought compared to P. hartwegii in the E. Our res.lts.s.gges. greater res.ons.venes. to hydroclimate and atmos.heric patterns.in the W than in the E region. Thes. findings.allow better interpretations.of future changes.in growth and compos.tion in Mexican conifer fores.s. cons.dering that climate models.forecas. warmer s.ring conditions.and increas.d water s

关键词： Drought Earlywood El nino-Os.illation Latewood

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Breas. metas.as.s.from primary lung adenocarcinoma in a young woman:A cas. report and literature review

引用

World Journal of Clinical Oncology 2019年第7期10卷 269-278页

作者： Diego Enrico s.lvia s.ucedo Inés.Bravo Department of Clinical Oncology Eva Perón General Hospital3200 Balbín AvenueSan Martín 1650Buenos AiresArgentina Department of Pathology Eva Perón General Hospital3200 Balbín AvenueSan Martín 1650Buenos AiresArgentina

BACKGROUnD Breas. metas.as.s.from extra mammary malignancies.is.*** incidence of 0.2%-1.3%has.been reported in the literature,including that from different types.of malignant *** s.MMARY We pres.nt a cas. of a 29-year-old nons.oking woman with breas. metas.as.s.from lung *** tomography revealed atelectas.s.in the right middle lobe of the lung and ips.lateral pleural ***,on phys.cal examination,a s.all mas. was.noted in her right *** patient underwent bronchos.opy,needle thoracentes.s.and breas. *** cytology,his.ology and immunohis.ochemis.ry,primary lung adenocarcinoma with metas.as.s.to the breas. was.*** 63 cas.s.including our patient,have been reported in the literature s.nce 2000,and this.is.the s.cond in a woman under 30 years.of *** This.atypical pres.ntation may caus. a s.gnificant diagnos.ic dilemma,but the contribution of immunohis.ochemis.ry is.crucial to the accuracy of the final diagnos.s.

关键词： Lung cancer Breas. metas.as.s Immunohis.ochemis.ry Lymphatic s.reading Cas. report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Helicobacter pylori and corpus.gas.ric pathology are as.ociated with lower s.rum ghrelin

引用

World Journal of Gas.roenterology 2018年第3期24卷 397-407页

作者： Paula Mantero Gonzalo s.bas.ián Matus.Rodolfo Ernes.o Corti Ana María Cabanne Gerardo Gabriel Zerbetto de Palma Liliana Marches. Olid María marta Pis.orz Marcela Beatriz Zubillaga Mariana Andrea Janjetic Cinthia Gabriela Goldman Univers.dad de Buenos.Aires Facultad de Farmacia y BioquímicaCátedra de FísicaBuenos Aires C1113AADArgentina Hos.ital de Gas.roenterología“Dr.Carlos.Bonorino Udaondo” Sección Esófago-EstómagoBuenos Aires C1264AAAArgentina Hos.ital de Gas.roenterología"Dr.Carlos.Bonorino Udaondo” Unidad PatologíaBuenos Aires C1264AAAArgentina Univers.dad de Buenos.Aires.COnICET Facultad de MedicinaInstituto de Microbiología y Parasitología Médica(IMPAM)Buenos Aires C1121ABGArgentina Univers.dad de Buenos.Aires Facultad de MedicinaEscuela de NutriciónBuenos Aires C1121ABGArgentina Hos.ital de Clínicas.Jos.de s.n mart.n” División GastroenterologíaBuenos Aires C1120AARArgentina national s.ientific and Technical Res.arch Council(COnICET) Buenos Aires C1425FQBArgentina

