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Current Zoology 2024年第1期70卷 1-12页

作者： Lucia V.Sommaro Juan J.Martinez marina b.chiappero Andrea R.Steinmann Cristina N.Gardenal JoséW.Priotto Laboratorio de Ecologia Evolutiva y biogeografia Instituto de Ecorregiones Andinas(INECoA)Universidad Nacional de Jujuy-Consejo Nacional de Investigaciones Cientificas y Tecnicas(CONICET)San Salvador de JujuyJujuyArgentina Instituto de Diversidad y Ecologia Animal(IDEA) Consejo Nacional de Investigaciones Cientificas y Técnicas(CONICET)and Universidad Nacionalde CordobaCordobaArgentina Catedra de Genética de Poblaciones y Evolucion Facultad de Ciencias ExactasFisicas y NaturalesUniversidad Nacional de CordobaCordobaArgentina Grupo de Investigaciones en Ecologia Poblacional y Comportamental(GIEPCO) Instituto de Ciencias de la TierraBiodiversidad y Ambiente(ICBiA)Universidad Nacional de Rio Cuarto-Consejo Nacional de Investigaciones Cientificas y Técnicas(CONICET)Rio CuartoCordobaArgentina

The sex-biased dispersal and kinship dynamics are important factors shaping the spatial distribution of individuals and are key parameters affecting a variety of ecological and evolutionary ***,we studied the spatial distribution of related individuals within a population of corn mice Calomys musculinus in a seasonal cycle to infer dispersal *** sampling was carried out from spring 2005 to winter 2006 in field borders of intensively managed *** data from 346 individuals with 9 microsatellites showed spatial genetic structure was weak for males,but not for *** results indicate a complex spatial kinship dynamic of related females across all ***,contrary to our expectations,dispersal distances decrease with the increase of the population ***,male dispersal distances were greater when population abundance increased and thus the availability of active *** disperse greater distances to mate and sire offspring with distant females as a possible inbreeding avoidance *** study shows that *** is capable of much greater scattering distances than previously reported and that dispersal occurs fluidly and without barriers across the *** indirect benefit of dispersal on individual fitness could be related to relaxing the competition in the natal area and increasing the mating *** study highlights the value of combining genetic relatedness,fieldwork observations,and behavioral data to estimate dispersal at a fine geographical scale.

关键词： dispersal distances kinship dynamics microsatellite small mammals spatial autocorrelation

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There is more to the knee joint than just the quadriceps:A systematic review with meta-analysis and evidence gap map of hamstring strength,flexibility,and morphology in individuals with gradual-onset knee disorders

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Journal of Sport and Health Science 2024年第4期13卷 521-536页

作者： Helder S.Lopes marina C.Waiteman Liliam b.Priore Neal R.Glaviano David M.bazett-Jones Ronaldo V.briani Fabio M.Azevedo School of Science and Technology Physical Therapy DepartmentSao Paulo State University(UNESP)Presidente Prudente 19060-900Brazil Department of Kinesiology College of AgricultureHealth and Natural ResourcesUniversity of ConnecticutStorrsCT 06269USA School of Exercise and Rehabilitation Sciences College of Health and Human ServicesUniversity of ToledoToledoOH 43606USA

