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Thinking outside the black box:are the brain endothelial cells the new main target in Alzheimer's disease?

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Neural Regeneration Research 2023年第12期18卷 2592-2598页

作者： Enrique Estudillo Adolfo López-Ornelas Alejandro Rodríguez-Oviedo Neptali Gutiérrez de la Cruz Marco Antonio Vargas-Hernández Adriana Jiménez laboratorio de Reprogramación Celular Instituto Nacional de Neurología y Neurocirugía Manuel Velasco SuárezMexico CityMexico División de Investigación Hospital Juárez de MéxicoMexico CityMexico Hospital Nacional Homeopático Hospitales Federales de ReferenciaMexico CityMexico Facultad de Ciencias Universidad Nacional Autónoma de MéxicoMexico CityMexico laboratorio de Morfología Escuela Militar de Graduados de SanidadSecretaría de la Defensa NacionalBatalla de CelayaLomas de SoteloMiguel HidalgoMexico CityMexico Escuela Militar de Graduados de Sanidad Secretaría de la Defensa NacionalBatalla de CelayaLomas de SoteloMiguel HidalgoMexico CityMexico

The blood-brain barrier is the interface through which the brain interacts with the milieu and consists mainly of a sophisticated network of brain endothelial cells that forms blood vessels and selectively moves molecules inside and outside the brain through multiple mechanisms of *** brain endothelial cell function is crucial for brain homeostasis,their role in neurodegenerative diseases has historically not been considered with the same importance as other brain cells such as microglia,astroglia,neurons,or even molecules such as amyloid beta,Tau,or ***'s disease is the most common neurodegenerative disease,and brain endothelial cell dysfunction has been reported by several ***,its impairment has barely been considered as a potential therapeutic *** we review the most recent advances in the relationship between Alzheimer's disease and brain endothelial cells commitment and analyze the possible mechanisms through which their alterations contribute to this neurodegenerative disease,highlighting their inflammatory phenotype and the possibility of an impaired secretory pattern of brain endothelial cells that could contribute to the progression of this ***,we discuss why shall brain endothelial cells be appreciated as a therapeutic target instead of solely an obstacle for delivering treatments to the injured brain in Alzheimer's disease.

关键词： dementia endothelial cells neurodegeneration neuroinflammation neuronal death paracellular transport transcellular transport

Ninety-day readmissions after inpatient cholecystectomy: A 5-year analysis

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World Journal of Gastroenterology 2017年第16期23卷 2972-2977页

作者： Alba manuel-Vázquez Raquel latorre-Fragua Carmen Ramiro-Pérez Aylhin López-Marcano Farah Al-Shwely Roberto de la Plaza-Llamas Josémanuel Ramia department of General and Digestive Surgery University Hospital of Guadalajara19002 GuadalajaraSpain

AIM To determine the incidence of readmission after cholecystectomy using 90 d as a time limit. METHODS We retrospectively reviewed all patients undergoing cholecystectomy at the General Surgery and Digestive System Service of the University Hospital of Guadalajara, Spain. We included all patients undergoing cholecystectomy for biliary pathology who were readmitted to hospital within 90 d. We considered readmission to any hospital service as cholecystectomyrelated complications. We excluded ambulatory cholecystectomy, cholecystectomy combined with other procedures, oncologic disease active at the time of cholecystectomy, finding of malignancy in the resection specimen, and scheduled re-admissions for other unrelated pathologies. RESULTS We analyzed 1423 patients. There were 71 readmissions in the 90 d after discharge, with a readmission rate of4.99%. Sixty-four point seven nine percent occurred after elective surgery(cholelithiasis or vesicular polyps) and 35.21% after emergency surgery(acute cholecystitis or acute pancreatitis). Surgical non-biliary causes were the most frequent reasons for readmission, representing 46.48%; among them, intra-abdominal abscesses were the most common. In second place were non-surgical reasons, at 29.58%, and finally, surgical biliary reasons, at 23.94%. Regarding time for readmission, almost 50% of patients were readmitted in the first week and most second readmissions occurred during the second month. Redefining the readmissions rate to 90 d resulted in an increase in re-hospitalization, from 3.51% at 30 d to 4.99% at 90 d. CONCLUSION The use of 30-d cutoff point may underestimate the incidence of complications. The current tendency is to use 90 d as a limit to measure complications associated with any surgical procedure.

关键词： Cholecystectomy 90-d Hospital readmission Readmission rate Cholelithiasis

Optimizing strategies to reduce alcohol consumption and relapses,improving abstinence in liver transplant recipients

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Hepatobiliary Surgery and Nutrition 2022年第1期11卷 153-155页

作者： Isabel Legaz manuel Muro department of Legal and Forensic Medicine Biomedical Research Institute(IMIB)Regional Campus of International Excellence“Campus Mare Nostrum”Faculty of MedicineUniversity of MurciaMurciaSpain Immunology Service Instituto Murciano de Investigación Biosanitaria(IMIB)Hospital Clínico Universitario Virgen de la Arrixaca(HCUVA)MurciaSpain

We have read with great attention and special interest the paper by Carrique and collaborators entitled:Results of Early Transplantation for Alcohol-Related Cirrhosis:Integrated Addiction Treatment with Low Rate of Relapse(1).In this prospective study,the authors initiated a pilot program to challenge the paradigm of the“6-month rule”of abstinence for patients with alcohol-related liver disease(ALD)requiring a transplant(2).

