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Vacuum Assisted Closure (VAC) and Platelet-Rich Plasma (PRP): A Successful Combination in a Challenging Case of Gastroschisis

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Open Journal of Pediatrics 2015年第3期5卷 274-278页

作者： Vincenzo Domenichelli Simona Straziuso maria domenica sabatino Silvana Federici Pediatric Surgical Unit “Infermi” Hospital AUSL Romagna Rimini Italy

Giant gastroschisis could be a surgical challenge concerning the abdominal wall reconstruction. Many techniques have been described for both primary or staged closure but sometimes neither of them is succesful in all patients. We are presenting the combined use of Vacuum Assisted Closure (VAC) and Platelet-Rich Plasma (PRP) to improve the result in this difficult case. The use of VAC device is a well known procedure in the treatment of adult difficult wounds closure. It consists of a sponge applied directly on the abdominal wall defect, covered with a transparent dressing and connected to a controlled continuous negative pressure system [1]. Platelet-rich plasma (PRP) is an autologous concentration of human platelets in a small volume of plasma. Due to this combination it provides multiple growth and healing factors actively secreted by platelets which have been shown to begin and accelerate wound healing [2] [3]. The association between VAC and PRP was effective in the shrinkage and reduction of the abdominal defect. Fifteen months after the removal of the VAC device the fascia appears competent with a cutaneus scar that will need a plastic correction in the future. The VAC should be considered as a helpful and effective device in case of complicated giant gastroschisis or omphalocele when traditional treatment is not sufficient.

关键词： Vacuum Assisted Closure Gastroschisis Platelet-Rich Plasma Abdominal Wall Defect

Lighting the shades of hidden pain:a role for spinal cord neurons and microglia in vestibulodynia

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Neural Regeneration Research 2025年第10期20卷 2898-2900页

作者： Rosmara Infantino Francesca Gargano Serena Boccella Carmela Belardo Andrea maria Morace Francesca Guida sabatino Maione Livio Luongo Department of Experimental Medicine Division of PharmacologyUniversitàdegli Studi della Campania“L.Vanvitelli”Italy UniversitàCampus Bio-medico di Roma RomeItaly

Vulvodynia,a chronic pain disorder affecting the vulvar region,represents a significant challenge in both diagnosis and treatment within the field of women’s *** condition is characterized by chronic pain that significantly affects the quality of life of afflicted *** present perspective paper examines the role of spinal sensitization and microglial activation in vulvodynia.

关键词： pain diagnosis activation

Large-area Analysis of Soil Erosion and Landslides Induced by Rainfall: A Case of Unsaturated Shallow Deposits

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Journal of Mountain Science 2015年第4期12卷 783-796页

作者： CUOMO sabatino DELLA SALA maria Department of Civil Engineering University of Salerno

Unsaturated shallow soil deposits may be affected by either superficial soil erosion or shallow landslides in adjacent or overlapping source areas and in different seasons when a different soil suction *** triggering analysis of both these processes is a relevant issue for the hazard analysis while the literature mostly provides specific approaches for erosion or for *** paper proposes a largearea analysis for a case study of Southern Italy,consisting of unsaturated shallow deposits of loose pyroclastic(air-fall) volcanic soils that have been repeatedly affected by erosion and landslides in special *** a past catastrophic event, the simulated source areas of shallow landslides are smaller than those observed in the field while the simulated eroded areas with thickness greater than 5cm are comparable with the in-situ evidences, if the analysis takes into account high rainfall intensity and a spatially variable soil cover *** in general, the results of the paper are consistent with the previous literature and also provide a methodological contribution about the application of distinct tools over large *** added value is that the paper shows how the combination of distinct large-area analyses may help with understanding the dominant slope instability *** once this goal is fully achieved, can specific physically-based analyses be confidently performed at detailed scales and for smaller specific areas.

关键词： Soil Erosion Landslide Soil Suction Slope instability mechanism Modelling

Hydrogeological hazards and weather events:Triggering and evolution of shallow landslides

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International Soil and Water Conservation Research 2014年第2期2卷 23-29页

作者： Salvatore Monteleone maria sabatino Dipartimento di Scienze della Terra e del Mare University of PalermoItaly

