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The timing of bowel preparation before colonoscopy determines the quality of cleansing,and is a significant factor contributing to the detection of flat lesions:A randomized study

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World Journal of Gastroenterology 2006年第38期12卷 6161-6166页

作者： adolfo Parra-Blanco David Nicolás-Pérez Antonio Gimeno-García Begoa Grosso Alejandro jiménez Juan Ortega Enrique Quintero Department of Gastroenterology Hospital Universitario de Canarias La Laguna 38109 Santa Cruz de Tenerife Spain Research Unit Hospital Universitario de Canarias La Laguna 38109 Santa Cruz de Tenerife Spain

AIM： To compare the cleansing quality of polyethylene glycol electrolyte solution and sodium phosphate with different schedules of administration, and to evaluate whether the timing of the administration of bowel preparation affects the detection of polyps. METHODS： One hundred and seventy-seven consecutive outpatients scheduled for colonoscopy were randomized in one of four groups to receive polyethylene glycol electrolyte solution or oral sodium phosphate with two different timing schedules. Quality of cleansing, polyp detection, and tolerance were evaluated. RESULTS： Patients receiving polyethylene glycol or sodium phosphate on the same day as the colonoscopy, obtained good to excellent global cleansing scores more frequently than patients who received polyethylene glycol or sodium phosphate on the day prior to the procedure （P 〈 0.001）. Flat lesions, but not fiat adenomas, were more frequent in patients prepared on the same day （P = 0.02）. CONCLUSION： The quality of colonic cleansing and the detection of fiat lesions are significantly improved when the preparation is taken on the day of the colonoscopy.

关键词： Colonoscopy Preparation Polyp Flat lesion Sodium phosphate Polyethylene glycol

Thinking outside the black box:are the brain endothelial cells the new main target in Alzheimer's disease?

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Neural Regeneration Research 2023年第12期18卷 2592-2598页

作者： Enrique Estudillo adolfo López-Ornelas Alejandro Rodríguez-Oviedo Neptali Gutiérrez de la Cruz Marco Antonio Vargas-Hernández Adriana jiménez Laboratorio de Reprogramación Celular Instituto Nacional de Neurología y Neurocirugía Manuel Velasco SuárezMexico CityMexico División de Investigación Hospital Juárez de MéxicoMexico CityMexico Hospital Nacional Homeopático Hospitales Federales de ReferenciaMexico CityMexico Facultad de Ciencias Universidad Nacional Autónoma de MéxicoMexico CityMexico Laboratorio de Morfología Escuela Militar de Graduados de SanidadSecretaría de la Defensa NacionalBatalla de CelayaLomas de SoteloMiguel HidalgoMexico CityMexico Escuela Militar de Graduados de Sanidad Secretaría de la Defensa NacionalBatalla de CelayaLomas de SoteloMiguel HidalgoMexico CityMexico

The blood-brain barrier is the interface through which the brain interacts with the milieu and consists mainly of a sophisticated network of brain endothelial cells that forms blood vessels and selectively moves molecules inside and outside the brain through multiple mechanisms of *** brain endothelial cell function is crucial for brain homeostasis,their role in neurodegenerative diseases has historically not been considered with the same importance as other brain cells such as microglia,astroglia,neurons,or even molecules such as amyloid beta,Tau,or ***'s disease is the most common neurodegenerative disease,and brain endothelial cell dysfunction has been reported by several ***,its impairment has barely been considered as a potential therapeutic *** we review the most recent advances in the relationship between Alzheimer's disease and brain endothelial cells commitment and analyze the possible mechanisms through which their alterations contribute to this neurodegenerative disease,highlighting their inflammatory phenotype and the possibility of an impaired secretory pattern of brain endothelial cells that could contribute to the progression of this ***,we discuss why shall brain endothelial cells be appreciated as a therapeutic target instead of solely an obstacle for delivering treatments to the injured brain in Alzheimer's disease.

