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3D-printed aerogels as theranostic implants monitored by fluorescence bioimaging

Bioactive Materials 2024年第11期41卷 471-484页

作者： Ana Iglesias-Mejuto Rui Pinto Pedro Faísca JoséCatarino João Rocha Luisa Durães maria manuela gaspar Catarina Pinto Reis Carlos A.García-González AerogelsLab I+D Farma Group(GI-1645)Department of PharmacologyPharmacy and Pharmaceutical TechnologyFaculty of PharmacyiMATUS and Health Research Institute of Santiago de Compostela(IDIS)Universidade de Santiago de CompostelaE-15782Santiago de CompostelaSpain Research Institute for Medicines(iMed.ULisboa) Faculty of PharmacyUniversidade de LisboaAv.Professor Gama Pinto1649-003LisboaPortugal Joaquim Chaves Saúde Joaquim Chaves Laboratório de Análises ClínicasMiraflores1495069AlgésPortugal CECAV-Faculty of Veterinary Medicina-Lusófona University-Lisbon University Center Campo Grande 3761749-024LisboaPortugal Faculty of Veterinary Medicina-Lusófona University-Lisbon University Center Campo Grande 3761749-024LisboaPortugal University of Coimbra CERES-Chemical Engineering and Renewable Resources for SustainabilityDepartment of Chemical Engineering3030-790CoimbraPortugal Instituto de Biofísica e Engenharia Biomédica(IBEB) Faculdade de CiênciasUniversidade de LisboaCampo Grande1749-016LisboaPortugal

Aerogel scaffolds are nanostructured materials with beneficial properties for tissue engineering *** tracing of the state of the aerogels after their implantation is challenging due to their variable biodegradation rate and the lack of suitable strategies capable of in vivo monitoring the *** nanoparticles(UCNPs)have emerged as advanced tools for in vitro bioimaging because of their fluorescence *** this work,highly fluorescent UCNPs were loaded into aerogels to obtain theranostic implants for tissue engineering and bioimaging applications.3D-printed alginate-hydroxyapatite aerogels labeled with UCNPs were manufactured by 3D-printing and supercritical CO2 drying to generate personalize-to-patient *** physicochemical performance of the resulting structures was evaluated by printing fidelity measurements,nitrogen adsorption-desorption analysis,and different microscopies(confocal,transmission and scanning electron microscopies).Stability of the aerogels in terms of physicochemical properties was also tested after 3 years of *** was evaluated in vitro by different cell and hemocompatibility assays,in ovo and in vivo by safety and bioimaging studies using different murine *** profile,tissue index and histological evaluations of the main organs unveiled an in vivo downregulation of the inflammation after implantation of the ***-decorated aerogels were first-time manufactured and long-term traceable by fluorescence-based bioimaging until 3 weeks post-implantation,thereby endorsing their suitability as tissue engineering and theranostic nanodevices(*** implants).

关键词： Upconversion nanoparticles Aerogels Theranostic implants In vivo fluorescence

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Musculoskeletal disorders in nursing staff

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World Journal of Methodology 2025年第2期15卷 9-14页

作者： Agapi Kolovou Asterios N Gkougkoulias Nikolaos Stefanou Elena manuela Samaila maria Tsekoura marianna Vlychou Charalampos Matzaroglou Zoe H Dailiana Department of Orthopaedic Surgery Faculty of MedicineSchool of Health SciencesUniversity of ThessalyLarissa 41500ThessaliaGreece Department of Radiology Faculty of MedicineSchool of Health SciencesUniversity of ThessalyLarissa 41500ThessaliaGreece Orthopaedic and Trauma Center University of VeronaVerona 37134Italy Department of Physiotherapy School of Health Rehabilitation SciencesUniversity of PatrasPatra 26504DytikíElládaGreece

Nursing staff provides patient care in an occupational environment that often imposes challenges that affect significantly the musculoskeletal ***-related musculoskeletal disorders are common in nursing stuff and have a negative impact in their professional and daily *** the current editorial,the duties of nursing staff,the types of musculoskeletal disorders,the predis-posing factors(including factors related to professional tasks/ergonomics and to working schedules,psychological,social and individual factors)and their impact on working ability and quality of life nursing staff are summarized and pre-ventive measures are proposed.

