Towards a new paradigm of microscopic colitis: Incomplete and variant forms

作     者：Danila Guagnozzi Stefania Landolfi Maria Vicario 

作者机构：Department of GastroenterologyHospital Universitario Vall d’Hebron08035 BarcelonaSpain Department of PathologyHospital Universitario Vall d’Hebron08035 BarcelonaSpain Translational Mucosal Immunology LabDigestive Diseases Research UnitVall d’Hebron Institut de RecercaDepartment of Gastroenterology.Hospital Universitario Vall d’HebronUniversitat Autónoma de Barcelona08035 BarcelonaSpain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas(CIBERehd)08035 BarcelonaSpain 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2016年第22卷第38期

页      面：8459-8471页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by Fondo de Investigación Sanitaria Instituto de Salud Carlos III Subdirección General de Investigación Sanitaria Ministerio de Economía y Competitividad CP10/00502 PI13/00935 and CIBERehd CB06/04/0021(MV) 

主　　题：Microscopic colitis Incomplete microscopic colitis Collagenous colitis Lymphocytic colitis 

摘      要：Microscopic colitis(MC) is a chronic inflammatory bowel disease that has emerged in the last three decades as a leading cause of chronic watery diarrhoea. MC classically includes two main subtypes: lymphocytic colitis(LC) and collagenous colitis(CC). Other types of histopathological changes in the colonic mucosa have been described in patients with chronic diarrhoea, without fulfilling the conventional histopathological criteria for MC diagnosis. Whereas those unclassified alterations remained orphan for a long time, the use of the term incomplete MC(MCi) is nowadays universally accepted. However, it is still unresolved whether CC, LC and MCi should be considered as one clinical entity or if they represent three related conditions. In contrast to classical MC, the real epidemiological impact of MCi remains unknown, because only few epidemiological studies and case reports have been described. MCi presents clinical characteristics indistinguishable from complete MC with a good response to budesonide and cholestiramine. Although a number of medical treatments have been assayed in MC patients, currently, there is no causal treatment approach for MC and MCi, and only empirical strategies have been performed. Further studies are needed in order to identify their etiopathogenic mechanisms, and to better classify and treat MC.