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Phenolic composition and inhibitory activity of Mangifera indica and Mucuna urens seeds extracts against key enzymes linked to the pathology and complications of type 2 diabetes

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Asian Pacific Journal of Tropical Biomedicine 2014年第11期4卷 903-910页

作者： Emmanuel Anyachukwu Irondi Ganiyu Oboh Afolabi Akintunde Akindahunsi Aline Augusti Boligon margareth linde athayde Department of Biochemistry Federal University of Technology.P.M.B.704Akure 340001Nigeria Biochemistry Unit Department of Biosciences and BiotechnologyKwara State UniversityMaleteP.M.B.1530IlorinNigeria Phytochemical Research Laboratory Department of Industrial PharmacyFederal University of Santa MariaBuilding 26.Room 1115.Santa Maria.CEP 97105-900.Brazil

Objective:To investigate the phenolic compounds composition and the inhibitory activity of Mangifera indica(***) and Mucuna urens(***) seeds extracts against some key enzymes(-amylase,-glucosidasc and aldose reductase) implicated in the pathology and complications of type 2 diabetes in ***:Reverse phase chromatographic quantification of the major flavonoids and phenolic acids in the seeds extracts was carried out using high performance liquid chromatography coupled with diode array *** inhibitory activities of the seeds extracts against-amylase and-glucosidase were estimated using soluble starch and p-nitrophenylglucopyranosidc as their respective *** of aldose reductase activity by the extracts was assayed using partially purified lens homogenate of normal male rat as source of enzyme;inhibition of Fe^(2+)-induced lipid peroxidation by extracts was tested in rat pancreas ***:The chromatography result revealed that extracts of both seeds had appreciable levels of some major flavonoids and phenolic acids of pharmacological importance,including gallic acid,chlorogenic acid,caffeic acid,ellagic acid,catechin,rutin,*** and *** of both seeds effectively inhibited-amylase,-glucosidase and aldose reductase activities in a dose-dependent manner,having inhibitory preference for these enzymes in the order of aldose reductase>-glucosidase>-*** lower half-maximal inhibitory concentrations(IC50)against-amylase,-glucosidase,and aldose reductase,*** had stronger inhibitory potency against these enzymes than *** of both seeds also inhibited Fe2+-induced lipid peroxidation in a dose-dependent pattern,with *** being more potent than ***:The results obtained provide support for a possible use of *** and *** seeds in managing hyperglycemia and preventing the complications associated with it in type 2diabetes.

关键词： Hyperglycemia Diabetic complications Enzyme inhibition Lipid peroxidation Mangifera indica Mucuna urens

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Phenolics extract of Tetrapleura tetraptera fruit inhibits xanthine oxidase and Fe^2+-induced lipid peroxidation in the kidney,liver,and lungs tissues of rats in vitro

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Food Science and Human Wellness 2016年第1期5卷 17-23页

作者： Emmanuel Anyachukwu Irondi Ganiyu Oboh Samson Olalekan Agboola Aline Augusti Boligon margareth linde athayde Biochemistry Unit Department of Biosciences and BiotechnologyKwara State UniversityMaleteP.M.B.1530IlorinNigeria Functional Foods and Nutraceuticals Unit Department of BiochemistryFederal University of TechnologyAkureNigeriaP.M.B.704Akure 340001Nigeria Department of Veterinary Physiology Biochemistry and PharmacologyUniversity of IbadanNigeria Phytochemical Research Laboratory Department of Industrial PharmacyFederal University of Santa MariaBuilding 26Room 1115Santa Maria CEP 97105-900Brazil