Landslides are the most intense and serious manifestations of the degradation of slopes and they are the main causes of geological hazard when they,directly or indirectly,involving towns and *** are a global environment problem;there are several examples that have produced untold damages and loss of human lives in many parts of the *** 1920 the landslides mobilization,as a result of a strong earthquake in China,in the province of Kansu,killed 200,000 people;in 1938 fast debris flow,triggered by heavy rainfalls in Japan,caused the death of 600 people;in 1963 in Italy the Vajont disaster caused the death of 1,899 people,as a result of a landslide localized in the underlying artificial *** the last years there have been many tragedies linked to intense rainfall events which have sparked many shallow landslides:1996 in Garfagnana,1998 in Sarno,2009 in the Ionic side of Messina,2011 in *** throw light on this problem,over the past decades,the assessment and mitigation of landslides hazard and the danger related to it,have become goals of paramount importance in territorial planning and,more generally,in its management and with it the safeguard of the historical and cultural heritage within *** occurrence of events which are considered exceptional thus implies a re-reading in terms of spatial planning to renovate the slopes and river-beds,as well as urban planning,infrastructural and socio-economic *** complex nature of these instability events that affect anthropized areas does not allow specific approaches for the defence of single good,but it finds a more effective solution based on the extensive knowledge of territory,perhaps at the scale of individual or several watersheds.

关键词： Geo-environmental hazard Hydrogeological instability Urban planning

Carboxylated-xyloglucan and peptide amphiphile co-assembly in wound healing

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Regenerative Biomaterials 2021年第5期8卷 75-86页

作者： Alessia Ajovalasit Carlos Redondo-Go´mez maria Antonietta sabatino Babatunde OOkesola Kristin Braun Alvaro Mata Clelia Dispenza Dipartimento di Ingegneria(DI) Universitadegli Studi di PalermoViale delle ScienzeEdificio 6Palermo 90128Italy School of Engineering&Materials Science Queen Mary University of LondonLondon E14NSUK Institute of Bioengineering Queen Mary University of LondonLondon E14NSUK Blizard Institute Barts and The London School of Medicine and DentistryThe Blizard Building4 Newark StreetLondon E12ATUK School of Pharmacy University of NottinghamNottingham NG72RDUK Department of Chemical and Environmental Engineering University of NottinghamNottingham NG72RDUK Biodiscovery Institute University of NottinghamNottinghamNG72RDUK Istituto di Biofisica(IBF) Consiglio Nazionale Delle Ricerche(CNR)Via U.La Malfa 153Palermo 90146Italy

Hydrogel wound dressings can play critical roles in wound healing protecting the wound from trauma or contamination and providing an ideal environment to support the growth of endogenous cells and promote wound *** work presents a self-assembling hydrogel dressing that can assist the wound repair process mimicking the hierarchical structure of skin extracellular *** this aim,the co-assembly behaviour of a carboxylated variant of xyloglucan(CXG)with a peptide amphiphile(PA-H3)has been investigated to generate hierarchical constructs with tuneable molecular composition,structure,and *** electron microscopy and circular dichroism at a low concentration shows that CXG and PA-H3 co-assemble into nanofibres by hydrophobic and electrostatic interactions and further aggregate into nanofibre bundles and *** a higher concentration,CXG and PA-H3 yield hydrogels that have been characterized for their morphology by scanning electron microscopy and for the mechanical properties by smallamplitude oscillatory shear rheological measurements and compression tests at different CXG/PAH3 ratios.A preliminary biological evaluation has been carried out both in vitro with HaCat cells and in vivo in a mouse model.

关键词： self-assembly peptide nanofiber hydrogel wound healing skin tissue engineering

Scimitar Syndrome:Role of Right Atrial Longitudinal Strain.A Case Report

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Congenital Heart Disease 2021年第4期16卷 411-416页

作者： Isabella Leo Jolanda sabatino Sabrina La Bella Antonio Strangio Iolanda Aquila Concetta Procopio Carmen Anna maria Spaccarotella maria Petullà Salvatore De Rosa Ciro Indolfi Division of Cardiology Department of Medical and Surgical SciencesMagna Graecia UniversityCatanzaroItaly Cardiovascular Research Center Magna Graecia UniversityCatanzaroItaly Department of Paediatric Cardiology Royal Brompton HospitalLondonUK Department of Radiology Magna Graecia UniversityCatanzaroItaly Mediterranea Cardiocentro NapoliItaly

We describe a case of a rare congenital heart disorder,scimitar syndrome,diagnosed in an adult woman presenting with dyspnea on exertion,chest pain and recurrent episodes of pulmonary *** hallmark of the syndrome is the presence of an enlarged anomalous pulmonary vein draining into the inferior vena *** tracking echocardiography,including the often-forgotten atrial strain evaluation,is a sensitive parameter that should be routinely used for a better clinical and prognostic evaluation of patients with congenital heart disease(CHD).

