Beyond the gluten-free diet:Innovations in celiac disease therapeutics

作     者：Sara Massironi Marianna Franchina Alessandra Elvevi Donatella Barisani 

作者机构：Division of GastroenterologyFondazione IRCCS San Gerardo dei TintoriUniversity of Milano-BicoccaMonza 20900Italy Department of GastroenterologyIRCCS San Gerardo dei TintoriMonza 20900LombardyItaly School of Medicine and SurgeryUniversity of Milano-BicoccaMonza 20900Italy 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文）)

年 卷 期：2024年第30卷第38期

页      面：4194-4210页

核心收录：

学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学] 

主　　题：Celiac disease Gluten tolerance Enzymatic degradation Therapeutic advances Transglutaminase inhibitors Tight junction modulators 

摘      要：Celiac disease(CD)is an autoimmune disorder exacerbated by the ingestion of gluten in genetically susceptible individuals,leading to intestinal inflammation and *** chronic disease affects approximately 1%of the world’s po-pulation and is a growing health challenge due to its increasing *** development of CD is a complex interaction between genetic predispositions and environmental factors,especially gluten,culminating in a dysregulated immune *** only effective treatment at present is a strict,lifelong gluten-free ***,adherence to this diet is challenging and often incomplete,so research into alternative therapies has *** advances in under-standing the molecular and immunological aspects of CD have spearheaded the development of novel pharmacologic strategies that should provide more effec-tive and manageable treatment *** review examines the latest inno-vations in CD *** focus is on drugs in advanced clinical phases and targeting specific signaling pathways critical to the disease *** dis-cuss both quantitative strategies such as enzymatic degradation of gluten,and qualitative approaches including immunomodulation and induction of gluten *** treatments currently under investigation include transglu-taminase inhibitors,which prevent the modification of gluten peptides,and nano-particle-based therapies to recalibrate the immune *** new therapies not only promise to improve patient outcomes but are also expected to improve quality of life by reducing the burden of dietary *** integration of these new therapies could revolutionize the treatment of CD and shift the para-digm from strict dietary restrictions to a more flexible and patient-friendly thera-peutic *** review provides a comprehensive overview of the future prospects of CD treatment and emphasizes the importance of continued research and multidisciplinary collab-oration to inte