关键词： alcohol liver initiated

The Iberian Roma Population Variant Server(IRPVS)

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Journal of Genetics and Genomics 2024年第7期51卷 769-773页

作者： Fabiola Mavillard Javier Perez-Florido Francisco M.Ortuño Amador Valladares Miren L.Álvarez-Villegas Gema Roldán Rosario Carmona manuel Soriano Santiago Susarte Pilar Fuentes Daniel López-López Ana María Nuñez-Negrillo Alejandra Carvajal Yolanda Morgado Daniel Arteaga Rosa Ufano Pablo Mir Juan F.Gamella Joaquín Dopazo Carmen Paradas Macarena Cabrera-Serrano Instituto de Biomedicina de Sevilla(IBiS) Hospital Universitario Virgen del Rocío/CSIC/Universidad de SevillaSevillaSpain Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas(CIBERNED) Instituto de Salud CarlosⅢSevillaSpain Plataforma Andaluza de Medicina Computacional Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevillaSpain Grupo de medicina computacional de sistemas Instituto de Biomedicina de Sevilla(IBiS)Hospital Virgen del RocíoSevillaSpain Nodo de Genómica Funcional (INB-ELIXIR-es)Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevilla 41013Spain Bioinformática en Enfermedades raras(BiER) Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER)Instituto de salud CarlosⅢSevillaSpain departamento de Ingeniería de Computadores Automática y RobóticaUniversidad de GranadaGranadaSpain Servicio de Urgencias de Atención Primaria Distrito SevillaSevillaSpain Centro de Servicios Sociales Negociado de Servicios EspecializadosAyuntamiento de SevillaSevillaSpain departamento de Enfermería Facultad de Ciencias de la SaludUniversidad de GranadaGranadaSpain departamento de Neurología Hospital Virgen de las NievesGranadaSpain departamento de Neurología Hospital Virgen de ValmeSevillaSpain Centro de Salud Utrera Sur SevillaSpain Centro de Salud Polígono Sur SevillaSpain Unidad de Trastornos del Movimiento Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain departamento de Medicina Facultad de MedicinaUniversidad de SevillaSevilleSpain departamento de Antropología Social Universidad de GranadaSpain Unidad Enfermedades Neuromusculares Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain

In recent years,the number of known disease genes has exponentially grown due to the widespread adoption of cost-effective massive parallel *** identify new disease variants,especially in monogenic disorders,a frequen... 详细信息

关键词： Server filtering massive

Hepatitis B viral infection and role of alcohol

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World Journal of Gastroenterology 2022年第35期28卷 5233-5236页

作者： manuel Muro Aurelia Collados-Ros Isabel Legaz department of Immunology Clinical University HospitaĺVirgen de la Arrixaca-IMIB(Murcian Institute of Biomedical Investigation)Murcia 30120Spain department of Legal and Forensic Medicine Biomedical Research Institute(IMIB)Regional Campus of International Excellence"Campus Mare Nostrum"Faculty of MedicineUniversity of Murcia(Spain)Universidad de MurciaEspinardo 30100MurciaSpain

End-stage liver disease is frequently caused by hepatitis B virus (HBV) andalcohol consumption. Notably, the mechanism by which alcohol affects the courseof HBV-associated liver disease is unknown, and additional research is needed inthis area. A reduced immunological response, oxidative stress, endoplasmicreticulum stress, Golgi apparatus stress, and enhanced HBV replication are a fewpotential causes.

关键词： Hepatitis B virus Alcohol Hepatocarcinoma Immunity Liver disease

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World Journal of Gastroenterology 2022年第30期28卷 4231-4234页

作者： manuel Muro Aurelia Collados-Ros Isabel Legaz Immunology Service Instituto Murciano de investigación biosanitaria(IMIB)Hospital Clínico Universitario Virgen de la Arrixaca(HCUVA)Murcia 30120Spain department of Legal and Forensic Medicine Biomedical Research Institute(IMIB)Regional Campus of International Excellence“Campus Mare Nostrum”Faculty of MedicineUniversity of MurciaMurcia 30100Spain

Alcohol intake is a risk factor for cancer development and metastatic disease *** vesicle(EV)-mediated interorgan communication is assumed to be significant in boosting tumorigenic pathways and disease *** research indicates that exosomes have a variety of roles in the development of cancer during pathophysiological *** involvement of EV signaling during cancer progression in the alcohol environment is ***,understanding communication networks and the role of EVs as biomarkers can contribute significantly to developing strategies to address the serious public health problems associated with alcohol consumption and cancer.