The phenolics composition and inhibitory activity of Tetrapleura tetraptera fruit extract on xanthine oxidase(XO)and Fe2+-induced lipid peroxidation in the kidney,liver and lungs tissues of rats were evaluated in ***(flavonoids and phenolic acids)were quantified using reverse-phase high performance liquid chromatrography coupled with diode array detection(HPLC-DAD).The XO and Fe2+-induced lipid peroxidation inhibitory abilities of the extract were evaluated using spectrophotometric *** extract contained some flavonoids and phenolic acids,including catechin,epicatechin,rutin,quercetin,luteolin,apigenin;gallic,chlorogenic,caffeic and ellagic acids that are beneficial to *** extract inhibited XO in the kidney,liver and lungs tissues in a dose-dependent *** half-maximal inhibitory concentrations(IC50)of the extract on XO from the tissues varied significantly(Pkidney>*** extract also inhibited Fe2+-induced lipid peroxidation in a dose-dependent pattern,having IC50 in the order of liver>lungs>*** fruit extract could be a promising nutraceutical for preventing and managing hyperuricaemia and the associated disease conditions,due to its ability to inhibit XO;this bioactivity is attributable to combined effect of its flavonoids and phenolic acids.

关键词： peroxidation kidney inhibited

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Phenolics from grapefruit peels inhibit HMG-CoA reductase and angiotensin-I converting enzyme and show antioxidative properties in endothelial *** 926 cells

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Food Science and Human Wellness 2015年第2期4卷 80-85页

作者： Ayokunle O.Ademosun Ganiyu Oboh Sabina Passamonti Federica Tramer Lovro Ziberna Aline Augusti Boligon margareth linde athayde Functional Foods and Nutraceuticals Unit Department of BiochemistryFederal University of TechnologyAkureNigeria Department of Life Sciences University of Triestevia L.Giorgieri 134127 TriesteItaly Program of Post-Graduation in Pharmaceutical Sciences Federal University of Santa MariaCampus CamobiSanta MariaRS 97105-900Brazil

This study sought to investigate the possible mechanisms for the use of phenolic extracts from grapefruit peels in the management/prevention of cardiovascular *** effects of the phenolic extracts on key enzymes relevant to cardiovascular diseases[3-hydroxy-methyl-3-glutaryl coenzyme A reductase(HMG-CoA reductase)and angiotensin-I converting enzyme(ACE)],cellular antioxidant activity in human endothelial cells(*** 926)and radicals[1,1-diphenyl-2 picrylhydrazyl(DPPH)and 2,2-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid)(ABTS)]scavenging abilities were *** phenolic contents of the extracts were investigated using HPLC–*** was no significant(P>0.05)difference in the HMG-CoA reductase inhibitory ability of the two extracts,while the bound phenolic extracts had a stronger ACE inhibitory ability than the soluble free *** extracts also showed intracellular antioxidant activity in human endothelial(*** 926)***,the bound phenolics had significantly higher radicals(DPPH*and ABTS*)scavenging abilities than the free *** HPLC analysis revealed the presence of flavonoids(quercetin and kaempferol),phenolics acids(resveratrol,gallic acid,ellagic acid and caffeic acid)and tannin(catechin).The cellular antioxidative properties and inhibition of enzymes relevant to the management of cardiovascular complications showed that grapefruit peels could be used as nutraceuticals for the management of such conditions.

关键词： prevention cardiovascular phenolic

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Ethylacetate extract of red onion(Allium cepa L.)tunic affects hemodynamic parameters in rats

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Food Science and Human Wellness 2015年第3期4卷 115-122页

作者： Olanrewaju Sam Olayeriju Mary Tolulope Olaleye Olamide Olajusi Crown Kayode Komolafe Aline Augusti Boligon margareth linde athayde Akintunde Afolabi Akindahunsi Department of Biochemistry School of SciencesThe Federal University of TechnologyPMB 704AkureNigeria Department of Biochemistry Faculty of ScienceFederal University Oye-EkitiPMB 373Oye-EkitiNigeria Department of Industrial Pharmacy Federal University of Santa Maria97105-900 Santa MariaRSBrazil