关键词： dementia endothelial cells neurodegeneration neuroinflammation neuronal death paracellular transport transcellular transport

Endoscopic submucosal dissection training with pig models in a Western country

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World Journal of Gastroenterology 2010年第23期16卷 2895-2900页

作者： adolfo Parra-Blanco María Rosa Arnau David Nicolás-Pérez Antonio Z Gimeno-García Nicolás González Juan A Díaz-Acosta Alejandro jiménez Enrique Quintero Department of Gastroenterology University Hospital of the Canary Islands Ofra s/n Endoscopy Unit Department of GastroenterologyAsturias Central University HospitalCelestino Villamil s/n Research Animal Laboratory Ofra s/nLa Laguna University Department of Gastroenterology Montevideo Clinic HospitalAvda Italia s/n Research Unit University Hospital of the Canary IslandsOfra s/n

AIM:To test a strategy for endoscopic submucosal dissection(ESD) training in animal models designed to overcome the initial learning ***:ESD was attempted in ex vivo and in vivo pig *** ESD procedures were attempted in the esophagus(n=9) or the stomach(n=21).The ex vivo model was used until initial competence was *** the in vivo model,several ESD procedures were performed in up to 3 *** following variables were analyzed:specimen size,complete and en bloc resection rate,time for circumferential incision,time for submucosal dissection,total ESD duration,and ***:Complete resection was achieved in 28 cases(en bloc 27);2 could not be completed(one perforation,one technical diff iculty).The mean ± SD time for circumferential incision was 36.2±16.8 min(range:8-87 min),and the mean±SD time for submucosal dissection was 45.1±35.7 min(range:9-196 min).The mean±SD size of the resected specimens was 45.2±17.8 *** mean±SD total resection time was signif icantly increased for the gastric cases performed in the f irst half of the study(n=13) than in the second half(n=8)(98.9±62.4 min vs 61.7±17.6 min,P=0.04),although the specimen size did not ***:Training in animal models could help endoscopists overcome the learning curve before starting ESD in humans.

关键词： Endoscopic submucosal dissection Training Animal model

Validation of Fujinon intelligent chromoendoscopy with high definition endoscopes in colonoscopy

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World Journal of Gastroenterology 2009年第42期15卷 5266-5273页

作者： adolfo Parra-Blanco Alejandro jiménez Bjrn Rembacken Nicolás González David Nicolás-Pérez Antonio Z Gimeno-García Marta Carrillo-Palau Takahisa Matsuda Enrique Quintero Department of Gastroenterology University Hospital of the Canary Islandsc/Ofra s/nLa Laguna 38320TenerifeSpain Department of Gastroenterology Hospital Universitario Central de AsturiasCelestino Villamil s/n33006 OviedoPrincipado de AsturiasSpain Research Unit University Hospital of the Canary Islandsc/Ofra s/nLa Laguna 38320TenerifeSpain Centre for Digestive Diseases The General Infirmary at LeedsGreat George StLeedsLS1 3EXUnited Kingdom Department of Gastroenterology Hospital de Clínicas de MontevideoAvda.Italia s/nMontevideo 11600Uruguay Division of Endoscopy National Cancer Center Hospital5-1-1 TsukijiChuo-kuTokyo 104-0045Japan

AIM:To validate high definition endoscopes with Fujinon intelligent chromoendoscopy(FICE) in ***:The image quality of normal white light endoscopy(WLE),that of the 10 available FICE filters and that of a gold standard(0.2% indigo carmine dye) were ***:FICE-filter 4 [red,green,and blue(RGB) wavelengths of 520,500,and 405 nm,respectively] provided the best images for evaluating the vascular pattern compared to white *** mucosal surface was best assessed using filter ***,the views obtained were not rated significantly better than those observed with white *** "gold standard",indigo carmine(IC) dye,was found to be superior to both white light and filter *** 6(RGB wavelengths of 580,520,and 460 nm,respectively) allowed for exploration of the IC-stained *** assessing mucosal polyps,both FICE with magnification,and magnification following dye spraying were superior to the same techniques without magnification and to white light *** the presence of suboptimal bowel preparation,observation with the FICE mode was possible,and endoscopists considered it to be superior to observation with white ***:FICE-filter 4 with magnification improves the image quality of the colonic vascular patterns obtained with WLE.

关键词： Colonoscopy Computed virtual chromoendoscopy Fujinon intelligent chromoendoscopy Magnifying colonoscopy Polyp diagnosis

Optimal Control of Nonlinear Systems Using Experience Inference Human-Behavior Learning

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IEEE/CAA Journal of Automatica Sinica 2023年第1期10卷 90-102页

作者： adolfo Perrusquía Weisi Guo IEEE the School of Aerospace Transport and ManufacturingCranfield UniversityBedfordUK

Safety critical control is often trained in a simulated environment to mitigate *** migration of the biased controller requires further *** this paper,an experience inference human-behavior learning is proposed to solve the migration problem of optimal controllers applied to real-world nonlinear *** approach is inspired in the complementary properties that exhibits the hippocampus,the neocortex,and the striatum learning systems located in the *** hippocampus defines a physics informed reference model of the realworld nonlinear system for experience inference and the neocortex is the adaptive dynamic programming(ADP)or reinforcement learning(RL)algorithm that ensures optimal performance of the reference *** optimal performance is inferred to the real-world nonlinear system by means of an adaptive neocortex/striatum control policy that forces the nonlinear system to behave as the reference *** and convergence of the proposed approach is analyzed using Lyapunov stability *** studies are carried out to verify the approach.

