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direct laser writing of volumetric gradient index lenses and waveguides

Light(Science & Applications) 2020年第1期9卷 89-102页

作者： Christian R.Ocier Corey A.Richards daniel A.Bacon-Brown Qing ding Raman Kumar Tanner j.Garcia jorik van de Groep jung-Hwan Song Austin j.Cyphersmith Andrew Rhode Andrea N.Perry Alexander j.Littlefield jinlong Zhu dajie Xie Haibo Gao jonah F.Messinger mark L.Brongersma Kimani C.Toussaint jr Lynford L.Goddard Paul V.Braun department of Materials Science and Engineering University of Illinois at Urbana-ChampaignUrbanaILUSA Materials Research Laboratory University of Illinois at Urbana-ChampaignUrbanaILUSA Beckman Institute for Advanced Science and Technology University of Illinois at Urbana-ChampaignUrbanaILUSA department of Electrical and Computer Engineering University of Illinois at Urbana-ChampaignUrbanaILUSA department of Materials Science and Engineering Stanford UniversityStanfordCAUSA Carl R.Woese Institute for Genomic Biology University of Illinois at Urbana-ChampaignUrbanaILUSA department of Mechanical Science and Engineering University of Illinois at Urbana-ChampaignUrbanaILUSA

direct laser writing(dLW)has been shown to render 3d polymeric optical components,including lenses,beam expanders,and mirrors,with submicrometer ***,these printed structures are limited to the refractive index and dispersive properties of the ***,we present the subsurface controllable refractive index via beam exposure(SCRIBE)method,a lithographic approach that enables the tuning of the refractive index over a range of greater than 0.3 by performing dLW inside photoresist-filled nanoporous silicon and silica *** the laser exposure during printing enables 3d submicron control of the polymer infilling and thus the refractive index and chromatic *** SCRIBE’s unprecedented index range and 3d writing accuracy has realized the world’s smallest(15μm diameter)spherical Luneburg lens operating at visible ***’s ability to tune the chromatic dispersion alongside the refractive index was leveraged to render achromatic doublets in a single printing step,eliminating the need for multiple photoresins and writing *** also has the potential to form multicomponent optics by cascading optical elements within a *** a demonstration,stacked focusing structures that generate photonic nanojets were fabricated inside porous ***,an all-pass ring resonator was coupled to a subsurface 3d *** measured quality factor of 4600 at 1550 nm suggests the possibility of compact photonic systems with optical interconnects that traverse multiple *** is uniquely suited for constructing such photonic integrated circuits due to its ability to integrate multiple optical components,including lenses and waveguides,without additional printed supports.

关键词： index refractive render

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EGFR signaling augments TLR4 cell surface expression and function in macrophages via regulation of Rab5a activation

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Protein & Cell 2020年第8期11卷 144-149页

作者： jing Tang Bowei Zhou Melanie jScott Linsong Chen dengming Lai Erica KFan Yuehua Li Qiang Wu Timothy RBilliar mark AWilson Ping Wang jie Fan The department of Anesthesiology Affiliated hospital of Guangdong Medical UniversityZhanjiang 524000China department of Surgery University of Pittsburgh School of MedicinePittsburghPA 15213USA Research and development Veterans Affairs Pittsburgh Healthcare SystemPittsburghPA 15240USA department of Anesthesiology Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China department of Thoracic Surgery Shanghai Pulmonary HospitalTongji University School of MedicineShanghai 200433China department of Cardiovascular Surgery The Children's Hospital of Zhejiang University School of MedicineHangzhou 310052China University of Pittsburgh The Graduate School of Public Health PittsburghPA 15213USA Laboratory of Tropical Biomedicine and Biotechnology School of Tropical Medicine and Laboratory MedicineHainan Medical UniversityHaikou 571199China The Feinstein Institute for Medical Research ManhassetNY 11030USA McGowan Institute for Regenerative Medicine University of PittsburghPittsburghPA 15219USA Key Laboratory of Organ Injury/Protection and Translational Medicine of Zhanjiang Zhanjiang 524000China

