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Genes & Diseases 2024年第2期11卷 1084-1084页

作者： Giovanna Forte Filomena Cariola antonia Lucia Buonadonna Anna Filomena Guglielmi Andrea Manghisi Katia De Marco Valentina Grossi Candida Fasano Martina Lepore Signorile Paola Sanese Rosanna Bagnulo Nicoletta Resta Vittoria Disciglio Cristiano Simone Medical Genetics National Institute of Gastroenterology “S. de Bellis” Research Hospital Castellana Grotte Bari 70013 Italy Medical Genetics Department of Precision and Regenerative Medicine and Jonic Area (DiMePRe-J) University of Bari Aldo Moro Bari 70124 Italy

Real drive cycles analysis by ordered power methodology applied to fuel consumption,C0_(2),NO_(x) and PM emissions estimation

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Frontiers of Environmental Science & Engineering 2021年第1期15卷 77-90页

作者： Pol Masclans Abello Vicente Medina Iglesias M.antonia de los Santos Lopez Jesus Alvarez-Florez Center for Engines and Heat Installation Research(CREMIT-UPC).Universitat Politecnica de Catalunya-BarcelonaTech.Av.Diagonal 547(ETSEIB)08028 Barcelona Spain Department of Thermal Machinery of Universitat Politecnica de Catalunya-BarcelonaTech and CREMIT-UPC.-BarcelonaTech.Av.Diagonal 547(ETSEIB)08028 Barcelona Spain 3 Department of Mechanical Engineering of Universitat Politecnica de Catalunya-BarcelonaTech and CREMIT-UPC.-BarcelonaTech.Av.Diagonal 547(ETSEIB)08028 Barcelona Spain

In this work three fuel consumption and exhaust emission models,ADVISOR,VT-MICRO and the European Environmental Agency Emission factors,have been used to obtain fuel consumption(FC)and exhaust *** models have been used at micro-scale,using the two signal treatment methods *** manuscript presents:1)a methodology to collect data in real urban driving cycles,2)an estimation of FC and tailpipe emissions using some available models in literature,and 3)a novel analysis of the results based on delivered wheel *** results include Fuel Consumption(FC),CO_(2),NO_(x) and PM_(10) emissions,which are derived from the three *** the first part of the paper we present a new procedure for incomplete drive cycle data treatment,which is necessary for real drive cycle acquisition in high density *** the models are used to obtain second by second FC and exhaust ***,a new methodology named Cycle Analysis by Ordered Power(CAbOP)is presented and used to compare the *** method consists in the re-ordering of time dependant data,considering the wheel mechanical power domain instead of the standard time *** new strategy allows the 5 situations in drive cycles to be clearly visualized:hard breaking zone,slowdowns,idle or stop zone,sustained speed zone and acceleration *** complete methodology is applied in two real drive cycles surveyed in Barcelona(Spain)and the results are compared with a standardized WLTC urban cycle.

关键词： Cycle Analysis by Ordered Power(CAbOP) Micro and macro models Real drive cycle NO_(x)/PM_(10)/CO_(2)emissions Wheel mechanical power domain Worldwide Harmonized Light-Duty Vehicles Test Cycle(WLTC)

Composition and Thermal Behavior of Oils from Native Seeds and Fruits of Argentina and Uruguay

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Journal of Food Science and Engineering 2015年第2期5卷 49-57页

作者： maria antonia Grompone Bruno Irigaray Denisse Rodriguez Silvia Maidana Norma Samman Departamento de Ciencia y Tecnologia de los Alimentos Facultad de Quimica Universidad de la Repfiblica Montevideo Gral.Flores 2124 Uruguay Departamento Bioquimica de la Nutricion Instituto Superior de Investigaciones Biologieas (INSIBIO) Universidad Nacional deTueumon Tucumon Chacabueo 461 Argentina