关键词： Experience inference hippocampus learning system linear time-variant(LTV)systems neocortex/striatum learning systems nonlinear systems optimal control

The Implementation of the Global Minimum Tax(GloBE):The Need for an Effective Dispute Prevention and Resolution Mechanism

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Belt and Road Initiative Tax Journal 2023年第2期4卷 64-68页

作者： Robert Danon Daniel Gutmann Guglielmo Maisto adolfo Martín jiménez University of Lausanne CMS Francis Lefebvre Avocats France Maisto e Associati Italy University of Cadiz Spain

The successful implementation of the Global Anti-Base Erosion(GloBE)rules on a global scale cannot be achieved without an international effective dispute prevention and resolution ***,the development of a dispute prevention and resolution framework for the GloBE rules faces significant *** article offers two possible options for an effective dispute prevention and resolution mechanism:a model based on reciprocal domestic legislations and the multilateral convention model.

关键词： Global Anti-Base Erosion rules Dispute prevention and resolution mechanism Multilateral convention

PLANE WAVES NUMERICAL STABILITY OF SOME EXPLICIT EXPONENTIAL METHODS FOR CUBIC SCHRODINGER EQUATION

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Journal of Computational Mathematics 2016年第4期34卷 385-406页

作者： Begona Cano adolfo Gonzalez-Pachon Departamento de Matemdtica Aplicada Universidad de Valladolid IMUVA Paseo de Beldn 7 47011 VaUadolid Spain Departamento de Matemdtica Aplicada Universidad de Valladolid IMUVA Paseo de Beldn 7 47011 Valladolid Spain

Numerical stability when integrating plane waves of cubic SchrSdinger equation is thor- oughly analysed for some explicit exponential methods. We center on the following second- order methods： Strang splitting and Lawson method based on a one-parameter family of 2-stage 2nd-order explicit Runge-Kutta methods. Regions of stability are plotted and numerical results are shown which corroborate the theoretical results. Besides, a tech- nique is suggested to avoid the possible numerical instabilities which do not correspond to continuous ones.

关键词： Numerical stability Exponential splitting Lawson methods Projection ontoinvariant quantities Plane waves SchrSdinger equation.

A novel approach to the dynamic response analysis of Euler-Bernoulli beams resting on a Winkler soil model and subjected to impact loads

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Earthquake Engineering and Engineering Vibration 2024年第2期23卷 389-401页

作者： adolfo Foriero Filippo Santucci de Magistris Giovanni Fabbrocino Département de génie civil et de génie des eaux Pavillon Adrien-PouliotUniversitéLavalQuébecCanada Dipartimento di Bioscienze e Territorio Universitàdegli Studi del MoliseCampobassoItaly Construction Technologies Institute National Research CouncilITC-CNRL’AquilaItaly

This work presents a novel approach to the dynamic response analysis of a Euler-Bernoulli beam resting on a Winkler soil model and subjected to an impact *** approach considers that damping has much less importance in controlling the maximum response to impulsive loadings because the maximum response is reached in a very short time,before the damping forces can dissipate a significant portion of the energy input into the *** development of two sine series solutions,relating to different types of impulsive loadings,one involving a single concentrated force and the other a distributed line load,are *** study revealed that when a simply supported Euler-Bernoulli beam,resting on a Winkler soil model,is subject to an impact load,the resulting vertical displacements,bending moments and shear forces produced along the span of the beam are considerably *** particular,the quantification of this effect is best observed,relative to the corresponding static solution,via an amplification *** computed impact amplification factors,for the sub-grade moduli used in this study,were in magnitude greater than 2,thus confirming the multiple-degree-of-freedom nature of the problem.

关键词： beam-Winkler-soil model sub-grade moduli impact load impact distributed line load dynamic solution impact amplification factor

Training,Certification and Qualification of Translators and Interpreters:reflections on the present and the future

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中国翻译 2016年第6期37卷 48-52页

作者： adolfo Gentile 澳大利亚翻译资格认证局

We are in a world of instantaneous communication where professional and academic connections are only a clic *** I do not believe we can say that we have a unitary approach to the concept of Translation and therefore to training,certification and *** Gambier and Ubaldo Stecconi have embarked on a proj ect called World Atlas of Translation

关键词：英语翻译方法阅读知识阅读材料