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Device-assisted enteroscopy: Are we ready to dismiss the spiral?

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World Journal of Gastroenterology 2024年第26期30卷 3185-3192页

作者： Alessandro Mussetto Elettra Merola Cesare Casadei Daniele Salvi Fabiola Fornaroli Silvia Cocca margherita Trebbi Armando Gabbrielli Cristiano Spada Andrea Michielan Department of Gastroenterology S Maria della Croci HospRavenna 48121Italy Department of Gastroenterology Unit G.B.Grassi Hospital(ASL Roma 3)Roma 00122Italy Section of Digestive Endoscopy and Gastroenterology Fondazione PoliambulanzaBrescia 25124Italy Gastroenterology and Endoscopy Unit Department of Medicine and SurgeryUniversity of ParmaParma 43125Italy Gastroenterology and Endoscopy Unit Azienda Ospedaliero Universitaria Policlinico di ModenaModena 41121Italy Center for Medical Sciences(CISMed) University of TrentoTrento 38122Italy Gastroenterology and Digestive Endoscopy Unit Santa Chiara HospitalAzienda Provinciale per i Servizi SanitariTrento 38122Italy Digestive Endoscopy Unit Fondazione Policlinico Universitario A.Gemelli IRCSSRoma 00168Italy

Motorized spiral enteroscopy(MSE)is the latest advance in device-assisted *** events related to MSE were discussed in a recent large systematic review and meta-analysis and were directly compared with those of balloon enteroscopy in a case-matched study and a randomized controlled *** the real-life application of MSE,an unexpected safety issue emerged regarding esophageal injury and the technique has been withdrawn from the global market,despite encouraging results in terms of diagnostic and therapeutic *** conducted an Italian multicenter real-life prospective study,which was prematurely terminated after the withdrawal of MSE from the *** primary goals were the evaluation of MSE performance(both diagnostic and therapeutic)and its safety in routine endoscopic practice,particularly in the early phase of introduction in the endoscopic unit.A subanalysis,which involved patients who underwent MSE after unsuccessful balloon enteroscopy,demonstrated,for the first time,the promising performance of MSE as a rescue *** its remarkable performance in clinical practice and its potential role as a backup technique following a previously failed enteroscopy,it may be more appropriate to refine and enhance MSE in the future rather than completely abandoning it.

关键词： Motorized spiral enteroscopy Rescue enteroscopy Diagnostic yield Adverse events AGREE classification

脑卒中伴融合型脑白质病变患者的他汀类药物治疗

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脑卒中伴融合型脑白质病变患者的他汀类药物治疗

How physical and motor training affect cognitive performance: lessons from an inflammatory molecule

2013年全国老年性痴呆与相关疾病学术会议

作者：熊云云 Adrian Wong margherita cavalieri Reinhold Schmidt Winnie W.C.Chu Ka Sing Wong 刘新峰 Vincent Mok 南京军区南京总医院神经内科香港中文大学药物与治疗学系香港教育学院心理学研究部心理健康和老龄化中心

目的:脑白质病变(white matter hyperintensity,WMH)和腔隙性脑梗死是两种脑小血管病。他汀类药物可降低各类脑卒中的复发率,其中包括腔隙性脑梗死。本文旨在研究他汀类药物对脑卒中伴融合型WMH的患者是否存在延缓WMH进展和/或认知功能...

目的:脑白质病变(white matter hyperintensity,WMH)和腔隙性脑梗死是两种脑小血管病。他汀类药物可降低各类脑卒中的复发率,其中包括腔隙性脑梗死。本文旨在研究他汀类药物对脑卒中伴融合型WMH的患者是否存在延缓WMH进展和/或认知功能障碍的作用。方法:研究入组了100例基线MRI上存在融合型WMH的患者,其中81例完成了2年随访。使用MMSE和MDRS I/P量表分别评估总体认知功能和执行功能。比较他汀治疗组和非他汀治疗组WMH体积和认知的变化,同时评估他汀类药物对新发脑梗死灶和新发微出血发生率的影响。结果:他汀治疗组(50例)较非他汀治疗组(31例)的WMH体积进展慢(1.54±4.52cm VS 5.01±6.00 cm,P=0.01)。他汀类药物的使用是WMH体积进展的独立预测因子(β=-0.322,P=-0.010),并与MDRS I/P评分呈正相关(β=0.474,P=0.001),而与MMSE变化无相关性,与新发脑梗死灶和新发微出血无相关性。结论:对于脑卒中伴融合型白质病变的患者,他汀类药物可减缓WMH的进展以及执行功能的下降。