The purpose of this work was to study the thermal characterization of oils extracted from native seeds and fruits of the Argentina, Uruguayan region. This is important because it＇s necessary to find new applications for food industry. Uruguayan wild cardoon seed, Argentinian wild papaya seeds, Argentinian avocado pulp, Argentinian cherimoya seeds, Argentinian grapeseeds and four commercial brands of chia oils were studied. The thermal behaviors of the oils were analyzed on a differential scanning calorimetry （DSC）, TA Instrument, Q20 model equipped with an intercooler. These oils＇ thermal profiles presented differences, which are related to the compositions of fatty acids and triacylglycerols. The thermogram for the chia oil, with a high content of linolenic acid, presented a very important peak at about -40 ℃; whereas, the papaya oil with an oleic acid content of 74%, showed a peak at about -3 ℃. When comparing the thermal behaviors of these oils to commercial brand oils, it was found that the chia oil is similar to the flaxseed oil, the papaya similar to the olive oil and the avocado similar to the rice bran oil. The avocado oil, in particular, presents high solid content at cold store or winter temperatures, which would make its use in those conditions difficult （for example, a cosmetic cream or gourmet oil）. In conclusion, the thermal behavior of one oil sample as determined by DSC provides valuable information with regards to the possible use of new oils of American origin as replacement of usual commercial others.

关键词： South American oils thermal behavior DSC.

Revisiting the role of pathological analysis in transarterial chemoembolization-treated hepatocellular carcinoma after transplantation

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World Journal of Gastroenterology 2014年第37期20卷 13538-13545页

作者： Francesco Vasuri Deborah Malvi Francesca Rosini Pamela Baldin Michelangelo Fiorentino Alexandro Paccapelo Giorgio Ercolani Antonio Daniele Pinna Rita Golfieri Antonio maria Morselli-Labate Walter Franco Grigioni antonia D’Errico-Grigioni "F. Addarii" Institute of Oncology and Transplantation Pathology S.Orsola-Malpighi HospitalBologna University Department of Medical and Surgical Sciences Bologna University Department of Surgery and Transplantation S.Orsola-Malpighi HospitalBologna University Radiology Unit S.Orsola-Malpighi HospitalBologna University

AIM: To define the histopathological features predictive of post-transplant hepatocellular carcinoma (HCC) recurrence after transarterial chemoembolization, applicable for recipient risk stratification.

关键词： Chemoembolization Hepatocellular carcinoma Histopathology Orthotopic liver transplantation Cancer recurrence Transarterial chemoembolization

De novo autoimmune hepatitis in liver transplant: State-of-the-art review

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World Journal of Gastroenterology 2016年第10期22卷 2906-2914页

作者： Ranka Vukotic Giovanni Vitale antonia D'Errico-Grigioni Luigi Muratori Pietro Andreone Dipartimento di Scienze Mediche e Chirurgiche Università di BolognaPoliclinico Sant’Orsola-Malpighi Dipartimento di Medicina Specialistica Diagnostica e SperimentaleUniversità di Bologna"F.Addarii" Institute of Oncology and Transplantation PathologyPoliclinico Sant’Orsola-Malpighi

In the two past decades, a number of communications, case-control studies, and retrospective reports have appeared in the literature with concerns about the development of a complex set of clinical, laboratory and histological characteristics of a liver graft dysfunction that is compatible with autoimmune hepatitis. The de novo prefix was added to distinguish this entity from a pre-transplant primary autoimmune hepatitis, but the globally accepted criteria for the diagnosis of autoimmune hepatitis have been adopted in the diagnostic algorithm. Indeed, de novo autoimmune hepatitis is characterized by the typical liver necroinflammation that is rich in plasma cells, the presence of interface hepatitis and the consequent laboratory findings of elevations in liver enzymes, increases in serum gamma globulin and the appearance of nonorgan specific auto-antibodies. Still, the overall features of de novo autoimmune hepatitis appear not to be attributable to a univocal patho-physiological pathway because they can develop in the patients who have undergone liver transplantation due to different etiologies. Specifically, in subjects with hepatitis C virus recurrence, an interferon-containing antiviral treatment has been indicated as a potential inception of immune system derangement. Herein, we attempt to review the currently available knowledge about de novo liver autoimmunity and its clinical management.

关键词： De novo autoimmune hepatitis Plasma-cell hepatitis Liver transplant Hepatitis C virus recurrence Antiviral therapy Autoimmunity Differential diagnosis

Identify multiple myeloma stem cells: Utopia?