background:Impairments in hamstring strength,flexibility,and morphology have been associated with altered knee biomechanics,pain,and *** the presence of these impairments in individuals with gradual-onset knee disorders is important and may indicate targets for assessment and *** systematic review aimed to synthesize the literature to determine the presence of impairments in hamstring strength,flexibility,and morphology in individuals with gradual-onset knee ***:Five databases(MEDLINE,Embase,CINAHL,SPORTDiscus,and Web of Science)were searched from inception to September *** studies comparing hamstring outcomes(e.g.,strength,flexibility,and/or morphology)between individuals with gradual-onset knee disorders and their unaffected limbs or pain-free controls were ***-analyses for each knee disorder were ***-level certainty was assessed using the Grading of Recommendations Assessment,Development,and Evaluation,and evidence gap maps were ***:Seventy-nine studies across 4 different gradual-onset knee disorders(i.e.,knee osteoarthritis(OA),patellofemoral pain(PFP),chondromalacia patellae,and patellar tendinopathy)were *** with knee OA presented with reduced hamstring strength compared to pain-free controls during isometric(standard mean difference(SMD)=-0.76,95%confidence interval(95%CI):-1.32 to-0.21)and concentric contractions(SMD=-0.97,95%CI:-1.49 to-0.45).Individuals with PFP presented with reduced hamstring strength compared to painfree controls during isometric(SMD=-0.48,95%CI:-0.82 to-0.14),concentric(SMD=-1.07,95%CI:-2.08 to-0.06),and eccentric contractions(SMD=-0.59,95%CI:-0.97 to-0.21).No differences were observed in individuals with patellar *** with PFP presented with reduced hamstring flexibility when compared to pain-free controls(SMD=-0.76,95%CI:-1.15 to-0.36).Evidence gap maps identified insufficient evidence for chondromalacia patel

关键词： Chondromalacia patellae Knee flexors Knee osteoarthritis Patellar tendinopathy Patellofemoral pain

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Plant cell wall-mediated disease resistance:Current understanding and future perspectives

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Molecular Plant 2024年第5期17卷 699-724页

作者： Antonio Molina Lucıa Jorda Miguel Angel Torres marina Martın-Dacal Diego Jose berlanga Patricia Fernandez-Calvo Elena Gomez-Rubio Sonsoles Martın-Santamarıa Centro de biotecnología y Genómica de Plantas Universidad Politécnica de Madrid(UPM)-Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria(INIA/CSIC)Campus de Montegancedo UPMPozuelo de Alarcon(Madrid)Spain Departamento de biotecnologıa-biología Vegetal Escuela Técnica Superior de Ingenierıa AgronomicaAlimentarıa y de BiosistemasUPMMadridSpain Centro de Investigaciones biologicas Margarita Salas Consejo Superior de Investigaciones Científicas(CSIC)Ramiro de Maeztu 928040 MadridSpain Misión biológica de Galicia Consejo Superior de Investigaciones Científicas(CSIC)Campus de Montegancedo UPMPozuelo de Alarcón(Madrid)Spain

beyond their function as structural barriers,plant cell walls are essential elements for the adaptation of plants to environmental *** walls are dynamic structures whose composition and integrity can be altered in response to environmental challenges and developmental *** wall changes are perceived by plant sensors/receptors to trigger adaptative responses during development and upon stress *** cell wall damage caused by pathogen infection,wounding,or other stresses leads to the release of wall molecules,such as carbohydrates(glycans),that function as damage-associated molecular patterns(DAMPs).DAMPs are perceived by the extracellular ectodomains(ECDs)of pattern recognition receptors(PRRs)to activate pattern-triggered immunity(PTI)and disease ***,glycans released from the walls and extracellular layers of microorganisms interacting with plants are recognized as microbe-associated molecular patterns(MAMPs)by specific ECD-PRRs triggering PTI *** number of oligosaccharides DAMPs/MAMPs identified that are perceived by plants has increased in recent ***,the structural mechanisms underlying glycan recognition by plant PRRs remain ***,this knowledge is mainly focused on receptors of the LysM-PRR family,which are involved in the perception of various molecules,such as chitooligosaccharides from fungi and lipo-chitooligosaccharides(i.e.,Nod/MYC factors from bacteria and mycorrhiza,respectively)that trigger differential physiological ***,additional families of plant PRRs have recently been implicated in oligosaccharide/polysaccharide *** include receptor kinases(RKs)with leucine-rich repeat and Malectin domains in their ECDs(LRR-MAL RKs),Catharanthus roseus RECEPTOR-LIKE KINASE 1-LIKE group(CrRLK1L)with Malectin-like domains in their ECDs,as well as wall-associated kinases,lectin-RKs,and *** characterization of structural basis of glycans recogniti

