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Atypical presentation of pioderma gangrenosum complicating ulcerative colitis: Rapid disappearance with methylprednisolone

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World Journal of Gastroenterology 2008年第35期14卷 5471-5473页

作者： Paolo Aseni Stefano Di Sandro Plamen Mihaylov Luca Lamperti Luciano gregorio de Carlis Liver Transplantation Center Niguarda Ca' Granda HospitalMilan 20162Italy

Piodermal gangrenosum (PG) is an uncommon ulcerative cutaneous dermatosis associated with a variety of systemic diseases, including inflammatory bowel disease (IBD), arthritis, leukaemia, hepatitis, and primary billiary cirrhosis. Other cutaneous ulceration resembling PG had been described in literature. There has been neither laboratory finding nor histological feature diagnostic of PG, and diagnosis of PG is mainly made based on the exclusion criteria. We present here a patient, with ulcerative colitis (UC) who was referred to the emergency section with a large and rapidly evolving cutaneous ulceration. Laboratory and microbiological investigation associated with histological findings of the ulcer specimen allowed us to exclude autoimmune and systemic diseases as well as immuno-proliferative disorders. An atypical presentation of PG with UC was diagnosed. Pulse boluses of i.v. methyl-prednisolone were started, and after tapering steroids, complete resolution of the skin lesion was achieved in 3 wk. The unusual rapid healing of the skin ulceration with steroid mono-therapy and the atypical cutaneous presentation in this patient as well as the risk of misdiagnosis of PG in the clinical practice were discussed.

关键词： Ulcerative colitis Pioderma gangrenosum Steroids Cutaneous lesion Immunosuppression

Changes in nutritional status after liver transplantation

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World Journal of Gastroenterology 2014年第31期20卷 10682-10690页

作者： Michela Giusto Barbara Lattanzi Vincenza Di gregorio Valerio Giannelli Cristina Lucidi Manuela Merli Ⅱ Gastroenterologia Dipartimento di Medicina Clinica "Sapienza" Università di Roma00185 Roma Italy

Chronic liver disease has an important effect on nutritional status, and malnourishment is almost universally present in patients with end-stage liver disease who undergo liver transplantation. During recent decades,a trend has been reported that shows an increase in number of patients with end-stage liver disease and obesity in developed countries. The importance of carefully assessing the nutritional status during the workup of patients who are candidates for liver replacement is widely recognised. Cirrhotic patients with depleted lean body mass(sarcopenia) and fat deposits have an increased surgical risk; malnutrition may further impact morbidity, mortality and costs in the post-transplantation setting. After transplantation and liver function is restored, many metabolic alterations are corrected,dietary intake is progressively normalised, and lifestyle changes may improve physical activity. Few studies have examined the modifications in body composition that occur in liver recipients. During the first 12 mo, the fat mass progressively increases in those patients who had previously depleted body mass, and the muscle mass recovery is subtle and non-significant by the end of the first year. In some patients, unregulated weight gain may lead to obesity and may promote metabolicdisorders in the long term. Careful monitoring of nutritional changes will help identify the patients who are at risk for malnutrition or over-weight after liver transplantation. Physical and nutritional interventions must be investigated to evaluate their potential beneficial effect on body composition and muscle function after liver transplantation.

关键词： Liver transplantation Sarcopenia Malnutrition Obesity Metabolic syndrome Outcome Survival

Comparative Analysis of Composition and Biodiversity of Saltlicks Forest and Control Forests, TICOYA Resguardo, Tikuna Indigenous Community, San Martin de Amayacu Sector (Colombia Amazonian Trapeze)

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Open Journal of Forestry 2019年第4期9卷 355-380页

作者： Ana maria Monsalve-Cuartas Francisco Castro Rego Mamerto Antonio gregorio Vásquez Higher Institute of Agronomy (ISA) University of Lisbon Lisbon Portugal Scientific Coordinator Applied Ecology Center Higher Institute of Agronomy University of Lisbon Lisbon Portugal department of Forest Management and Wildlife Idaho University (USA) Lisbon Portugal Curaca San Martin de Amacayacu Community Puerto Narino Colombia