The effects of ethylacetate extract of red onion(Allium cepa)tunic(ACTE)on some hemodynamic and biochemical parameters were evaluated in normotensive albino *** pressure parameters were determined in anaesthetized rats orally administered ACTE(10-,20-,or 40 mg/kg)or ramipril(1 mg/kg)once daily for 14 ***,10-,20-,or 40 mg/kg ACTE produced significant(P<0.01),dose-dependent fall in systolic blood pressure,SBP(21%,27%,33%),diastolic blood pressure,DBP(6%,10%,16%),pulse pressure,PP(42%,49%,56%),mean arterial blood pressure,MAPB(13%,18%,23%)and heart rate,HR(4%,5%,7%).The highest effective dose(40 mg/kg)compared well with ramipril(1 mg/kg)with regards to SBP(41%),DBP(19%),PP(70%),MABP(29%)and HR(10%).Similar trends(decreases)were recorded for 40 mg/kg ACTE and ramipril,respectively,as regards the activities of serum enzymes:creatine kinase(60%and 65%),ALT(18%and 14%)and ALP(28%and 16%).HPLC fingerprints of the flavonoid-rich ACTE revealed that flavonols:quercetin,quercitrin,isoquercitrin,rutin and kaempferol are the active *** results demonstrate the hypotensive effect of *** tunic flavonoids initiating further investigation of their individual or synergistic contribution(s)to the observed effects.

关键词： acetate Blood rats

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Antiulcerogenic activity of Scutia buxifolia on gastric ulcers induced by ethanol in rats

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Acta Pharmaceutica Sinica B 2014年第5期4卷 358-367页

作者： Aline Augusti Boligon Robson Borba de Freitas Thiele Faccim de Brum Emily Pansera Waczuk Cláudia Vargas Klimaczewski Daiana Silva deÁvila margareth linde athayde Liliane de Freitas Bauermann Department of Industrial Pharmacy Center of Health SciencesFederal University of Santa MariaSanta Maria 97105-900RSBrazil Department of Physiology and Pharmacology Center of Health SciencesFederal University of Santa MariaSanta Maria 97105-900RSBrazil Department of Biochemistry Federal University of PampaUruguaiana 97500-970RSBrazil

Gastric ulcers affect many people around the world and their development is a result of the imbalance between aggressive and protective factors in the gastric *** buxifolia,commonly known as coronilha,has attracted the interest of the scientific community due to its pharmacological properties and its potential therapeutic *** this study,the preventive effects of the crude extract of Scutia buxifolia(ceSb)against gastric ulcer induced by 70%ethanol were evaluated in male Wistar *** addition,the composition of ceSb was clarified by high-performance liquid chromato-graphy(HPLC).*** extract(100,200 and 400 mg/kg body weight)attenuated oxidative and histopathological features induced by ***,all evaluated doses of ceSb caused significant(P<0.001 and P<0.0001)and dose-dependent increase in sulfhydryl groups(NPSH)levels,catalase(CAT)and superoxide dismutase(SOD)***,the administration of ceSb reversed the increase in lipid peroxidation produced by *** protective effect of the extract could be attributed to antioxidant compounds present in the ceSb,such as flavonoids and phenolic acids,which were quantified by ***,an antioxidant effect of the extract leads to a protection on gastric *** results indicate that *** could have a beneficial role against ethanol toxicity by preventing oxidative stress and gastric tissue injury.

关键词： Scutia buxifolia Antioxidant Gastric ulcer HPLC

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African eggplant(Solanum anguivi Lam.)fruit with bioactive polyphenolic compounds exerts in vitro antioxidant properties and inhibits Ca^(2+)-induced mitochondrial swelling

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Asian Pacific Journal of Tropical Biomedicine 2013年第10期3卷 757-766页

作者： Olusola Olalekan Elekofehinti Jean Paul Kamdem Aline Augusti Bolingon margareth linde athayde Seeger Rodrigo Lopes Emily Pansera Waczuk Ige Joseph Kade Isaac Gbadura Adanlawo Joao Batista Teixeira Rocha Department of Biochemistry Adekunle Ajasin UniversityAkungbaOndo StateNigeria Postgraduate Programme in Biochemical Toxicology Department of ChemistryCCNE.Federal University of Santa Maria.Campus CamobiSanta MariaRS.97105-900Brazil Postgraduate Programme in Pharmaceutical Sciences Federal University of Santa MariaCampus CamohiSanta MariaRS97105-900.Brazil Toxicologia de Produtos Naturais e Sinteticos.Universidade Federal do Pampa CEP 97500-970 UruguaianaRSBrazil Department of Biochemistry Federal University of TechnologyAkureOndo StateNigeria Department of Biochemistry University of Ado EkitiEkiti State.Nigeria

