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Food and Nutrition Sciences 2014年第14期5卷 1318-1325页

作者： Tomohiro Bito mariko yasui Toshio Iwaki Yukinori Yabuta Tsuyoshi Ichiyanagi Ryoichi Yamaji Yoshihisa Nakano Hiroshi Inui Fumio Watanabe Department of Clinical Nutrition Osaka Prefecture University Habikino Japan Division of Applied Biological Chemistry Graduate School of Life and Environmental Sciences Osaka Prefecture University Sakai Japan Division of Applied Biological Chemistry Graduate School of Life and Environmental Sciences Osaka Prefecture University Sakai Japan Department of Clinical Nutrition Osaka Prefecture University Habikino Japan Division of Applied Biological Chemistry Graduate School of Life and Environmental Sciences Osaka Prefecture University Sakai Japan Department of Life Science Osaka Women’s Junior College Fujiidera Japan Division of Applied Bioresources Chemistry The United Graduate School of Agricultural Sciences Tottori University Tottori Japan

We evaluated whether the dodecylamine derivative of hydroxocobalamin acts as a potent inhibitor of cobalamin-dependent enzymes in an African green monkey kidney cell, COS-7. When the dodecylamine derivative (1.0 μmol/L) did not show any cytotoxicity in the cultured cells, the derivative could not affect methylmalonyl-CoA mutase (holo-enzyme) activity, but significantly inhibit methionine synthase (holo-enzyme) activity in the cell homogenates of COS-7 grown in 1.0 μmol/L hydroxocobalamin-supplemented medium. An immunoblot analysis indicated that the dodecylamine derivative could not decrease the protein level of methionine synthase, but significantly inhibit the enzyme activity.

关键词： Dodecylamine Derivative Cobalamin COS-7 Cell Enzyme Inhibitor Hydroxocobalamin

Efficacy of transanal drainage tube in preventing anastomotic leakage after surgery for rectal cancer: A meta-analysis

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World Journal of Gastrointestinal Surgery 2023年第6期15卷 1202-1210页

作者： Shiki Fujino Masayoshi yasui Masayuki Ohue Norikatsu Miyoshi Innovative Oncology Research and Regenerative Medicine Osaka International Cancer InstituteOsaka 541-8567Japan Department of Surgery Osaka International Cancer InstituteOsaka 541-8567Japan

BACKGROUND Anastomotic leakage(AL)following rectal cancer surgery is an important cause of mortality and *** transanal drainage tubes(TDTs)are expected to reduce the rate of AL,their preventive effects are *** To reveal the effect of TDT in patients with symptomatic AL after rectal cancer *** A systematic literature search was performed using the PubMed,Embase,and Cochrane Library *** included randomized controlled trials(RCTs)and prospective cohort studies(PCSs)in which patients were assigned to two groups depending on the use or non-use of TDT and in which AL was *** results of the studies were synthesized using the Mantel-Haenszel randomeffects model,and a two-tailed P value>0.05 was considered statistically *** Three RCTs and two PCSs were included in this *** AL was examined in all 1417 patients(712 with TDT),and TDTs did not reduce the symptomatic AL *** a subgroup analysis of 955 patients without a diverting stoma,TDT reduced the symptomatic AL rate(odds ratio=0.50,95%confidence interval:0.29–0.86,P=0.012).CONCLUSION TDT may not reduce AL overall among patients undergoing rectal cancer ***,patients without a diverting stoma may benefit from TDT placement.

