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Evaluation of the analgesic activity of ethyl acetate,methanol and aqueous extracts of Pleurotus eous mushroom

Asian Pacific Journal of Tropical Medicine 2011年第2期4卷 117-120页

作者： Suseem SR Mary Saral A Neelakanda Reddy P marslin gregory Pharmaceutical Chemistry Division School of Advanced SciencesVIT UniversityVellore-632 014Tamil NaduIndia Department of Bio-organic chemistry CLRIChennai 600 020India Department of Pharmacology S.A.Raja Pharmacy College627116TirunelveliIndia

Objective:To evaluate the analgesic activity of the ethyl acetate,methanol and aqueous extracts of Plewotus eous(***) ***:The dried fruiting bodies were extracted with ethyl acetate,methanol and *** analgesic effect of extracts of *** were investigated at doses 250 500 and 1 000 mg/kg body weight,using acetic-acid induced writhing,hot-plate,tail immersion and tail-clip ***:*** extracts produced significant reduction in number of writhes induced by intraperitoneal injection of acetic-acid(P<0.05).Moreover,in hot-plate and tail immersion test,all the three extracts significantly raised the pain threshold at different time of observation(0-60 min) in comparison with control(P<0.05).In tail-clip test the extracts also caused a significant inhibition of pain at both the doses used(P<0.05).Conclusions:The results of present study suggest that extracts of *** possess potent analgesic property and could serve as a base for future drugs.

关键词： Writhing test Hotplate test Tail immersion method Tail clip test Pain

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Anti-ulcer activity of Ficus religiosa leaf ethanolic extract

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Asian Pacific Journal of Tropical Biomedicine 2013年第7期3卷 554-556页

作者： marslin gregory B. Divya Revina Ann Mary M. M. Hipolith Viji V. K. Kalaichelvan V. Palanivel Department of pharmacology Annamalai UniversityChidambaram India Centre for the Research and Technology of Agro-Environment and Biological Sciences (CITAB) Department of Biology University of MinhoPortugal Padmavathi College of Pharmacy and Research Institute Periyanahalli DharmapuriTamilnadu India Department of Nursing Science A.J College of Nursing ChennaiTamilnadu India Department of Phytochemistry Natural Remedies Research lab BangaloreKarnataka India

Objective:To evaluate the anti-ulcer activity and acute toxicity ofFicus religiosa(F. religiosa)leaf ethanolic extract in animal ***:Anti-ulcer activity ofF. religiosaethanolicextract(250 and 500 mg/kg body weight) was studied on stress induced ulcer animal *** was used as standard. The anti-ulcer activity ofF. religiosawas evaluated with thehelp of ulcer area and histopatholgical examination. Preliminary phyto-chemical screeningand acute toxicity studies ofF. religiosaalso carried ***:Results showed that theextract treatments prevented ulcer area and gastric secretion in a dose-dependent *** of 2000 mg/kg extract did not show any acute toxicity in albino mice. Preliminaryphytochemical analysis identified the presence of flavonoids in the ethanolic extract ofF. ***:The extract is non-toxic even at relatively high concentrations. The anti-ulceractivity is probably due to the presence of flavanoids.

关键词： Ficus religiosa Flavonoids Ethanolic extract Ulcer area Ranitidne

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Barringtonia acutangula improves the biochemical parameters in diabetic rats

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Chinese Journal of Natural Medicines 2014年第2期12卷 126-130页

作者： marslin gregory Vinoth Kumar Megraj Khandelwal Revina Ann Mary V.K.Kalaichelvan V.Palanivel Department of Pharmacology Faculty of Pharmacy Annamalai University Centre for the Research and Technology of Agro-Environment and Biological Sciences (CITAB) Department of Biology University of Minho Consorzio Mario Negri Sud Department of Translational Pharmacology Department of Nursing Science A.J. College of Nursing Padmavathi College of Pharmacy and Research Institute

AIM: This study was aimed at evaluating the anti-diabetic activity of the ethanol and aqueous extracts of the leaf material of Barringtonia acutangula in a diabetic animal model. METHODS: The ethanolic and aqueous extracts(250 and 500 mg kg 1body weight) of the leaves of B. acutangula were assessed for antidiabetic activity in a streptozotocin(STZ)-induced diabetes animal model following 21 days of treatment. Glibenclamide(0.6 mg kg 1p.o.) was used as a positive control. The hematological parameters, such as blood glucose level, urea, creatinin, cholesterol, HDL-C, and LDL-C levels were examined. RESULTS: An acute toxicity study(5 000 mg kg 1, p.o.) did not produce any symptoms of toxicity. Significant reductions in blood glucose level, and serum total cholesterol and triglyceride levels were noted in animals treated with the extract. The high density lipoprotein-cholesterol(HDLC) level was found to increase as compared with the diabetic control group. CONCLUSION: These results suggest that the leaf aqueous and ethanolic extracts of B. acutangula have anti-diabetic effects. The aqueous extract of B. acutangula produced a similar effect when compared with the ethanol extract. It is proposed that consumption of B. acutangula in some form like tea may help the management of diabetes.

关键词： Barringtonia acutangula Ethanolic extract Aqueous extract Anti-diabetic activity

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