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Diagnostic and prognostic performances of GALAD score in staging and 1-year mortality of hepatocellular carcinoma: A prospective study

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World Journal of Gastroenterology 2024年第17期30卷 2343-2353页

作者： Oraphan Jitpraphawan Witchakorn Ruamtawee mala Treewatchareekorn Supatsri Sethasine Division of Gastroenterology and Hepatology Department of MedicineNavamindradhiraj UniversityDusit 10300BangkokThailand Clinical Research Center Research Facilitation DivisionNavamindradhiraj UniversityDusit 10300BangkokThailand Division of Clinical Chemistry and Immunology Navamindradhiraj UniversityDusit 10300BangkokThailand

BACKGROUND The GALAD score has improved early hepatocellular carcinoma(HCC)detection *** role of the GALAD score in staging and predicting tumor characteristics or clinical outcome of HCC remains of particular *** To determine the diagnostic/prognostic performances of the GALAD score at various phases of initial diagnosis,tumor features,and 1-year mortality of HCC and compare the performance of the GALAD score with those of other serum *** This prospective,diagnostic/prognostic study was conducted among patients with newly diagnosed HCC at the liver center of Vajira *** patients had HCC staging allocation using the Barcelona Clinic Liver Cancer(BCLC)***,HCC etiology,and HCC features were *** and the GALAD score were obtained at *** performance of the GALAD score and biomarkers were prospectively *** Exactly 115 individuals were diagnosed with *** GALAD score increased with disease *** BCLC-0/A and BCLC-B/C/D,the GALAD score predicted HCC staging with an area under the curve(AUC)of 0.868(95%CI:0.80–0.93).For identifying the curative HCC,the AUC of GALAD score was significantly higher than that of Alpha-fetoprotein(AFP)(0.753)and Lens culinaris agglutinin-reactive fraction of AFP-L3(0.706),and as good as that of Protein induced by vitamin K absence-II(PIVKA-II)(0.897).For detecting aggressive features,the GALAD score gave an AUC of 0.839(95%CI:0.75–0.92)and significantly outperformed compared to that of AFP(0.761)and AFP-L3(0.697),with a trend of superiority to that of PIVKA-II(0.772).The performance to predict 1-year mortality of GALAD score(AUC:0.711,95%CI:0.60–0.82)was better than that of AFP(0.541)and as good as that of PIVKA-II(0.736).The optimal cutoff value of GALAD score was≥6.83,with a specificity of 72.63%for exhibiting substantial reduction in the 1-year *** The GALAD model can diagnose HCC at the curative stage,includin

关键词： Alpha-fetoprotein Barcelona clinic liver cancer GALAD score Hepatocellular carcinoma Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein Protein induced by vitamin K absence-II

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Bart’s Syndrome: A Neonatal Observation about a Case Report

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Open Journal of Pediatrics 2021年第3期11卷 406-412页

作者： Assetou Cissouma Djibril Kassogue mala sylla Guedioma Dembélé Soumaila Alama Traoré Abdoulaye Kissima-Traoré Dadé Ben Sidi Haidara Mamadou Bernard Coulibaly Madou Traore Mady Niakaté Sikasso Hospital Sikasso Region Mali Timbuktu Hospital Timbuktu Region Mali Bougouni Reference Health Centre Bougouni Mali Mali Hospital Bamako Mali Luxembourg Hospital Bamako Mali

Introduction: Bart’s syndrome is a rare neonatal pathology combining congenital skin aplasia affecting the extremities and congenital epidermolysis bullosa, exceptionally described on black skin. Observation: A 2-day-old male newborn was referred for multiple ulcerations of the limbs observed at birth. The clinical examination found an absence of bilateral and symmetrical skin occupying almost all of the two lower limbs with some flaccid bubbles. The vascular network was clearly visible. The rest of the skin coating was normal. The diagnosis of Bart syndrome in connection with epidermolysis bullosa was evoked clinically and despite pediatric and dermatological management, the evolution was rapidly fatal by severe sepsis. Discussion: Bart syndrome corresponds to a clinical picture of congenital skin aplasia associated with congenital epidermolysis bullosa suspected by areas of fragility and sometimes bubbles. All types of congenital epidermolysis bullosa may be associated with this syndrome. The clinical diagnosis is generally easy but the therapeutic management is difficult and the prognosis reserved. Conclusion: Bart syndrome is a curious congenital association of well-defined skin symptoms, the etiopathogeny of which still remains poorly elucidated, hence the difficulty of establishing an antenatal diagnostic strategy or giving appropriate genetic advice.