关键词： Arabidopsis thaliana cell wall damage-associated molecular patterns DAMPs disease resistance glycans oligosaccharides pattern-triggered immunity PTl pattern recognition receptor PRRs

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Probing the Gamma-Ray Emission Region of Five TeV Flat Spectrum Radio Quasars

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Research in Astronomy and Astrophysics 2024年第6期24卷 156-169页

作者： Hu-bing Xiao Hai-Tao Cao Rui Xue Jin-Ting Cai Ge-Ge Wang marina Manganaro Shao-Hua Zhang Zhi-Hao Ouyang Li-Ping Fu Jun-Hui Fan Shanghai Key Lab for Astrophysics Shanghai Normal UniversityShanghai 200234China School of Information Engineering Guangzhou Panyu PolytechnicGuangzhou 511483China Department of Physics Zhejiang Normal UniversityJinhua 321004China College of Mathematics and Physics Guangxi Minzu UniversityNanning 530006China Key Laboratory of Cosmology and Astrophysics(Liaoning) College of SciencesNortheastern UniversityShenyang 110819China Department of Physics University of RijekaRijeka 51000Croatia Center for Astrophysics Guangzhou UniversityGuangzhou 510006China Key Laboratory for Astronomical Observation and Technology of Guangzhou Guangzhou 510006China Astronomy Science and Technology Research Laboratory of Department of Education of Guangdong Province Guangzhou 510006China

The location ofγ-ray emission of blazars remains a contested topic,inspiring the development of numerous investigative techniques to address this *** this work,we analyzed Fermiγ-ray light curves in the GeV and MeV bands,employing the discrete cross-correlation function method to discern time lags between the two *** 4C+21.35,Ton 599,b21420+32,and PKS 1510-089,we identified a time lag spanning several days,while for PKS 1441+25,the time lag was not statistically *** results imply that the soft photons necessary for inverse Compton scattering predominantly originate from the dusty torus in the first four sources,whereas for PKS1441+25,they seem to be sourced mainly from the broad-line *** analysis of the opacity(τγγ)and the GeV spectra study supports the conclusion that the location of the dissipation region must be beyond the bLR to avoid significant ***,for PKS 1441+25,the emission region is also posited to lie outside yet proximate to the *** parameters of describing the emission region were obtained by fitting broadband spectral energy distribution with contemporaneous observation *** findings suggest that for the five TeV FSRQs,during Te V flaring events,the jet appears to maintain an equilibrium between the energy density of the magnetic field and that of the particles for all investigated sources,with the exceptions of 4C+21.35 and PKS1441+*** terms of the overall jet power,particle energy is the dominant contributor,and the observed blazar radiation cannot be solely attributed to the magnetic field,except in the case of 4C+***,magnetic reconnection is unlikely to be the primary mechanism behind particle acceleration in these systems.

关键词： galaxies:active gamma-rays:galaxies galaxies:jets

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Nutrient restriction-activated Fra-2 promotes tumor progression via IGF1R in miR-15a downmodulated pancreatic ductal adenocarcinoma

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1132-1146页

作者： Gian Luca Rampioni Vinciguerra marina Capece Luca Reggiani bonetti Giovanni Nigita Federica Calore Sydney Rentsch Paolo Magistri Roberto ballarin Fabrizio Di benedetto Rosario Distefano Roberto Cirombella Andrea Vecchione barbara belletti Gustavo baldassarre Francesca Lovat Carlo M.Croce Department of Cancer biology and Genetics and Comprehensive Cancer Center The Ohio State UniversityColumbus 43210 OHUSA Department of Clinical and Molecular Medicine Faculty of Medicine and PsychologySant’Andrea HospitalUniversity of Rome“Sapienza”Rome 00189Italy Department of Diagnostic Clinic and Public Health MedicineUniversity of Modena and Reggio EmiliaModena 41100Italy Hepato-pancreato-biliary Surgery and Liver Transplantation Unit University of Modena and Reggio EmiliaModena 41100Italy Division of Molecular Oncology Centro di Riferimento Oncologico di Aviano(CRO)Istituto di Ricovero e Cura a Carattere Scientifico(IRCCS)National Cancer InstituteAviano 33081Italy