关键词： Exosomes Liver metastasis Alcohol-associated liver disease Cancer

Analysis of hepatitis C virus-positive organs in liver transplantation

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World Journal of Hepatology 2022年第9期14卷 1840-1843页

作者： Isabel Legaz manuel Muro department of Legal and Forensic Medicine Biomedical Research InstituteRegional Campus of International Excellence"Campus Mare Nostrum"Faculty of MedicineUniversity of MurciaMurcia 30100Spain department of Immunology Service Instituto Murciano de Investigación BiosanitariaHospital Clínico Universitario Virgen de la ArrixacaMurcia 30120Spain

The authors of this study note that in liver transplantation(LT),the survival rates of hepatitis C virus(HCV)-positive donors and HCV-negative receivers are compa-rable to those of HCV-negative donors and ***-acting antiviral(DAA)therapies have nearly 100%effectiveness in treating *** 2006 and 2016,the percentages of HCV-positive patients on the waiting list and HCVpositive LT recipients fell by 8.2 percent and 7.6 percent,*** from April 1,2014,in which the donor and receiver were both at least 18 years old and had a positive HCV status,were the only ones eligible for the *** analysis for this study was restricted to the first transplant recorded for each patient using a data element that documented the number of prior transplants for each recipient,although some recipients appeared multiple times in the data ***-positive recipients or people with fulminant hepatic failure were the main beneficiaries of primary biliary cirrhosis among HCV-positive ***,there is still a reticence to use HCV-positive donor organs in HCV recipients due to clinical and ethical *** survival rates between HCV-positive donors and recipients and HCV-negative donors and receivers illustrate the efficacy of these DAA regimens.

关键词： Hepatitis C virus Liver transplant Graft survival United network for organ sharing Direct-acting antiviral

Observations of defect propagation in [100]-oriented opal-type photonic crystals

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Chinese Physics B 2008年第4期17卷 1298-1304页

作者：金崇君 Richard M.de la Rue Nigel P.Johnson department of Electronics & Electrical Engineering University of Glasgow School of Physics and Engineering Laboratory of Optoelectronic Materials and TechnologiesSun Yat-Sen University

Charged colloidal suspensions have been used as experimental models for the study of crystal nucleation. Here we propose that the technique of template-assisted colloidal self-assembly can be used to visualize the effects of defect propagation in atomic crystal films produced using epitaxial growth. Templates with periodic line defects were used to grow [100]-oriented three-dimensional photonic crystals by means of the template-assisted colloidal self-assembly method, aided by capillary and gravitational forces. The defect propagation in the [100]-oriented photonic crystal was observed using scanning electron microscopy, both at the surface of the crystal and on cleaved facets. This method is useful in the understanding of defect propagation in the growth of colloidal films on templates - and the same approach may also prove useful for the understanding of atomic crystal growth on substrates with defects. Additionally, the deliberate incorporation of line defects may prove valuable as a way of introducing waveguide channels into three-dimensional photonic crystals.

关键词： photonic crystal colloidal crystal self-assembly

decoupling the adsorption mechanisms of arsenate at molecular level on modified cube-shaped sponge loaded superparamagnetic iron oxide nanoparticles

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Journal of Environmental Sciences 2022年第11期34卷 1-12页

作者： Xiang-Yang Lou Roberto Boada Veronica Verdugo laura Simonelli Gustavo Pérez manuel Valiente GTS-UAB Research Group Department of ChemistryFacultat de CiènciesUniversitat Autonoma de Barcelona08193 BellaterraSpain ALBA Synchrotron Carrer de la llum 2-26Cerdanyola del Valles08290 BarcelonaSpain Centro de Excelencia en Nanotecnologia Leitat ChileSantiago 7500724Chile

In this study, a commercial cube-shaped open-celled cellulose sponge adsorbent was modified by in-situ co-precipitation of superparamagnetic iron oxide nanoparticles(SPION) and used to remove As(V) from aqueous solutions. Fe K-edge X-ray absorption spectroscopy(XAS) and TEM identified maghemite as the main iron phase of the SPION nanoparticles with an average size 13 nm. Batch adsorption experiments at 800 mg/L showed a 63% increase of adsorption capacity when loading 2.6 wt.% mass fraction of SPION in the *** determination of the adsorption thermodynamic parameters indicated that the As(V) adsorption on the composite material is a spontaneous and exothermic *** K-edge XAS results confirmed that the adsorption enhancement on the composite can be attributed to the nanoparticles loaded. In addition, adsorbed As(V) did not get reduced to more toxic As(Ⅲ) and formed a binuclear corner-sharing complex with SPION. The advantageous cube-shape of the sponge-loaded SPION composite together with its high affinity and good adsorption capacity for As(V), good regeneration capability and the enhanceddiffusion attributed to its open-celled structure make this adsorbent a good candidate for industrial applications.

关键词： Adsorption Cube composite adsorbent Arsenate removal Regeneration X-ray absorption spectroscopy