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Undernutrition, risk of malnutrition and obesity in gastroenterological patients: A multicenter study

World Journal of Gastrointestinal Oncology 2016年第7期8卷 563-572页

作者： Massimiliano Rizzi Silvia Mazzuoli Nunzia Regano Rosa Inguaggiato margherita bianco Gioacchino Leandro Elisabetta Bugianesi Donatella Noè Nicoletta Orzes Paolo Pallini Maria Letizia Petroni Gianni Testino Francesco William Guglielmi Gastroenterology Unit San Nicola Pellegrino Hospital Gastroenterology Unit I Saverio De Bellis IRCCS UCL Department of Liver and Digestive Health Division of Gastro-Hepatogy Department of Medical Sciences University of Torino AIGOCommittee on Nutrition and Alcoholism Dietetics and Clinical Nutrition Unit S. Carlo Borromeo Hospital Gastroenterology Unit S. Giovanni di Dio Hospital Gastroenterology Unit Umberto I Hospital Nutritional and Gastroenterological Unit IRCCS Alcoholism and Related Conditions Unit IRCCS-AOU S. Martino-IST

AIM: To investigate the prevalence of undernutrition, risk of malnutrition and obesity in the Italian gastroenterological population. METHODS: The Italian Hospital Gastroenterology Association conducted an observational, cross-sectional multicenter study. Weight, weight loss, and body mass index were evaluated. Undernutrition was defined as unintentional weight loss > 10% in the last threesix months. Values of Malnutrition Universal Screening Tool(MUST) > 2, NRS-2002 > 3, and Mini Nutritional Assessment(MNA) from 17 to 25 identified risk of malnutrition in outpatients, inpatients and elderly patients, respectively. A body mass index ≥ 30 indicated obesity. Gastrointestinal pathologies were categorized into acute, chronic and neoplastic diseases. RESULTS: A total of 513 patients participated in the study. The prevalence of undernutrition was 4.6% in outpatients and 19.6% in inpatients. Moreover, undernutrition was present in 4.3% of the gastrointestinal patients with chronic disease, 11.0% of those with acute disease, and 17.6% of those with cancer. The risk of malnutrition increased progressively and significantly in chronic, acute and neoplastic gastrointestinal diseases in inpatients and the elderly population. Logistical regression analysis confirmed that cancer was a risk factor for undernutrition(OR = 2.7; 95%CI: 1.2-6.44, P = 0.02). Obesity and overweight were more frequent in outpatients. CONCLUSION: More than 63% of outpatients and 80% of inpatients in gastroenterological centers suffered from significant changes in body composition and required specific nutritional competence and treatment.

关键词： Obesity Malnutrition Risk of Malnutrition NRS2002 Gastrointestinal disease

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Small heat shock protein B8:from cell functions to its involvement in diseases and potential therapeutic applications

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Neural Regeneration Research 2025年第10期20卷 2872-2886页

作者： Marta Chierichetti Riccardo Cristofani Valeria Crippa Veronica Ferrari Marta Cozzi Elena Casarotto Paola Pramaggiore Laura Cornaggia Guglielmo Patelli Ali Mohamed margherita Piccolella Mariarita Galbiati Paola Rusmini Barbara Tedesco Angelo Poletti Laboratory of Experimental Biology Dipartimento di Scienze Farmacologiche e Biomolecolari“Rodolfo Paoletti”(DiSFeB)Universitàdegli Studi di MilanoMilanItaly

Heat shock protein family B(small)member 8(HSPB8)is a 22 kDa ubiquitously expressed protein belonging to the family of small heat shock ***8 is involved in various cellular mechanisms mainly related to proteotoxic stress response and in other processes such as inflammation,cell division,and ***8 binds misfolded clients to prevent their aggregation by assisting protein refolding or degradation through chaperone-assisted selective *** line with this function,the pro-degradative activity of HSPB8 has been found protective in several neurodegenerative and neuromuscular diseases characterized by protein misfolding and *** cancer,HSPB8 has a dual role being capable of exerting either a pro-or an anti-tumoral activity depending on the pathways and factors expressed by the model of cancer under ***,HSPB8 exerts a protective function in different diseases by modulating the inflammatory response,which characterizes not only neurodegenerative diseases,but also other chronic or acute conditions affecting the nervous system,such as multiple sclerosis and intracerebellar *** note,HSPB8 modulation may represent a therapeutic approach in other neurological conditions that develop as a secondary consequence of other *** is the case of cognitive impairment related to diabetes mellitus,in which HSPB8 exerts a protective activity by assuring mitochondrial *** review aims to summarize the diverse and multiple functions of HSPB8 in different pathological conditions,focusing on the beneficial effects of its ***-based and alternative therapeutic approaches targeting HSPB8 and its regulated pathways will be discussed,emphasizing how new strategies for cell and tissue-specific delivery represent an avenue to advance in disease treatments.

