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Nano-drug delivery systems integrated with low radiation doses for enhanced therapeutic efficacy in cancer treatment

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World Journal of Clinical Cases 2025年第10期13卷 14-27页

作者： Antonio Pontoriero Paola Critelli Marco Zeppieri Alberto Bosurgi stefania Guercio maria Caffo Filippo Flavio Angileri Silvana Parisi Salvatore Lavalle Stefano Pergolizzi Radiation Oncology Unit Department of BiomedicalDental Science and Morphological and Functional ImagesUniversity of MessinaMessina 98125Italy Department of Ophthalmology University Hospital of UdineUdine 33100Italy Neurosurgery Unit Department of BiomedicalDental Science and Morphological and Functional ImagesMessinaItalyMessina 98125Italy Lavalle Department of Medicine and SurgeryUniversity of Enna"Kore"Enna 94100Italy

BACKGROUND Precision medicine is an emerging field that includes tumor-targeted delivery and tumor *** review explores the synergistic potential of combining nano-drug delivery systems with low radiation doses to achieve optimized therapeutic outcomes,particularly in the context of cancer ***-based drug carriers offer precise and targeted delivery,enhancing the therapeutic index of anticancer *** use of lower radiation doses has become a focus in radiation oncology to minimize off-target effects on healthy tissues in palliation treatment with high-target volume *** To conduct a bibliometric review of nanomedicine and glioblastoma(GBM),all relevant studies from the last two decades were *** The search strategy comprised the keywords“nanomedicine”and“glioblastoma”in the title and/or *** English-language documents from 1 January 2000 to 31 December 2023 were considered for the analysis.R code(version 4.2.0)with R Studio(version 2022.12.0-353)and the Bibliometrix package(version 4.0.1)were used for the analysis.A total of 680 documents were *** We analyzed the bibliometric features of nanomedicine in *** the limitations of the research,our analysis aims to highlight the increasing interest of researchers in the precision medicine field in GBM treatment and lead us to suggest further studies focusing on the association between nanomedicine and *** Due to the poor prognosis associated with GBM,new therapeutic approaches are *** is an increasing interest in precision medicine,which includes nanomedicine and radiotherapy,for GBM *** integration enhances the efficacy of targeted treatments and provides a promising avenue for reducing adverse effects,signifying a notable advancement in precision oncology.

关键词： Nanomedicine Nanoparticles Drug-delivery Radiotherapy Combination therapy

Towards a new paradigm of microscopic colitis: Incomplete and variant forms

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World Journal of Gastroenterology 2016年第38期22卷 8459-8471页

作者： Danila Guagnozzi stefania Landolfi maria Vicario Department of Gastroenterology Hospital Universitario Vall d’Hebron08035 BarcelonaSpain Department of Pathology Hospital Universitario Vall d’Hebron08035 BarcelonaSpain Translational Mucosal Immunology Lab Digestive Diseases Research UnitVall d’Hebron Institut de RecercaDepartment of Gastroenterology.Hospital Universitario Vall d’HebronUniversitat Autónoma de Barcelona08035 BarcelonaSpain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas(CIBERehd) 08035 BarcelonaSpain

Microscopic colitis(MC) is a chronic inflammatory bowel disease that has emerged in the last three decades as a leading cause of chronic watery diarrhoea. MC classically includes two main subtypes: lymphocytic colitis(LC) and collagenous colitis(CC). Other types of histopathological changes in the colonic mucosa have been described in patients with chronic diarrhoea, without fulfilling the conventional histopathological criteria for MC diagnosis. Whereas those unclassified alterations remained orphan for a long time, the use of the term incomplete MC(MCi) is nowadays universally accepted. However, it is still unresolved whether CC, LC and MCi should be considered as one clinical entity or if they represent three related conditions. In contrast to classical MC, the real epidemiological impact of MCi remains unknown, because only few epidemiological studies and case reports have been described. MCi presents clinical characteristics indistinguishable from complete MC with a good response to budesonide and cholestiramine. Although a number of medical treatments have been assayed in MC patients, currently, there is no causal treatment approach for MC and MCi, and only empirical strategies have been performed. Further studies are needed in order to identify their etiopathogenic mechanisms, and to better classify and treat MC.

关键词： Microscopic colitis Incomplete microscopic colitis Collagenous colitis Lymphocytic colitis

Predictive immune biomarkers: an unattainable chimera?