Pancreatic ductal adenocarcinoma(PDAC)is a lethal disease,characterized by an intense desmoplastic reaction that compresses blood vessels and limits nutrient *** aggressiveness largely relies on its extraordinary capability to thrive and progress in a challenging tumor *** of the onco-suppressor miR-15a has been extensively documented in ***,we identified the transcription factor Fos-related antigen-2(Fra-2)as a miR-15a target mediating the adaptive mechanism of PDAC to nutrient *** report that the IGF1 signaling pathway was enhanced in nutrient deprived PDAC cells and that Fra-2 and IGF1R were significantly overexpressed in miR-15a downmodulated PDAC ***,we discovered that miR-15a repressed IGF1R expression via Fra-2 *** miR-15a-low context,IGF1R hyperactivated mTOR,modulated the autophagic flux and sustained PDAC growth in nutrient *** a genetic mouse model,Mir15aKO PDAC showed Fra-2 and Igf1r upregulation and mTOR activation in response to diet ***,nutrient restriction improved the efficacy of IGF1R inhibition in a Fra-2 dependent ***,our results point to a crucial role of Fra-2 in the cellular stress response due to nutrient restriction typical of pancreatic cancer and support IGF1R as a promising and vulnerable target in miR-15a downmodulated PDAC.

关键词： IGF1R Fra miR

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A new oxidative pathway of nitric oxide production from oximes in plants

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Molecular Plant 2024年第1期17卷 178-198页

作者： Pedro Lopez-Gomez Javier buezo marina Urra Alfonso Cornejo Raquel Esteban Jorge Fernandez de los Reyes Estibaliz Urarte Estefania Rodriguez-Dobreva Alejandro Chamizo-Ampudia Alejandro Eguaras Sebastian Wolf Daniel Marino Victor Martinez-Merino Jose F.Moran Institute for Multidisciplinary Research in Applied biology(IMAb) Department of SciencesPublic University of Navarre(UPNA)Avda.de Pamplona 12331192 MutilvaSpain Institute for Advanced Materials and Mathematics(INAMAT2) Department of SciencesPublic University of Navarre(UPNA)Campus de Arosadia31006 PamplonaSpain Department of Plant biology and Ecology University of the Basque Country(UPV/EHU)Sarriena s/nApdo.64448080 BilbaoSpain Center for Plant Molecular biology(ZMbP) University of TubingenGeschwister-Scholl-Platz72074 TubingenGermany Institute of Natural Resources and Agrobiology of Salamanca(IRNASA) Department of Plant-Microorganism InteractionsSpanish National Research Council(CSIC)Cordel de Merinas40-5237008SalamancaSpain Department of biochemistry Area of Molecular BiologyVeterinary FacultyUniversity of LeonCampus de Vegazanas/n.24071 LeonSpain

Nitric oxide(NO)is an essential reactive oxygen species and a signal molecule in *** several studies have proposed the occurrence of oxidative NO production,only reductive routes for NO production,such as the nitrate(NO_(3)^(-))-upper-reductase pathway,have been evidenced to date in land ***,plants grown axenically with ammonium as the sole source of nitrogen exhibit contents of nitrite and NO3−,evidencing the existence of a metabolic pathway for oxidative production of *** hypothesized that oximes,such as indole-3-acetaldoxime(IAOx),a precursor to indole-3-acetic acid,are intermediate oxidation products in NO *** detected the production of NO from IAOx and other oximes catalyzed by peroxidase(POD)enzyme using both 4-amino-5-methylamino-2′,7′-difluorescein fluorescence and *** stimulated the reaction,while superoxide dismutase inhibited ***,mouse NO synthase can also use IAOx to produce NO at a lower rate than *** provided a full mechanism for POD-dependent NO production from IAOx consistent with the experimental data and supported by density functional theory *** showed that the addition of IAOx to extracts from Medicago truncatula increased the in vitro production of NO,while in vivo supplementation of IAOx and other oximes increased the number of lateral roots,as shown for NO donors,and a more than 10-fold increase in IAOx dehydratase ***,we found that in vivo supplementation of IAOx increased NO production in Arabidopsis thaliana wild-type plants,while prx33-34 mutant plants,defective in POD33-34,had reduced *** data show that the release of NO by IAOx,as well as its auxinic effect,explain the superroot ***,our study reveals that plants produce NO utilizing diverse molecules such as oximes,POD,and flavins,which are widely distributed in the plant kingdom,thus introducing a long-awaited oxidative pathway to NO production in plants.T