Objective:To evaluate the antioxidant and radical scavenging activities of Solanum anguivi fruit(SAG)and its possible effect on mitochondrial permeability transition pore as well as mitochondrial membrane potential(△Ψ_m)isolated from rat ***:Antioxidant activity of SAG was assayed by using 2,2-diphenyl-1-picrylhydrazyl(DPPH),reducing power,iron chelation and ability to inhibit lipid peroxidation in both liver and brain homogenate of ***,the effect of SAG on mitochondrial membrane potential and mitochondrial swelling were *** and quantification of bioactive polyphenolics was done by ***:SAG exhibited potent and concentration dependent free radical-scavenging activity(IC_(50)/DPPH=275.03±7.8μg/mL).Reductive and iron chelation abilities also increase with increase in SAG *** also inhibited peroxidation of cerebral and hepatic lipids subjected to iron oxidative *** protected against Ca^(2+)(110μmol/L)-induced mitochondrial swelling and maintained the△Ψ_*** analysis revealed the presence of gallic acid[(17.54±0.04)mg/g],chlorogenic acid(21.90±0.02 mg/g),caffeic acid(16.64±0.01 mg/g).rutin[(14.71±0.03)mg/g]and quercetin[(7.39±0.05)mg/g].Conclusions:These effects could be attributed to the bioactive polyphenolic compounds present in the *** results suggest that SAG extract is a potential source of natural antioxidants that may be used not only in pharmaceutical and food industry but also in the treatment of diseases associated with oxidative stress.

关键词： Solanum anguivi fruit Antioxidant activity Oxidative stress Mitochondrial swelling HPLC Polyphenolic compounds MPTP

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Protective Role of Golden Flaxseed (Linum usitatissimum L.) Against Oxidative Damage in Lipids and Proteins of Healthy Volunteers

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Journal of Biosciences and Medicines 2015年第10期3卷 45-53页

作者： Luisa Zuravski Ritiele Pinto Coelho Jonathaline Apollo Duarte Manoelly Oliveira Rocha Juliana Mezzomo Bruna Cocco Pilar Leandro Leal Galarca margareth linde athayde Aline Augusti Boligon Michel Mansur Machado Vanusa Manfredini Postgraduate Program in Biochemistry Federal University of PampaUruguaianaBrazil Course of Pharmacy Federal University of PampaUruguaianaBrazil Postgraduate Program in Pharmaceutical Sciences Federal University of PampaUruguaianaBrazil Postgraduate Program in Pharmaceutical Sciences Federal University of Santa MariaSanta MariaBrazil

Flaxseed (Linum usitatissimum L.) is composed mainly of bioactive components such as polyphenols, polyunsaturated fatty acids, fiber and lignans. Flaxseed can be found in different presentation forms (grain or flour) and varieties (brown or golden);however, questions have arisen as to whether the presentation form and/or variety may influence the health effects. The objective of this study was to evaluate the effects on blood pressure, anthropometric and oxidative parameters in healthy human volunteers. All subjects received 40 gram aliquots of flaxseed and were instructed to consume them in their entirety mixed with water in the morning for a period of 14 days. Oxidative parameters showed significant reductions (p < 0.05) in oxidative damage to lipids and proteins via dietary intervention with golden flaxseed grains. There were no significant differences in anthropometric parameters, blood pressure, DNA damage and micronuclei frequency after 14-day supplementation. This research indicates that golden flaxseed grains can be a valuable adjunct for disease prevention and protecting the organism against oxidative damage.

关键词： Golden Flaxseed Grains Antioxidant Oxidative Damage

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全钒液流电池的容量恢复与保持

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电池 2024年第1期54卷 82-85页

作者：王晓颖杨霖霖李林德魏冬上海电气(安徽)储能科技有限公司安徽合肥238014

电解液的性能和充放电期间的行为会影响全钒液流电池的性能和系统成本。电池运行时,正负极电解液穿过离子交换膜的迁移会导致电解液体积失衡,引起电解液容量损失,限制放电容量、削弱循环稳定性、减少寿命。通过实验探索电解液在充放电... 详细信息

