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Immunomodulatory extracellular matrix hydrogel induces tissue regeneration in a model of partial glossectomy

Bioactive Materials 2024年第8期38卷 528-539页

作者： Emma I.Zelus Aaron Panduro Isha Deshmukh Jacqueline Grime marianna alperin Andrew M.Vahabzadeh-Hagh Karen L.Christman Shu Chien-Gene Lay Department of Bioengineering UC San Diego9500 Gilman Dr.MC 0412La JollaCA92093-0412USA Department of Obstetrics Gynecologyand Reproductive SciencesDivision of Female Pelvic Medicine and Reconstructive SurgeryUC San Diego School of Medicine9300 Campus PointMC 7433La JollaCA92037-7433USA Department of Otolaryngology-Head&Neck Surgery UC San Diego School of Medicine9300 Campus PointMC 7400La JollaCA92037-7400USA Sanford Consortium for Regenerative Medicine 2880 Torrey Pines Scenic DriveLa JollaCA92037USA Sanford Stem Cell Institute 2880 Torrey Pines Scenic DriveLa JollaCA92037USA

While oropharyngeal cancer treatment regimens,including surgical resection,irradiation,and chemotherapy,are effective at removing tumors,they lead to muscle atrophy,denervation,and fibrosis,contributing to the pathogenesis of oropharyngeal dysphagia-difficulty *** standard of care of rehabilitative tongue strengthening and swallowing exercises is ***,we evaluate an alternative approach utilizing an acellular and injectable biomaterial to preserve muscle content and reduce fibrosis of the tongue after *** muscle extracellular matrix(SKM)hydrogel is fabricated from decellularized porcine skeletal muscle tissue.A partial glossectomy injury in the rat is used to induce tongue fibrosis,and SKM hydrogels along with saline controls are injected into the site of scarring two weeks after *** are harvested at 3 and 7 days post-injection for gene expression and immunohistochemical analyses,and at 4 weeks post-injection to evaluate histomorphological *** hydrogel reduces scar formation and improves muscle regeneration at the site of injury compared to *** additionally modulates the immune response towards an anti-inflammatory *** study demonstrates the immunomodulatory and tissue-regenerative capacity of an acellular and minimally invasive ECM hydrogel in a rodent model of tongue injury.

关键词： Extracellular matrix Biomaterial Hydrogel Skeletal muscle regeneration Partial glossectomy Dysphagia Immunomodulation

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Musculoskeletal disorders in nursing staff

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World Journal of Methodology 2025年第2期15卷 9-14页

作者： Agapi Kolovou Asterios N Gkougkoulias Nikolaos Stefanou Elena Manuela Samaila Maria Tsekoura marianna Vlychou Charalampos Matzaroglou Zoe H Dailiana Department of Orthopaedic Surgery Faculty of MedicineSchool of Health SciencesUniversity of ThessalyLarissa 41500ThessaliaGreece Department of Radiology Faculty of MedicineSchool of Health SciencesUniversity of ThessalyLarissa 41500ThessaliaGreece Orthopaedic and Trauma Center University of VeronaVerona 37134Italy Department of Physiotherapy School of Health Rehabilitation SciencesUniversity of PatrasPatra 26504DytikíElládaGreece

Nursing staff provides patient care in an occupational environment that often imposes challenges that affect significantly the musculoskeletal ***-related musculoskeletal disorders are common in nursing stuff and have a negative impact in their professional and daily *** the current editorial,the duties of nursing staff,the types of musculoskeletal disorders,the predis-posing factors(including factors related to professional tasks/ergonomics and to working schedules,psychological,social and individual factors)and their impact on working ability and quality of life nursing staff are summarized and pre-ventive measures are proposed.

关键词： Musculoskeletal disorders Nursing staff Predisposing factors Ergonomics Prevention

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Rare case of cryptogenic brain abscess caused by Raoultella ornithinolityca

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World Journal of Clinical Cases 2017年第7期5卷 299-302页

作者： marianna Luongo Department of Neurosurgery San Carlo Hospital

Cerebral abscess is a potentially fatal neurosurgical condition,despite improvements in technology,new antimicrobial agents and modern neurosurgical instruments and techniques.I report the case of a 64-yearold woman,affected by a right frontobasal brain abscess,compressing the homolateral frontal horn of lateral ventricle,with a second mass partially occupying the right orbital *** presented also with inflammatory sinusopathy involving the right maxillary,ethmoid and frontal *** 14 d of clinical observation and antimicrobial therapy,the patient received a computed tomography scan,which showed growth of the cerebral mass,with a ring of peripheral contrast enhancement and surrounding *** promptly underwent neurosurgical treatment and recovered well,except for the sight in her right eye,which remained compromised,as before the *** is believed to be the first case of cryptogenic cerebral abscess caused by Raoultella ornithinolityca isolated from the brain,with more than 1-year follow-up.

