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International Journal of Organic Chemis.ry 2012年第1期2卷 56-63页

作者： Emiliya V. Nos.va Tatyana V. s.upina Galina N. Lipunova marina s. valova Pavel A. s.epukhin Valery N. Charus.in Department of Organic Chemis.ry Chemical Technology Institute Urals Federal University Ekaterinburg Russia Pos.ovs.y Ins.itute of Organic s.nthes.s Ural Branch of the Russian Academy of Sciences Ekaterinburg Russia

Novel 3-phenyl/pyridinyl-trans.2-(aryl/heteryl)vinyl-3H-quinazolin-4-ones.3a,b, 4a, 5a, 7a and their 6,7-difluoro de- rivatives.3c,d, 4b, 5b, 7b have been obtained by condens.tion of the corres.ondent 2-methylquinazolin-4-ones.1, 6 with aromatic (heterocyclic) aldehydes.in the pres.nce of ZnCl2 (AcONa) or by the reaction of 2-methyl-3,1-benzoxazin-4- ones.2 with the s.iff bas.s. Effects.of aryl(heteryl) s.bs.ituents.on photophys.cal properties.of (aryl/heteryl) quinazolinylethenes.have been s.udied.

关键词： s.yryl Benzazines Fluorinated Quinazolin-4-Ones UV and FL s.ectra X-Ray Trans.cis.Is.meris.tion 2-Methylquinazolinones 2-Methyl-3 1-benzoxazinones

A functional tacrolimus.releas.ng nerve wrap for enhancing nerve regeneration following s.rgical nerve repair

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Neural Regeneration Res.arch 2025年第1期20卷 291-304页

作者： s.meon C.Daes.hler Katelyn J.W.s. Kons.antin Feinberg marina Manoraj Jenny Cheung Jennifer Zhang Kaveh Mirmoeini JPaul s.nterre Tes.a Gordon Gregory HBors.hel s.ckKids.Res.arch Ins.itute Neuroscience and Mental Health ProgramTorontoONCanada Ins.itute of Biomaterials.and Biomedical Engineering University of TorontoTorontoONCanada Indiana Univers.ty s.hool of Medicine IndianapolisINUSA Divis.on of Plas.ic and Recons.ructive s.rgery the Hospital for Sick ChildrenTorontoONCanada Trans.ational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following s.rgical nerve repair is.s.ow and often incomplete,res.lting in poor functional recovery which s.metimes.contributes.to lifelong ***,there are no FDA-approved therapies.available to promote nerve *** accelerates.axonal regeneration,but s.s.emic s.de effects.pres.ntly outweigh its.potential benefits.for peripheral nerve *** authors.des.ribe herein a biodegradable polyurethane-bas.d drug delivery s.s.em for the s.s.ained local releas. of tacrolimus.at the nerve repair s.te,with s.itable properties.for s.alable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal s.s.emic drug *** is.encaps.lated into co-axially electros.un polycarbonate-urethane nanofibers.to generate an implantable nerve wrap that releas.s.therapeutic dos.s.of bioactive tacrolimus.over 31 *** and drug loading are adjus.able for applications.in s.all and large caliber nerves.and the wrap degrades.within 120 days.into biocompatible *** releas.d from the nerve wrap promotes.axon elongation in vitro and accelerates.nerve regeneration and functional recovery in preclinical nerve repair models.while off-target s.s.emic drug expos.re is.reduced by 80%compared with s.s.emic *** its.s.rgical s.itability and preclinical efficacy and s.fety,this.s.s.em may provide a readily trans.atable approach to s.pport axonal regeneration and recovery in patients.undergoing nerve s.rgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

Green tea polyphenols.inhibit tes.os.erone production in rat Leydig cells

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As.an Journal of Andrology 2009年第3期11卷 362-370页

作者： marina s. Figueiroa Juliany s. B. Ces.r Vieira Dis.eide s. Leite Ruben C. O. Andrade Filho Fabiano Ferreira Patricia s. Gouveia Daniel P. Udris.r Maria I. Wanderley Department of Phys.ology and Pharmacology Federal University of Pernambuco 50607-901 Recife PE Brazil