关键词： Skin Aplasia Congenital Newborn Skin Black

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Bilateral Central Serous Chorioretinopathy (CRSC) in Pregnancy Complicated with Retroplacental Hematoma: About a Case

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Open Journal of Ophthalmology 2023年第1期13卷 13-22页

作者： Daouda Goita Moro Sidibe mala sylla Nana Wangara Mamadou Kolé Sidibe Adama Dembele Gounon Saye Abdoulaye Napo Nouhoum Guirou Adama Guindo Mamadou Adama Togo Abdoulaye Nouhoum Coulibaly Oumar Diallo Japhet Popanou Thera Lamine Traore BOUGOUNI Reference Health Center Bougouni Mali Sikasso Regional Hospital Mali/Alliance for the Development of Community Ophthalmology (ADOC) Bamako Mali Institute of Tropical Ophthalmology of Africa Bamako Mali/Alliance for the Development of Community Ophthalmology (ADOC) Bamako Mali Alliance for the Development of Community Ophthalmology (ADOC) Bamako Mali National Eye Health Program Bamako Mali

Introduction: Central serous chorioretinopathy (CSCR) is associated with serous sensorineural retinal detachment in the macular region. The condition that affects the male gender more than their female counterpart results from focal leakage disturbance of retinal pigment epithelial cells and choroidal abnormalities. The corticosteroid is highlighted as one of the major factors that promote the occurrence of CSCR. Stress and pregnancy, especially in the third trimester, have also been reported by some authors. Central serous chorioretinopathy associated with pregnancy complicated by retroplacental hematoma is a rare event. Observation: We report the case of a pregnant woman at approximately 34 weeks of amenorrhea who presented a sudden and severe drop in visual acuity on a pregnancy complicated by retroplacental hematoma and delivered by cesarean section. The diagnosis was based on clinical arguments associated with photos of the retina made by the MII Ret Cam device (Made In India, Retinoscope Camera) highlighting the lifting of the macular region. Ophthalmological monitoring without medical or physical treatment was instituted. At two months of progression without treatment, bilateral visual acuity was 10/10. Conclusion: Central serous chorioretinopathy and pregnancy is not unusual;however, its bilateral and brutal form in a context of pregnancy complicated by retroplacental hematoma is rare. Despite this favorable evolution, monitoring remains necessary in order to prevent recurrences and complications.

关键词： MII Ret Cam Central Serous Chorioretinitis Retroplacental Hematoma

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Preserving Privacy of Software-Defined Networking Policies by Secure Multi-Party Computation

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Journal of Computer Science & Technology 2020年第4期35卷 863-874页

作者： Maryam Zarezadeh Hamid mala Homa Khajeh Faculty of Computer Engineering University of IsfahanIsfahan ***Iran Independent Researcher Isfahan ***Iran

In software-defined networking(SDN),controllers are sinks of information such as network topology collected from *** often like to protect their internal network topology and keep their network policies *** borrow techniques from secure multi-party computation(SMC)to preserve the privacy of policies of SDN controllers about status of *** the other hand,the number of controllers is one of the most important concerns in scalability of SMC application in *** address this issue,we formulate an optimization problem to minimize the number of SDN controllers while considering their reliability in SMC *** use Non-Dominated Sorting Genetic Algorithm II(NSGA-II)to determine the optimal number of controllers,and simulate SMC for typical SDNs with this number of *** results show that applying the SMC technique to preserve the privacy of organization policies causes only a little delay in SDNs,which is completely justifiable by the privacy obtained.

关键词： software-defined networking (SDN) privacy secure multi-party computation (SMC) structure function multi-objective optimization

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Impossible Differential Attacks on 13-Round CLEFIA-128

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Journal of Computer Science & Technology 2011年第4期26卷 744-750页

作者： Hamid mala Mohammad Dakhilalian Mohsen Shakiba Cryptography and System Security Research Laboratory Department of Electrical and Computer Engineering Isfahan University of Technology

CLEFIA, a new 128-bit block cipher proposed by Sony Corporation, is increasingly attracting cryptanalysts＇ attention. In this paper, we present two new impossible differential attacks on 13 rounds of CLEFIA-128. The proposed attacks utilize a variety of previously known techniques, in particular the hash table technique and redundancy in the key schedule of this block cipher. The first attack does not consider the whitening layers of CLEFIA, requires 21~9＂5 chosen plaintexts, and has a running time equivalent to about 2112.9 encryptions. The second attack preserves the whitening layers, requires 2117.8 chosen plaintexts, and has a total time complexity equivalent to about 2121.2 encryptions.

