Phenolics from grapefruit peels inhibit HMG-CoA reductase and angiotensin-I converting enzyme and show antioxidative properties in endothelial *** 926 cells

作     者：Ayokunle O.Ademosun Ganiyu Oboh Sabina Passamonti Federica Tramer Lovro Ziberna Aline Augusti Boligon Margareth Linde Athayde 

作者机构：Functional Foods and Nutraceuticals UnitDepartment of BiochemistryFederal University of TechnologyAkureNigeria Department of Life SciencesUniversity of Triestevia L.Giorgieri 134127 TriesteItaly Program of Post-Graduation in Pharmaceutical SciencesFederal University of Santa MariaCampus CamobiSanta MariaRS 97105-900Brazil 

出 版 物：《Food Science and Human Wellness》 (食品科学与人类健康（英文）)

年 卷 期：2015年第4卷第2期

页      面：80-85页

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 08[工学] 083201[工学-食品科学] 

基　　金：Education Trust Fund TRIL University of Technology, Akure and Training and Research in Italian Laboratory Abdus Salam International Centre for Theoretical Physics, ICTP Eesti Teadusfondi, ETF 

主　　题：prevention cardiovascular phenolic 

摘      要：This study sought to investigate the possible mechanisms for the use of phenolic extracts from grapefruit peels in the management/prevention of cardiovascular *** effects of the phenolic extracts on key enzymes relevant to cardiovascular diseases[3-hydroxy-methyl-3-glutaryl coenzyme A reductase(HMG-CoA reductase)and angiotensin-I converting enzyme(ACE)],cellular antioxidant activity in human endothelial cells(*** 926)and radicals[1,1-diphenyl-2 picrylhydrazyl(DPPH)and 2,2-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid)(ABTS)]scavenging abilities were *** phenolic contents of the extracts were investigated using HPLC–*** was no significant(P0.05)difference in the HMG-CoA reductase inhibitory ability of the two extracts,while the bound phenolic extracts had a stronger ACE inhibitory ability than the soluble free *** extracts also showed intracellular antioxidant activity in human endothelial(*** 926)***,the bound phenolics had significantly higher radicals(DPPH*and ABTS*)scavenging abilities than the free *** HPLC analysis revealed the presence of flavonoids(quercetin and kaempferol),phenolics acids(resveratrol,gallic acid,ellagic acid and caffeic acid)and tannin(catechin).The cellular antioxidative properties and inhibition of enzymes relevant to the management of cardiovascular complications showed that grapefruit peels could be used as nutraceuticals for the management of such conditions.