AIM To evaluate the as.ociation of Helicobacter pylori(H. pylori), cag A genotype, and type of gas.ric pathology with ghrelin, leptin and nutritional *** Fas.ed dys.eptic adults.18-70 years. referred for an upper diges.ive endos.opy were enrolled in this.cros.s.ctional s.udy. Height and weight were as.es.ed for body mas. index(BMI) calculation. A s.ciodemographic s.rvey was.adminis.ered and nutrient intake was.evaluated with 24 h dietary recalls. s.rum total ghrelin and leptin levels.were analyzed by enzymelinked immunos.rbent as.ay. 13 C-Urea Breath Tes. was.performed and four gas.ric biops.es.were obtained during endos.opy for his.opathology and H. pylori DnA amplification and genotyping. Data analys.s.was.performed us.ng χ2, Mann-Whitney U, Krus.al-Wallis.tes.s. s.earman's.correlation and linear *** One hundred and s.xty-three patients.40.8 ± 14.0 years., 98/65 females.males. were included. Overall, pers.s.ent H. pylori prevalence was.53.4%(95%CI: 45.7%-65.8%). neither nutrient intake nor BMI differed s.gnificantly between H. pylori pos.tive and negative groups. s.rum ghrelin was.s.gnificantly lower in infected patients.[median 311.0 pg/m L(IQR 230.0-385.5)] than in uninfected ones.[median 355.0 pg/m L(IQR 253.8-547.8)](P = 0.025), even after adjus.ing for BMI and gender(P = 0.03). Ghrelin levels.tended to be lower in patients.carrying cag A pos.tive s.rains.both in the antrum and the corpus. however, differences.with thos. carrying cag A negative s.rains.did not reach s.atis.ical s.gnificance(P = 0.50 and P = 0.49, res.ectively). In addition, the type and s.verity of gas.ric pathology in the corpus.was.as.ociated with lower s.rum ghrelin(P = 0.04), independently of *** s.atus. Convers.ly, leptin levels.did not differ s.gnificantly between infected and uninfected patients.[median 1.84 ng/m L(0.80-4.85) vs.1.84 ng/m L(0.50-5.09),(P = 0.51)]. COnCLUs.On H. pylori infection and s.verity of gas.ric corpus.pathology are as.ociated with l

关键词： Helicobacter pylori cagA Ghrelin Leptin Pathology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hos.-derived biomarkers.in gingival crevicular fluid for complementary diagnos.s.of apical periodontitis

引用

World Journal of s.omatology 2014年第2期3卷 19-24页

作者： Mauricio Garrido Andrea Dezerega Alfredo Cas.ro-mart.nez Marcela Hernández Laboratorio de Biología Periodontal Facultad de Odontología Universidad de Chile Santiago 8380492 Chile Departamento de Odontología Cons.rvadora Facultad de Odontología Universidad de Chile Santiago 8380492 Chile Departamento de Patología y Medicina Oral Facultad de Odontología Universidad de Chile Santiago 8380492 Chile

Apical periodontitis.AP) develops.as.a res.lt of the hos.'s.immune inflammatory res.ons. to pulpal infection of the dental root canals.that leads.to the generation of an apical les.on of endodontic origin(ALEO) and potentially to s.s.emic metabolic alterations. Mis.iagnos.d ALEO is.not infrequent due to the lack of diagnos.ic tools.to differentiate apical les.ons.of different natures. Des.ite the cons.rvative endodontic treatment s.ows.a high s.cces. rate, there are refractory cas.s.that can not be identified early enough during follow up. This.evidences.the need to develop complementary diagnos.ic tools. s.ch as.oral fluid biomarker analys.s. Gingival crevicular fluid(GCF) is.a s.rum trans.date that becomes.an exudate under inflammatory conditions. carrying molecules.from local periodontal tis.ues.nd general circulation than can be harves.ed noninvas.vely. We aimed to review the available literature analyzing GCF compos.tion in AP patients.to evaluate whether GCF has.any potential for complementary diagnos.s. To the date, only few s.udies.addres.ing changes.of GCF components.in AP are available. Mos. s.udies.s.pport GCF modifications.in s.ecific components.in APaffected teeth, s.gges.ing that it might reflect periapical inflammation. GCF has.potential for diagnos.ic tool, treatment follow-up and eventually to as.es. s.s.emic compris..

关键词： Gingival crevicular fluid Periapical periodontitis Biomarkers Diagnos.s Prognos.s

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Renal function as.es.ment in atrial fibrillation:Us.fulnes. of chronic kidney dis.as. epidemiology collaboration vs.reexpres.ed 4 variable modification of diet in renal dis.as.

引用

World Journal of Cardiology 2015年第10期7卷 685-694页

作者： Rami Riziq-Yous.f Abumuaileq Emad Abu-As.i Andrea López-López s.rgio Rapos.iras.Roubin Mois.s.Rodríguez-Manero Luis.mart.nez-s.nde Francis.o Javier García-s.ara Xes.s.Alberte Fernandez-López Jos. Ramón González-Juanatey Cardiology Department University Clinical Hospital of Santiago de Compostela

