Evaluation of the analgesic activity of ethyl acetate,methanol and aqueous extracts of Pleurotus eous mushroom

作     者：Suseem SR Mary Saral A Neelakanda Reddy P Marslin Gregory 

作者机构：Pharmaceutical Chemistry DivisionSchool of Advanced SciencesVIT UniversityVellore-632 014Tamil NaduIndia Department of Bio-organic chemistryCLRIChennai 600 020India Department of PharmacologyS.A.Raja Pharmacy College627116TirunelveliIndia 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2011年第4卷第2期

页      面：117-120页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 1002[医学-临床医学] 100602[医学-中西医结合临床] 10[医学] 

主　　题：Writhing test Hotplate test Tail immersion method Tail clip test Pain 

摘      要：Objective:To evaluate the analgesic activity of the ethyl acetate,methanol and aqueous extracts of Plewotus eous(***) ***:The dried fruiting bodies were extracted with ethyl acetate,methanol and *** analgesic effect of extracts of *** were investigated at doses 250 500 and 1 000 mg/kg body weight,using acetic-acid induced writhing,hot-plate,tail immersion and tail-clip ***:*** extracts produced significant reduction in number of writhes induced by intraperitoneal injection of acetic-acid(P0.05).Moreover,in hot-plate and tail immersion test,all the three extracts significantly raised the pain threshold at different time of observation(0-60 min) in comparison with control(P0.05).In tail-clip test the extracts also caused a significant inhibition of pain at both the doses used(P0.05).Conclusions:The results of present study suggest that extracts of *** possess potent analgesic property and could serve as a base for future drugs.