关键词： Meta-analysis Drainage Transanal Anastomotic leakage Surgical stomas Rectal cancer

Successful embolization of an intrahepatic portosystemic shunt using balloon-occluded retrograde transvenous obliteration:A case report

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World Journal of Clinical Cases 2022年第6期10卷 2023-2029页

作者： Hidemasa Saito Satoru Murata Fumie Sugihara Tatsuo Ueda Daisuke yasui Izumi Miki Hiromitsu Hayashi Shin-Ichiro Kumita Department of Radiology Nippon Medical SchoolTokyo 113-8602Japan Center for Interventional Radiology Teikyo University Chiba Medical CenterChiba 299-0011Japan

BACKGROUND A congenital intrahepatic portosystemic shunt(IPSVS)is a rare vascular abnormality that is characterized by an anomalous intrahepatic venous tract that connects the intrahepatic portal vein with the hepatic venous *** encephalopathy is an indication for IPSVS embolization,which is technically challenging because rapid blood flow through shunts can induce the migration of embolization material to systemic *** case report discusses the efficacy of percutaneous balloon-occluded retrograde transvenous obliteration for treating patients with *** SUMMARY A 75-year-old woman presented with a six-month history of repeated hepatic encephalopathy due to an IPSVS without liver *** successfully embolized the IPSVS using percutaneous balloon-occluded retrograde transvenous obliteration with interlocking detachable *** the procedure,the patient exhibited no symptoms of hepatic encephalopathy for 14 *** Balloon-occluded retrograde transvenous obliteration with detachable coils can be effective for the endovascular treatment of an IPSVS.

关键词： Hepatic veins Portal vein Hepatic encephalopathy Endovascular procedures Embolization Therapeutic Case report

Laparoscopic repair of diaphragmatic hernia associating with radiofrequency ablation for hepatocellular carcinoma:A case report

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World Journal of Clinical Cases 2022年第20期10卷 7020-7028页

作者： Junya Tsunoda Tomohiko Nishi Takafumi Ito Gaku Inaguma Tomohiko Matsuzaki Hiroaki Seki Nobutaka yasui Michio Sakata Akihiko Shimada Hidetoshi Matsumoto Department of Surgery Keiyu HospitalYokohama 220-8521Japan Department of Internal Medicine Keiyu HospitalYokohama 220-8521Japan

BACKGROUND Radiofrequency ablation(RFA)is an effective treatment for early-stage hepatocellular carcinoma(HCC).Although RFA is a relatively safe technique compared with surgery,several complications have been reported to be following/accompanying this *** diaphragmatic hernia caused by RFA is rare;however,the best surgical approach for its treatment is *** present a case of laparoscopic repair of diaphragmatic hernia due to *** SUMMARY An 80-year-old woman with segment VIII HCC was treated twice in 5 years with RFA;28 mo after the second RFA,the patient complained of right hypochondriac *** tomography revealed that the small intestine was incarcerated in the right *** patient was diagnosed with diaphragmatic hernia and underwent laparoscopic repair by non-absorbable running *** patient’s postoperative course was favorable,and the patient was discharged on postoperative day *** diaphragmatic hernia has not recurred 24 mo after *** Laparoscopic treatment of iatrogenic diaphragmatic hernia is effective and minimally invasive.

关键词： Diaphragmatic hernia Radiofrequency ablation Hepatocellular carcinoma Complication Laparoscopic surgery Case report

Views Regarding Management Skills Required Currently and in the Future for Middle Managers in Perinatal Medicine: Their Differences Depending Working Position in Advanced Midwives

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Open Journal of Obstetrics and Gynecology 2022年第1期12卷 43-55页

作者： Megumi Abe Toshiyuki yasui Yukie Matsuura Graduate School of Health Sciences Tokushima University Tokushima Japan Department of Nursing Kagawa University Hospital Kagawa Japan Department of Reproductive and Menopausal Medicine Graduate School of Biomedical Sciences Tokushima University Tokushima Japan

Similar to any other discipline/field, management skills are important in perinatal nursing/medicine. What kinds of management skills are required/important currently and also in the future? The view for this might be different according to the present position of midwives. We here attempted to determine this;we divided study population into three (head nurses, assistant head nurses and advanced midwives). A self-administered questionnaire survey was conducted for 1652 advanced midwives in hospitals in Japan during 2018 and 2019. Scores in 8 items showed significant differences among the three groups. The skill with the largest difference among the three groups was the ability to participate in and provide support for social activity. Although higher levels of management skills will be required for nursing managers in the next generation, the levels differ depending on current working positions in advanced midwives.