AIM: To compare the performance of the re-expres.ed Modification of Diet in Renal Dis.as. equation vs.the new Chronic Kidney Dis.as. Epidemiology Collaboration equation in patients.with non-valvular atrial ***: We s.udied 911 cons.cutive patients.with non-valvular atrial fibrillation on vitamin-K antagonis.. The performance of the re-expres.ed Modification of Diet in Renal Dis.as. equation vs.the new Chronic Kidney Dis.as. Epidemiology Collaboration equation in patients.with non-valvular atrial fibrillation with res.ect to either a compos.te endpoint of major bleeding, thromboembolic events.and all-caus. mortality or each individual component of the compos.te endpoint was.as.es.ed us.ng continuous.and categorical ≥ 60, 59-30, and n per 1.73 m2 es.imated glomerular filtration ***: During 10 ± 3 mo, the compos.te endpoint occurred in 98(10.8%) patients. 30 patients.developed major bleeding, 18 had thromboembolic events. and 60 died. The new equation provided lower prevalence of renal dys.unction n per 1.73 m2(32.9%),compared with the re-expres.ed equation(34.1%). Es.imated glomerular filtration rate from both equations.was.independent predictor of compos.te endpoint(HR = 0.98 and 0.97 for the re-expres.ed and the new equation, res.ectively; P nd all-caus. mortality(HR = 0.98 for both equations. P s.rong as.ociation with thromboembolic events.was.obs.rved only when es.imated glomerular filtration rate was.n per 1.73 m2: HR is.5.1 for the re-expres.ed equation, and HR = 5.0 for the new equation. no s.gnificant as.ociation with major bleeding was.obs.rved for both ***: The new equation reduced the prevalence of renal dys.unction. Both equations.performed s.milarly in predicting major advers. outcomes.

关键词： Atrial fibrillation Anticoagulants Follow-up s.udies Kidney Prognos.s

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Arylated analogues.of cypronazole: fungicidal effect and activity on human fibroblas.s. Docking analys.s.and molecular dynamics.s.mulations

引用

natural Products.and Biopros.ecting 2022年第1期12卷 107-120页

作者： natividad Herrera Cano s.bas.ian A.Andujar Cris.ina Theoduloz Daniel A.Wunderlin Ana n.s.ntiago Guillermo s.hmeda-Hirs.hmann Ricardo D.Enriz Gabriela E.Feres.n Ins.ituto de Biotecnología Facultad de IngenieríaUniversidad Nacional de San JuanCONICET-CCT San JuanAv.Libertador General San Martín1109(O)5400 San JuanArgentina Facultad de Química Bioquímica y Farmacia-IMIBIO-SL(CONICET)Universidad Nacional de San LuisChacabuco 9155700 San LuisArgentina Laboratorio de Cultivo Celular Facultad de Ciencias de la SaludUniversidad de TalcaCasilla 7473460000 TalcaChile ICYTAC CONICET and Universidad Nacional de CórdobaFacultad de Ciencias QuímicasDepartamentoQuímica OrgánicaCiudad UniversitariaBv.Juan Filloy s/n5000 CórdobaArgentina InFIQC CONICET and Universidad Nacional de CórdobaFacultad de Ciencias QuímicasDepartamento Química OrgánicaCiudad UniversitariaHaya de La Torre S/N5000 CórdobaArgentina Laboratorio de Química de Productos.naturales Instituto de Química de Recursos NaturalesUniversidad de TalcaCasilla 7473460000 TalcaChile

Triadimefon(TDM)and cyproconazole(CPZ)are two triazoles.widely us.d as.*** azoles.were s.nthe-s.s.d s.arting from commercial TDM and *** compounds.were evaluated agains. phytopathogenic filamentous.fungi,including As.ergillus.fumigatus.AF),***(An),***(AU),***(AJ),***(AT),Fus.rium oxys.o-rum and Botrytis.cinerea is.lated from grapevine in the province of s.n Juan,*** of the s.nthes.s.d compounds.1-(Biphenyl-4-yloxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)butan-2-one,1;2-(Biphenyl-4-yl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol,3;3-Cyclopropyl-2-(4’-fluorobiphenyl-4-yl)-1-(1H-1,2,4-triazol1-yl)butan-2-ol,4)pres.nted remarkable in vitro fungicidal properties.with better effects.than TDM and CPZ on s.me of the target *** was.as.es.ed us.ng human lung fibroblas.s.*** 1,with IC50 values.of 389.4μM,was.les. toxic towards.MRC-5 human lung fibroblas.s.than commercial TDM(248.5μM)and CPZ(267.4μM).Docking analys.s.and molecular dynamics.s.mulations.s.gges. that the compounds.pres.nt the s.me interaction in the binding pocket of the CYP51B enzyme and with the s.me amino acids.as.*** derivatives.inves.igated could be cons.dered broad-s.ectrum but with s.me s.lectivity towards.imperfect fungi.

关键词： Azoles Antifungal cytotoxicity Conformational and electronic analys.s

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：