关键词： Scimitar syndrome RV overload congenital heart disease myocardial strain

Indications and results of renal biopsy in children:a 36-year experience

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World Journal of Pediatrics 2018年第2期14卷 127-133页

作者： Luisa Santangelo Giuseppe Stefano Netti Paolo Giordano Vincenza Carbone Marida Martino Diletta domenica Torres Michele Rossini Anna maria Di Palma Loreto Gesualdo Mario Giordano Unit of Pediatric Nephrology and Dialysis Pediatric Hospital"GiovanniⅩⅩⅢ"BariItaly Clinical Pathology Department of Medical and Surgical SciencesUniversity of FoggiaFoggiaItaly Unit of Nephrology Dialysis and TransplantationDepartment of Emergency and OrganTransplantationUniversity"Aldo Moro"BariItaly

Background This study was conducted to investigate retrospectively the indications for renal biopsy(RB)in native kidneys and to analyze pathological findings in a single tertiary pediatric hospital in Southern Italy for the last 36 *** All patients who underwent RB at our hospital from 1979 to 2014 were *** renal tissue specimens were studied under light and immunofluorescent microscopy,while electron microscopy was performed only for specific clinical *** The study group included 213 patients(female 43.2%)who underwent 225 percutaneous native kidney *** age was 10.4 years(range 0.6-24 years).The most frequent indication for RB was nephrotic syndrome(44.4%),fol-lowed by proteinuria(27.6%),asymptomatic hematuria(17.3%)and acute kidney injury(9.8%).Gross hematuria appeared after biopsy in less than 5%of the patients,but none of them needed blood *** renal tissue sample was obtained in 95.5%of the renal *** glomerulonephritis(GN)was the most common finding(61.4%),followed by secondary GN(21.4%),tubulointerstitial diseases(3.7%)and hereditary nephropathy(2.8%),while in 10.7%of the cases,normal renal tissues were *** to histopathological diagnosis,the most common causes of primary GN were IgA nephropathy(20.9%),followed by minimal change disease(18.1%)and focal segmental glomerulosclerosis(11.6%).Conclusions The epidemiology of glomerular disease in our single-center cohort is similar to that shown in other national and international ***,our study shows that percutaneous ultrasound-guided RB is a safe,reliable and effec-tive technique in children.

关键词： Epidemiology Glomerular diseases Nephropathy Pediatric patients Renal biopsy

The Basilica of Santa maria di Collemaggio in L＇Aquila： Modern Provisional Measures

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Journal of Civil Engineering and Architecture 2014年第1期8卷 56-65页

作者： sabatino Cecchini Francesca Curotti Department of Architectural Technologies and Design (TAED) University of Architecture Florence 50125 Italy

The case in analysis is Santa maria di Collemaggio, the church symbol of the town of L＇Aquila and the most important example of Romanesque style in Abruzzi, tragically damaged by the earthquake in 2009. The following paper starts with an accurate analysis of the Basilica, whose historical, stylistical cultural characteristics make it an unicum in the whole urban environment. The authors tried to identify in which way these values have been compromised or altered after the earthquake through several analysis （surveys, historical researches etc.） aiming at the recognition of collapses, the cracks profile, the structural transformations caused by the provisional measures： the goal is to provide a kind of Basilica ＂cognitive manual＂ that will be useful for the future interventions. This first analysis allowed to understand many aspects： on the one hand, the constructive phases and which damages were caused by past careless interventions of restoration, drawing attention to the vulnerability elements of the Basilica; on the other hand, the innovative technologies and materials of the post-seismic provisional measures and their exact location.

关键词： Earthquake L'Aquila 2009 Santa maria di Collemaggio damages provisional measures abacus of measures.

Is hyperhomocysteinemia relevant in patients with celiac disease?

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World Journal of Gastroenterology 2011年第24期17卷 2941-2944页

作者： Giovanni Casella Gabrio Bassotti Vincenzo Villanacci Camillo Di Bella Fabio Pagni Gian Luigi Corti Giuseppe sabatino Mara Piatti Vittorio Baldini Division of Internal Medicine Desio General Hospital Gastroenterology and Hepatology Section Department of Clinical and Experimental MedicineOspedale Santa Maria della Misericordia 2nd Pathology Section Spedali Civili Pathology Unit Desio General Hospital Endoscopy Unit Division of SurgeryDesio General Hospital Laboratory Medicine Unit Desio General Hospital

AIM： TO investigate whether this might be related to the presence of hyperhomocysteinemia. METHODS： From January 1998 to December 2008, we evaluated the presence of hyperhomocysteinemia in a series of 165 adult celiac disease （CD） patients （138 females and 27 males, mean age 43 years）.RESULTS： Hyperhomocysteinemia was evident in 32 patients （19.3%）, although most of them had moderate levels （mean value 25 mcg/ml; range 15-30）. Only one patient had a history of myocardial infarction （heterozygosis for N5-N10-metil tetrahydrofolate reductase mutation）. CONCLUSION： The systematic assessment of hyperhomocysteinemia seems, at present, unjustified in CD patients.

关键词： Celiac disease Endoscopy Histology Hyperhomocysteinemia