Mechanisms of altered bone remodeling in children with type 1 diabetes

作     者：Giacomina Brunetti Gabriele D'Amato Stefania De Santis Maria Grano Maria Felicia Faienza 

作者机构：Department of BiosciencesBiotechnologies and BiopharmaceuticsUniversity"A.Moro"of BariBari 70125Italy Department of Women’s and Children’s HealthASL BariNeonatal Intensive Care UnitDi Venere HospitalBari 70124Italy Department of Pharmacy-Drug ScienceUniversity of Bari Aldo MoroBari 70126Italy Department of Emergency and Organ TransplantationUniv BariBari 70124Italy Department of Biomedical Sciences and Human OncologyPediatric UnitUniversity"A.Moro"Bari 70124Italy 

出 版 物：《World Journal of Diabetes》 (世界糖尿病杂志（英文版）（电子版）)

年 卷 期：2021年第12卷第7期

页      面：997-1009页

核心收录：

学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学] 

主　　题：Type 1 diabetes Children Bone remodeling Osteoclasts Osteoblasts 

摘      要：Bone loss associated with type 1 diabetes mellitus(T1DM)begins at the onset of the disease,already in childhood,determining a lower bone mass peak and hence a greater risk of osteoporosis and fractures later in *** mechanisms underlying diabetic bone fragility are not yet completely *** and insulin deficiency can affect the bone cells functions,as well as the bone marrow fat,thus impairing the bone strength,geometry,and *** factors,like insulin and growth hormone/insulin-like growth factor 1,can control bone marrow mesenchymal stem cell commitment,and the receptor activator of nuclear factor-κB ligand/osteoprotegerin and Wnt-b catenin pathways can impair bone *** myokines may have a key role in regulating metabolic control and improving bone mass in T1DM *** aim of this review is to provide an overview of the current knowledge of the mechanisms underlying altered bone remodeling in children affected by T1DM.