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Diabetic peripheral neuropathy and neuromodulation techniques:a systematic review of progress and prospects

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Neural Regeneration Research 2025年第8期20卷 2218-2230页

作者： Rahul mittal Keelin McKenna Grant Keith Evan McKenna Joana R.N.Lemos Jeenu mittal Khemraj Hirani Diabetes Research Institute University of Miami Miller School of MedicineMiamiFLUSA Department of Otolaryngology University of Miami Miller School of MedicineMiamiFLUSA Herbert Wertheim College of Medicine Florida International UniversityMiamiFLUSA School of Medicine and Public Health University of WisconsinMadisonWIUSA

Neuromodulation for diabetic peripheral neuropathy represents a significant area of interest in the management of chronic pain associated with this *** peripheral neuropathy,a common complication of diabetes,is characterized by nerve damage due to high blood sugar levels that lead to symptoms,such as pain,tingling,and numbness,primarily in the hands and *** aim of this systematic review was to evaluate the efficacy of neuromodulatory techniques as potential therapeutic interventions for patients with diabetic peripheral neuropathy,while also examining recent developments in this *** investigation encompassed an array of neuromodulation methods,including frequency rhythmic electrical modulated systems,dorsal root ganglion stimulation,and spinal cord *** systematic review suggests that neuromodulatory techniques may be useful in the treatment of diabetic peripheral *** the advantages of these treatments will enable physicians and other healthcare providers to offer additional options for patients with symptoms refractory to standard pharmacologic *** these efforts,we may improve quality of life and increase functional capacity in patients suffering from complications related to diabetic neuropathy.

关键词： diabetes mellitus diabetic peripheral neuropathy neuromodulation neurostimulation therapy non-pharmacological treatment pain management

Advancement in utilization of magnetic resonance imaging and biomarkers in the understanding of schizophrenia

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World Journal of Clinical Cases 2025年第1期13卷 11-15页

作者： Aidan K Tirpack Danyaal G Buttar mandeep Kaur Department of Psychiatry Campbell University School of Osteopathic MedicineBuies CreekNC 27506United States Department of Psychiatry and Behavioral Health Mercyhealth Hospital and Trauma CenterJanesvilleWI 53548United States

Historically,psychiatric diagnoses have been made based on patient’s reported symptoms applying the criteria from diagnostic and statistical manual of mental *** utilization of neuroimaging or biomarkers to make the diagnosis and manage psychiatric disorders remains a distant *** have been several studies that examine brain imaging in psychiatric disorders,but more work is needed to elucidate the complexities of the human *** this editorial,we examine two articles by Xu et al and Stoyanov et al,that show developments in the direction of using neuroimaging to examine the brains of people with schizo-phrenia and *** et al used magnetic resonance imaging to examine the brain structure of patients with schizophrenia,in addition to examining neurotransmitter levels as *** et al used functional magnetic resonance imaging to look at modulation of different neural circuits by diagnostic-specific scales in patients with schizophrenia and *** two studies provide crucial evidence in advancing our understanding of the brain in prevalent psychiatric disorders.

关键词： Schizophrenia Magnetic resonance imaging Biomarkers Neurotransmitters Psychiatric disorders

Rayleigh wave propagation with two temperature and diffusion in context of three phase lag thermoelasticity

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Journal of Ocean Engineering and Science 2024年第4期9卷 317-325页

作者： mandeep Singh Sangeeta Kumari Department of Mathematics Chandigarh UniversityGharuan(Mohali)PunjabIndia

The primary objective of this research problem is to analyze the Rayleigh wave propagation in homogeneous isotropic half space with mass diffusion in Three Phase Lag(TPL)thermoelasticity at two *** governing equations of thermodiffusive elastic half space have been solved using the normal mode analysis in order to obtain the Rayleigh wave frequency equation at relevant boundary *** variation of various parameters like non-dimensional speed,attenuation coefficient,penetration depth and specific loss corresponding to thermodiffusion parameter,relaxation time,wave number and frequency has been *** effect of these parameters on Rayleigh wave propagation in thermoelastic half space are graphically demonstrated and variations of all these parameters have been compared within Lord-Shulman(L-S),Green-Nagdhi(GN-III)and Three Phase Lag(TPL)theory of thermoelasticity.