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World Journal of Stem Cells 2015年第1期7卷 84-95页

作者： Ilaria Saltarella Aurelia Lamanuzzi antonia Reale Angelo Vacca Roberto Ria Department of Biomedical Sciences and Human Oncology Section of Internal Medicine "G. Baccelli" University of Bari "Aldo Moro" Medical School Policlinico I-70124 Bari Italy

Multiple myeloma(MM) is a hematologic malignancy of monoclonal plasma cells which remains incurable despite recent advances in therapies. The presence of cancer stem cells(CSCs) has been demonstrated in many solid and hematologic tumors, so the idea of CSCs has been proposed for MM, even if MM CSCs have not been define yet. The existence of myeloma CSCs with clonotypic B and clonotypic non B cells was postulated by many groups. This review aims to focus on these distinct clonotypic subpopulations and on their ability to develop and sustain MM. The bone marrow microenvironment provides to MM CSCs self-renewal, survival and drug resistance thanks to the presence of normal and cancer stem cell niches. The niches and CSCs interact each other through adhesion molecules and the interplay between ligands and receptors activate stemness signaling(Hedgehog, Wnt and Notch pathways). MM CSCs are also supposed to be responsible for drug resistance that happens in three steps from the initial cancer cell homing microenvironment-mediated to development of microenvironment-independent drug resistance. In this review, we will underline all these aspects of MM CSCs.

关键词： Bone marrow microenvironment Cancerstem cells Multiple myeloma Stem cells niche Stemness

Localized amyloidosis of the stomach:A case report

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World Journal of Gastroenterology 2007年第12期13卷 1877-1878页

作者： Gianluca Rotondano Raffaele Salerno Fabio Cipolletta maria antonia Bianco Antonino De Gregorio Raffaele Miele Antonio Prisco maria Lucia Garofano Livio Cipolletta Division of Gastroenterology Hospital Maresca Torre del Greco Italy University of Naples School of Medicine Department of Gastroenterology Naples Italy Division of Pathology Hospital Maresca Torre del Greco Italy

We report an unusual case of primary amyloidosis of the stomach in a patient complaining of dyspeptic symptoms. The diagnosis was confirmed histologically and other gastrointestinal site or systemic involvement was ru... 详细信息

关键词： Amyloidosis Gastrointestinal tract Dyspepsia

Fatty Acids and Triglycerides Composition in Uruguayan Cow, Sheep and Goat Cheeses

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Journal of Food Science and Engineering 2013年第7期3卷 379-387页

作者： Ignacio Vieitez Nicolas Callejas Marcela Saibene Leandro Cabrera Bruno Irigaray maria antonia Laboratorio de Grasas y Aceites Departamento de Cieneia y Tecnologla de Alimentos Facultad de Quimica Universidad de laRepfiblica Montevideo 1157-11800 Uruguay

Adverse health consequences are associated with consumption of so-called trans fatty acids （FAs） generated during chemical hydrogenation processes. Naturally-occurring trans fats, including trans vaccenic acid （TVA） derived from a conjugated isomer of linoleic acid （18：2 cis-9, trans-11）, （CLA） in contrast, are recognized as having potentially beneficial effects on human health. These natural trans FAs are found in fat from dairy products and meat of ruminants, and have distinct effects compared with trans FAs industrially produced. The lipid composition of cheeses depends on the milk used. In this work was determined CLA and TVA content in milk fat of sheep and cow to be 1.4% and 3.2%, respectively, and from goat, 0.7% and 1.8%. Also, differences in CLA and TVA content were found in fat extracted from samples of the same cheese type made from cow＇s milk from the same company but with different production dates during a year. The levels of CLA and TVA found in Uruguayan cheeses were generally higher than levels reported in previous studies with comparable cheeses produced in other countries. Milk fat is well-known to confer specific properties to foods. This in turn will affect the rheology and sensory attributes as food. For this reason, it is of interest to determine the triglyceride （TAG） composition in milk-derived foods. Results show that there are characteristic differences in the TAG composition of the different cheeses. We found minimal differences between cheeses from goat and sheep but found distinct characteristics for TAGs from cow milk-derived cheese.

关键词： Trans fatty acids vaccenic acid conjugated linoleic acid triglycerides cheeses.