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Cellular & Molecular Immunology 2018年第8期15卷 740-742页

作者： Anna maria Trotta Roberto Pacelli stefania Scala Functional Genomics Istituto Nazionale per lo Studio e la Cura dei TumoriFondazione‘G.Pascale’Via SemmolaNaplesItaly Dipartimento di Scienze Biomediche Avanzate.UniversitàFederico II.Via Pansini NaplesItaly

Immune checkpoint blockade(ICB)with antibodies interfering with cytotoxic T lymphocyte antigen 4(CTLA-4)and the programmed cell death 1(PD-1)protein tremendously revolutionized therapy for advanced ***,the activity of such agents(ipilimumab and nivolumab)is limited to a 10–45%response rate in the context of unselected populations with advanced solid *** common cancer types have demonstrated a very low frequency of response(breast,prostate and colon cancers),and heterogeneous responses have been observed between distinct tumors within the same *** to broad clinical applicability include identifying patients most likely to benefit from checkpoint inhibitors and overcoming resistance to *** immune response is a dynamic and constantly evolving process due primarily to patient-dependent factors,including genetic and tumor microenvironment(TME)features,and secondarily to treatment interventions.

关键词： immune colon likely

Evidence for accuracy of pain assessment and painkillers utilization in neuropsychiatric symptoms of dementia in Calabria region,Italy

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Neural Regeneration Research 2018年第9期13卷 1619-1621页

作者： Damiana Scuteri maria Roberta Garreffa stefania Esposito Giacinto Bagetta maria Diana Naturale maria Tiziana Corasaniti Preclinical and Translational Pharmacology Department of Pharmacy Health Science and NutritionUniversity of Calabria Pharmacy Unit "Mater Domini" University Hospital Department of Health Sciences University "Magna Graecia" of Catanzaro

During the clinical course of dementia,beside cognitive impairment and memory loss,a very complex challenge is posed by the neuropsychiatric symptoms（NPSs）.Accurate evaluation and treatment of pain impacts positively the agitation of demented patients aged ≥ 65 *** gather information on the utilization of pain killers in demented patients a preliminary survey has been conducted in collaboration with the Calabrian Pharmacovigilance Territorial Service of the health district of Catanzaro（Italy）.The study has taken into consideration the prescriptions of acetylcholinesterase inhibitors and memantine during the period ranging from July 2015 to June 2016 and the percentage of patients treated against pain with non steroidal antinflammatory drugs,opioids,and anticonvulsants have been *** latter have been evaluated statistically for difference between the treatment before（pre） and after（post） the settlement of acetylcholinesterase inhibitors（ACh EI） or memantine *** results do support accuracy in painkillers utilization in the course of dementia in the regional population of Calabria（Italy）.

关键词： Alzheimer's disease dementia neuropsychiatric symptoms pain appropriate prescriptions aromatherapy opioids α2δ-1 ligands

Protein kinase CK2: a potential therapeutic target for diverse human diseases

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Signal Transduction and Targeted Therapy 2021年第6期6卷 1698-1717页

作者： Christian Borgo Claudio D'Amore stefania Sarno Mauro Salvi maria Ruzzene Department of Biomedical Sciences University of PaduaPaduaItaly CNR Institute of Neuroscience University of PaduaPaduaItaly

CK2 is a constitutively active Ser/Thr protein kinase,which phosphorylates hundreds of substrates,controls several signaling pathways,and is implicated in a plethora of human *** best documented role is in cancer,where it regulates practically all malignant *** well-known functions of CK2 are in human infections;in particular,several viruses exploit host cell CK2 for their life *** recently,also SARS-CoV-2,the virus responsible for the COVID-19 pandemic,has been found to enhance CK2 activity and to induce the phosphorylation of several CK2 substrates(either viral and host proteins).CK2 is also considered an emerging target for neurological diseases,inflammation and autoimmune disorders,diverse ophthalmic pathologies,diabetes,and *** addition,CK2 activity has been associated with cardiovascular diseases,as cardiac ischemia-reperfusion injury,atherosclerosis,and cardiac *** hypothesis of considering CK2 inhibition for cystic fibrosis therapies has been also entertained for many ***,psychiatric disorders and syndromes due to CK2 mutations have been recently *** these bases,CK2 is emerging as an increasingly attractive target in various fields of human medicine,with the advantage that several very specific and effective inhibitors are already ***,we review the literature on CK2 implication in different human pathologies and evaluate its potential as a pharmacological target in the light of the most recent findings.