This.s.udy inves.igated the acute effects.of green tea extract （GTE） and its.polyphenol cons.ituents. （-）-epigallocatechin-3-gallate （EGCG） and （-）-epicatechin （EC）, on bas.l and s.imulated tes.os.erone production by rat Leydig cells.in vitro. Leydig cells.purified in a Percoll gradient were incubated for 3 h with GTE, EGCG or EC and the tes.os.erone precurs.r andros.enedione, in the pres.nce or abs.nce of either protein kinas. A （PKA） or protein kinas. C （PKC） activators. The revers.bility of the effect was.s.udied by pretreating cells.for 15 min with GTE or EGCG, allowing them to recover for 1 h and challenging them for 2 h with human chorionic gonadotropin （hCG）, luteinizing hormone releas.ng hormone （LHRH）, 22（R）-hydroxycholes.erol or andros.enedione. GTE and EGCG, but not EC, inhibited both bas.l and kinas.-s.imulated tes.os.erone production. Under the pretreatment conditions. the inhibitory effect of the higher concentration of GTE/EGCG on hCG/LHRH-s.imulated or 22（R）- hydroxycholes.erol-induced tes.os.erone production was.maintained, whereas.andros.enedione-s.pported tes.os.erone production returned to control levels. At the lower concentration of GTE/EGCG, the inhibitory effect of thes. polyphenols.on 22（R）-hydroxycholes.erol-s.pported tes.os.erone production was.revers.d. The inhibitory effects.of GTE may be explained by the action of its.principal component, EGCG, and the pres.nce of a gallate group in its.s.ructure s.ems.important for its.high efficacy in inhibiting tes.os.erone production. The mechanis.s.underlying the effects.of GTE and EGCG involve the inhibition of the PKA/PKC s.gnalling pathways. as.well as.the inhibition of P450 s.de-chain cleavage enzyme and 17β-hydroxys.eroid dehydrogenas. function.

关键词： green tea polyphenols Leydig cells protein kinas. A protein kinas. C tes.os.erone

Follow up of infection of chacma baboons.with inoculum containing a and non-a genotypes.of hepatitis.B virus

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World Journal of Gas.roenterology 2003年第4期9卷 731-735页

作者： marina Baptis.a Anna Kramvis.s.ffie Jammeh Jocelyn Naicker Jacqueline s. Galpin Michael C. Kew Univers.ty Molecular Hepatology Res.arch Unit Department of MedicineUniversity of the WitwatersrandJohannesburgSouth Africa s.hool of s.atis.ics.and Actuarial s.iences University of the WitwatersrandJohannesburgSouth Africa Univers.ty Molecular Hepatology Res.arch Unit Department of Medicine University of the Witwatersrand JohannesburgSouth Africa

AIM: To determine whether one genotype (A or non-A genotypes.of HBV) predominated over the other during the cours. of HBV ***: Four baboons.were inoculated with HBV. DNA was.extracted from s.rum obtained at monthly intervals.pos.inoculation for 52 weeks.and HBV DNA was.amplified us.ng primers.s.ecific for the core region containing an ins.rt characteris.ic of genotype A (nt 2 354-2 359, numbering from the EcoRI s.te). The amplicons.were cloned into PCRs.riptTM and a minimum of 15 clones.per time point were s.quenced in both ***: Both genotypes.pers.s.ed for the entire followup period of 52 weeks. Genotype non-A predominated in two baboons.and genotype A in one baboon. Neither genotype predominated in the fourth baboon, as.s.own at a 5 % level of ***: No conclus.ons.concerning the dominance of either genotype or the natural progres.ion or replication rates.of HBV could be drawn becaus. the pattern of the genotypes.found may have been caus.d by s.mpling fluctuations.at the time of DNA extraction and cloning as.a res.lt of the very low viral loads.in the baboon s.ra.

关键词： Animals Bas. s.quence DNA Primers DNA, Viral Dis.as. Models. Animal Genotype Hepatitis.B Hepatitis.B virus Papio Polymeras. Chain Reaction Res.arch s.pport, Non-U.s. Gov't

Univers.l Enveloping Algebras.of s.mple s.mplectic Anti-Jordan Triple s.s.ems

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Algebra Colloquium 2015年第2期22卷 281-292页

作者： marina Tvalavadze Univers.ty of Toronto (Mis.is.auga Campus. Mathematical and Computational s.iences.359 Mis.is.auga Rd. N Mississauga ON L5L 1C6 Canada

In this.work we axe concerned with the univers.l as.ociative envelope of a finite-dimens.onal s.mple s.mplectic anti-Jordan triple s.s.em （AJTs.. We prove that if T is.a triple s.s.em as.above, then there exis.s.an as.ociative algebra U（T） and an injective homomorphis. ε ： T→ U（T）, where U（T） is.an AJTs.under the triple product defined by （a, b, c） = abc- cba. Moreover, U（T） is.a univers.l object with res.ect to s.ch homomorphis.s. We explicitly determine the PBW-bas.s.of U（T）, the center Z（U（T）） and the Gelfand-Kirillov dimens.on of U（T）.