dear Editor,oll-like receptor 4(TLR4)is a key receptor sensing bacterial lipopolysaccharide(LPS),and is the most investigated member of the Tol-like receptor family(Kawai and Akira,2007;Kayagaki et al,2013;Klein et al.,2015).Cell surface TLR4 expression is determined by the balance between receptor trafficking from the Golgi apparatus to the cell membrane,and internalization of the cell surface receptor into endosomal compartments(Saltoh,2009).In bone mar-row-derived macrophages(BMdM),we observed LPS-in-duced EGFR phosphorylation on the surface of BMdM,and this was inhibited by pretreatment with Pd168393 or TAPI-1(Fig.S1).Next,we measured dynamic changes in cell sur-face TLR4 expression after LPS ***6,12,and 24 h after LPS treatment,TLR4 expression on the surface of BMdM was increased^2-,~6-,and^9-fold,respectively,as compared with controls.

关键词： Pd1 TLR4 inhibited

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西米替丁和硫糖铝治疗消化性溃疡出血的比较(摘要)

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淮海医药 1986年第1期 127-128页

作者： joelp Goldfarb M.d. mark j Czaja M.d 李明礼蚌埠市第三人民医院内科

西米替丁是一种H2-受体拮抗剂,能抑制胃酸和胃蛋白酶的分泌,有促进胃、十二指肠溃疡愈合作用。硫糖铝是一种较新的抗溃疡剂。这两种药物治疗消化性溃疡出血是否有效还不清楚。本研究设计,在于比较西米替丁和硫糖铝在治疗消化性溃疡出血... 详细信息

西米替丁是一种H2-受体拮抗剂,能抑制胃酸和胃蛋白酶的分泌,有促进胃、十二指肠溃疡愈合作用。硫糖铝是一种较新的抗溃疡剂。这两种药物治疗消化性溃疡出血是否有效还不清楚。本研究设计,在于比较西米替丁和硫糖铝在治疗消化性溃疡出血和进而预防再出血的效果。材料和方法所有显著上消化道出血的现症患者,在入院8小时内一律行内窥镜检查。只要符合下述标准的一项或多项系研究对象:①活动出血的溃疡。②血凝块附着在溃疡上。③溃

关键词：硫糖铝消化性溃疡消化道溃疡胃肠病西米替丁

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EUS FNA of Altered Left Adrenal Gland Morphology Suggests Amending CT and PET-CT Attenuation Threshold Values That Predict Malignancy

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journal of Cancer Therapy 2012年第6期3卷 1029-1036页

作者： Ferga C. Gleeson Allison j. Clapp Robert C. Murphy jonathan E. Clain Prasad G. Iyer Elizabeth Rajan mark d. Topazian Kenneth K. Wang Michael j. Levy department of Radiology Mayo Clinic College of Medicine Rochester USA division of Gastroenterology and Hepatology Mayo Clinic College of Medicine Rochester USA

Introduction: In the setting of an extra-adrenal malignancy, it is a recognized clinical challenge to try and distinguish a benign adrenal mass from a metastatic deposit. Current non-invasive diagnostic tools for adrenal gland evaluation include CT, MRI, PET and PET-CT. diagnostic interpretative error can occur as evaluations rarely have complete cytologic or histologic correlation for concordance purposes. Aims: To establish the performance characteristics of non-contrast CT attenuation values (Hounsfield units-HU) and the optimal PET-CT maximum standard uptake value (SUVmax) for predicting adrenal malignancy when correlated with adrenal gland endoscopic ultrasound fine needle aspiration (EUS FNA) cytology results. Methods: A prospectively maintained EUS database was reviewed to identify consecutive patients who underwent a left adrenal gland FNA. Non-contrast CT attenuation values and SUVmax scores were calculated. EUS FNA cytology results were used as the reference standard for determining the presence of benign versus malignant adrenal gland status. Results: Sixty-two patients (69 ± 11 years) underwent adrenal EUS FNA, 34 (54.8%) of whom had a clinically suspected or established extra-adrenal malignancy. Non-invasive imaging was suggestive of abnormal adrenal morphology or altered PET-CT FdG activity in 45 (72.6%) patients. Elevated attenuation values (≥10 HU) by non-enhanced CT had a sensitivity and specificity of 100% and 34.6%, respectively. The SUVmax for malignant altered morphology was significantly higher than that for benign lesions [(8.5 ± 3.1 vs 3.3 ± 0.7;(p = 0.0001)]. ROC curve analysis indicated that an optimum cutoff SUVmax of ≥4.1 (AUC 0.92) yielded the best power distinction for malignancy with a sensitivity and specificity of 89% and 100%. Conclusion: When evaluating altered adrenal morphology by non-invasive methods, the performance characteristics of elevated CT attenuation values are suboptimal. But by adopting a SUVmax cut-off value of ≥4.1

