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Psychology Research 2011年第5期1卷 340-349页

作者： manfred Malzahn United Arab Emirates University AI-Ain United Arab Emirates

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金属板材激光弯曲成形规律的研究

中国激光 1998年第9期25卷 859-864页

作者：李纬民 manfred Geiger Frank Vollertsen 燕山大学机械工程学院锻压所德国Erlangen-Nuerberg大学

用大变形弹塑性有限元法对金属板材柔性成形新工艺——激光弯曲进行了动态数值模拟。论证了板料的几何参数和工艺参数与变形的相互关系。模拟结果与试验吻合较好。

关键词：激光弯曲柔性成形数值模拟金属板材激光加工

Recent advances in microvascular autologous breast reconstruction after ablative tumor surgery

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World Journal of Clinical Oncology 2016年第1期7卷 114-121页

作者： Michael S Pollhammer Dominik Duscher manfred Schmidt Georg M Huemer Section of Plastic Aesthetic and Reconstru-ctive Surgery Department of General Surgery Kepler University Hospital Linz MAZ - Microsurgical Training and Research Center

Breast cancer is a ubiquitous disease and one of the leading causes of death in women in western societies. With overall increasing survival rates, the number of patients who need post-mastectomy reconstruction is on the rise. Especially since its psychological benefits have been broadly recognized, breast reconstruction has become a key component of breast cancer treatment. Evolving from the early beginnings of breast reconstruction with synthetic implants in the 1960 s, microsurgical tissue transfer is on the way to become the gold standard for post oncology restoration of the breast. Particularly since the advent of perforator based free flap surgery, free tissue transfer has become as safe option for breast reconstruction with low morbidity. The lower abdominal skin and subcutaneous fat tissue typically offer enough volume to create an aesthetically satisfying breast mound. Nowadays, the most commonly used flap from this donor site is the deep inferior epigastric artery perforator flap. If the lower abdomen is not available as a donor site, the gluteal area and thigh provide a number of flaps suitable for breast recon-struction. If the required breast volume is small, and there is enough tissue available on the upper medial thigh, then a transverse upper gracilis flap may be a practicable method to reconstruct the breast. In case of a higher amount of required volume, a gluteal artery perforator flap is the best choice. However, what is crucial in addition to selecting the best flap option for the individual patient is the timing of the operation. In patients with confirmed post-mastectomy radiation therapy, it is advisable to perform microvascular breast reconstruction only in a delayed fashion.

关键词： Breast cancer Microsurgery Autologous tissue transfer Breast reconstruction Flap Transverse musculocutaneous gracilis Fasciocutaneous infragluteal Deep inferior epigastric perforator

Simultaneous flowering of umbrella bamboo (Fargesia murieliae) at its native home in Central China

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Journal of Forestry Research 2006年第4期17卷 293-297页

作者： LI Zhao-hua manfred DENICH Thomas BORSCH School of Resources and Environmental Science Hubei University Wuhan 430062 P. R. China Center for Development Research University of Bonn D-53113 Bonn Germany Institute of Botany University of Bonn D-53115 Bonn Germany

Flowering pattern and seedling establishment of umbrella bamboo （Fargesia murieliae （Gamble） Yi） were studied in its native habitat, Mount Shennongjia in Central China. Here in 1996-2000, over 95% of the bamboo plants simultaneously flowered and died, extending from lower elevations to the higher mountains along the altitude and from southwest to northeast along the mountain settings. Bamboo seedlings emerged after the simultaneous flowering, achieving an average density of 5 460 seedlings·m^-2 in the autumn of the year following the flowering. After a high mortality throughout the first winter, bamboo seedlings remained a stable density in following 2-4 years （1130-1230 seedlings·m^-2）. Seedling density positively related to the coverage of parent bamboo, but negatively to the herb layers.

关键词： Altitudinal scale bamboo sites flowering pattern seedling establishment Shennongjia.