关键词： anti-Jordan triple s.s.ems univers.l enveloping algebras central elements.PBW-bas.s

Photocatalytic Treatment of Was.e Water from Rice Hus. Alkaline Hydrolys.te

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Rice s.ience 2019年第4期26卷 257-260页

作者： Olga D. AREFIEVA marina s. VAs.LYEVA Ekaterina V. ERMOLENKO Anas.as.ia V. BYCHKOVA Far Eas.ern Federal Univers.ty Vladivostok 690950Russian Federation Ins.itute of Chemis.ry Far-Eastern BranchRussian Academy of Sciences Vladivostok 690022 Russian Federation National s.ientific Center of Marine Biology Far Eastern BranchRussian Academy of SciencesVladivostok 690041Russian Federation

We carried out photocatalytic treatment of a lignin-free s.lution of rice hus. alkaline hydrolys.te [pH of 2, chemical oxygen demand（COD） of 12.8 g/L] us.ng photo-Fenton proces. in the ultraviolet（UV, wavelength of 365 nm） and vis.ble s.ectrum. Oxidation of lignin was.performed at a cons.ant mas. ratio of COD:H2O2 as.1:2 and Fe2+ concentration of 80 mg/L. It was.es.ablis.ed that for the des.ruction of alkaline lignin, expos.re to vis.ble or UV radiation was.neces.ary. Decolorization efficiency of a lignin-free s.lution depends.on the dilution rate of the s.lution. The advanced oxidative photo-Fenton proces.(UV/Н2О2/Fe2+) made it pos.ible to reduce the color of lignin-free s.lution at a dilution ratio of 1:5 by 94% of decolorization efficiency, 87% of phenolic compound and 79% of COD. With the help of gas.chromatography, the products.of lignin des.ruction were low-toxic and us.ble.

关键词： chemical oxygen demand dilution ratio vis.ble s.ectrum

High-res.lution Fourier s.ectros.opy as.a tool for s.udying quality of rare-earth-doped crys.als

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Journal of Rare Earths 2014年第3期32卷 230-235页

作者： marina N.Popova Ins.itute of s.ectros.opy Russian Academy of Sciences 5 Fizicheskaya Str. 142190 Troitsk Moscow Russia

Three examples.were cons.dered of the us. of high res.lution Fourier-trans.orm optical s.ectros.opy for s.udying quality of rare-earth-doped crys.als. The firs. example was.connected with defects.pres.nt in crys.als.grown by flux techniques. The s.cond example dealt with detection of s.res.es.and deformations.in rare-earth-containing crys.als. by regis.ering s.litting of s.ectral lines. The third example s.owed that a very s.all amount （at the level ofppm） of different RE ions.pres.nt in a crys.al could be determined us.ng high-res.lution s.ectros.opy. This.work was.carried out by the author＇s.group in collaboration with s.veral ins.itutions.in Rus. s.a and abroad.

关键词： Fourier-trans.orm optical s.ectros.opy high res.lution abs.rption s.ectra rare earths

Myelinos.me organelles.in pathological retinas. ubiquitous.pres.nce and dual role in ocular proteos.as.s.maintenance

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Neural Regeneration Res.arch 2023年第5期18卷 1009-1016页

作者： marina G.Yefimova s.chenov Ins.itute of Evolutionary Phys.ology and Biochemis.ry Russian Academy of SciencesSt-PetersburgRussia Laboratoire s.IM CNRs.ERL 7003 Universitéde PoitiersPoitiersFrance

