Neurotrophic factor-based pharmacological approaches in neurological disorders
Neurotrophic factor-based pharmacological approaches in neurological disorders作者机构：Department of LifeHealth and Environmental SciencesUniversity of L’AquilaL’AquilaItaly
出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)
年 卷 期：2023年第18卷第6期
页 面：1220-1228页
核心收录：
学科分类：1002[医学-临床医学] 100203[医学-老年医学] 10[医学]
主 题：Alzheimer’s disease brain brain-derived neurotrophic factor glial cell-derived neurotrophic factor nerve growth factor neurotrophins neurturin Parkinson’s disease stroke tropomyosin receptor kinase receptors
摘 要：Aging is a physiological event dependent on multiple pathways that are linked to lifespan and processes leading to cognitive *** process represents the major risk factor for aging-related diseases such as Alzheimer’s disease,Parkinson’s disease,and ischemic *** incidence of all these pathologies increases exponentially with *** on aging biology has currently focused on elucidating molecular mechanisms leading to the development of those *** deficit and neurodegeneration,common features of aging-related pathologies,are related to the alteration of the activity and levels of neurotrophic factors,such as brain-derived neurotrophic factor,nerve growth factor,and glial cell-derived neurotrophic *** this reason,treatments that modulate neurotrophin levels have acquired a great deal of interest in preventing neurodegeneration and promoting neural regeneration in several neurological *** treatments include both the direct administration of neurotrophic factors and the induced expression with viral vectors,neurotrophins’binding with biomaterials or other molecules to increase their bioavailability but also cell-based *** neurotrophins’crucial role in aging pathologies,here we discuss the involvement of several neurotrophic factors in the most common brain aging-related diseases and the most recent therapeutic approaches that provide direct and sustained neurotrophic support.
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