关键词： Advanced Midwives Nursing Middle Managers Management Skills Working-Position

Effect of Double Air Injection on Performance Characteristics of CentrifugalCompressor

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Journal of Thermal Science 2017年第1期26卷 11-17页

作者： Toshiyuki Hirano Tatsuya Ogawa Ryutaro yasui Hoshio Tsujita Mechanical Engineering Course Department of Science and Engineering Kokushikan University 4-28-1 SetagayaSetagaya City Tokyo 154-8515 Japan Graduate School of Engineering Program in Mechanical Engineering Kokushikan University Nexco-East Engineering Company Limited Department of Mechanical Engineering Faculty of Science and Engineering Hosei University 3-7-2 Kajino-choKoganei City Tokyo 184-8584 Japan

In the operation of a centrifugal compressor of turbocharger, instability phenomena such as rotating stall and surge are induced at a lower flow rate close to the maximum pressure ratio. In this study, the compressed air at the exit of centrifugal compressor was re-circulated and injected to the impeller inlet by using two injection nozzles in order to suppress the surge phenomenon. The most effective circumferential position was examined to reduce the flow rate at the surge inception. Moreover, the influences of the injection on the fluctuating property of the flow field before and after the surge inception were investigated by examining the frequency of static pressure fluctuation on the wall surface and visualizing the compressor wall surface by oil-film visualization technique.

关键词： Centrifugal Compressor, Performance, Nozzle Injection, Surge

Transileocolic endovascular treatment by a hybrid approach for severe acute portal vein thrombosis with bowel necrosis:Two case reports

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World Journal of Clinical Cases 2022年第6期10卷 1876-1882页

作者： Sayaka Shirai Tatsuo Ueda Fumie Sugihara Daisuke yasui Hidemasa Saito Hiroyasu Furuki Shiei Kim Hiroshi Yoshida Shoji Yokobori Hiromitsu Hayashi Shin-ichiro Kumita Department of Radiology Nippon Medical School HospitalBunkyo-ku 113-8603TokyoJapan Department of Radiology Nippon Medical School Musashi Kosugi HospitalKawasaki-shi 211-8533KanagawaJapan Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery Nippon Medical School Tamanagayama HospitalTama-shi 206-8512TokyoJapan Department of Emergency and Critical Care Medicine Nippon Medical School HospitalBunkyo-ku 113-8603TokyoJapan Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery Nippon Medical School HospitalBunkyo-ku 113-8603TokyoJapan

BACKGROUND Acute portal vein thrombosis(PVT)with bowel necrosis is a fatal condition with a 50%-75%mortality *** report describes the successful endovascular treatment(EVT)of two patients with severe *** SUMMARY The first patient was a 22-year-old man who presented with abdominal pain lasting 3 *** second patient was a 48-year-old man who presented with acute abdominal *** contrast-enhanced computed tomography,both patients were diagnosed with massive PVT extending to the splenic and superior mesenteric *** treatment(simultaneous necrotic bowel resection and EVT)was performed in a hybrid operating room(OR).EVTs,including aspiration thrombectomy,catheter-directed thrombolysis(CDT),and continuous CDT,were performed via the ileocolic vein under *** portal veins were patent 4 and 6 mo posttreatment in the 22-year-old and 48-year-old patients,*** Hybrid necrotic bowel resection and transileocolic EVT performed in a hybrid OR is effective and safe.

关键词： Bowel necrosis Endovascular treatment Hybrid operating room Hybrid treatment Portal vein thrombosis Transileocolic approach Case report

The Influence of Shanghanlun on Japanese Kampo Medicine

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World Journal of Traditional Chinese Medicine 2022年第3期8卷 436-445页

作者： Li-Rong Zeng Tao Zhang Hui-Jun Wang Kai Zhong Lin-Lin Shao Guo-Jun Zhang Hiromichi yasui Department of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Japan Institute of TCM Research Mie 510-0091Japan

