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Recent advances on pathogenesis,diagnosis,prevention,immunological aspects,and vectors of dengue:A review

Asian Pacific Journal of Tropical Biomedicine 2023年第8期13卷 325-338页

作者： mahesh chandra sahu Rakesh Kumar Samantaray Aditi Pal Sanghamitra Pati Division of Medical Entomology ICMR-Regional Medical Research CentreChandrasekharpurBhubaneswar-751023OdishaIndia ICMR-Regional Medical Research Centre ChandrasekharpurBhubaneswar-751023OdishaIndia

Dengue is a vector-borne disease caused by the dengue virus(DENV)of family *** fever is common in both developed and developing ***,approximately 400 million cases of dengue fever are reported annually,resulting in approximately 22000 *** cases in India have progressively increased in the last *** recent years,substantial progress has been made in understanding various aspects of dengue,including its pathogenesis,diagnosis,prevention strategies,immunological responses,and the role of vectors in its *** transmission of a positive RNA virus occurs through Aedes mosquitoes,specifically Aedes aegypti and Aedes *** virus is associated with a wide spectrum of symptoms,ranging from mild undifferentiated fever to severe hemorrhagic fever and shock,posing a potential threat to human *** are 4 types of antigenically distinct dengue serotypes(DENV-1 to DENV-4)and among them,DENV-2 is more lethal and extremely *** overcome the severity of dengue,Dengvaxia is administered to children 9 to 16 years old with evidence of previous dengue *** diagnosis of dengue is carried out by ELISA-based non-structural protein(NS1)and immunoglobulin ***,there are no specific biomarkers to identify severe disease *** factors and temperature play an important role in complex interaction among host,vector,and virus to manifest the severity of *** is a need for the refinement of climate-based disease forecasting models in India to effectively control the spread of *** mosquito repellent should be used periodically to kill or repel the Aedes mosquito to prevent the spread of dengue in humans.

关键词： Dengue Aedes mosquitoes Insecticide NS1 Immunoglobulin

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Surveillance of antibiotic sensitivity pattern in chronic suppurative otitis media of an Indian teaching hospital

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2019年第2期5卷 88-94页

作者： mahesh chandra sahu Santosh Kumar Swain IMS and SUM Hospital Siksha'O'Anusandhan UniversityK8KalinganagarBhubaneswar751003OdishaIndia Department of Otorhinolaryngology IMS and SUM HospitalSiksha'O'Anusandhan UniversityK8KalinganagarBhubaneswar751003OdishaIndia

Introduction:Chronic suppurative otitis media (CSOM) is a common problem in worldwide and untreated CSOM leads to fatal complications like facial nerve paralysis,lateral sinus thrombosis,labyrinthitis,meningitis and brain abscess in developing country like ***:To isolate causative bacteria and antibiotic sensitivity pattern for CSOM and to know the prevalence of extended spectrum beta lactamases (ESBL) and Metallobetalactamases (MBL) in CSOM ***:A total of 500 ear swabs of clinical suspected CSOM patients were cultured on specific cultured medium and identified the bacteria with conventional *** all the identified bacteria were subjected with specific antibiotics by the Kirby-Bauer's method to know the resistance pattern of *** and MBL strains were detected by double disc diffusion ***:A total of 384 bacteria were isolated from 500 CSOM patients,among them 86 *** (22.40%),112 Staphylococcus aureus (29.17%),53 *** (13.80%),32 *** (18%),26 *** (6.77%),24 *** (6.25%),23 *** (5.99%),18 *** (4.69%) and 10 *** (2.60%) identified with conventional *** antibiotic disc diffusion methods 74.22% ESBL strains and 9.90%MBL strains were *** resistant strains of *** (86/384,22.40%) were more prevalent than those of *** (112/384,29.17%) and other bacteria in ear *** and vancomicin could control to gram negative bacteria and gram positive bacteria ***:Continuous and periodic evaluation of microbiological profile and antimicrobial sensitivity pattern of bacterial is essential for optimum management of CSOM patients.

关键词： Antibiotics Chronic suppurative otitis media Gram negative bacteria ESBL MBL

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In-silico and in-vitro evaluation of docetaxel and berberine as potential p53 modulating apoptotic inducers in oral squamous cell carcinoma

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Asian Pacific Journal of Tropical Biomedicine 2022年第12期12卷 530-540页

作者： Smrutipragnya Samal Rajesh Kumar Meher Debasmita Dubey Showkat Ahmad Mir Binata Nayak mahesh chandra sahu Pradeep Kumar Naik Goutam Rath Santosh Kumar Swain Department of Otorhinolaryngology and Head and Neck Surgery IMS and SUM HospitalSiksha‘O’Anusandhan Deemed to be UniversityK8Kalinga NagarBhubaneswar-751003OdishaIndia Centre of Excellence in Natural Products and Therapeutics Department of Biotechnology and BioinformaticsSambalpur UniversityJyotiviharBurlaSambalpurOdishaIndia Medical Research Laboratory IMS and SUM HospitalSiksha‘O’Anusandhan Deemed to be UniversityK8Kalinga NagarBhubaneswar-751003OdishaIndia School of Life Sciences Sambalpur UnivesityJyotiviharBurlaSambalpurOdishaIndia ICMR-Regional Medical Research Centre ChandrasekharpurBhubaneswar-751023India School of Pharmaceutical Sciences Siksha‘O’Anusandhan Deemed to be UniversityBhubaneswar-751030India