关键词： Brain abscess Headache Raoultel a ornithinolityca Visual loss

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The intricacies of neurotrophic factor therapy for retinal ganglion cell rescue in glaucoma: a case for gene therapy

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Neural Regeneration Research 2016年第6期11卷 875-877页

作者： marianna Foldvari Ding Wen Chen School of Pharmacy Waterloo Institute of Nanotechnology and Center for Bioengineering and Biotechnology University of Waterloo

Regeneration of damaged retinal ganglion cells（RGC） and their axons is an important aspect of reversing vision loss in glaucoma patients. While current therapies can effectively lower intraocular pressure, they do not provide extrinsic support to RGCs to actively aid in their protection and regeneration. The unmet need could be addressed by neurotrophic factor gene therapy, where plasmid DNA, encoding neurotrophic factors, is delivered to retinal cells to maintain sufficient levels of neurotrophins in the retina. In this review, we aim to describe the intricacies in the design of the therapy including： the choice of neurotrophic factor, the site and route of administration and target cell populations for gene delivery. Furthermore, we also discuss the challenges currently being faced in RGC-related therapy development with special considerations to the existence of multiple RGC subtypes and the lack of efficient and representative in vitro models for rapid and reliable screening in the drug development process.

关键词： neurotrophic glaucoma ganglion RGCs retina intraocular Regeneration administration representative populations

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Damage detection with image processing: a comparative study

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Earthquake Engineering and Engineering Vibration 2023年第2期22卷 333-345页

作者： marianna Crognale Melissa De Iuliis Cecilia Rinaldi Vincenzo Gattulli Department of Structural and Geotechnical Engineering Sapienza University of Romevia Eudossiana 18Rome 00167Italy

Large structures,such as bridges,highways,etc.,need to be inspected to evaluate their actual physical and functional condition,to predict future conditions,and to help decision makers allocating maintenance and rehabilitation *** assessment of civil infrastructure condition is carried out through information obtained by inspection and/or monitoring *** techniques in structural health monitoring(SHM)involve visual inspection related to inspection standards that can be time-consuming data collection,expensive,labor intensive,and *** address these limitations,machine vision-based inspection procedures have increasingly been investigated within the research *** this context,this paper proposes and compares four different computer vision procedures to identify damage by image processing:Otsu method thresholding,Markov random fields segmentation,RGB color detection technique,and K-means clustering *** first method is based on segmentation by thresholding that returns a binary image from a grayscale *** Markov random fields technique uses a probabilistic approach to assign labels to model the spatial dependencies in image *** RGB technique uses color detection to evaluate the defect ***,K-means algorithm is based on Euclidean distance for clustering of the *** benefits and limitations of each technique are discussed,and the challenges of using the techniques are *** show the effectiveness of the described techniques in damage detection of civil infrastructures,a case study is *** show that various types of corrosion and cracks can be detected by image processing techniques making the proposed techniques a suitable tool for the prediction of the damage evolution in civil infrastructures.

关键词： damage detection image processing image classification civil infrastructure inspection structural health monitoring analysis

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Impact of gynecological cancers on women’s mental health

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World Journal of Psychiatry 2024年第9期14卷 1294-1300页

作者： Giuseppe Marano marianna Mazza Department of Neurosciences Unit of PsychiatryFondazione Policlinico Universitario A Gemelli IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy

Gynecological cancers and their treatments are associated with both specific and non-specific long-term physiological *** patients face transformations in their lifestyle,body image,role,and social interactions and suffer from physical,psychological,and economic *** mental health of cancer patients is of great importance and requires special attention,as growing evidence demonstrates its influence not only on quality of life but also on treatment *** cancers have peculiar psychological consequences,which are linked to the specificity of the site of the *** should be aware of the importance of protecting the psychophysical health of these patients and the fact that their physical health and quality of life also depend on the quality of their mental *** is possible to structure targeted and effective prevention interventions and treatments to reduce psychological distress and improve the quality of life of subjects living with gynecological cancers.