Human iPSC-derived iMSCs improve bone regeneration in mini-pigs

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Bone Research 2019年第4期7卷 399-409页

作者： Pascal Jungbluth Lucas-Sebastian Spitzhorn Jan Grassmann Stephan Tanner David Latz Md Shaifur Rahman Martina Bohndorf Wasco Wruck Martin sager Vera Grotheer Patric Kropil Mohssen Hakimi Joachim Windolf Johannes Schneppendahl James Adjaye Department of Trauma and Hand Surgery Heinrich Heine University Hospital DüsseldorfMoorenstr.540225 DüsseldorfGermany Institute for Stem Cell Research and Regenerative Medicine Medical FacultyHeinrich Heine UniversityDüsseldorfMoorenstr.540225 DüsseldorfGermany Animal Research Institute Heinrich Heine UniversityDüsseldorfMoorenstr.540225 DüsseldorfGermany Department of Diagnostic and Interventional Radiology Medical FacultyHeinrich Heine UniversityDüsseldorfMoorenstr.540225 DüsseldorfGermany Vivantes Klinikum Am Urban Dieffenbachstraβe 110967 BerlinGermany

Autologous bone marrow concentrate(BMC)and mesenchymal stem cells(MSCs)have beneficial effects on the healing of bone *** address the shortcomings associated with the use of primary MSCs,induced pluripotent stem cell(iPSC)-derived MSCs(iMSCs)have been proposed as an *** aim of this study was to investigate the bone regeneration potential of human iMSCs combined with calcium phosphate granules(CPG)in critical-size defects in the proximal tibias of mini-pigs in the early phase of bone healing compared to that of a previously reported autograft treatment and treatment with a composite made of either a combination of autologous BMC and CPG or CPG *** were derived from iPSCs originating from human fetal foreskin fibroblasts(HFFs).They were able to differentiate into osteoblasts in vitro,express a plethora of bone morphogenic proteins(BMPs)and secrete paracrine signaling-associated cytokines such as PDGF-AA and *** and histomorphometrically,HFF-iMSC+CPG transplantation resulted in significantly better osseous consolidation than the transplantation of CPG alone and produced no significantly different outcomes compared to the transplantation of autologous BMC+CPG after 6 *** results of this translational study imply that iMSCs represent a valuable future treatment option for load-bearing bone defects in humans.

关键词： healing alone treatment

Interfacial Electronic Structure of Thin Cu Films Grown on Ar^+-ion Sputter-cleaned α-Al_2O_3 Substrates

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Journal of Materials Science & Technology 2002年第2期18卷 117-120页

作者： Christina Scheu, Min Gao and manfred RuhleMax-Planck-Institut fur Metallforschung, Seestr. 92, 70174 Stuttgart, Germany [ Manuscript received October 17, 2001] Max-Planck-Inst. für Metall. 70174 Stuttgart Seestr. 92 Germany

The bonding and electronic structure of Cu/(0001)Al2O3 and Cu/(1120)Al2O3 interfaces has been studied experimentally using spatially-resolved transmission electron energy loss spectroscopy. The specimen were prepared by depositing Cu on single-crystal α-AI2O3 substrates, which have been Ar+-ion sputter-cleaned prior to the growth of Cu. For both orientations of the α-Al2O3 substrate, atomically abrupt interfaces formed as determined by high-resolution transmission electron microscopy. The investigations of the interfacial Cu-L2,3, Al-L2,3 and 0-K energy loss near-edge structures, which are proportional to the site- and angular-momentum-projected unoccupied density of states above the Fermi level, indicate the existence of metallic Cu-AI bonds at the Cu/AI2O3 interface independent of the substrate orientation.