关键词： Rayleigh waves Attenuation coefficient Normal mode analysis Thermoelasticity Diffusion Three phase lag

A Study on the Far Wake of Elliptic Cylinders

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Computer Modeling in Engineering & Sciences 2017年第1期113卷 35-55页

作者： Subhankar Sen Sanjay mittal Department of Mechanical Engineering Indian Institute of Technology KanpurIndia Department of Aerospace Engineering Indian Institute of Technology KanpurIndia

The evolution of far wake of stationary elliptic cylinders with angle of attack is investigated for the unsteady flow at Re=200 using a stabilized finite-element *** Reynolds number,Re,is based on the major axis of cylinder and free-stream *** aspect ratios,AR considered are 0.2,0.5 and 0.8 while the angle of attack,αvaries from 0° to 90°.With increasingα,the Karman or primary shedding frequency of each cylinder decreases monotonically while the primary wavelength and time-averaged as well as *** increase *** time-averaged lift and moment coefficients initially increase withαand then *** power spectrum analysis of unsteady transverse velocity signal at various stations along the wake centerline is used to study the associated *** Karman or primary shedding frequency exists for eachα.For the AR=0.2 cylinder,the secondary and subsequently,low magnitude tertiary frequencies appear in the wake asαcontinues to increase from 30°.In contrast to the decaying nature of primary frequency withα,secondary frequency exhibits a nonmonotonic *** secondary frequency in general is not a sub-harmonic of the *** suggests that the secondary structures do not form due to merging of primary *** increasingα,the location of formation of secondary structures advances *** a given orientation,the upstream advancement is more dominant with decreasing *** spectrum analysis indicates that the wake state for confined flow is characterized by the primary frequency alone,*** imposition of blockage suppresses the formation of secondary structures.

关键词： Elliptic cylinder stabilized finite-element far wake angle of attack blockage

Local and biglobal linear stability analysis of parallel shear flows

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Computer Modeling in Engineering & Sciences 2017年第2期113卷 219-237页

作者： Sanjay mittal Anubhav Dwivedi Department of Aerospace Engineering Indian Institute of Technology KanpurUP 208016India

Linear Stability Analysis(LSA)of parallel shear flows,via local and global approaches,is *** local analysis is carried out by solving the Orr-Sommerfeld(OS)equation using a spectral-collocation method based on Chebyshev polynomials.A stabilized finite element formulation is employed to carry out the global analysis using the linearized disturbance equations in primitive *** local and global analysis are *** per the Squires theorem,the two-dimensional disturbance has the largest growth ***,only two-dimensional disturbances are *** its very nature,the local analysis assumes the disturbance field to be spatially periodic in the streamwise *** global analysis permits a more general ***,to enable a comparison with the local analysis,periodic boundary conditions,at the inlet and exit of the domain,are imposed on the *** are carried out for the LSA of the Plane Poiseuille Flow(PPF).The relationship between the wavenumber,a,of the disturbance and the streamwise extent of the domain,L,in the global analysis is explored for Re=*** is found that a and L are related by L=2pn/a,where n is the number of cells of the instability along the streamwise direction within the domain length,*** procedure to interpret the results from the global analysis,for comparison with local analysis,is described.

关键词： Linear stability analysis local analysis plane Poiseuille flow Orr-Sommerfeld equation global analysis

The mechanism and effects of subgrade fluidisation under ballasted railway tracks

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Railway Engineering Science 2020年第2期28卷 113-128页

作者： Buddhima Indraratna mandeep Singh Thanh Trung Nguyen Centre for Geomechanics and Railway Engineering University of WollongongWollongong CityNSW 2522Australia Australian Research Council(ARC)Industrial Transformation Training Centre ITTC-RailUniversity of WollongongWollongong CityNSW 2522Australia