关键词： Musculoskeletal disorders Nursing staff Predisposing factors Ergonomics Prevention

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Experimental evidence for heritable reproductive time in 2 allochronic populations of pine processionary moth

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Insect Science 2017年第2期24卷 325-335页

作者： manuela Branco maria-Rosa Paiva Helena maria Santos Christian Burban Carole Kerdelhue Centro de Estudos Florestais (CEF) Instituto Superior de Agronomia (ISA) Universidade de Lisboa (ULisboa) 1349-017 Lisboa Portugal CENSE Faculty of Sciences and Technology (FCT) Universidade Nova de Lisboa (UNL) 2829-516 Caparica Portugal INRA Centre de Bordeaux UMR1202 BIOGECO Cestas cedex France INRA Centre de Montpellier UMR CBGP F-34988 Montferrier-sur-Lez cedex France

Phenology allows organisms to overcome seasonally variable conditions through life-cycle adjustment. Changes in phenology can drastically modify the evolutionary tra- jectory of a population, while a shift in the reproductive time may cause allochronic differentiation. The hypothesis of heritable reproductive time was experimentally tested, by studying a unique population of the pine processionary moth Thaumetopoeapityocampa （Den. ＆ Schiff.） which has a shifted phenology, and however co-occurs with the typical population following the classical life cycle. When populations of both types were reared under controlled conditions, the reproductive time was maintained asynchronous, as ob- served in the field. The shifted population was manipulated in the laboratory to reproduce later than usual, yet the offspring emerged in the next year at the expected dates thus ＂com- ing back＂ to the usual cycle. Hybrids from crosses performed between the 2 populations showed an intermediate phenology. From the emergence times of parents and offspring, a high heritability of the reproductive time （h = 0.76） was observed. The offspring ob- tained from each type of cross was genetically characterized using microsatellite markers. Bayesian clustering analysis confirmed that hybrids can he successfully identified and separated from the parental genetic classes by genotyping. Findings support the hypothesis that, for this particular population, incipient allochronic speciation is due to a heritable shift in the reproductive time that further causes assortative mating and might eventually cause ecological adaptation/maladaptation in response to environmental changes.

关键词： allochronic speciation experimental crossings heritability phenology reproductive isolation Thaumetopoeapityocampa

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Structural characteristics and the label-free detection of poly(3,4-ethylenedioxythiophene/cucurbit[7]uril)pseudorotaxane at single molecule level

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Nano Research 2023年第2期16卷 2728-2737页

作者： Aurica Farcas Hadjer Ouldali Corneliu Cojocaru manuela Pastoriza-Gallego Ana-maria Resmerita Abdelghani Oukhaled “Petru Poni”Institute of Macromolecular Chemistry 700487 IasiRomania CY Cergy Paris Université CNRSLAMBE95000 CergyFrance

A multi-technique approach to prove the preparation of poly(3,4-ethylenedioxythiophene/cucurbit[7]uril)pseudorotaxanes(PEDOT∙CB7-PPs)is *** docking simulation and matrix-assisted laser desorption/ionization mass spectrometry(MALDI MS)validate the complexation ability of the CB7 molecule towards 3,4-ethylenedioxythiophene(EDOT),which leads to the EDOT∙CB7 inclusion *** polymerization of EDOT∙CB7 enabled the synthesis of PEDOT∙*** water-soluble part of PEDOT∙CB7-PPs was selected,freeze-dried,and chemically ***,dynamic light scattering(DLS)has been used to study the particle size and z-potential(ZP-ζ)of PEDOT∙*** ZP-ζvalue(35 mV)evidenced that the PEDOT∙CB7-PPs formed stable water *** combining the emerging nanopore resistive pulse sensing technique(Np-RPS)and computational modeling,we identified strong interactions of PEDOT∙CB7-PPs with the aerolysin(Ael)***∙CB7-PPs behave as positive charged species,and thus trans negative bias promotes its interactions with the Ael *** computational modeling results are fully consistent with the Np-RPS detection,which also reveals strong interactions between PEDOT∙CB7-PPs and the Ael *** this study,we hope to provide new insights and a better understanding of the interactions between supramolecular complexes based on CB7 and biological entities,which is instrumental for future applications in the field of nanobiotechnology.

关键词： supramolecular encapsulation poly(3,4-ethylenedioxythiophene)(PEDOT) cucurbituril aerolysin electrical detection computational modeling

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Could a Cutaneous Lesion Mean Gastric Cancer? Case Report of a Rare Diagnostic Tool and the Management of a Cardiac Complication during Chemotherapy

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Journal of Cancer Therapy 2020年第10期11卷 639-645页

作者： Cátia Fava gaspar maria João Leitão manuela Machado Medical Oncology Department Portuguese Institute of Oncology of Porto (IPO Porto) Porto Portugal

Cutaneous presentation of gastric cancer is very rare. This case report is about a patient with a metastatic gastric cancer in which the diagnosis was made by a cutaneous biopsy. Following this unusual diagnostic tool, the patient had an intracardiac thrombus, during the chemotherapy regimen, which wasn’t a contraindication for pursuing chemotherapy treatment for over 12 months. This case report is presented to make clinicians aware of a possible atypical sign of presentation of gastrointestinal tract cancer, as well as the importance of clinical suspicion of a well-known problem affecting cancer patients such as venous thromboembolism and its repercussions in the treatment options.