关键词： Electronic structure Cu film Ion sputtering α-Al2O3

Misoprostol and the Sildenafil analog(PHAR-0099048)Modulate Cellular Efflux of cAMP and cGMP Differently

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Pharmacology & Pharmacy 2013年第1期4卷 104-109页

作者： Elin Orvoll Roy A.Lysaa Aina W.Ravna Georg sager Medical Pharmacology and Toxicology Department of Medical BiologyFaculty of Health SciencesUniversity of TromsoTromsoNorway

In the present study we have characterized ATP-dependent transport of cAMP and cGMP in physiological, but also supraphysiological concentrations. The uptake into inside-out vesicles from human erythrocytes could be dissected into two components with high and low affinity. The respective Km-values were 30.8 ± 5.2 and 352 ± 26 μM for cAMP and 2.6 ± 0.4 and 260 ± 15 μM for cGMP. The two cyclic nucleotides were unable to mutually inhibit cellular efflux for concentrations up to about 100 μM. At higher concentrations the inhibition curve showed a steep fall. The IC50-value for cAMP reduction of high affinity [3H]-cGMP transport was 695 ± 9 μM. The respective value for cGMP inhibition of [3H]-cAMP efflux was 284 ± 20 μM. These observations are compatible with two selective high affinity transport systems. Other endogenous substances such as prostaglandins did not discriminate between cyclic nucleotide transport. The IC50 values for inhibition of [3H]-cAMP and [3H]-cGMP were 4.1 and 4.2 μM for PGE1, 2.7 and 4.4 μM for PGE2, respectively. However, the prostaglandin analog misoprostol discriminated distinctly between cAMP and cGMP transport with respective IC50-values of 4.5 and 24 μM. The assumption that the specific PDE5-inhibitor sildenafil could distinguish between the two cyclic nucleotides was disproved with respective IC50 values of 3.8 and 2.9 μM for inhibition of [3H]-cAMP and [3H]-cGMP, respectively. However, at least one sildenafil analog (PHAR0099048) showed a clear difference with respective IC50 values of 2.0 and 0.52 μM. The other tested sildenafil analogs showed no or minor ability to discriminate with IC50 values of 0.16 and 0.17 μM for IS-39213, and 0.35 and 0.16 μM for IS-60049, respectively. In agreement with previous reports, the present study shows that proteins responsible for cyclic nucleotide transport are multiorganic anion pumps. However, the observation that drug analogs may discriminate between these two efflux systems makes them potential drug t

关键词： ABC-Transporters cAMP cGMP Misoprostol Sildenafil

Growth-induced Stacking Faults of ZnO Nanorods Probed by Spatial Resolved Cathodoluminescence

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Chinese Physics Letters 2012年第7期29卷 261-264页

作者： XIE Yong JIE Wan-Qi WANG Tao WIEDENMANN Michael NEUSCHL Benjamin MADEL manfred WANG Ya-Bin FENEBERG Martin THONKE Klaus State Key Laboratory of Solidification Processing School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072 Institut fur Quantenmaterie/Gruppe Halbleiterphysik Universitat Ulm89069 UlmGermany Institut fur Experimentelle Physik Otto-von-Guericke-Universitat Magdeburg39106 MagdeburgGermany

Low density ZnO nanorods are grown by modified chemical vapor deposition on silicon substrates using gold as a *** use high resolution photoiuminescence spectroscopy to gain the optical properties of these nanorods in large *** as-grown samples show sharp near-band-gap luminescence with a full width at half maximum of bound exciton peaks at about 300μeV,and the ratio of ultraviolet/yellow luminescence larger than *** spatial and spectral resolved scanning electron microscope-cathodoluminescence is performed to excite the ZnO nanorods in single rods or different positions of single rods with the vapour-solid grovth *** bottom of the nanorod has a 3.31-eV luminescence,which indicates that basal plane stacking faults are related to the defects that are created at the first stage of growth due to the misfit between ZnO and Si.