关键词： ammonium oxidation auxin nitric oxide oxime peroxidase root phenotype

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Universal Enveloping Algebras of Simple Symplectic Anti-Jordan Triple Systems

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Algebra Colloquium 2015年第2期22卷 281-292页

作者： marina Tvalavadze University of Toronto (Mississauga Campus) Mathematical and Computational Sciences3359 Mississauga Rd. N Mississauga ON L5L 1C6 Canada

In this work we axe concerned with the universal associative envelope of a finite-dimensional simple symplectic anti-Jordan triple system （AJTS）. We prove that if T is a triple system as above, then there exists an associative algebra U（T） and an injective homomorphism ε ： T→ U（T）, where U（T） is an AJTS under the triple product defined by （a, b, c） = abc- cba. Moreover, U（T） is a universal object with respect to such homomorphisms. We explicitly determine the PbW-basis of U（T）, the center Z（U（T）） and the Gelfand-Kirillov dimension of U（T）.

关键词： anti-Jordan triple systems universal enveloping algebras central elements,PbW-bases

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Study of tree shrew biology and models: A booming and prosperous field for biomedical research

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Zoological Research 2024年第4期45卷 877-909页

作者： Yong-Gang Yao Li Lu Rong-Jun Ni Rui bi Ceshi Chen Jia-Qi Chen Eberhard Fuchs marina Gorbatyuk Hao Lei Hongli Li Chunyu Liu Long-bao Lv Kyoko Tsukiyama-Kohara Michinori Kohara Claudia Perez-Cruz Gregor Rainer bao-Ci Shan Fang Shen An-Zhou Tang Jing Wang Wei Xia Xueshan Xia Ling Xu Dandan Yu Feng Zhang Ping Zheng Yong-Tang Zheng Jumin Zhou Jiang-Ning Zhou Key Laboratory of Genetic Evolution and Animal Models Yunnan Key Laboratory of Animal Models and Human Disease MechanismsKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650204China National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility) and National Resource Center for Non-Human PrimatesKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China KIZ-CUHK Joint Laboratory of bioresources and Molecular Research in Common Diseases Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650204China Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnan 650204China Mental Health Center and Psychiatric Laboratory West China HospitalSichuan UniversityChengduSichuan 610041China Sichuan Clinical Medical Research Center for Mental Disorders ChengduSichuan 610044China German Primate Center Leibniz Institute of Primate ResearchGöttingen 37077Germany Department of Optometry and Vision Science School of OptometryUniversity of Alabama at BirminghamBirminghamAL 35294USA State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Innovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhanHubei 430071China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhanHubei 430074China Soong Ching Ling Institute of Maternity and Child Health International Peace Maternity and Child Health HospitalShanghai Jiao Tong University School of MedicineShanghai 200030China Transboundary Animal Diseases Center Joint Faculty of Veterinary MedicineKagoshima UniversityKagoshima-cityKagoshima 890-8580Japan Department of Microbiology and Cell biology Tokyo Metropolitan Institute of Medical ScienceTokyo 156-8506Japan Pharmacology Department CinvestavMexico City 07360Mexico Department of Medicine University of FribourgFribourg CH-1700Switzerland beijing Engineering Research Center of Radiog