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Neural Regeneration Research 2022年第12期17卷 2689-2690页

作者： margherita Maffei Marco Mainardi Institute of Clinical Physiology National Research Council(IFC-CNR)and Obesity/Lipodystrophies CenterPisa University HospitalPisaItaly Neuroscience Institute National Research Council(IN-CNR)PisaItaly

Our phenotype includes not only physical features,but also behavioral outputs such as motor schemes and learned skills,and is the result of a complex interaction between genetic background and *** fact,a good fraction of last decades’biomedical efforts were dedicated to understanding how different elements(e.g.,genetic polymorphisms,lifestyle components)participate in this interplay,ultimately contributing to affect a given phenotype up to the point of steering it towards *** and epigenetic elements are relatively easy to analyze individually using a reductionist approach,for instance via loss-or gain-of-function studies in cellular and animal models;the effects of nutrients,drugs,pollutants can be similarly tested as single specific stimuli.

关键词： instance drugs lesson

Platelet-rich plasma:the role in neural repair

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Neural Regeneration Research 2015年第12期10卷 1920-1921页

作者： margherita Giorgetti Gabriele Siciliano Department of Hand Surgery and Reconstructive Microsurgery University of Pisa Department of Clinical and Experimental Medicine Neurological ClinicUniversity of Pisa

The efficacy of platelet-rich plasma（PRP）to promote tissue regeneration has been largely confirmed in several clinical settings,such as in human maxillo-facial（Froum et al.,2002）,heart（Vu et al.,2015）and orthopa... 详细信息

关键词： Platelet-rich plasma PRP

The impact of Gunnera tinctoria(Molina)Mirbel invasions on soil seed bank communities

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Journal of Plant Ecology 2009年第3期2卷 153-167页

作者： margherita Gioria Bruce Osborne UCD School of Biology and Environmental Science University College DublinBelfieldDublin 4Ireland

Aims In recent years,there has been an increasing interest in the impact of invasive alien plant species on the soil seed *** seed banks play an important role in determining the composition and dynamics of the vegetation through ***,an ability to form a persistent seed bank and/or a capacity to alter the structure of the seed bank of invaded communities could be important factors in determining the success of many alien plant *** this study,we report on a detailed assessment of the characteristics of the seed bank community associated with the herbaceous plant invader,Gunnera tinctoria,a newly emerging and potentially globally significant invasive plant *** species,native to South America,is invasive in a range of wet habitats in Europe,Australasia and the *** A comprehensive assessment of the seed bank of invaded and comparable uninvaded areas was made at two points in time(May and October),at three sites in western *** seedling emergence approach was used to assess the structure(diversity,dominance and abundance)of the soil seed *** between invaded and uninvaded seed bank communities were investigated at the spatial scales of site,plot and *** Findings Gunnera tinctoria formed a large persistent seed bank at the study *** 30000 seedlings per square metre emerged from soils collected from invaded areas,of which 30%were found in deep soil *** of this invader represented 53–86%of the total number of seedlings associated with invaded *** the transient and the more persistent component of the seed bank of invaded communities were significantly less diverse and abundant than those of uninvaded areas,and were characterized by higher dominance,even when seedlings of the invader were not included in the *** seed bank of invaded areas was largely composed of seeds of agricultural weeds in addition to those of the *** results suggest that ***

关键词： invasive species soil seed bank diversity dominance Gunnera tinctoria

Neurotrophic factor-based pharmacological approaches in neurological disorders

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Neural Regeneration Research 2023年第6期18卷 1220-1228页

作者： margherita Alfonsetti Michele d’Angelo Vanessa Castelli Department of Life Health and Environmental SciencesUniversity of L’AquilaL’AquilaItaly

