Carboxylated-xyloglucan and peptide amphiphile co-assembly in wound healing

作     者：Alessia Ajovalasit Carlos Redondo-Go´mez Maria Antonietta Sabatino Babatunde OOkesola Kristin Braun Alvaro Mata Clelia Dispenza 

作者机构：Dipartimento di Ingegneria(DI)Universitadegli Studi di PalermoViale delle ScienzeEdificio 6Palermo 90128Italy School of Engineering&Materials ScienceQueen Mary University of LondonLondon E14NSUK Institute of BioengineeringQueen Mary University of LondonLondon E14NSUK Blizard InstituteBarts and The London School of Medicine and DentistryThe Blizard Building4 Newark StreetLondon E12ATUK School of PharmacyUniversity of NottinghamNottingham NG72RDUK Department of Chemical and Environmental EngineeringUniversity of NottinghamNottingham NG72RDUK Biodiscovery InstituteUniversity of NottinghamNottinghamNG72RDUK Istituto di Biofisica(IBF)Consiglio Nazionale Delle Ricerche(CNR)Via U.La Malfa 153Palermo 90146Italy 

出 版 物：《Regenerative Biomaterials》 (再生生物材料（英文版）)

年 卷 期：2021年第8卷第5期

页      面：75-86页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 10[医学] 

基　　金：support of the ERC Starting Grant(STROFUNSCAFF) the UK Regenerative Medicine Platform(UKRMP2)Acellular/Smart Materials.C.D.acknowledges the support of University of Palermo FFR 2018/2021 

主　　题：self-assembly peptide nanofiber hydrogel wound healing skin tissue engineering 

摘      要：Hydrogel wound dressings can play critical roles in wound healing protecting the wound from trauma or contamination and providing an ideal environment to support the growth of endogenous cells and promote wound *** work presents a self-assembling hydrogel dressing that can assist the wound repair process mimicking the hierarchical structure of skin extracellular *** this aim,the co-assembly behaviour of a carboxylated variant of xyloglucan(CXG)with a peptide amphiphile(PA-H3)has been investigated to generate hierarchical constructs with tuneable molecular composition,structure,and *** electron microscopy and circular dichroism at a low concentration shows that CXG and PA-H3 co-assemble into nanofibres by hydrophobic and electrostatic interactions and further aggregate into nanofibre bundles and *** a higher concentration,CXG and PA-H3 yield hydrogels that have been characterized for their morphology by scanning electron microscopy and for the mechanical properties by smallamplitude oscillatory shear rheological measurements and compression tests at different CXG/PAH3 ratios.A preliminary biological evaluation has been carried out both in vitro with HaCat cells and in vivo in a mouse model.