Tikuna indigenous believe that the saltlicks are natural sacred spaces in the Amazon Rainforest. Those are health and nutrition spaces of important species of fauna, especially mammals and birds. The perception, knowledge, usage and spiritual management of saltlicks for Tikuna help the conservation of more than 130 species of flora identified in forest inventories. Saltlicks forests have few studies in the Colombian Amazon region. The objective of this study was to identify and compare the composition and structure in a sample of 6 saltlicks, and control forests, present in the perimeter of each one of them, to know if they have similarities or differences. The genres (or species as far as possible) and frequent botanical families were identified. The information was obtained through fieldwork with inventories carried out in the saltlicks and control forests in the years 2015, 2016 and 2017, with the help of local guides and knowledgeable people about flora of Tikuna community (gregorio family, Cascabel clan), San Martin de Amacayacu village, TICOYA resguardos. In the saltlicks sample, 336 trees in 29 families were identified. The families with more number of trees are Arecaceae, Myristicaceae and Fabaceae. In control forests 345 trees in 27 families were identified;the families with more number of trees are Arecaceae, Myristicaceae, and Sapotaceae. Control forests present a little higher value of richness and diversity that saltlick forests, but they are not statistically significant. The family Arecaceae is the one that predominates in the 6 saltlicks and control forests inventories without being dominant. Control forests have higher values of richness and diversity, but they are not statistically significant. In both samples of inventoried forests, they have little dominance of species. Their species have equity in the saltlicks and control forests.

关键词： Saltlicks Forests Amazon Tikuna Indigenous

Effect of Solution Concentration on the Electrospray/Electrospinning Transition and on the Crystalline Phase of PVDF

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Materials Sciences and Applications 2010年第4期1卷 247-252页

作者： Lígia maria Manzine Costa Rosário Elida Suman Bretas Rinaldo gregorio 不详

A study was conducted regarding the effect of concentration of poly (vinylidene fluoride) (PVDF)/N,N-dimethylformamide (DMF) and PVDF/DMF/acetone solutions on the transition between electrospray and electrospinning and on the formation of the ? and ? crystalline phases of PVDF. The crystalline phases present in the samples, crystallinity and morphology were determined by Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) and scanning electron microscopy (SEM), respectively. Low concentration solutions resulted in films consisting of small droplets (electrospray) containing predominantly the ? phase. High concentration solutions resulted in a non-woven mesh of nano-to-micron diameter fibers (electrospinning) containing exclusively the ? phase. These results showed that, the formation of this phase in the electrospinning is related mainly to the solvent evaporation rate, and not to drawing experienced by the polymer during the process. Solvent type affected the amount of crystalline phase present, the boundary concentration between the two processes and the average diameter of fibers. Meshes processed by electrospinning display a degree of crystallinity higher than the films obtained by electrospray.

关键词： Poly(Vinylidene Fluoride) (PVDF) Electrospinning Electrospray Crystalline Phase Fibers Morphology

Focus on limbal stem cell deficiency and limbal cell transplantation

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World Journal of Transplantation 2023年第6期13卷 321-330页

作者： Emanuele Tonti gregorio Antonio Manco Leopoldo Spadea Marco Zeppieri Eye Clinic Policlinico Umberto I"Sapienza"University of RomeRome 00142Italy department of Ophthalmology University Hospital of UdineUdine 33100Italy

Limbal stem cell deficiency(LSCD)causes severe vision impairment and can lead to blindness,representing one of the most challenging ocular surface *** cell deficiency can be congenital or,more often,*** categorization of ocular surface transplantation techniques is crucial to achieving treatment homogeneity and quality of care,according to the anatomic source of the tissue being transplanted,genetic source,autologous or allogenic transplantation(to reflect histocompatibility in the latter group),and cell culture and tissue engineering *** aim of this minireview is to provide a summary of the management of LSCD,from clinical characteristics and therapeutic outcomes to the development of novel therapeutic *** manuscript also briefly summarizes recent findings in the current literature and outlines the future challenges to overcome in the management of the major types of ocular surface failure.