The rapid growth in railway infrastructure and the construction of high-speed heavy-haul rail network,especially on ground that is basically unsuitable,poses challenges for geotechnical engineers because a large part of the money invested in the development of railway lines is often spent on track *** fact around the world,the mud pumping of subgrade fines is one of the common reasons why track performance deteriorates and track stability is *** article presents a series of laboratory tests to examine following aspects of mud pumping:(1)the mechanisms of subgrade fluidisation under undrained condition,(2)the effects of mud pumping on the engineering characteristics of ballast,and(3)the use of vertical drains to stabilize subgrade under cyclic *** undrained cyclic triaxial testing on vulnerable soft subgrade was performed by varying the cyclic stress ratio(CSR)from 0.2 to 1.0 and the loading frequency f from 1.0 to 5.0 *** is seen from the test results that for a specimen compacted at an initial dry density of 1790 kg/m3,the top portion of the specimen fluidises at CSR=0.5,irrespective of the applied loading *** cyclic railway loading,the internal redistribution of water at the top of the subgrade layer softens the soil and also reduces its *** response to these problems,this paper explains how the inclusion of vertical drains in soft subgrade will help to prevent mud pumping by alleviating the build-up of excess pore pressures under moving train loads.

关键词： Mud pumping Ballasted track Subgrade fluidisation Fouled ballast Prefabricated vertical drains

Connections between biomechanics and higher infectivity: a tale of the D614G mutation in the SARS-CoV-2 spike protein

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Signal Transduction and Targeted Therapy 2021年第2期6卷 193-194页

作者： Anshumali mittal Vikash Verma Luxmi Nagar JaspurUttarakhandIndiaUniversity of MassachusettsAmherstMAUSA Biology Department University of MassachusettsAmherstMAUSA

Mutations are known to play a critical role in how a species *** a recent article that appeared in the journal Cell,Yurkovetskiy et al.1 reported the structural and functional properties of the SARS-CoV-2 spike protein variant D614G that explains the basis of its increased *** observed that the mutant(D614G)was 4 to 9-fold more infectious than the wild type(D614),and the increased infectivity was not limited to human angiotensin-converting enzyme 2(ACE2).1 The cryo-EM structure suggested that D614G mutation weakens the stability of the homotrimer that shifts protein conformation towards an ACE2-binding fusion-competent state.1 The authors additionally showed that the D614G variant is neutralized by monoclonal antibodies targeting the spike protein receptor-binding domain(RBD).

关键词： ACE2 al. D61

Strength and elongation of spray formed Al–Si–Pb alloys

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International Journal of Minerals,Metallurgy and Materials 2014年第12期21卷 1222-1227页

作者： Aruna Tomar Rashmi mittal Devendra Singh Department of Metallurgical and Materials Engineering Indian Institute of Technology Roorkee

The strength and elongation to fracture of spray deposited Al-Si-Pb alloys were studied as a function of lead content, silicon content, and distance from the centre to periphery of the deposit. It is found that the ultimate tensile strength, proof stress and elongation to fracture decrease, linearly and exponentially, with the increase in lead content and porosity of the deposit, respectively. Both the strengths and elongation to fracture linearly increase with increasing distance from the centre to periphery of the deposit. The ultimate tensile strength and proof stress are higher at a higher silicon content and they have a linear relationship with the hardness of the deposit.

关键词： aluminum silicon alloys spray forming tensile strength proof stress elongation

Integrated search technique for parameter determination of SVM for speech recognition

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Journal of Central South University 2016年第6期23卷 1390-1398页

作者： Teena mittal R.K.Sharma Department of Electronics and Communication Engineering Thapar University Department of Computer Science and Engineering Thapar University

Support vector machine(SVM)has a good application prospect for speech recognition problems;still optimum parameter selection is a vital issue for *** improve the learning ability of SVM,a method for searching the optimal parameters based on integration of predator prey optimization(PPO)and Hooke-Jeeves method has been *** PPO technique,population consists of prey and predator *** prey particles search the optimum solution and predator always attacks the global best prey *** solution obtained by PPO is further improved by applying Hooke-Jeeves *** method is applied to recognize isolated words in a Hindi speech database and also to recognize words in a benchmark database TI-20 in clean and noisy environment.A recognition rate of 81.5%for Hindi database and 92.2%for TI-20 database has been achieved using proposed technique.

关键词： support vector machine (SVM) predator prey optimization speech recognition Mel-frequency cepstral coefficients wavelet packets Hooke-Jeeves method