关键词： Gynecological cancer Psycho-oncology Women Quality of life Psycho-logical distress

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Nonalcoholic fatty liver disease and vascular disease:State-of-the-art

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World Journal of Gastroenterology 2014年第37期20卷 13306-13324页

作者： Silvia Fargion marianna Porzio Anna Ludovica Fracanzani Department of Pathophysiology and Transplantation Metabolic Liver Diseases Research CenterCa’ Granda IRCCS FoundationPoliclinico Hospital Pad Granelli

Nonalcoholic fatty liver disease(NAFLD), the most common of chronic liver disease in Western Country, is closely related to insulin resistance and oxidative stress and includes a wide spectrum of liver diseases ranging from steatosis alone, usually a benign and non-progressive condition, to nonalcoholic steatohepatitis(NASH), which may progress to liver fibrosis and cirrhosis. NAFLD is considered the hepatic manifestation of the metabolic syndrome with which shares several characteristics, however recent data suggest that NAFLD is linked to increased cardiovascular risk independently of the broad spectrum of risk factors of metabolic syndrome. Accumulating evidence suggests that the clinical burden of NAFLD is not restricted to liver-related morbidity and mortality, with the majority of deaths in NAFLD patients related to cardiovascular disease and cancer and not to the progression of liver disease. Retrospective and prospective studies provide evidence of a strong association between NAFLD and subclinical manifestation of atherosclerosis(increased intima-media thickness, endothelial dysfunction, arterial stiffness, impaired left ventricular function and coronary calcification). A general agreement emerging from these studies indicates that patients with NASH are at higher risk of cardiovascular diseases than those with simple steatosis, emphasizing the role of chronic inflammation in the pathogenesis of atherosclerosis of these patients. It is very likely that the different mechanisms involved in the pathogenesis of atherosclerosis in patients with NAFLD have a different relevance in the patients according to individual genetic background. In conclusion, in the presence of NAFLD patients should undergo a complete cardiovascular evaluation to prevent future atherosclerotic complications. Specific lifestyle modification and aggressive pharmaceutical modification will not only reduce the progression of liver disease, but also reduce morbidity for cardiovascular diseas

关键词： Intima-media thickness Steatosis Nonalcoholic fatty liver disease Non-alcoholic steatohepatitis Early atherosclerosis Cardiovascular risk Inflammation Epicardic fat

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Cultivating Pleurotus ostreatus and Pleurotus eryngii mushroom strains onagro-industrial residues in solid-state fermentation. Part II: Effect onproductivity and quality of carposomes

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Carbon Resources Conversion 2022年第1期5卷 52-60页

作者： Eirini-Maria Melanouri marianna Dedousi Panagiota Diamantopoulou Laboratory of Edible Fungi Institute of Technology of Agricultural ProductsHellenic Agricultural Organization-Demeter1 S.Venizelou Street14123 LykovrysiAttiki Greece

The potential of selected Pleurotus ostreatus and P. eryngii wild-type and commercial strains to colonize andproduce carposomes after solid-state fermentation of five substrates constituted of agro-residues namely wheatstraw (WS), beech wood shavings (BWS), coffee residue (CR), barley and oats straw (BOS), rice bark (RB),supplemented with wheat bran was investigated. The effect of substrate composition on bioprocess feasibilitywas assessed for the different strains by quantitative (i.e., mushroom yield and Biological Efficiency-BE %) andcarposome qualitative parameters (i.e., weight, size, colour, firmness). P. ostreatus strains produced carposomesearlier than P. eryngii ones. Early fruiting formation was promoted in WS for P. ostreatus strains, whereas forP. eryngii the lowest values of earliness were observed on BOS substrate. As for crop productivity, P. ostreatusstrain AMRL 150 provided the highest BE (>70%) in all substrates except for RB, while P. ostreatus strain AMRL144 achieved the highest yield and BE in BOS and BWS (75.30 and 64.26%, respectively). P. eryngii stainsproduced less number but heavier carposomes. The highest values of BE% for these strains were recorded on WSand BOS substrates. The BE was further correlated to growth parameters of fungal vegetative phase. As formushroom colour, P. ostreatus were lighter than P. eryngii and BOS substrate promoted lightness in both *** P. ostreatus mushrooms were produced at CR. No differences in the whiteness and firmness were detectedamong P. eryngii mushrooms and at any substrate used. The data included in this paper showed that Pleurotusmushrooms can be cultivated on low- or zero-value agro-industrial residues of great financial and environmentalimportance towards the production of value-added food products.