电解液的性能和充放电期间的行为会影响全钒液流电池的性能和系统成本。电池运行时,正负极电解液穿过离子交换膜的迁移会导致电解液体积失衡,引起电解液容量损失,限制放电容量、削弱循环稳定性、减少寿命。通过实验探索电解液在充放电过程中的迁移规律,使用二水合草酸作为还原剂还原正极侧过量的VO_(2)^(+),将衰减失效电解液的容量恢复至初始容量的94.33%。改善储液罐设计,当电解液体积向正极侧偏移5%时,进行手动溢流操作,以100 mA/cm~2在1.0~1.7 V循环100次后,电池的放电容量保持率为88.08%。

关键词：全钒液流电池电解液迁移二水合草酸容量恢复溢流设计

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催化燃烧工艺在制药行业VOCs废气治理中的应用

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浙江化工 2024年第2期55卷 48-54页

作者：陈东陈军辉姜涛梅林德四川省生态环境科学研究院四川成都610041 四川省环保科技工程有限责任公司四川成都610045

针对中小企业采用蓄热式燃烧技术治理VOCs存在建设和运行成本高、运行管理难度大等难题,本文对制药行业VOCs废气排放特征及催化燃烧工艺应用进行分析,利用自主研发的小型催化燃烧工艺设备,在某制药企业开展了应用示范,调试运行结果显示,... 详细信息

针对中小企业采用蓄热式燃烧技术治理VOCs存在建设和运行成本高、运行管理难度大等难题,本文对制药行业VOCs废气排放特征及催化燃烧工艺应用进行分析,利用自主研发的小型催化燃烧工艺设备,在某制药企业开展了应用示范,调试运行结果显示,在250℃~350℃温度范围内,对乙酸乙酯、丙酮、甲苯、四氢呋喃等典型制药行业VOCs的去除效率达到90%以上,实际排放VOCs废气的去除效率达到92.5%~97.8%,处理后的废气满足地方排放标准要求。同时对催化燃烧工艺在制药行业应用中存在的问题进行分析探讨。

关键词：催化燃烧 VOCs治理制药行业排放特征应用示范

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吲哚菁绿荧光胆管造影在复杂性腹腔镜胆囊切除术中有效性及安全性的meta分析

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中国当代医药 2024年第11期31卷 14-19,24页

作者：武林得涂勇浪高国华李刚昆明医科大学第一附属医院肝胆外科云南昆明650032 云南省妇幼保健院普通外科云南昆明650051

目的比较吲哚菁绿荧光胆管造影(ICG)联合腹腔镜胆囊切除术(LC)与常规LC在复杂性LC中的有效性及安全性。方法通过检索库检索2018—2022年,ICG荧光胆管造影LC试验组与常规LC对照组在复杂性LC疗效比较的研究,纳入的文献进行质量评估并提取... 详细信息

目的比较吲哚菁绿荧光胆管造影(ICG)联合腹腔镜胆囊切除术(LC)与常规LC在复杂性LC中的有效性及安全性。方法通过检索库检索2018—2022年,ICG荧光胆管造影LC试验组与常规LC对照组在复杂性LC疗效比较的研究,纳入的文献进行质量评估并提取相关研究数据后,使用RevMan Manager 5.4进行meta分析。结果本研究最终纳入14篇相关文献,含1116份病例资料。经分析后发现,与常规LC治疗组相比,ICG联合LC组手术时间短(MD=-24.37,95%CI:-32.87~-15.86),术中出血量少(MD=-11.36,95%CI:-15.34~-7.37),术中胆道结构识别时间短(MD=-16.79,95%CI:-31.00~-2.58),术后住院时间短(MD=-0.61,95%CI:-1.13~-0.09),术后肛门排气功能恢复时间短(MD=-2.61,95%CI:-5.40~-0.17),术后并发症总发生率低(OR=0.57,95%CI:0.16~0.44),住院花费少(MD=-1549.69,95%CI:-2647.34~-452.04);两组术后拔除引流管时间和术中中转开腹率比较,差异无统计学意义(P>0.05)。结论复杂性胆囊疾病行LC中,ICG胆管造影可降低对胆道损伤的风险且安全有效。

关键词：胆囊切除术腹腔镜吲哚菁绿 meta分析

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