关键词： diseases inflammation potential

A tree counting algorithm for precision agriculture tasks

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International Journal of Digital Earth 2013年第1期6卷 94-102页

作者： Franco Santoro Eufemia Tarantino Benedetto Figorito stefania Gualano Anna maria D’Onghia Centre International de Hautes Etudes Agronomiques Me´diterrane´ennes(CIHEAM) BariItaly School of Environmental Engineering Polytechnic University of BariBariItaly Institute of Intelligent Systems for Automation(ISSIA CNR) BariItaly

This study proposes an automatic procedure for individual fruit tree identification using GeoEye-1 sensor *** on site-specific pruning practices,the morphologic characteristics of tree crowns may generate one or more brightness peaks(tree top)on the *** optimize tree counting and to minimize typical background noises from orchards(*** soil,weeds,and man-made objects),a four-step algorithm was implemented with spatial transforms and functions suitable for spaced stands(asymmetrical smoothing filter,local minimum filter,mask layer,and spatial aggregation operator).System perfor-mance was evaluated through objective criteria,showing consistent results in fast capturing tree position for precision agriculture tasks.

关键词： individual tree identification image processing GeoEye-1 data precision agriculture geospatial data integration remote sensing sensor agri-culture

Benefits of Biochars and NPK Fertilizers for Soil Quality and Growth of Cowpea (Vigna unguiculata L. Walp.) in an Acid Arenosol

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Pedosphere 2019年第3期29卷 311-333页

作者： Rogerio Borguete Alves RAFAEL maria Luisa FERNANDEZ-MARCOS stefania COCCO maria Letizia RUELLO Flavio FORNASIER Giuseppe CORTI Department of Rural Engineering Faculty of Agronomy and Forestry Engineering Universidade Eduardo Mondlane Maputo 257 (Mozambique) Department of Agriculture Food and Environmental Sciences Univ er sit a Politecnica delle Marche Ancona 60131 (Italy) Department of Soil Science and Agricultural Chemistry Universidad de Santiago de Compostela Lugo 27002 (Spain) Department of Materials Environmental Sciences and Urban Planning Universita Politecnica delle Marche Ancona 60131 (Italy) Centro di Ricerca Viticoltura ed Enologia Gorizia 34170 (Italy) Instituto de Biodiv ersidade Agraria e Desenvolvimento Rural Universidad de Santiago de Compostela Lugo 27002 (Spain)

Fertilization is required for optimum plant growth, particularly in unfertile soils, while optimizing nutrient use effciency is an alternative to reduce inorganic fertilizer needs and reduce environmental problems caused by nutrient leaching. This study investigated soil properties and cowpea yield responses to biochars(BCs) made from different feedstocks, baby corn peel biochar(BC1), branches of mango tree biochar(BC2), and rice husk biochar(BC3), applied in combination with nitrogen-phosphorus-potassium(NPK) *** experiment was conducted in a greenhouse, using an acid sandy soil(Arenosol) that was submitted for 70 d to the following eight treatments: i) control;ii) full dose of NPK(a commercial compound fertilizer(12-24-12 of N-P2O5-K2O)+ urea(46% N));iii) BC1+ half dose of NPK;iv) BC1 + full dose of NPK;v) BC2 + half dose of NPK;vi) BC2 + full dose of NPK;vii) BC3 + half dose of NPK;and viii) BC3 + full dose of NPK. All biochars were applied at a rate of 0.9%(weight/weight), and each type of biochar was combined with half and full doses of NPK fertilizers. Soil pH increased significantly(P < 0.05) in treatments with BC1 and BC2,while cation exchange capacity(CEC) and available P were higher in the treatments with BC1;BC1 and BC2 also induced higher activity of enzymes related to the P cycle and higher cowpea yield. Similar soil properties and cowpea yield parameters were obtained with the full and half doses of NPK fertilizers for each type of biochar used. In conclusion, biochars in the combination with NPK fertilizers improved soil chemistry and enzymatic activities, allowing reduced fertilizer application and food production costs in the acid soil studied.