关键词： Oyster mushrooms Biological efficiency Carposomes Pileus Stipe Colour Texture

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Carposome productivity of Pleurotus ostreatus and Pleurotus eryngii growing on agro-industrial residues enriched with nitrogen,calcium salts and oils

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Carbon Resources Conversion 2023年第2期6卷 150-165页

作者： marianna Dedousi Eirini-Maria Melanouri Panagiota Diamantopoulou Laboratory of Edible Fungi Institute of Technology of Agricultural Products(ITAP)Hellenic Agricultural Organization-Dimitra1 S.Venizelou Str14123 LykovryssiGreece Laboratory of Food Microbiology and Biotechnology Department of Food Science and NutritionAgricultural University of Athens75 Iera Odos Str11855 AthensGreece

The suitability of the abundant agro-industrial residues wheat straw(WS;control),barley and oats straw(BOS)and rice husk(RH),supplemented with various sources of oils(sunflower,corn oil),nitrogen(peptone,yeast extract)and calcium salts(CaSO_(4)⋅2H_(2)O,CaCl2),as novel substrates in solid-state fermentation of selected Pleurotus ostreatus and *** mushrooms was *** possible effect of different additives on mycelial growth rate,biomass production and endoglucanase,laccase and lipase biosynthesis were ***,their impact on essential cultivation aspects(earliness,total mushroom yield,biological efficiency)and carposome quality parameters(weight,morphological characteristics)was *** fungi showed their highest growth rates on BOS substrates and the most positive implementation was CaSO_(4)⋅2H_(2)O 6%w/w(Kr=9.58 mm/day;***,Kr=9.42 mm/day;***),while different additives led to enhancement of biomass *** species demonstrated minimal levels of endoglucanase activity,with values ranging from 0.01 to 0.42 U/g of dry weight,regardless of the substrate and the stage of *** the contrary,the maximum values of laccase activity were observed at 50%of colonization on BOS and RH,while supplementation with nitrogen and calcium sources positively affected its *** and *** cultivated on BOS supplemented with peptone at 2 and 5%w/w,synthesized significant laccase amounts,i.e.,12,165.78 and 8,624.55 U/g d.w.,*** amounts of lipase were produced,especially in substrates supplemented with sunflower 2%w/w,in quantities up to 1.42 U/g d.w.,whereas the highest lipase activity was achieved by *** on WS supplemented with corn oil at 2%w/w,with a value of 4.25 U/g *** *** fermentation of Pleurotus species in polypropylene bags,WS and BOS supported faster colonization and shorter earliness period than RH substrates,whereas supplementation did no

关键词： Oyster mushrooms Residues Additives Biomass Endoglucanase Laccase Lipase Weight

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Beyond the gluten-free diet:Innovations in celiac disease therapeutics

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World Journal of Gastroenterology 2024年第38期30卷 4194-4210页

作者： Sara Massironi marianna Franchina Alessandra Elvevi Donatella Barisani Division of Gastroenterology Fondazione IRCCS San Gerardo dei TintoriUniversity of Milano-BicoccaMonza 20900Italy Department of Gastroenterology IRCCS San Gerardo dei TintoriMonza 20900LombardyItaly School of Medicine and Surgery University of Milano-BicoccaMonza 20900Italy

Celiac disease(CD)is an autoimmune disorder exacerbated by the ingestion of gluten in genetically susceptible individuals,leading to intestinal inflammation and *** chronic disease affects approximately 1%of the world’s po-pulation and is a growing health challenge due to its increasing *** development of CD is a complex interaction between genetic predispositions and environmental factors,especially gluten,culminating in a dysregulated immune *** only effective treatment at present is a strict,lifelong gluten-free ***,adherence to this diet is challenging and often incomplete,so research into alternative therapies has *** advances in under-standing the molecular and immunological aspects of CD have spearheaded the development of novel pharmacologic strategies that should provide more effec-tive and manageable treatment *** review examines the latest inno-vations in CD *** focus is on drugs in advanced clinical phases and targeting specific signaling pathways critical to the disease *** dis-cuss both quantitative strategies such as enzymatic degradation of gluten,and qualitative approaches including immunomodulation and induction of gluten *** treatments currently under investigation include transglu-taminase inhibitors,which prevent the modification of gluten peptides,and nano-particle-based therapies to recalibrate the immune *** new therapies not only promise to improve patient outcomes but are also expected to improve quality of life by reducing the burden of dietary *** integration of these new therapies could revolutionize the treatment of CD and shift the para-digm from strict dietary restrictions to a more flexible and patient-friendly thera-peutic *** review provides a comprehensive overview of the future prospects of CD treatment and emphasizes the importance of continued research and multidisciplinary collab-oration to inte

关键词： Celiac disease Gluten tolerance Enzymatic degradation Therapeutic advances Transglutaminase inhibitors Tight junction modulators

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