The tree shrew(Tupaia belangeri)has long been proposed as a suitable alternative to non-human primates(NHPs)in biomedical and laboratory research due to its close evolutionary relationship with *** recent years,significant advances have facilitated tree shrew studies,including the determination of the tree shrew genome,genetic manipulation using spermatogonial stem cells,viral vector-mediated gene delivery,and mapping of the tree shrew brain ***,the limited availability of tree shrews globally remains a substantial challenge in the ***,determining the key questions best answered using tree shrews constitutes another *** shrew models have historically been used to study hepatitis b virus(HbV)and hepatitis C virus(HCV)infection,myopia,and psychosocial stress-induced depression,with more recent studies focusing on developing animal models for infectious and neurodegenerative *** these efforts,the impact of tree shrew models has not yet matched that of rodent or NHP models in biomedical *** review summarizes the prominent advancements in tree shrew research and reflects on the key biological questions addressed using this *** emphasize that intensive dedication and robust international collaboration are essential for achieving breakthroughs in tree shrew *** use of tree shrews as a unique resource is expected to gain considerable attention with the application of advanced techniques and the development of viable animal models,meeting the increasing demands of life science and biomedical research.

关键词： Tree shrew Animal model Neurodegenerative diseases Infectious diseases Neuroscience Phenome

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Global-in-time Uniform Convergence for Linear Hyperbolic-Parabolic Singular Perturbations

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Acta Mathematica Sinica,English Series 2006年第4期22卷 1161-1170页

作者： marina GHISI Massimo GObbINO Universitàdegli Studi di Pisa Dipartimento di Matematicavia M.Buonarroti 256127 PISAItaly Universitàdegli Studi di Pisa Dipartimento di Matematica Applicata "Ulisse Dini"via Bonanno 25/B56126 PISAItaly

We consider the Cauchy problem εu^″ε ＋ δu′ε ＋ Auε = 0, uε（0） = uo, u′ε（0） = ul, where ε 〉 0, δ 〉 0, H is a Hilbert space, and A is a self-adjoint linear non-negative operator on H with dense domain D（A）. We study the convergence of （uε） to the solution of the limit problem ,δu＇＋ Au = 0, u（0） = u0. For initial data （u0, u1） ∈ D（A1/2）× H, we prove global-in-time convergence with respect to strong topologies. Moreover, we estimate the convergence rate in the case where （u0, u1）∈ D（A3/2） ∈ D（A1/2）, and we show that this regularity requirement is sharp for our estimates. We give also an upper bound for ｜u′ε（t）｜ which does not depend on ε.

关键词： Parabolic equations Damped hyperbolic equations Singular perturbations

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Development of fatal acute liver failure in HIV-HbV coinfected patients

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World Journal of Gastroenterology 2010年第32期16卷 4107-4111页

作者： Albert M Anderson marina b Mosunjac Melody P Palmore Melissa K Osborn Andrew J Muir Emory University School of Medicine Grady Health System Infectious Diseases Program341 Ponce de Leon AvenueAtlantaGA 30308United States Duke University School of Medicine DUMC 3913DurhamNorth CarolinaCA 27710United States

Coinfection with hepatitis b virus(HbV) is not uncommon in human immunodeficiency virus(HIV)-infected individuals and patients with HIV-HbV coinfection are at high risk for progression of liver *** guidelines regarding the treatment of HIV infection recommend that patients who are coinfected with HIV and HbV receive highly active antiretroviral therapy(HAART) with activity against hepatitis *** HIVHbV coinfected patients often experience liver enzyme elevations after starting antiretroviral therapy,acute liver failure(ALF) is rare and typically occurs with older antiretroviral agents with known potential for *** describe two cases of fatal ALF in the setting of HIV-HbV coinfection after initiation of *** cases occurred despite treatment with antiretrovirals that have activity against HbV and highlight the challenges in distinguishing drug hepatotoxicity and HbV immune reconstitution inflammatory ***-HbV coinfected patients should be monitored closely when initiating HAART,even when treatment includes agents that have activity against HbV.

关键词： Hepatitis b virus Human immunodeficiency virus Liver failure

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