Efficacy of transanal drainage tube in preventing anastomotic leakage after surgery for rectal cancer: A meta-analysis

作     者：Shiki Fujino Masayoshi Yasui Masayuki Ohue Norikatsu Miyoshi 

作者机构：Innovative Oncology Research and Regenerative MedicineOsaka International Cancer InstituteOsaka 541-8567Japan Department of SurgeryOsaka International Cancer InstituteOsaka 541-8567Japan 

出 版 物：《World Journal of Gastrointestinal Surgery》 (世界胃肠外科杂志（英文版）（电子版）)

年 卷 期：2023年第15卷第6期

页      面：1202-1210页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Grants-in-Aid for Scientific Research [21K08709] Funding Source: KAKEN 

主　　题：Meta-analysis Drainage Transanal Anastomotic leakage Surgical stomas Rectal cancer 

摘      要：BACKGROUND Anastomotic leakage(AL)following rectal cancer surgery is an important cause of mortality and *** transanal drainage tubes(TDTs)are expected to reduce the rate of AL,their preventive effects are *** To reveal the effect of TDT in patients with symptomatic AL after rectal cancer *** A systematic literature search was performed using the PubMed,Embase,and Cochrane Library *** included randomized controlled trials(RCTs)and prospective cohort studies(PCSs)in which patients were assigned to two groups depending on the use or non-use of TDT and in which AL was *** results of the studies were synthesized using the Mantel-Haenszel randomeffects model,and a two-tailed P value0.05 was considered statistically *** Three RCTs and two PCSs were included in this *** AL was examined in all 1417 patients(712 with TDT),and TDTs did not reduce the symptomatic AL *** a subgroup analysis of 955 patients without a diverting stoma,TDT reduced the symptomatic AL rate(odds ratio=0.50,95%confidence interval:0.29–0.86,P=0.012).CONCLUSION TDT may not reduce AL overall among patients undergoing rectal cancer ***,patients without a diverting stoma may benefit from TDT placement.