关键词： aggregation autophagy cancer chaperone chaperone-assisted selective autophagy cognitive impairment HSPB8 neuroinflammation neuromuscular diseases therapy

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How physical and motor training affect cognitive performance: lessons from an inflammatory molecule

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Neural Regeneration Research 2022年第12期17卷 2689-2690页

作者： margherita Maffei Marco Mainardi Institute of Clinical Physiology National Research Council(IFC-CNR)and Obesity/Lipodystrophies CenterPisa University HospitalPisaItaly Neuroscience Institute National Research Council(IN-CNR)PisaItaly

Our phenotype includes not only physical features,but also behavioral outputs such as motor schemes and learned skills,and is the result of a complex interaction between genetic background and *** fact,a good fraction of last decades’biomedical efforts were dedicated to understanding how different elements(e.g.,genetic polymorphisms,lifestyle components)participate in this interplay,ultimately contributing to affect a given phenotype up to the point of steering it towards *** and epigenetic elements are relatively easy to analyze individually using a reductionist approach,for instance via loss-or gain-of-function studies in cellular and animal models;the effects of nutrients,drugs,pollutants can be similarly tested as single specific stimuli.

关键词： instance drugs lesson

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Platelet-rich plasma:the role in neural repair

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Neural Regeneration Research 2015年第12期10卷 1920-1921页

作者： margherita Giorgetti Gabriele Siciliano Department of Hand Surgery and Reconstructive Microsurgery University of Pisa Department of Clinical and Experimental Medicine Neurological ClinicUniversity of Pisa

The efficacy of platelet-rich plasma（PRP）to promote tissue regeneration has been largely confirmed in several clinical settings,such as in human maxillo-facial（Froum et al.,2002）,heart（Vu et al.,2015）and orthopa... 详细信息

关键词： Platelet-rich plasma PRP

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The impact of Gunnera tinctoria(Molina)Mirbel invasions on soil seed bank communities

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Journal of Plant Ecology 2009年第3期2卷 153-167页

作者： margherita Gioria Bruce Osborne UCD School of Biology and Environmental Science University College DublinBelfieldDublin 4Ireland

Aims In recent years,there has been an increasing interest in the impact of invasive alien plant species on the soil seed *** seed banks play an important role in determining the composition and dynamics of the vegetation through ***,an ability to form a persistent seed bank and/or a capacity to alter the structure of the seed bank of invaded communities could be important factors in determining the success of many alien plant *** this study,we report on a detailed assessment of the characteristics of the seed bank community associated with the herbaceous plant invader,Gunnera tinctoria,a newly emerging and potentially globally significant invasive plant *** species,native to South America,is invasive in a range of wet habitats in Europe,Australasia and the *** A comprehensive assessment of the seed bank of invaded and comparable uninvaded areas was made at two points in time(May and October),at three sites in western *** seedling emergence approach was used to assess the structure(diversity,dominance and abundance)of the soil seed *** between invaded and uninvaded seed bank communities were investigated at the spatial scales of site,plot and *** Findings Gunnera tinctoria formed a large persistent seed bank at the study *** 30000 seedlings per square metre emerged from soils collected from invaded areas,of which 30%were found in deep soil *** of this invader represented 53–86%of the total number of seedlings associated with invaded *** the transient and the more persistent component of the seed bank of invaded communities were significantly less diverse and abundant than those of uninvaded areas,and were characterized by higher dominance,even when seedlings of the invader were not included in the *** seed bank of invaded areas was largely composed of seeds of agricultural weeds in addition to those of the *** results suggest that ***

关键词： invasive species soil seed bank diversity dominance Gunnera tinctoria

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Neurotrophic factor-based pharmacological approaches in neurological disorders

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Neural Regeneration Research 2023年第6期18卷 1220-1228页

作者： margherita Alfonsetti Michele d’Angelo Vanessa Castelli Department of Life Health and Environmental SciencesUniversity of L’AquilaL’AquilaItaly

Aging is a physiological event dependent on multiple pathways that are linked to lifespan and processes leading to cognitive *** process represents the major risk factor for aging-related diseases such as Alzheimer’s disease,Parkinson’s disease,and ischemic *** incidence of all these pathologies increases exponentially with *** on aging biology has currently focused on elucidating molecular mechanisms leading to the development of those *** deficit and neurodegeneration,common features of aging-related pathologies,are related to the alteration of the activity and levels of neurotrophic factors,such as brain-derived neurotrophic factor,nerve growth factor,and glial cell-derived neurotrophic *** this reason,treatments that modulate neurotrophin levels have acquired a great deal of interest in preventing neurodegeneration and promoting neural regeneration in several neurological *** treatments include both the direct administration of neurotrophic factors and the induced expression with viral vectors,neurotrophins’binding with biomaterials or other molecules to increase their bioavailability but also cell-based *** neurotrophins’crucial role in aging pathologies,here we discuss the involvement of several neurotrophic factors in the most common brain aging-related diseases and the most recent therapeutic approaches that provide direct and sustained neurotrophic support.

