Microbiota and the gut-liver axis:Bacterial translocation,inflammation and infection in cirrhosis

作     者：Valerio Giannelli Vincenza Di Gregorio Valerio Iebba Michela Giusto Serena Schippa Manuela Merli Ulrich Thalheimer 

作者机构：Gastroenterology Department of Clinical Medicine Sapienza University of Rome Department of Public Health and Infectious Diseases Sapienza University of Rome The Exeter Liver Unit Royal Devon and Exeter Foundation Trust 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2014年第20卷第45期

页      面：16795-16810页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Dysbiosis Cirrhosis Bacterial translocation Inflammation Infection Bacterial overgrowth Rifaximine Lactulose Liver Gut Portal hypertension 

摘      要：Liver disease is associated with qualitative and quantitative changes in the intestinal microbiota. In cirrhotic patients the alteration in gut microbiota is characterized by an overgrowth of potentially pathogenic bacteria (i.e., gram negative species) and a decrease in autochthonous familiae. Here we summarize the available literature on the risk of gut dysbiosis in liver cirrhosis and its clinical consequences. We therefore described the features of the complex interaction between gut microbiota and cirrhotic host, the so called “gut-liver axis, with a particular attention to the acquired risk of bacterial translocation, systemic inflammation and the relationship with systemic infections in the cirrhotic patient. Such knowledge might help to develop novel and innovative strategies for the prevention and therapy of gut dysbiosis and its complication in liver cirrhosis.