关键词： acid soil nutrient use effciency organic amendment plant growth potential enzyme activity soil fertility soil pH

Increased phosphorus availability to corn resulting from the simultaneous applications of phosphate rock, calcareous rock, and biochar to an acid sandy soil

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Pedosphere 2020年第6期30卷 719-733页

作者： Rogério Borguete Alves RAFAEL maria Luisa FERNÁNDEZ-MARCOS stefania COCCO maria Letizia RUELLO Flavio FORNASIER Giuseppe CORTI Department of Rural Engineering Faculty of Agronomy and Forestry EngineeringUniversidade Eduardo MondlaneMaputo 257Mozambique Department of Agriculture Food and Environmental SciencesUniversitàPolitecnica delle MarcheAncona 60131Italy Department of Soil Science and Agricultural Chemistry Universidad de Santiago de CompostelaLugo 27002Spain Department of Materials Environmental Sciences and Urban PlanningUniversitàPolitecnica delle MarcheAncona 60131Italy Consiglio per la Ricerca e la Sperimentazione in Agricoltura Centro di Ricerca per lo Studio delle Relazioni tra Pianta e Suolo(C.R.E.A.-R.P.S.)Gorizia 34170Italy Instituto de Biodiversidade Agraria e Desenvolvemento Rural Universidad de Santiago de CompostelaLugo 27002Spain

Phosphorus(P)deficiency is one of the main constraints on crop production in Arenosols(acid sandy soil).The high cost of P fertilizers may represent an insurmountable obstacle in many poor countries,leaving the exploitation of their own calcareous and phosphate rocks as the only low-cost and long-term *** is suggested to have positive effects on soil properties;however,there is no published research on the synergistic effects of biochar and rocky materials in modifying soil *** aim of this study was to investigate the chemical and biochemical responses of an acid Arenosol treated with phosphate rock(PR),calcareous rock(CR),and biochar(BC),and the implications for corn yield.A soil from Marracuene District,Mozambique was used,where corn was grown for 90 d with the soil treated with:no addition(control),water-soluble zinc phosphite fertilizer(WSP),PR,WSP+CR,WSP+BC,WSP+CR+BC,PR+BC,and PR+CR+*** was produced by pyrolysis of babycorn peels for 4 h at 450?C and applied at 11 g *** soil pHH2 Oincreased from about 4.54 in the control to 7.38 in the PR+CR+BC *** oxidizable organic carbon,cation exchange capacity,and available P were higher in the treatments containing BC than in the *** treatments containing CR and/or BC led to the highest activities of alkaline phosphomonoesterase,phosphodiesterase,andα-glucosidase,which increased P availability and gave the greatest biomass and *** suggest that biochar provides additional soluble P and supplies adsorption sites for phosphate,preventing its evolution to unavailable ***,PR applied together with BC contributed to an 840%yield increase compared to the *** treatments containing WSP and BC facilitated phosphite oxidation to phosphate and increased crop yield.

关键词： Arenosols available P enzyme activity phosphite oxidation soil fertility

Mechanisms of altered bone remodeling in children with type 1 diabetes

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World Journal of Diabetes 2021年第7期12卷 997-1009页

作者： Giacomina Brunetti Gabriele D'Amato stefania De Santis maria Grano maria Felicia Faienza Department of Biosciences Biotechnologies and BiopharmaceuticsUniversity"A.Moro"of BariBari 70125Italy Department of Women’s and Children’s Health ASL BariNeonatal Intensive Care UnitDi Venere HospitalBari 70124Italy Department of Pharmacy-Drug Science University of Bari Aldo MoroBari 70126Italy Department of Emergency and Organ Transplantation Univ BariBari 70124Italy Department of Biomedical Sciences and Human Oncology Pediatric UnitUniversity"A.Moro"Bari 70124Italy

Bone loss associated with type 1 diabetes mellitus(T1DM)begins at the onset of the disease,already in childhood,determining a lower bone mass peak and hence a greater risk of osteoporosis and fractures later in *** mechanisms underlying diabetic bone fragility are not yet completely *** and insulin deficiency can affect the bone cells functions,as well as the bone marrow fat,thus impairing the bone strength,geometry,and *** factors,like insulin and growth hormone/insulin-like growth factor 1,can control bone marrow mesenchymal stem cell commitment,and the receptor activator of nuclear factor-κB ligand/osteoprotegerin and Wnt-b catenin pathways can impair bone *** myokines may have a key role in regulating metabolic control and improving bone mass in T1DM *** aim of this review is to provide an overview of the current knowledge of the mechanisms underlying altered bone remodeling in children affected by T1DM.

关键词： Type 1 diabetes Children Bone remodeling Osteoclasts Osteoblasts