关键词： vapour Spatial ultraviolet

Upregulation of cathepsin W-expressing T cells is specific for autoimmune atrophic gastritis compared to other types of chronic gastritis

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World Journal of Gastroenterology 2005年第38期11卷 5951-5957页

作者： Doerthe Kuester Michael Vieth Ulrich Peitz Stefan Kahl manfred Stolte Albert Roessner Ekkehard Weber Peter Malfertheiner Thomas Wex Department of Gastroenterology Institute of Pathology Institute of Physiological Chemistry

AIM： To investigate a pathophysiological role of cathepsin W （CatW）, a putative thiol-dependent cysteine protease, which is specifically expressed in cytotoxic lymphocytes, in different types of chronic inflammation of the gastric mucosa. METHODS： Gastric and duodenal biopsies of patients with Heliobacter pylori （ Hpylort）-assodated active gastritis （Hp, n = 19）, chemically induced reactive gastritis （CG, n = 17）, autoimmune atrophic gastritis （AIG, n = 20）, lymphocytic corpus gastritis （LG, n = 29）, celiac disease （CD, n = 10）, and corresponding controls （n = 24） were analyzed by immunohistochemistry for the expression of CatW and CD45. Furthermore, immunohistochemical double staining with anti-CD3 and anti-cathepsin was performed for the samples of AIG. RESULTS： Median values of CatW-expressing cells among CD45-positive immune cells were between 2% and 6% for normal gastric mucosa, CG, and LG, whereas the corresponding value was significantly increased for AIG （24.7%, P〈0.001） and significantly decreased for HP （0.7%, P〈0.05）. Double staining with anti-CD3 and antiCatW antibodies revealed that 〉90% of CatW-expressing cells in gastric mucosa of AIG were T cells. Duodenal mucosa had significantly more CatW/CD45-positive cells than normal gastric mucosa （median： 17.8% vs 2%, P〈0.01）. The corresponding proportion of CatW/CD45-positive cells was decreased in CD compared to duodenal mucosa （median： 2.1% vs 17.8%, P〈0.05）. CONCLUSION： The opposite findings regarding the presence of CatW-positive cells in AIG （increase） and CD （decrease） reflects the different cellular composition of immune cells involved in the pathogenesis of these diseases.

关键词： Cathepsin W Inflammation Gastritis Immuno-histochemistry NK cells

Prospective evaluation of small bowel preparation with bisacodyl and sodium phosphate for capsule endoscopy

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World Journal of Gastroenterology 2008年第13期14卷 2061-2064页

作者： Andreas Franke Frank Hummel Phillip Knebel Christoph Antoni Ulrich Bcker manfred V Singer Matthias Lhr Department of Medicine Ⅱ (Gastroenterology Hepatology and Infectious Diseases) University Hospital of Heidelberg at Mannheim Mannheim D-68167 Germany Department of Medicine Ⅱ (Gastroenterology Hepatology and Infectious Diseases) University Hospital of Heidelberg at Mannheim Mannheim D-68167 Germany Department of Medicine Rotes Kreuz Krankenhaus Kassel Kassel D-34121 Germany

AIM： To determine the effect of Prepacol, a combination of sodium phosphate and bisacodyl, on transit and quality of capsule endoscopy （CE）. METHODS： Fivety two consecutive patients were included in this prospective study. CE was performed following a 12 h fasting period. Twenty six patients were randomized for additional preparation with Prepacol. The quality of CE was assessed separately for the proximal and the distal small bowel by 3 experienced endoscopists on the basis of a graduation which was initially developed with 20 previous CE. RESULTS： Preparation with Prepacol accelerated small bowel transit time （262 ± 55 rain vs 287 ± 97 min）, but had no effect on the quality of CE. Visibility was significantly reduced in the distal compared to the proximal small bowel. CONCLUSION： The significantly reduced visibility of CE in the distal small bowel allocates the need for a good preparation. Since Prepacol has no beneficial effect on CE the modality of preparation and the ideal time of application remains unclear. Further standardized examinations are necessary to identify sufficient preparation procedures and to determine the impact of the volume of the preparation solution.

关键词： Small bowel Capsule endoscopy Preparation Laxative Visibility Transit time