New approach for time-resolved and dynamic investigations on nanoparticles agglomeration

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Nano Research 2020年第10期13卷 2847-2856页

作者： Neda Iranpour Anaraki Amin Sadeghpour Kamran Iranshahi Claudio Toncelli Urszula Cendrowska Francesco Stellacci Alex Dommann Peter Wick antonia Neels Center for X-ray Analytics EmpaSwiss Federal Laboratories for Materials Science and Technology St.Gallen 9014Switzerland Laboratory of Particles Biology Interactions EmpaSwiss Federal Laboratories for Materials Science and TechnologySt.Gallen 9014Switzerland Department of Chemistry University of FribourgChemin du MuseeFribourg 1700Switzerland Laboratory for Biomimetic Membranes and Textiles EmpaSwiss Federal Laboratories for Materials Science and TechnologySt.Gallen 9014Switzerland Department of Environmental Systems Science Swiss FPederal Institute of TechnologyETH-ZurichZurich 8092Switzerland Institute of Materials EPFLLausanne 1015Switzerland Cellular and Biomedical Sciences Faculty of MedicineUniversity of BernBern 3012Swizerland

Nanoparticle (NP) colloidal stability plays a crucial role in biomedical application not only for human and environmental safety but also for NP efficiency and functionality. NP agglomeration is considered as a possible process in monodispersed NP colloidal solutions, which drastically affects colloidal stability. This process is triggered by changes in the physicochemical properties of the surrounding media, such as ionic strength (IS), pH value, or presence of biomolecules. Despite different available characterization methods for nanoparticles (NPs), there is a lack of information about the underlying mechanisms at the early stage of dynamic behaviors, namely changing in NP size distribution and structure while placing them from a stable colloidal solution to a new media like biological fluids. In this study, an advanced in situ approach is presented that combines small angle X-ray scattering (SAXS) and microfluidics, allowing label-free, direct, time-resolved, and dynamic observations of the early stage of NP interaction/agglomeration initiated by environmental changes. It is shown for silica NPs that the presence of protein in the media enormously accelerates the NP agglomeration process compared to respective changes in IS and pH. High IS results in a staring agglomeration process after 40 min, though, in case of protein presence in media, this time decreased enormously to 48 s. These time scales show that this method is sensitive and precise in depicting the dynamics of fast and slow NP interactions in colloidal conditions and therefore supports understanding the colloidal stability of NPs in various media concluding in safe and efficient NP designing for various applications.

关键词： microfluidic small-angle X-ray scattering(SAXS) in situ dynamic measurements nanoparticle agglomeration biological environment label-free

Histopathological evaluation of recurrent hepatitis C after liver transplantation:A review

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World Journal of Gastroenterology 2014年第11期20卷 2810-2824页

作者： Francesco Vasuri Deborah Malvi Elisa Gruppioni Walter F Grigioni antonia D'Errico-Grigioni "F. Addarii" Institute of Oncology and Transplantation Pathology S. Orsola-Malpighi HospitalBologna University40138 BolognaItaly

Although the morphological features of hepatitis C virus(HCV)recurrence after orthotopic liver transplantation(OLT)have been well established in the last decades,the differential diagnosis still represents a challenge for the pathologist,especially early recurrent hepatitis C vs mild acute cellular *** present review focuses on the role of the pathologist and the pathology laboratory in the management of recipients with recurrent hepatitis C,the usefulness of early and late post-OLT liver biopsies,and the potential role of ancillary techniques(immunohistochemistry and reverse transcription-polymerase chain reaction,RT-PCR).The English literature on the topic is reviewed,focusing on the histopathology,the immunohistochemistry and the use of RT-PCR on HCV-positive post-OLT *** different histopathological illustrations of early and chronic recurrent hepatitis C are presented,with special focus on the main differential diagnoses and those features with prognostic relevance(cholestasis above all).The usefulness of ancillary techniques are discussed,especially HCV RNA quantitation by ***,the usefulness of long-term protocol biopsies is addressed:their usefulness for the study of allograft disease progression is clear,but their meaning in the long term is still *** significance of plasma cell infiltrate in HCV-positive allografts,the prognostic weight of graft steatosis,and the impact of donor age in recurrent hepatitis C also represent additional open issues.

关键词： Hepatitis C virus Histopathology Immunohistochemistry Orthotopic liver transplantation Recurrent hepatitis C Polymerase chain reaction