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Chemical composition of Rosmarinus officinalis essential oil and antioxidant action against gastric damage induced by absolute ethanol in the rat

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Asian Pacific Journal of Tropical Biomedicine 2016年第8期6卷 677-681页

作者： Christiane Takayama Felipe Meira de-Faria Ana Cristina Alves de Almeida Ricardo jose Dunder Luis Paulo Manzo Eduardo Augusto Rabelo Socca Leonia Maria Batista marcos jose salvador Alba Regina Monteiro Souza-Brito Anderson Luiz-Ferreira Functional and Structural Biology Department Biology Institute Campinas State University Pharmacology Department Faculty of Medical Sciences Campinas State University Department of Pharmaceutical Sciences Federal University of Paraiba Plant Physiology Department Biology Institute Campinas State University Federal University of Goias Institute of Biotechnology Nucleus of Biological Sciences Regional Catalao

Objective: To evaluate the antioxidant activity of the essential oil obtained from Rosmarinus officinalis(R. officinalis) in ethanol-induced gastric ulcer model in ***: The antioxidant properties of the essential oil obtained from R. officinalis were evaluated against gastric injury induced by absolute ethanol. Gastric tissues were prepared to enzymatic assays. The levels of glutathione, lipid peroxides, and the activities of glutathione peroxidase, superoxide dismutase and myeloperoxidase were ***: Ethanol produced severe hemorrhagic lesions in the stomach with ulcerative lesion of(140.2 ± 37.2) mm2. In animals pretreated with essential oil of R. officinalis(50 mg/kg, p.o.), a significant inhibition of mucosal injury of(21.2 ± 7.1) mm2(84%inhibition) was observed. The essential oil of R. officinalis protected the gastric mucosa probably by modulating the activities of the enzymes(superoxide dismutase and glutathione peroxidase) and increasing or maintaining the levels of glutathione. In addition,lipid peroxides levels were reduced. The essential oil of R. officinalis was analyzed by gas chromatography–mass spectrometer and the main constituents were cineole(28.5%),camphor(27.7%) and alpha-pinene(21.3%).Conclusions: We suggest that the monoterpenes present in the essential oil obtained from R. officinalis may be among the active principles responsible for the antioxidant activity shown by essential oil of R. officinalis.

关键词： Rosmarinus officinalis L. Antioxidant activity Gastric ulcer Antioxidant enzymes

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Imprinting in plants

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Chinese Science Bulletin 2009年第14期54卷 2383-2389页

作者： GUTIERREZ-marcos jose Warwick HRI University of WarwickWellesbourneCV35 9EF UK

Genomic imprinting leads to the differential expression of parental alleles after fertilization. Imprinting appears to have evolved independently in mammals and flowering plants to regulate the development of nutrient-transfer placental tissues. In addition, the regulation of imprinting in both mammals and flowering plants involves changes in DNA methylation and histone methylation, thus suggesting that the epigenetic signals that regulate imprinting have been co-opted in these distantly related species.

关键词：开花植物 DNA甲基化基因组印记哺乳类动物差异表达基因胎盘组织养分转移信号调节

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An overview on nucleation theories and models

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Journal of Rare Earths 2019年第10期37卷 1015-1022页

作者： marcos Flavio de Campos jose Adilson de Castro Department of Mechanical Engineering Federal Fluminense University

Several different models for coercivity are discussed. There are two main situations: i) nanocrystalline magnets, with grain size bellow the single domain particle size, and ii) magnets with grain size above single domain particle size. The described theories and models are general, and can be applied in either NdFeB magnets, SmFeCoCuZr or strontium ferrite magnets. The spring effect observed in isotropic nanocrystalline magnets can be explained with the Stoner-Wohlfarth model. Modifications of the StonerWohlfarth model are necessary to take into account the effect of interaction between grains. When the grain size is above the single domain size, energy considerations show that nucleation should occur at the surface of grains. Nucleation is interpreted as a two-step process, where domain wall displacement occurs for grain size above single domain size, after a nucleus is first formed. The effect of grain size on the coercive field is discussed.

关键词： Coercivity Nucleation Grain size Spring effect Nd-Fe-B Permanent magnet

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Genetic and epigenetic control of transfer cell development in plants

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Journal of Genetics and Genomics 2016年第9期43卷 533-539页

作者： Jing Yuan Perry Bateman jose Gutierrez-marcos State Key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental BiologyChinese Academy of Sciences School of Life Sciences University of Warwick

The inter-cellular translocation of nutrients in plant is mediated by highly specialized transfer cells （TCs）. TCs share similar functional and structural features across a wide range of plant species, including location at plant exchange surfaces, rich in secondary wall ingrowths, facilitation of nutrient flow, and passage of select molecules. The fate of endosperm TCs is determined in the TC fate acquisition stage （TCF）, before the structure features are formed in the TC differentiation stage （TCD）. At present, the molecular basis of TC development in plants remains largely unknown. In this review, we summarize the important roles of the signaling molecules in different development phases, such as sugars in TCF and phytohormones in TCD, and discuss the genetic and epigenetic factors, including TC-specific genes and endogenous plant peptides, and their crosstalk with these signaling molecules as a complex regulatory network in regulation of TC develonment in olants.