关键词： Altered Adrenal Morphology Endoscopic Ultrasound Fine Needle Aspiration Unenhanced CT Attenuation Value PET Standardized Uptake Value

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delaying Postpartum Supplementation in Cows Consuming Low-Quality Forage does Not Alter Cow and Calf Productivity

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Agricultural Sciences 2016年第9期7卷 642-649页

作者： j. Travis Mulliniks jason E. Sawyer Richard C. Waterman mark K. Petersen department of Animal Science University of Tennessee Knoxville TN USA department of Animal Science Texas A&M University College Station TX USA USdA-ARS Fort Keogh Livestock & Range Research Laboratory Miles City MT USA

Reducing the amount of supplemental feed postpartum without affecting productivity may enhance profitability of cow-calf operations. Therefore, sixteen 2-yr-old fall calving cows were used to evaluate effects of delaying postpartum supplementation on milk production, serum metabolites, and cow and calf BW change. Cows were stratified by calving date and randomly assigned to one of two treatments: 908 g/d of a 46% CP supplement beginning 5 d postpartum (Supp5, n = 7);or 908 g/d of the same supplement beginning 30 d postpartum (Supp30, n = 9). Supplements were formulated to provide 425 g/d of CP with 225 g coming from ruminally undegradable protein (RUP), and were fed twice weekly. Cows were daily fed 8.2 kg chopped sudangrass hay (5.5% CP, 74% NdF, OM basis) during lactation. Cows and calves were weighed before feeding on two consecutive days on d 0, d 30, and d 80 postpartum. Milk production and constituents were evaluated on d 90. Cow BW was not different at d 0 (P = 0.21) and 80 (P = 0.12) between treatment groups. Cows receiving supplement starting on d 5 postpartum were heavier (P = 0.04) than Supp30 cows on d 30. However, no differences (P ≥ 0.17) were found in BW change or AdG during the duration of the study. Milk production was similar (P = 0.99) for postpartum supplementation treatments. No differences (P ≥ 0.27) were observed in milk fat, lactose, protein, or solids-non-fat. However, there was a tendency (P = 0.09) for milk urea nitrogen to be greater for cows receiving supplement on d 5 than d 30 of lactation. Serum urea nitrogen was greater (P = 0.02) in cows receiving Supp5 than cows receiving Supp30. Serum non-esterified fatty acid (NEFA) and glucose concentrations were not different (P ≥ 0.40) between treatment groups. Calf BW and average daily gain (AdG) was not influenced (P ≥ 0.81) by timing of initial postpartum supplementation. These results indicate that withholding supplementation during the first 30 d postpartum may change pattern of cow BW lo

关键词： Beef Heifers Postpartum Supplementation

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direct detection and measurement of wall shear stress using a filamentous bio-nanoparticle

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Nano Research 2015年第10期8卷 3307-3315页

