Indications and results of renal biopsy in children:a 36-year experience

作     者：Luisa Santangelo Giuseppe Stefano Netti Paolo Giordano Vincenza Carbone Marida Martino Diletta Domenica Torres Michele Rossini Anna Maria Di Palma Loreto Gesualdo Mario Giordano Luisa Santangelo;Giuseppe Stefano Netti;Paolo Giordano;-Vincenza Carbone;Marida Martino;Diletta Domenica Torres;Michele Rossini;Anna Maria Di Palma;Loreto Gesualdo;Mario Giordano

作者机构：Unit of Pediatric Nephrology and DialysisPediatric Hospital"GiovanniⅩⅩⅢ"BariItaly Clinical PathologyDepartment of Medical and Surgical SciencesUniversity of FoggiaFoggiaItaly Unit of NephrologyDialysis and TransplantationDepartment of Emergency and OrganTransplantationUniversity"Aldo Moro"BariItaly 

出 版 物：《World Journal of Pediatrics》 (世界儿科杂志（英文版）)

年 卷 期：2018年第14卷第2期

页      面：127-133页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

主　　题：Epidemiology Glomerular diseases Nephropathy Pediatric patients Renal biopsy 

摘      要：Background This study was conducted to investigate retrospectively the indications for renal biopsy(RB)in native kidneys and to analyze pathological findings in a single tertiary pediatric hospital in Southern Italy for the last 36 *** All patients who underwent RB at our hospital from 1979 to 2014 were *** renal tissue specimens were studied under light and immunofluorescent microscopy,while electron microscopy was performed only for specific clinical *** The study group included 213 patients(female 43.2%)who underwent 225 percutaneous native kidney *** age was 10.4 years(range 0.6-24 years).The most frequent indication for RB was nephrotic syndrome(44.4%),fol-lowed by proteinuria(27.6%),asymptomatic hematuria(17.3%)and acute kidney injury(9.8%).Gross hematuria appeared after biopsy in less than 5%of the patients,but none of them needed blood *** renal tissue sample was obtained in 95.5%of the renal *** glomerulonephritis(GN)was the most common finding(61.4%),followed by secondary GN(21.4%),tubulointerstitial diseases(3.7%)and hereditary nephropathy(2.8%),while in 10.7%of the cases,normal renal tissues were *** to histopathological diagnosis,the most common causes of primary GN were IgA nephropathy(20.9%),followed by minimal change disease(18.1%)and focal segmental glomerulosclerosis(11.6%).Conclusions The epidemiology of glomerular disease in our single-center cohort is similar to that shown in other national and international ***,our study shows that percutaneous ultrasound-guided RB is a safe,reliable and effec-tive technique in children.