关键词： Transfer cells Differentiation Signals and genes network

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Effects of obstructive sleep apnea and its treatment over the erectile function： a systematic review

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Asian Journal of Andrology 2017年第3期19卷 303-310页

作者： Felix Campos-Juanatey marcos Fernandez-Barriales Monica Gonzalez jose A Portillo-Martin Urology Department Marques de Valdecilla University Hospital Santander 39008 Spain Institute of Investigation Marques de Valdecilla Santander 39011 Spain Oral and Maxillofacial Surgery Department Araba University Hospital Araba 01004 Spain Sleep and Ventilation Unit Marques de Valdecilla University Hospital Santander 39008 Spain Medical and Surgical Sciences Department School of Medicine University of Cantabria Santander 39011 Spain.

Erectile dysfunction （ED） is considered a condition with a broad range of etiologies. Obstructive sleep apnea （OSA） syndrome is one of the lesser studied risk factors for ED. We intend to summarize the current evidence on the relationship between OSA and sexual impairment, focusing on the results in terms of erectile function of the different therapies offered to OSA patients. A systematic review was conducted, selecting articles related to the physiology of OSA and ED, and to the treatments of OSA syndrome and their reported outcomes in erectile and sexual function. Higher prevalences of ED in the OSA groups have been published. However, whether this effect on the erectile function occurs in the entire range of OSA severities remains unclear. Several hypotheses were proposed to explain the physiology of this association. Continuous Positive Airway Pressure as a treatment for OSA patients with ED has achieved a significative improvement in the sexual parameters in most of the studies. Phosphodiesterase type 5 inhibitors （iPDE5） on demand are useful as a treatment for ED in this subgroup of patients, with high satisfaction rates. The surgical treatment for the OSA evidenced benefits over the erectile function, and the effect on the sexual satisfaction of the therapy using Mandibular Advancement Devices is still undefined.

关键词： continuous positive airway pressure erectile dysfunction obstructive sleep apnea operative surgical procedures phosphodiesterase type 5 inhibitors

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Kinetic and morphology study of alginate-vineyard pruning waste biocomposite vs. non modified vineyard pruning waste for dye removal

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Journal of Environmental Sciences 2015年第12期27卷 158-167页

作者： Xanel Vecino Rosa Devesa-Rey salvador Villagrasa jose M.Cruz Ana B.Moldes Chemical Engineering Department School of Industrial Engineering (EEI)University of VigoCampus As Lagoas-Marcosende Defense University Center Naval AcademyUniversity of Vigo Materials Engineering Department School of Industrial Engineering (EEI)University of VigoCampus As Lagoas-Marcosende

In this work a comparative bioadsorption study between a biocomposite consisting of hydrolysed vineyard pruning waste entrapped in calcium alginate spheres and non entrapped vineyard residue was carried *** have demonstrated that the biocomposite based on lignocellulose-calcium alginate spheres removed 77.3% of dyes,while non entrapped lignocellulose eliminated only removed 27.8% of colour *** experimental data were fitted to several kinetic models（pseudo-first order,pseudo-second order,Chien-Clayton model,intraparticle diffusion model and Bangham model）; being pseudo-second order the kinetic model that better described the adsorption of dyes onto both *** addition,a morphological study（roughness and shape） of alginate-vineyard biocomposite was established under extreme conditions,observing significant differences between hydrated and dehydrated alginate-vineyard *** techniques used to carry out this morphological study consisted of scanning electron microscopy（SEM）,perfilometry and 3D surface analysis.

关键词： Immobilized alginate-vineyard Dyes Kinetic studies Roughness Spherical shape

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Inner ear hair cell regeneration A look from the past to the future

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Neural Regeneration Research 2013年第24期8卷 2284-2289页

作者： Francisco Santaolalla Carlos salvador Agustín Martínez jose María Sánchez Ana Sánchez del Rey Department of Otorhinolaryngology Basurto University Hospital Department of Dermatology Ophthalmology and Otorhinolaryngology School of Medicine University of the Basque Country (UPV/EHU)

Most recent studies on regeneration of inner ear hair cells focus on use of stem cells, gene therapy and neurotrophic factors. Cochlear gene therapy has been successfully used in the treatment of neu- rosensory hearing loss. This suggests that cochlear hair cell regeneration is possible. The objective of this paper is to review research and clinical application of inner near hair cell regeneration.