关键词： Limbal stem cell deficiency Conjunctival limbal autograft Conjunctival limbal allograft Keratolimbal allograft Cultivated limbal epithelial transplantation Simple limbal epithelial transplantation

Relationship between vegetation structure and microenvironment in Fagus grandifolia *** forest relicts in Mexico

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Journal of Plant Ecology 2018年第2期11卷 237-247页

作者： Ernesto ChRodríguez-Ramírez Arturo Sánchez-González gregorioÁngeles-Pérez Laboratorio de Biogeografía y Sistemática Facultad de CienciasUniversidad Nacional Autónoma de MéxicoCiudad de MéxicoMéxico Laboratorio de Ecología de Poblaciones Centro de Investigaciones BiológicasUniversidad Autónoma del Estado de HidalgoCiudad UniversitariaCarretera Pachuca-Tulancingo Km.4.5Mineral de la Reforma 42184Hidalgo Postgrado en Ciencias Forestales Colegio de PostgraduadosMontecillo 56230TexcocoEstado de MéxicoMéxico

Aims Changes in the structure and composition of forests,whether caused by natural or anthropic events,alter the microenviron-ment,sometimes *** the local environment has a direct impact on basic ecological processes,this has become a key component of *** beech forests(Fagus grandi-folia ***)in the Sierra Madre Oriental are restricted to sites with specific climate,soils and topography,making them an ideal natural system for ecological *** objectives of this study were to identify the relationship between the microen-vironment and the tree and shrub structure and composition of Mexican beech forests in the state of Hidalgo,and to compare the floristic similarity of these forests on the country scale using data from seven *** Specimens were collected for a period of one year at all locali-ties in the state of Hidalgo where beech forests are *** each locality,five 400 m2 plots were established,and structural attributes(basal area,coverage,density and species richness)and six environmental variables were measured in the *** relationship between structure and microenvironment was estimated by simple correlation and canonic correspondence analysis(CCA).in addition,floristic similarity between different beech forest localities in the Sierra Madre Oriental was esti-mated by correspondence analysis(CA).Important Findings Twenty tree species and eight shrub species were identified;at all localities studied *** *** dominated the *** multivariate analysis indicated that(i)in the four localities in the state of Hidalgo,all microenvironmental variables except pH are related to the variation observed in species composition and structure;(ii)the El Gosco locality had both tree and shrub species and microenvironmental factors different from those observed in the Fagus forests at the other localities in the study and(iii)the localities studied in order to draw country-scale compa

关键词： Canonical correspondence analysis fagus forest floristic composition Mexico montane cloud forest richness

detailing the ultrastructure’s increase of prion protein in pancreatic adenocarcinoma

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World Journal of Gastroenterology 2021年第42期27卷 7324-7339页

作者： Matteo Bianchini maria Anita Giambelluca maria Concetta Scavuzzo gregorio Di Franco Simone Guadagni Matteo Palmeri NiccolòFurbetta desirée Gianardi Niccola Funel Claudio Ricci Raffaele Gaeta Luca Emanuele Pollina Alfredo Falcone Caterina Vivaldi Giulio Di Candio Francesca Biagioni Carla Letizia Busceti Luca Morelli Francesco Fornai General Surgery Unit Department of Translational Research and New Technologies in Medicine and SurgeryUniversity of PisaPisa 56124Italy Human Anatomy Department of Translational Research and New Technologies in Medicine and SurgeryUniversity of PisaPisa 56124Italy Division of Surgical Pathology Department of SurgicalMedicalMolecular Pathology and Critical AreaUniversity of PisaPisa 56124Italy Division of Medical Oncology Department of Translational Research and New Technologies in Medicine and SurgeryUniversity of PisaPisa 56124Italy IRCCS Neuromed Istituto Neurologico MediterraneoPozzilli 86077Italy EndoCAS(Center for Computer Assisted Surgery) University of PisaPisa 56124Italy

BACKGROUND Recent evidences have shown a relationship between prion protein(PrPc)expression and pancreatic ductal adenocarcinoma(PDAC).Indeed,PrPc could be one of the markers explaining the aggressiveness of this ***,studies investigating the specific compartmentalization of increased PrPc expression within PDAC cells are lacking,as well as a correlation between ultrastructural evidence,ultrastructural morphometry of PrPc protein and clinical *** data,as well as the quantitative stoichiometry of this protein detected by immuno-gold,provide a significant advancement in understanding the biology of disease and the outcome of surgical *** To analyze quantitative stoichiometry and compartmentalization of PrPc in PDAC cells and to correlate its presence with prognostic data METHODS Between June 2018 and december 2020,samples from pancreatic tissues of 45 patients treated with pancreatic resection for a preoperative suspicion of PDAC at our Institution were *** the frozen section excluded a PDAC diagnosis,or the nodules were too small for adequate sampling,patients were ruled out from the present *** blotting was used to detect,quantify and compare the expression of PrPc in PDAC and control tissues,such as those of non-affected neighboring pancreatic tissue of the same *** quantify the increase of PrPc and to detect the subcellular compartmentalization of PrPc within PDAC cells,immuno-gold stoichiometry within specific cell compartments was analyzed with electron ***,an analysis of quantitative PrPc expression according to prognostic data,such as cancer stage,recurrence of the disease at 12 mo after surgery and recurrence during adjuvant chemotherapy was *** The amount of PrPc within specimen from 38 out of 45 patients was determined by semi-quantitative analysis by using Western blotting,which indicates that PrPc increases almost three-fold in tumor pancreatic tissue compared with healthy panc