作者： daniela P. Lobo Alan M. Wemyss david j. Smith Anne Straube Kai B. Betteridge Andrew H. j. Salmon Rebecca R. Foster Hesham E. Elhegni Simon C. Satchell Haydn A. Little Raul Pacheco-Gomez mark j. Simmons Matthew R. Hicks david O. Bates Alison Rodger Timothy R. dafforn Kenton P. Arkill departmentofChemistryandWarwickAnalyticalScienceCentre UniversityofWarwickCoventryCV47ALUK MOACdoctoralTrainingCentre UniversityofWarwickCoventryCV47ALUK Mathematics UniversityofBirminghamEdgbastonBirminghamWestMidlandsB152TTUK CentreforMechanochemicalCellBiology WarwickMedicalSchoolUniversityofWarwickCoventryCV47ALUK PhysiologyandPharmacology UniversityofBristolUniversityWalkBristolBS81TDUK ClinicalSciences WhitsonStreetUniversityofBristolBristolBS13NYUK SchoolofChemistry UniversityofBirminghamEdgbastonBirminghamWestMidlandsB152TTUK Biosciences UniversityofBirminghamEdgbastonBirminghamWestMidlandsB152TTUK ChemicalEngineering UniversityofBirminghamEdgbastonBirminghamWestMidlandsB152TTUK SchoolofMedicine UniversityofNottinghamQueen'sMedicalCentreNottinghamNG27UHUK Biochemistry UniversityofBristolUniversityWalkBristolBS81TDUK

The wall shear stress （WSS） that a moving fluid exerts on a surface affects many processes including those relating to vascular function. WSS plays an important role in normal physiology （e.g. angiogenesis） and affects the microvasculature＇s primary function of molecular transport. Points of fluctuating WSS show abnormalities in a number of diseases; however, there is no established technique for measuring WSS directly in physiological systems. All current methods rely on estimates obtained from measured velocity gradients in bulk flow data. In this work, we report a nanosensor that can directly measure WSS in microfluidic chambers with sub-micron spatial resolution by using a specific type of virus, the bacteriophage M13, which has been fluorescently labeled and anchored to a surface. It is demonstrated that the nanosensor can be calibrated and adapted for biological tissue, revealing WSS in micro-domains of cells that cannot be calculated accurately from bulk flow measurements. This method lends itself to a platform applicable to many applications in biology and microfluidics.

关键词： microfluidics nanoparticle M13 bacteriophage wall shear stress fluorescent microscopy

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differential Cross Sections and Collision-Induced Rotational Alignment in Inelastic Scattering of NO(X)by Xe

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Chinese journal of Chemical Physics 2020年第2期33卷 217-233,I0003,J0001-J0017页

作者： mark Brouard Helen Chadwick Sean dSGordon Cornelia GHeid Balazs Hornung Bethan Nichols jacek Klos Pablo Gjambrina Fjavier Aoiz The department of Chemistry University of OxfordThe Chemistry Research Laboratory12 Mans-field RoadOxford OX13TAUK department of Chemistry and Biochemistry University of MarylandCollege ParkMaryland 20742USA departamento de Química Física Facultad de Ciencias QuímicasUniversity of SalamancaSala-mancaSpain departamento de Química Física Facultad de QuímicaUniversidad Complutense28040 MadridSpain

Fully A-doublet resolved differential cross sections and collision-induced rotational alignment moments have been measured for the NO(X)-Xe collision system at a collision energy of 519 cm^-*** experiments combine initial quantum state selection,employing a hexapole inhomogeneous electric field,with quantum state resolved detection,using(1+1')resonantly enhanced multiphoton ionization and velocity map ion *** differential cross sections and polarization dependent differential cross sections are shown to agree well with quantum mechanical scattering calculations performed on ab initio potential energy surfaces[*** et ***.137,014312(2012)].By comparison with quasi-classical trajectory calculations,quantum mechanical scattering calculations on a hard-shell potential,and kinematic apse model calculations,the effects of the attractive part of the potential on the measured differential cross sections and collision-induced rotational alignment moments are assessed.