关键词： Gastric Cancer Cutaneous Metastasis Intracardiac Thrombus

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Deficit Irrigation as a Strategy to Save Water:Physiology and Potential Application to Horticulture

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Journal of Integrative Plant Biology 2007年第10期49卷 1421-1434页

作者： J.Miguel Costa maria F.Ortuo M.manuela Chaves InstitutoSuperior de Agronomia Universidade Técnica de LisboaTapada da Ajuda1349-017 LisboaPortugal Laboratório de Ecofisiologia MolecularInstituto de Tecnologia Química e BiológicaApartado 1272780-901 OeirasPortugal Instituto

Water is an increasingly scarce resource worldwide and irrigated agriculture remains one of the largest and most inefficient users of this resource. Low water use efficiency （WUE） together with an increased competition for water resources with other sectors （e.g. tourism or industry） are forcing growers to adopt new irrigation and cultivation practices that use water more judiciously. In areas with dry and hot climates, drip irrigation and protected cultivation have improved WUE mainly by reducing runoff and evapotranspiration losses. However, complementary approaches are still needed to increase WUE in irrigated agriculture. Deficit irrigation strategies like regulated deficit irrigation or partial root drying have emerged as potential ways to increase water savings in agriculture by allowing crops to withstand mild water stress with no or only marginal decreases of yield and quality. Grapevine and several fruit tree crops seem to be well adapted to deficit irrigation, but other crops like vegetables tend not to cope so well due to losses in yield and quality. This paper aims at providing an overview of the physiological basis of deficit irrigation strategies and their potential for horticulture by describing the major consequences of their use to vegetative growth, yield and quality of different crops （fruits, vegetables and ornamentals）.

关键词： deficit irrigation horticulture partial rootzone drying regulated deficit irrigation water saving.

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Food quality,food-borne diseases,and food safety in the Brazilian food industry

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Food Quality and Safety 2017年第1期1卷 13-27页

作者： maria manuela Camino Feltes Adriana Pavesi Arisseto-Bragotto Jane Mara Block Department of Food Science and Technology Federal University of Santa CatarinaRod.Admar GonzagaItacorubiFlorianópolisBrazil Department of Food Science State University of CampinasRua Monteiro LobatoSão PauloBrazil

INTRODUCTION:In the recent decades,a global effort from food suppliers,industries,and governments has ensured that food production would meet the high quality required by the sanitary authorities,minimizing public health implications and economic losses caused by food-borne ***:Several programmes and initiatives have been developed worldwide both by government agencies and the private sector to achieve this ***-borne diseases,caused by pathogens,natural toxins,and chemical contaminants,remain a global public health challenge,since new threats are continuously emerging while others are being ***,in many countries,the consumption of food prepared outside the home increases the exposure to the risks posed by poor hygiene in food *** this context,a reliable sanitary surveillance system is urgently needed to identify potential hazards,conduct risk analysis,and control food-borne diseases outbreaks *** SAFETY POLICIES AND REGULATORY FRAMEWORKS:Brazil national agencies are tasked with controlling the hazards in the food chain by means of federal regulations based on a set of global sanitary authorities’***:The occurrence of food-borne diseases,control measures,policies,and regulatory frameworks in Brazil drawn to ensure the quality and safety of food are presented in this paper.

关键词： Brazilian food regulation Food policies Public health Food safety

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Current policies in Brazil for ensuring nutritional quality

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Food Quality and Safety 2017年第4期1卷 275-288页

作者： Jane Mara Block Adriana Pavesi Arisseto-Bragotto maria manuela Camino Feltes Department of Food Science and Technology Federal University of Santa Catarina-UFSCFlorianópolis Department of Food Science State University of Campinas-UNICAMPRua Monteiro LobatoCampinasSão PauloBrazil

Objectives:In this work the current policies and regulatory actions of the government agencies in Brazil for ensuring nutritional quality are *** and methods:Information on the efforts of industry,academia and nongovernmental organizations to achieve the proposed goals,the results achieved and the challenges that must still be faced by the different sectors of the Brazilian society are presented and ***:The joint action of regulatory agencies,the food production sector,non-governmental entities and academia resulted in the reduction of saturated and trans fats,salt and sugar in foods produced in ***:Most of the information related to the food industries in Brazil is made available by ABIA(Brazilian Association of Food Industries)which represents around 60%of the food market in *** regarding the rest of the market is ***:The reduction of saturated and‘trans’fats,sodium,and sugar in industrialized foods seems an effective strategy for reducing the intake of these compounds by the Brazilian *** addition the adequate nutrition labeling and consumer education will allow healthier food choices by the population.