关键词： block cipher cryptanalysis impossible differential CLEFIA

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Post COVID-19 mucormycosis:A case series

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Asian Pacific Journal of Tropical Medicine 2021年第11期14卷 517-524页

作者： mala Vinod Kaneria Kallappa Baligeri Abhijeet Budhe Department of Medicine Topiwala National Medical College and B.Y.L.Nair Ch.HospitalMumbaiIndia

Objective:To evaluate the associated factors between COVID-19 and ***:Twenty-two patients of COVID-19 associated mucormycosis(including 3 asymptomatic patients who were cured of COVID-19)from a single medical unit of our institute were included.A detailed history was noted,with special emphasis on the time of onset of mucormycosis symptoms,presence of comorbidities,including new onset diabetes,severity of COVID-19,oxygen requirement,details of receipt of steroids and immunomodulators such as tocilizumab,imaging findings,including the number of sinuses involved,bony erosions,orbital and cerebral involvement,microscopy,culture and histopathology reports and antifungals *** interventions including number of debridements,orbital exenteration,maxillectomy,and the vaccination status were ***:All 22 patients had rhino-orbital cerebral mucormycosis,27.27%in the first wave and 72.73%during the second *** was the commonest comorbidity,and 40.91%patients were newly detected *** time of presentation in relation to their COVID-19 symptoms was 8-15 days(average 12.5 days).Ten out of 22(45.45%)had asymptomatic or mild COVID-19 and 40.91%did not require supplemental *** out of 22(22.73%)did not receive *** out of 22(54.55%)had orbital involvement,3(13.64%)had palatal ulcer and 4(18.18%)had cerebral involvement and all these had progressed in spite of treatment with appropriate ***:COVID-19 associated mucormycosis is a frequent,lethal,post COVID-19 complication,occurring even in mild and asymptomatic cases who have not received steroids or oxygen.

关键词： Mucormycosis COVID-19 Steroids Amphotericin B

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Solid extraintestinal malignancies in patients with inflammatory bowel disease

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World Journal of Gastrointestinal Oncology 2021年第12期13卷 1956-1980页

作者： Anastasia mala Kalliopi Foteinogiannopoulou Ioannis E Koutroubakis University Hospital of Heraklion Heraklion 71110CreteGreece Department of Gastroenterology University Hospital of HeraklionHeraklion 71110CreteGreece

Malignancies constitute the second cause of death in patients with inflammatory bowel diseases(IBD),after cardiovascular *** it has been postulated that IBD patients are at greater risk of colorectal cancer compared to the general population,lately there has been evidence supporting that this risk is diminishing over time as a result of better surveillance,while the incidence of extraintestinal cancers(EICs)is *** could be attributed either to systemic inflammation caused by IBD or to long-lasting immunosuppression due to IBD *** seems that the overall risk of EICs is higher for Crohn’s disease patients and it is mainly driven by skin cancers,and liver-biliary cancers in patients with IBD and primary sclerosing *** aims of this review were first to evaluate the prevalence,characteristics,and risk factors of EICs in patients with IBD and second to raise awareness regarding a proper surveillance program resulting in early diagnosis,better prognosis and survival,especially in the era of new IBD treatments that are on the way.

关键词： Extraintestinal malignancies Crohn’s disease Ulcerative colitis Thiopurines Anti-tumor necrosis factor

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Early Detection of Pancreatic Cancer Using Jaundiced Eye Images

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Computer Systems Science & Engineering 2022年第5期41卷 677-688页

作者： R.Reena Roy G.S.Anandha mala Department of Information Technology Easwari Engineering CollegeChennaiTamilnadu600089India

Pancreatic cancer is one of the deadliest cancers,with less than 9%survival *** Ductal Adeno Carcinoma(PDAC)is common with the general public affecting most people older than *** detection of PDAC is often challenging because cancer symptoms will progress only at later stages(advanced stage).One of the earlier symptoms of PDAC is *** with diabetes,obesity,and alcohol consumption are also at higher risk of having pancreatic cancer.A decision support system is developed to detect pancreatic cancer at an earlier stage to address this *** such as Mean Hue,Mean Saturation,Mean Value,and Mean Standard Deviation are computed after color space conversion from RGB to *** k-Nearest Neighbor(F-kNN)is designed for *** system proposed is trained and tested using features extracted from jaundiced eye *** proposed system results indicate that this model can predict pancreatic cancer as earlier as possible,helping clinicians make better decisions for surgical planning.