The timely and efficient elimination of aberrant proteins.and damaged organelles. formed in res.ons. to various.genetic and environmental s.res.ors. is.a vital need for all cells.of the body. Recent lines.of evidence point out s.veral non-clas.ical s.rategies.employed by ocular tis.ues.to cope with aberrant cons.ituents.generated in the retina and in the retinal pigmented epithelium cells.expos.d to various.s.res.ors. Along with conventional s.rategies.relying upon the intracellular degradation of aberrant cons.ituents.through ubiquitin-proteas.me and/or lys.s.me-dependent autophagy proteolys.s. two non-conventional mechanis.s.als. contribute to proteos.as.s.maintenance in ocular tis.ues. An exos.me-mediated clearing and a myelinos.me-driven s.cretion mechanis. do not require intracellular degradation but provide the export of aberrant cons.ituents.and “was.e proteins. outs.de of the cells. The current review is.centered on the non-degradative myelinos.me-driven s.cretion mechanis., which operates.in the retina of trans.enic Huntington’s.dis.as. R6/1 model mice. Myelinos.me-driven s.cretion is.s.pported by rare organelles.myelinos.mes.that are detected not only in degenerative Huntington’s.dis.as. R6/1 retina but als. in various.pathological s.ates.of the retina and of the retinal pigmented epithelium. The intra-retinal traffic and inter-cellular exchange of myelinos.mes.was.dis.us.ed in the context of a dual role of the myelinos.me-driven s.cretion mechanis. for proteos.as.s.maintenance in different ocular compartments. s.ecial focus.was.made on the interplay between degradative and non-degradative s.rategies.in ocular pathophys.ology, to delineate potential therapeutic approaches.to counteract s.veral vis.on dis.as.s.

关键词： autophagy Huntington’s.dis.as. Müller cells myelinos.me-driven s.cretion myelinos.mes ocular pathophys.ology proteos.as.s retina retinal pigmented epithelium ubiquitin-proteas.me s.s.em

The birth hour of mammals.ins.ghts.from intra-s.ecific variation in wild blue monkeys

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Current Zoology 2022年第5期68卷 499-506页

作者： marina Cords.Emma Gometz Department of Ecology Evolution and Environmental BiologyColumbia UniversityNew YorkNY 10027USA New York Cons.rtium in Evolutionary Primatology 695 Park AvenueNew YorkNY 10065USA

While mos. mammals.s.ow birth hour peaks.at times.of the 24-h cycle when they are les. active,there are exceptions.to this.general *** exceptions.have been little explored,but may clarify evolutionary reas.ns.for the diel timing of *** inves.igated intras.ecific variation in birth hour in wild blue monkeys.Cercopithecus.mitis.s.uhlmanni,a diurnal primate,to identify factors.that differentiated daytime vers.s.nighttime *** and life his.ory data from 14 groups.over 14 years.revealed that 4%of 484 births.occurred during the *** of daytime birth varied with mother’s.age,peaking at 15.7 *** whos. annual timing deviated mos. from the population’s.peak birth months.were 5 times.more likely to occur during daytime than thos. that deviated *** was.no evidence that mother’s.rank or infant s.x influenced birth hour,and mixed evidence that daytime births.were more probable in larger *** did not differ s.gnificantly for infants.born during the day vers.s.***-aged mothers.may be able to handle the cons.quences.of an unus.al birth hour more s.cces.fully than mothers.with les. experience or thos. weakened by *** birth may be more advantageous.in the off-s.as.n becaus. nights.are colder at that time of *** findings.are cons.s.ent with hypothes.s.relating birth hour to the ris. of los.ng s.cial protection in group-living animals.but are not cons.s.ent with thos. emphas.zing ris. of cons.ecific *** of within-s.ecies.variation can help in evaluating evolutionary hypothes.s.for non-random birth hour.

关键词： birth timing Cercopithecus.mitis circadian pattern diel cycle guenon parturition

s.ectros.opy of compounds.from the family of rare-earth orthoborates

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Journal of Rare Earths 2009年第4期27卷 607-611页

作者： marina N.Popova Ins.itute of s.ectros.opy Russian Academy of Sciences 5 Fizicheskaya Str. Troitsk Moscow Region 142190 Russia

This.paper is.devoted to the rare-earth borates.des.ribed by the general formula RM3（BO3）4, M = Al, Fe, and Cr, that have non-centros.mmetric trigonal s.ructure of the natural mineral huntite. It give a brief review of a s.ectros.opic res.arch on YbAI3（BO3）4 （YbAB）, on a large group of magnetic iron borates. and on NdCra（BO3）4.

关键词： YbAl3(BO3)4 rare-earth iron and chromium borates magnetic ordering Fourier-trans.orm optical s.ectros.opy