关键词： Brazilian food industry healthy foods ‘trans’fats salt sugar

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Food quality and safety progress in the Brazilian food and beverage industry:chemical hazards

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Food Quality and Safety 2017年第2期1卷 117-129页

作者： Adriana Pavesi Arisseto-Bragotto maria manuela Camino Feltes Jane Mara Block Department of Food Science State University of Campinas-UNICAMPRua Monteiro LobatoCampinas-SPBrazil Department of Food Science and Technology Federal University of Santa Catarina-UFSCRod.Admar GonzagaFlorianópolis-SCBrazil

INTRODUCTION:Ensuring food safety is a challenge for developed and developing countries and depends on the combined efforts of government,regulators,academia,consumers,food producers,and ***:In this work,an overview of the main regulatory aspects related to chemical hazards in the Brazilian food and beverage industry is *** presence of contaminants,food additives,and residues of pesticides and veterinary drugs,including current regulations and their impacts on the safety and quality of locally produced foods,are ***:In Brazil,the assessment,management,and communication of human health risks in food and beverage are the joint responsibility of the Ministry of Health and the Ministry of Agriculture,Livestock and Food Supply,which enforce the international regulations established mainly by the Codex Alimentarius Commission,the European Commission,and the US Food and Drug ***:Constant updates of the national legislation following internationally recognized standards,the intensification of the existing monitoring plans and efficient actions of sanitary surveillance,major investments in scientific research,and a greater awareness among the food producers may contribute to the safety and quality of the food produced in Brazil.

关键词： Food safety Regulation Food and beverage Industry Health risks Chemical contamination.

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From landslide characterization to nature reserve management:The“Scialimata Grande di Torre Alfina”landslide Geosite(Central Apennines,Italy)

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Journal of Mountain Science 2023年第3期20卷 585-606页

作者： Gianluca TRONTI Francesca VERGARI Irene maria BOLLATI Filippo BELISARIO Maurizio DELMONTE manuela PELFINI Paola FREDI Earth Sciences Department"Ardito Desio" University La StataleMilan 20133(MI)Italy Monte Rufeno Nature Reserve Acquapendente 01021(VT)Italy Earth Sciences Department University La SapienzaRome 00185(RM)Italy

Italy is characterized by widespread geomorphological instability,among which landslides leave impressive marks on the ***,landslide bodies may represent key sites for thematic and educational itineraries,especially in protected areas,where their management becomes an important *** study focuses on the"Monte Rufeno Nature Reserve"(Central Apennines,Italy),where iconic landslides are ***,the"Scialimata Grande di Torre Alfina"landslide(SGTA)is listed in the regional Geosite *** work aims to propose a multiscale procedure for landslide analysis,in terms of both hazard sources but also educational and geoheritage enhancement opportunities in natural *** performing a Landslide Susceptibility conditional Analysis(LSA)for the reserve territory,attention was focused on the SGTA,to define properly its features and morphodynamics.A multi-disciplinary approach was adopted,by applying both remote sensing(UAV structure from motion,Photointerpretation)and field survey(geomorphological and GPS monitoring).From the LSA,based on drainage density,curvature,and slope triggering factors,the road and trail susceptibility maps were derived,as base tools for future risk assessments and trail paths management within the *** the SGTA scale,the monitoring showed a displacement of up to 23 m during the time interval between 2015 and *** landslide dynamics seem to be driven by alternating dry and extremely wet periods;moreover,leaks from the aqueduct in the detachment area and piping effects through clays may have also decreased the substrate *** SGTA complex influence on the Paglia River valley geometry was also hypothesized,underlining the action of landslide through different spatial scales(on-site and off-site)and on different environment features(sediment connectivity,hydrology).Finally,the SGTA appears highly representative of the geomorphic dynamics within the Nature Reserve(i.e.,scientific value)and it could be

关键词： Landslides Geoheritage Geosites Nature reserves management UAV structure from motion Landslides conditional analyses

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