关键词： Alzheimer’s disease brain brain-derived neurotrophic factor glial cell-derived neurotrophic factor nerve growth factor neurotrophins neurturin Parkinson’s disease stroke tropomyosin receptor kinase receptors

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Frugality and Luxury： Morality, Market, and Consumption in Late Imperial China

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Frontiers of History in China 2015年第3期10卷 457-485页

作者： margherita Zanasi Department of History Louisiana State University Baton Rouge LA 70803 USA

This article contributes to a wider critique of the use of European capitalist, patterns of industrialization in studies of the economic history of modern China--studies commonly supposed to be universally valid. This sort of analytical framework denies not only the value of alternative economic models, but also that of Chinese independent economic thought. In this context, the present article argues that most of the intellectual changes of seventeenth-century Europe that led to the formulation of liberal capitalism--resistance to government intervention, support for luxury consumption as well as a new understanding of the market and of the relationship between private interests and morality--had taken place in China more than a century earlier. The background against which the two processes emerged, however, varied significantly, leading to distinctive ramifications. Unprecedented population growth and a widening gap between hinterland and coastal economies led Chinese officials and intellectuals to discard ideas of free market and focus instead on solutions for increasing production, maximizing the circulation of resources, and fighting poverty. It was not, therefore, a lack of a ＂scientific＂ understanding of the economy that led China to turn away from European-style laissez fare, but rather an evaluation of the Empire＇s circumstances, raising questions on whether the European model is indeed universally applicable regardless of local conditions.

关键词： Late-imperial China economic thought market consumption morality Tang Zhen Lu Ji

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Plant invasions

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Journal of Plant Ecology 2018年第1期11卷 1-3页

作者： Bruce Osborne margherita Gioria UCD School of Biology and Environmental Science and UCD Earth Institute University College DublinBelfieldDublin 4Ireland Institute of Botany Department of Invasion EcologyThe Czech Academy of SciencesZámek 1CZ-25243 PrůhoniceCzech Republic

Almost everyone now seems to have a view about alien plant introductions and their significance and there is an ever increasing body of information,both in the scien-tific and popular press,about the dangers of allowing the uncontrolled spread of alien *** all possible impacts of plant invasions have been reported,including alterations in biogeochemical cycling,disruption of food webs,alterations in plant-plant,plant-insect and plant-microbe interactions and reductions in biodiversity,leading to the proposal that this is resulting in the creation of novel or emerging ecosystems that have no historical analogue(Hobbs et al.2009).

关键词： analogue alterations everyone

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Role of molecular analysis in the adjuvant treatment of gastrointestinal stromal tumours: It is time to define it

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World Journal of Gastroenterology 2013年第16期19卷 2583-2586页

作者： margherita Nannini Maria A Pantaleo Guido Biasco Department of Hematology and Oncological Sciences "LA Seràgnoli" Sant'Orsola-Malpighi Hospital University of Bologna "Giorgio Prodi" Cancer Research Center University of Bologna

Sendur et al pointed out the attention on the importance of mutational analysis for adjuvant treatment of gastrointestinal stromal tumor (GIST) in an article published in World Journal of Gastroenterology . In particular, they suggested that the optimal dose and duration of adjuvant therapy could be defined by the mutational status of the primary disease. This comment would underline the importance of centralised laboratories, given the increasingly important role of molecular analysis in the work-flow of all GIST, and the need of retrospective analyses for subgroups population stratified for the mutational status from the available studies in the adjuvant setting, in order to define the role of mutational analysis in choosing the optimal dose and duration of adjuvant therapy.

关键词： Gastrointestinal stromal tumours Plateletderived growth factor receptor alpha KIT Wild-type Molecular analysis Imatinib Adjuvant treatment

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Post-coital death in chronic sildenafil abuser

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Journal of Geriatric Cardiology 2020年第3期17卷 169-172页

作者： Stefano D'Errico Diana Bonuccelli margherita Neri Department of Medicine Surgery and HealthUniversity of TriesteItaly Department of Legal Medicine Azienda USL Toscana NordovestLuccaItaly Department of Morphology Experimental Medicine and SurgerySection of Legal Medicine and LTTA CentreUniversity of FerraraFerraraItaly

Sex-related cardiovascular arrest is a rare event occurring typically among middle-aged men with cardiovascular risk.[1,2]The main etiologies of sex-related sudden cardiovascular arrest are acute coronary syndrome and subarachnoid hemorrhage and,to a lesser extent,chronic coronary artery disease and structural non-ischemic heart disease.[3]Coital angina that occurs during the minutes or hours after sexual activity represents<5%of all anginal attacks and it is rare in patients who do not have angina during strenous physical exertion.[4]Moreover,sexual activity is the cause of<1%of all acute myocardial infarctions.[5]Sudden death during sexual intercourse is reported with an incidence of 0.6%–1.7%.[6–8]The investigation of sudden death related to sexual activity may be difficult as it may be regarded as shameful or disgraceful to the family members and,especially to the remaining *** of rarity of epidemiological data,considerable bias in the investigation of sudden death related to sexual activity has to be expected.[9–11]Extramarital sexual activity with younger partner and unfamiliar setting seems to represent risk factor as well as excessive food and alcohol consumption.[7]

关键词： Cardiovascular events Sex Sildenafil Sudden death

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