Shanghanlun is a classic work in traditional Chinese medicine(TCM),which systematically discusses diagnosis and treatment ideas based on syndrome differentiation and records a large number of highly practical *** Shanghanlun was introduced into Japan along with the communication between China and Japan in the Sui and Tang Dynasties,it had a profound influence on the development of Kampo medicine in *** sorting out the works related to Shanghanlun in the medical history literature of Kampo medicine before the Meiji Restoration,this paper discusses the relationship between Shanghanlun and the Koho school of Kampo medicine,as well as the influence of the thought“formula corresponding to pattern identification,”originating from the Koho school,on the development of modern Kampo *** study of Shanghanlun by Kampo medicine nowadays not only attaches great importance to clinical practicality but also has theoretical *** is expected that future medical exchanges between China and Japan will complement each other from the perspectives of both sides and promote the theoretical and clinical development of TCM.

关键词： Formula corresponding to pattern identification Kampo medicine Koho school Shanghanlun

Air-Fuel Ratio Controls for Clean Gasoline Engines

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Air-Fuel Ratio Controls for Clean Gasoline Engines

Clinicopathological features of minute pharyngeal lesions diagnosed by narrow-band imaging endoscopy and biopsy

第三十届中国控制会议

作者： Yuji yasui Honda R＆D CO. Ltd.4630 ShimotakanezawaHaga-machiHaga-gunTochigi321-3393 Japan

ISBN: (纸本)9789881725592

＜正＞The mainstream of low emission technology for gasoline engines is an accurate air-fuel ratio *** air-fuel ratio control maintains air-fuel ratio of combustion gas at the suitable target value to maximize emission conversion efficiency of three-way *** model based controls have been applied to air-fuel ratio controls in order to meet strict emission legislations in the *** this paper,modeling methods and control algorithms for air-fuel ratio controls will be introduced.

关键词： Adaptive control Sliding mode control Air-fuel ratio Gasoline engine

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World Journal of Gastroenterology 2012年第44期18卷 6468-6474页

作者： Takashi Kumamoto Kazuhiro Sentani Shiro Oka Shinji Tanaka Wataru yasui Kumamoto Gastrointestinal Clinic Hiroshima 730-0051Japan Department of Molecular Pathology Hiroshima University Graduate School of Biomedical SciencesHiroshima 734-8551Japan Department of Endoscopy Hiroshima University HospitalHiroshima 734-8551Japan

AIM:To evaluate the utility of magnified narrow-band imaging(NBI) endoscopy for diagnosing and treating minute pharyngeal ***:Magnified NBI gastrointestinal examinations were performed by the first author.A magnification hood was attached to the tip of the endoscope for quick *** of the examinations were performed under *** NBI examinations were performed for all of the pharyngeal lesions that had noticeable brownish areas under unmagnified NBI observation,and an intrapapillary capillary loop(IPCL) classification was made.A total of 93 consecutive pharyngeal lesions were diagnosed as IPCL type Ⅳ and were suspected to represent ***-two lesions of approximately 1 mm in diameter were biopsied in the clinic,and 17 lesions with larger diameters were resected by endoscopic submucosal dissection(ESD) at the Hiroshima University *** addition to the histological diagnoses,the lesion diameters were microscopically measured in 45 of the 62 *** of the 62 biopsied patients received endoscopic follow ***:Minute pharyngeal lesions were diagnosed in 93 of approximately 3000 patients receiving magnified NBI examinations at the *** the 93 patients with IPCL type Ⅳ lesions,80 were men,and 13 were ***-six were drinkers,and 57 were *** had esophageal ***-one lesions were located on the posterior hypopharyngeal wall,and 72 lesions were located on the posterior oropharyngeal *** 93 lesions were flat and showed similar findings in the magnified and unmagnified NBI *** almost all of the IPCL type Ⅳ lesions showed faint redness when examined under white light,it was difficult to diagnose the lesions using only this technique because the contrast was weaker than that achieved in the NBI *** the 93 lesions,only 3 had diameters greater than 2.1 ***-two lesions of approximately 1 mm were biopsied in the clinic,whereas 17 larger lesions were tre

关键词：病理诊断肠道检查病变活检内镜病理特征临床成像