关键词： Pancreatic adeno carcinoma fuzzy-based classifier jaundiced eye classification system

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Relationship between hepatitis C virus infection and type 2 diabetes mellitus:Meta-analysis

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World Journal of Gastroenterology 2012年第14期18卷 1642-1651页

作者： Cho Naing Joon Wah Mak Syed Imran Ahmed mala Maung Faculty of Medicine and Health International Medical UniversityKuala Lumpur 57000Malaysia

AIM:To investigate the association between hepatitis C infection and type 2 diabetes ***:Observational studies assessing the relationship between hepatitis C infection and type 2 diabetes mellitus were identified via electronic and hand *** published between 1988 to March 2011 were screened,according to the inclusion criteria set for the present *** performed separate analyses for the comparisons between hepatitis C virus(HCV) infected and not infected,and HCV infected and hepatitis B virus *** included studies were further subgrouped according to the study *** was assessed using I2 *** summary odds ratios with their corresponding 95% CIs were calculated based on a random-effects *** included studies were subgrouped according to the study *** assess any factor that could potentially affect the outcome,results were further stratified by age group(proportion of ≥ 40 years),gender(proportion of male gender),body mass index(BMI)(pro-portion of BMI ≥ 27),and family history of diabetes(i.e.,self reported).For stability of results,a sensitivity analysis was conducted including only prospective ***:Combining the electronic database and hand searches,a total of 35 observational studies(in 31 articles) were identified for the final *** on random-effects model,17 studies(n = 286 084) compared hepatitis C-infected patients with those who were uninfected [summary odds ratio(OR):1.68,95% CI:1.15-2.45].Of these 17 studies,7 were both a cross-sectional design(41.2%) and cohort design(41.2%),while 3 were case-control studies(17.6%).Nineteen studies(n = 51 156) compared hepatitis C-infected participants with hepatitis B-infected(summary OR:1.92,95% CI:1.41-2.62).Of these 19 studies,4(21.1%),6(31.6%) and 9(47.4%) were cross-sectional,cohort and case-control studies,respectively.A sensitivity analysis with 3 prospective studies indicated that hepatitis C-infected patients had a

关键词： Hepatitis C Type 2 diabetes mellitus Observational studies Meta-analysis

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Bioactivity of compounds isolated from the leaves of the Lantana camara Linn plant

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Journal of Chinese Pharmaceutical Sciences 2019年第5期28卷 360-368页

作者： Suryati Elida Mardiah Mai Efdi Kartika MZ Yuni mala Sari Department of Chemistry Faculty of Mathematics and Sciences Andalas University

Two compounds with different bioactivities were isolated from the leaves of the Lantana camara Linn *** 1 was triterpenoid(Lantadene B)(22β-dimethylacroyloxy-3-oxoolean-12-en-28-oic-acid,C_(35)H_(52)O_5),which was isolated from n-hexane fraction and obtained as white solid(amorphous).Compound 2 was glycoside flavonoid(5-hydroxy-6,4′-dimethoxy flavon-7-O-glucopyranose,C_(23)H_(24)O_(11)),which was isolated from ethyl acetate and obtained as pale yellow solid(amorphous).Extraction was performed with maceration method using methanol ***,fractionation was carried out using n-hexane and ethyl acetate *** and purification of both fractions were conducted using chromatography *** structure of the isolated compounds was determined through spectral analyses of ultraviolet(UV),infrared(IR),and nuclear magnetic resonance(~1H NMR and ^(13)C NMR),distortionless enhancement by polarization transfer(DEPT),heteronuclear multiple bond connectivity(HMBC),heteronuclear single quantum correlation(HSQC),and H-H COSY(~1H-~1H homonuclear correlated spectroscopy).The cytotoxic activity of compound 1 was tested against MCF-7 breast cancer cells in vitro using MTT assay(3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide),showing very strong cytotoxic activity in inhibiting the growth of MCF-7 breast cancer cells,and the IC_(50) value was 1.1336μ*** antioxidant activity of compound 2 was tested using DPPHassay(1,1-diphenyl-2-picrylhydrazyl),showing strong activity in inhibiting free radicals,and its IC_(50) value was 71.03 mg/L.

关键词： Lantana camara Linn Lantadene B Glycosides flavonoid MCF-7 breast cell cancer Cytotoxic Antioxidant activity

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