关键词： neural regeneration reviews hearing loss hair cells cochlea genes stem cells viral vectors regeneration neuroregeneration

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Hydrogen sulfide:A novel component in Arabidopsis peroxisomes which triggers catalase inhibition

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Journal of Integrative Plant Biology 2019年第7期61卷 871-883页

作者： Francisco J.Corpas Juan B.Barroso salvador Gonzalez-Gordo Maria A.Munoz-Vargas jose M.Palma Group of Antioxidants Free Radicals and Nitric Oxide in BiotechnologyFood and AgricultureDepartment of BiochemistryCell and Molecular Biology of PlantsEstacion Experimental del ZaidfnCSICC/Profesor Albareda 1E-18008 GranadaSpain Group of Biochemistry and Cell Signaling in Nitric oxide Department of Biochemistry and Molecular BiologyCampus"Las Lagunillas"E-23071University of JaenJaenSpain

Plant peroxisomes have the capacity to gen erate different reactive oxygen and nitrogen species(ROS and RNS),such as H2O2,superoxide radical(O2^·-),nitric oxide and peroxynitrite(ONOO^-).These organelles have an active nitrooxidative metabolism which can be exacerbated by adverse stress *** sulfide(H2S)is a new signaling gasotransmitter which can mediate the posttranslational modification(PTM)*** used Arabidopsis thaliana transgenic seedlings expressing cyan fluorescent protein(CFP)fused to a canonical peroxisome targeting signal 1(PTS1)to visualize peroxisomes in living cells,as well as a specific fluorescent probe which showed that peroxisomes contain H2S.H2S was also detected in chloroplasts under glyphosate-induced oxidative stress *** enzyme activities,including catalase,photorespiratory H2O2-generating glycolate oxidase(GOX)and hydroxypyruvate reductase(HPR),were assayed in vitro with a H2S *** line with the persulfidation of this enzyme,catalase activity declined significantly in the presence of the H2S *** corroborate the inhibitory effect of H2S on catalase activity,we also assayed pure catalase from bovine liver and pepper fruit-enriched samples,in which catalase activity was *** together,these data provide evidenee of the presence of H2S in plant peroxisomes which appears to regulate catalase activity and,consequently,the peroxisomal H2O2 metabolism.

关键词： Hydrogen sulfide triggers catalase inhibition

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Contrasting levels of genotype by environment interaction for life history and morphological traits in invasive populations of Zaprionus indianus(Diptera:Drosophilidae)

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Insect Science 2020年第5期27卷 1090-1100页

作者： Nicolas J.Lavagnino marcos Imberti Victoria E.Ortizj Nicolas Flaibani Juan jose Fanara Laboratorio de Evolucion Departamento de EcologiaGenetica y EvolucidnFacultad de Ciencias Exactas y NaturalesUniversidad de Buenos AiresArgentina IEGEBA-CONICET Facultad de Ciencias Exactas y NaturalesUniversidad de Buenos AiresArgentina

It has been demonstrated that phenotypic plasticity and genotype by envi-ronment interaction are important for coping with new and heterogeneous environments during *** indianus Gupta(Diptera:Drosophilidae)is an Afrotropical invasive fly species introduced to the South American continent in *** species is generalist and polyphagous,since it develops and feeds in several different fruit *** characteristics of *** suggest that phenotypic plasticity and genotype by environment interaction may be important in this species invasion *** this sense,our aim was to investigate the role of genetic variation for phenotypic plasticity(geno-type by environment interaction)in *** invasion of the South American ***,we quantified quantitative genetic variation and genotype by environment in-teractions of morphological and life history traits in different developmental environments,that is,host *** was done in different populations in the invasive range of ***-anus in *** showed that *** populations have considerable amounts of quantitative genetic ***,genotype by environment interactions was detected for the different traits analyzed in response to the different developmental ***,the amounts and patterns of these parameters differed between *** interpreled these results as the existence of diferences in evolutionary potential be-tween populations that have an important role in the short-and long-term success of the *** invasion process.

关键词： biological invasion genotype by env ironment interaction invaded range life history traits morphological traits Zaprionus indianus

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Games-Based Learning Framework

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Computer Technology and Application 2011年第11期2卷 906-911页

作者： Antonio Garcia-Cabot Eva Garcia Roberto Barchino Luis de-marcos jose-Maria Gutierrez jose-Antonio Gutierrez jose-Javier Martinez salvador Oton jose-Ramon Hilera Computer Science Department University of Alcala Alcala de Henares Madrid 28871 Spain

This work presents the authors＇ experience in the field of mobile technologies, from which several initiatives have emerged. As result of this, a games-based framework for learning has been developed in these last years. This framework is composed by a competition called Mobigame, which has as main aim to stimulate the participation of the students. By participating in this competition participants learn to develop for mobile devices. A game to practice Japanese is also presented in this article, which was presented in the above mentioned competition. This game has been developed for mobile phones or PDAs （Personal Digital Assistants） based on the JME （Java Mobile Edition） technology. Finally, another initiative is also presented： A free download platform of digital contents for mobile devices based on info-educational games.

关键词： Game-based learning mobile framework.

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