关键词： Chemical Physics Reaction dynamics Inelastic scattering

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Biologically Enabled Syntheses of Nanostructured 3-d Sensor Materials:the Potential for 3-d Genetically Engineered Microdevices (3-d GEMs)

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稀有金属材料与工程 2006年第A3期35卷 13-14页

作者： Kenneth H. Sandhage Samuel Shian Christopher S. Gaddis Michael R. Weatherspoon Ye Cai Sehoon Yoo Michael S. Haluska Robert L. Snyder Ying Liu Meilin Liu Nicholas Ferrell derek j. Hansford mark Hildebrand Brian Palenik School of Materials Science and Engineering Georgia Institute of Technology Atlanta GA USA Biomedical Engineering department the Ohio State University Columbus OH USA Microbiology department Scripps Institution of Oceanography University of California at San Diego La Jolla CA USA

Three-dimensional (3-d)self-assembly of nanos- tructures and nanodevices on a large scale remains a grand quest for *** nanostructured assemblies with controlled 3-d shapes can exhibit attractive properties for sensor and other applications. Protocols for 3-d self-assembly that can be scaled up for mass production on a large up to tonnage)scale, while preserving morphological features on a small (down to nanometer)scale,are needed to allow for widespread use of 3-d nanostructures in advanced ***,these often conflicting requirements of scalability and precision pose a difficult challenge for synthetic (man-made)processing routes.

关键词： d GEMs Biologically Enabled Syntheses of Nanostructured 3-d Sensor Materials

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Hybrids of gold nanoparticles and oligo(p-phenyleneethynylene)s end-functionalized with alkynylruthenium groups:Outstanding two-photon absorption in the second biological window

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Nano Research 2020年第10期13卷 2755-2762页

作者： Cristóbal Quintana Mahbod Morshedi jun du joseph P.L.Morrall jan K.Zaręba Marek Samoc Marie P.Cifuentes mark G.Humphrey I Research School of Chemistry Australian National UnriversityCanberraACT 2601Australia Advanced Materials Engineering and Modelling Group Wroclaw University of Science and TechnologyWroclaw 50370Poland

Oligo(p-phenyleneethynylene)s(OPEs)end-capped with(alkynyl)bis(diphosphine)ruthenium and thiol/thiolate groups stabilize ca.2 nm diameter gold nanoparticles(AuNPs).The morphology,elemental composition and stability of the resultant organometallic OPE/AuNP hybrid materials have been defined using a combination of molecular-and nano-material chacterization *** hybrids display long-term stability in solution(more than a month),good solubility in organic solvents,reversible rutheniumcentered oxidation,and transparency beyond 800 nm,and possess very strong nonlinear absorption activity at the first biological window,and unprecedented two-photon absorption activity in the second biological window(σ2 up to 38,000 GM at 1,050 nm).

关键词： gold nanoparticles inorganic materials metal alkynyl complexes nonlinear optics organometallics

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Temporal,Matter-Wave-dispersion Talbot Effect

Temporal,Matter-Wave-Dispersion Talbot Effect

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CCAST“激光冷却：玻色—爱因斯坦凝聚和原子激射器”研讨会

作者： L.deng E.W.Hagley j.denschlag j.E.Simsarian mark Edwards C.W.Clark K.Helmerson S.L.Rolston W.d.Phillips National Institute of Standards and Technology Gaithersburg Maryland 20899 Permanent address:department of Physics Georgia Southern University StatesboroGA 30460

We analyze and experimentally demonstrate a new(temporal)Talbot effect,where a pulsed phasegrating is applied to a cloud of cold atoms(Bose-Einstein condensate).In contrast to the usual(spatial)Talbot effect,our atoms gain kinetic energy when diffracted by the pulsed *** energy gain andthe matter-wave-dispersion relation result in an exact(no pxraxial approximation)Talbot effect where theinitial wave front is reconstructed at multiples of a“Talbot tune”*** demonstrate the Talbot effectby applying a second pulsed phase grating after a variable *** this second grating is applied ateven(odd)multiples of r/2,it doubles(cancels)the effect of the first pulsed grating.

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