Focus on limbal stem cell deficiency and limbal cell transplantation
作者机构：Eye ClinicPoliclinico Umberto I"Sapienza"University of RomeRome 00142Italy Department of OphthalmologyUniversity Hospital of UdineUdine 33100Italy
出 版 物：《World Journal of Transplantation》 (世界移植杂志)
年 卷 期：2023年第13卷第6期
页 面：321-330页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Limbal stem cell deficiency Conjunctival limbal autograft Conjunctival limbal allograft Keratolimbal allograft Cultivated limbal epithelial transplantation Simple limbal epithelial transplantation
摘 要：Limbal stem cell deficiency(LSCD)causes severe vision impairment and can lead to blindness,representing one of the most challenging ocular surface *** cell deficiency can be congenital or,more often,*** categorization of ocular surface transplantation techniques is crucial to achieving treatment homogeneity and quality of care,according to the anatomic source of the tissue being transplanted,genetic source,autologous or allogenic transplantation(to reflect histocompatibility in the latter group),and cell culture and tissue engineering *** aim of this minireview is to provide a summary of the management of LSCD,from clinical characteristics and therapeutic outcomes to the development of novel therapeutic *** manuscript also briefly summarizes recent findings in the current literature and outlines the future challenges to overcome in the management of the major types of ocular surface failure.
维普期刊数据库