关键词： Pancreatic ductal adenocarcinoma Prion protein Western blotting Electron microscopy Cellular compartmentalization Neuroinvasion

Microbiota and the gut-liver axis:Bacterial translocation,inflammation and infection in cirrhosis

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World Journal of Gastroenterology 2014年第45期20卷 16795-16810页

作者： Valerio Giannelli Vincenza Di gregorio Valerio Iebba Michela Giusto Serena Schippa Manuela Merli Ulrich Thalheimer Gastroenterology department of Clinical Medicine Sapienza University of Rome department of Public Health and Infectious Diseases Sapienza University of Rome The Exeter Liver Unit Royal Devon and Exeter Foundation Trust

Liver disease is associated with qualitative and quantitative changes in the intestinal microbiota. In cirrhotic patients the alteration in gut microbiota is characterized by an overgrowth of potentially pathogenic bacteria (i.e., gram negative species) and a decrease in autochthonous familiae. Here we summarize the available literature on the risk of gut dysbiosis in liver cirrhosis and its clinical consequences. We therefore described the features of the complex interaction between gut microbiota and cirrhotic host, the so called “gut-liver axis”, with a particular attention to the acquired risk of bacterial translocation, systemic inflammation and the relationship with systemic infections in the cirrhotic patient. Such knowledge might help to develop novel and innovative strategies for the prevention and therapy of gut dysbiosis and its complication in liver cirrhosis.

关键词： Dysbiosis Cirrhosis Bacterial translocation Inflammation Infection Bacterial overgrowth Rifaximine Lactulose Liver Gut Portal hypertension

Hydration status,body composition,and anxiety status in aeronautical military personnel from Spain:a crosss-ectional study

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Military Medical Research 2022年第2期9卷 184-192页

作者： Alejandra Carretero-Krug Nataliaúbeda Carlos Velasco Juan Medina-Font Trinidad Trujillo Laguna gregorio Varela-Moreiras Ana Montero departamento Ciencias Farmacéuticas y de la Salud Facultad de FarmaciaUniversidad San Pablo-CEUCEU UniversitiesUrbanización Montepríncipe28660 Boadilla del MonteSpain Centro de Instrucción de Medicina Aeroespacial Ejército del Aire28850 Torrejón de ArdozMadridSpain

Background: An adequate hydration status is critical to ensure efficiency during mental and physical *** goal was to assess the hydration status of a Spanish group of aeronautical military men and to determine the association of hydration status with body composition and ***: A total of 188 men were evaluated through a validated hydration questionnaire, anthropometric and biochemical parameters, and an anxiety questionnaire. Based on these methods, the criteria of hydration were ***: Of the total sample, 81% met the hydration criteria(urine color = well hydrated, water balance ≥0 ml, and total water intake/weight ≥35 ml/kg), and 19% did not meet the hydration criteria(urine color = not sufficiently hydrated or dehydrated, water balance dex [(26.3±3.1) kg/m;vs.(25.2±2.8) kg/m;], body fat [(22.3±5.6)% vs.(18.3±6.5)%], urine specific gravity, and urine color. Using a logistic binary regression model, hydration status was related significantly with the percentage of body fat(P=0.004), but no relation was found with age, comorbidities, or medications. Furthermore, total water intake/weight was positively correlated with percentage of body water(r=0.357, P=0.000) and negatively with body fat(kg)(r=–0.427, P=0.000), percentage of body fat(r=–0.405, P=0.000), and waist/hip ratio(r=–0.223, P=0.002). Based on a linear regression model, total water intake/weight was related significantly with percentage of body fat(P=0.001) and percentage of body water content(P=0.035). No relation was found, however, with waist/hip ratio, age, comorbidities, or ***: These findings all suggest a relationship between hydration status and body composition but

关键词： Hydration status Military aeronautical personnel Body composition Anxiety status Water intake