Aging is a physiological event dependent on multiple pathways that are linked to lifespan and processes leading to cognitive *** process represents the major risk factor for aging-related diseases such as Alzheimer’s disease,Parkinson’s disease,and ischemic *** incidence of all these pathologies increases exponentially with *** on aging biology has currently focused on elucidating molecular mechanisms leading to the development of those *** deficit and neurodegeneration,common features of aging-related pathologies,are related to the alteration of the activity and levels of neurotrophic factors,such as brain-derived neurotrophic factor,nerve growth factor,and glial cell-derived neurotrophic *** this reason,treatments that modulate neurotrophin levels have acquired a great deal of interest in preventing neurodegeneration and promoting neural regeneration in several neurological *** treatments include both the direct administration of neurotrophic factors and the induced expression with viral vectors,neurotrophins’binding with biomaterials or other molecules to increase their bioavailability but also cell-based *** neurotrophins’crucial role in aging pathologies,here we discuss the involvement of several neurotrophic factors in the most common brain aging-related diseases and the most recent therapeutic approaches that provide direct and sustained neurotrophic support.

关键词： Alzheimer’s disease brain brain-derived neurotrophic factor glial cell-derived neurotrophic factor nerve growth factor neurotrophins neurturin Parkinson’s disease stroke tropomyosin receptor kinase receptors

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布拉德伯里工作坊综合体

世界建筑导报 2024年第2期39卷 126-128,F0003页

作者： Maegan Icke Elena Gruber Roxani Tseranidou margherita Zompa Carolina Borgatti Ezmira Peraj Ainhoa Valle French+Tye(摄影) 不详

布拉德伯里工作坊综合体建筑位于达尔斯顿吉勒特广场,现已重新向新老租户开放。新大楼涵盖600平方米经济适用工作空间的翻新、10个迷你零售单元的更换,以及在两层扩建部分中打造近500平方米的额外工作区域。布拉德伯里工作坊综合体是该... 详细信息

布拉德伯里工作坊综合体建筑位于达尔斯顿吉勒特广场,现已重新向新老租户开放。新大楼涵盖600平方米经济适用工作空间的翻新、10个迷你零售单元的更换,以及在两层扩建部分中打造近500平方米的额外工作区域。布拉德伯里工作坊综合体是该地区以社区为中心、最独特的公共空间,代表了该建筑类型发展历程的未来。

关键词：工作坊扩建部分公共空间综合体发展历程

Frugality and Luxury： Morality, Market, and Consumption in Late Imperial China

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Frontiers of History in China 2015年第3期10卷 457-485页

作者： margherita Zanasi Department of History Louisiana State University Baton Rouge LA 70803 USA

This article contributes to a wider critique of the use of European capitalist, patterns of industrialization in studies of the economic history of modern China--studies commonly supposed to be universally valid. This sort of analytical framework denies not only the value of alternative economic models, but also that of Chinese independent economic thought. In this context, the present article argues that most of the intellectual changes of seventeenth-century Europe that led to the formulation of liberal capitalism--resistance to government intervention, support for luxury consumption as well as a new understanding of the market and of the relationship between private interests and morality--had taken place in China more than a century earlier. The background against which the two processes emerged, however, varied significantly, leading to distinctive ramifications. Unprecedented population growth and a widening gap between hinterland and coastal economies led Chinese officials and intellectuals to discard ideas of free market and focus instead on solutions for increasing production, maximizing the circulation of resources, and fighting poverty. It was not, therefore, a lack of a ＂scientific＂ understanding of the economy that led China to turn away from European-style laissez fare, but rather an evaluation of the Empire＇s circumstances, raising questions on whether the European model is indeed universally applicable regardless of local conditions.

关键词： Late-imperial China economic thought market consumption morality Tang Zhen Lu Ji

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Plant invasions

Journal of Plant Ecology 2018年第1期11卷 1-3页

作者： Bruce Osborne margherita Gioria UCD School of Biology and Environmental Science and UCD Earth Institute University College DublinBelfieldDublin 4Ireland Institute of Botany Department of Invasion EcologyThe Czech Academy of SciencesZámek 1CZ-25243 PrůhoniceCzech Republic

Almost everyone now seems to have a view about alien plant introductions and their significance and there is an ever increasing body of information,both in the scien-tific and popular press,about the dangers of allowing the uncontrolled spread of alien *** all possible impacts of plant invasions have been reported,including alterations in biogeochemical cycling,disruption of food webs,alterations in plant-plant,plant-insect and plant-microbe interactions and reductions in biodiversity,leading to the proposal that this is resulting in the creation of novel or emerging ecosystems that have no historical analogue(Hobbs et al.2009).

关键词： analogue alterations everyone