Objective:To investigate the interaction of p53 with docetaxel and berberine and their anticancer activities against oral squamous cell ***:The interaction between p53 with docetaxel and berberine was investigated and their mechanisms of action against oral squamous cell carcinoma were *** studies were performed to determine any toxic impact of the drugs on the vital organs of tested ***:In silico results revealed the molecular interaction of docetaxel and berberine with p53 and the molecules were found to be potential p53 *** and berberine inhibited the proliferation of cancer cells in a concentration-dependent *** cytometry analysis revealed that docetaxel and berberine at IC50 concentrations upregulated the expression of p53 in oral squamous cell carcinoma cells,thus triggering apoptotic cell *** addition,no toxicity was observed in the liver and kidney tissues of mice after docetaxel and berberine ***:Docetaxel and berberine significantly suppressed the proliferation of oral cancer cells by activating p53 expression and causing apoptotic cell *** compounds can be potential agents for the treatment of oral cancer,with little to no toxicity at the tissue level.

关键词： Docetaxel Berberine PC-3 OVCAR-3 OSCC SCC-29B p53 Anticancer Apoptosis

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Effect of exogenous progesterone on cumulus characteristics of buffalo oocytes by allowing passage of more number of sperm through cumulus but not essentially fertilization

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Asian pacific Journal of Reproduction 2018年第2期7卷 79-86页

作者： Madhusmita Panda Asmita Sandeep Kumar Purusottam Mishra mahesh chandra sahu Sachinandan De Tirtha Kumar Datta Rakesh Kumar Nodal Officer Chief District Veterinary OfficeKadambedaBhadrak756100OdishaIndia Institute of Microbial Technology Council of Scientific and Industrial ResearchChandigarhIndia BSL-4 National Institute of VirologySus RoadPashanPune-411021India Goat Breeding Farm AT/PO-SalapadaDistrict-KeonjharPin code-758020State-OdishaIndia Directorate of Medical Research IMS and SUM HospitalSiksha'O'Anusandhan UniversityK8Kalinga NagarBhubaneswar-751003OdishaIndia Animal Biotechnology Centre National Dairy Research InstituteKarnal132001HaryanaIndia

Objective:To understand the level of progesterone (P4) in different quality of buffalo cumulus oocyte complexes (COCs) and further to evaluate the effect of exogenous P4 supplementation on maturation and subsequent developmental ability of poor quality brilliant cresyl blue (BCB-)***: Progesterone secreted by different quality of buffalo oocytes was estimated by enzyme linked immunosorbent assay and the concentration differences were translated into P4 doses to be incorporated in the maturation medium of BCB-ve COCs followed by expression analysis of genes involved in the cumulus expansion, extracellular matrix disintegration and progesterone receptor signalling. In addition, the study also evaluated the effect of exogenous P4 on sperm-cumulus interaction. Results: More than 10-fold up-regulated expression of progesterone receptor in P4 supplemented oocytes signified that P4 might be acting predominantly through this receptor. Also, exogenous P4 supplementation had significant effect on transcatheter arterial chemoembolization protease regulated by P4-progesterone receptor pathway which in turn had an important role in extracellular matrix disintegration. On the contrary, cumulus expansion genesHAS2,TNFAIP6,AREG were not altered upon P4 supplementation. Also, it was observed that P4 addition did facilitate passage of significantly more number of spermatozoa through P4 treated cumulus cells. Further, incorporation of different doses of P4 did not improve significantly the cleavage and blastocyst rates of BCB-ve ***: Different qualities of buffalo COCs secrete substantially diverse levels of P4, and its supplementation has a role in oocyte maturation via modulation of cumulus characteristics but perhaps not fertilization.

关键词： BCB screening Progesterone Sperm cumulus interaction Fertilizing ability

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Chemical composition and source apportionment of PM2.5 and PM2.5-10 in Trombay （Mumbai, India）, a coastal industrial area

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Particuology 2018年第2期16卷 143-153页

作者： Sandeep Police Sanjay Kumar sahu mahesh Tiwari Gauri Girish Pandit Environmental Monitoring and Assessment Section Bhabha Atomic Research Centre Mumbai 400085 India Homi Bhabha National Institute Anushakti Nagar Mumbai 400094 India

PM2.5 and PM2.5 lo concentrations, elemental constituents, and sources in a densely populated coastal industrial area （Trombay, Mumbai） were investigated in 2010 and *** PM2.s and PM2.s lo concentra- tions were 13.50-71.60 and 22.40-127.78 p^g/m3, respectively. The daily PM25 concentrations exceeded the Indian Central Pollution Control Board limit （60 μg/m3） several days in winter. Of the elements analyzed, Si then Al had the highest concentrations in PM2.5- 10, but black carbon then Si had the highest concentrations in PM2.s. The element concentrations varied widely by season. Al, Ca, Fe, Si, and Ti con- centrations were highest in summer, Cl, Mg, and Na concentrations were highest in the monsoon season, and the other trace metal concentrations in both PM2.5 and PM2.5-10 were highest in winter. The PM2.5 and PM2.5-10 sources were apportioned by positive matrix factorization. PM2.5 and PM2.5-10 had six dominant sources, crustal material （8.7% and 25.3%, respectively）, sea salt spray （6.1% and 15.0%, respectively）, coal/biomass combustion （25.5% and 13.8%, respectively）, fuel oil combustion （19.0% and 11.2%, respectively）, road traffic （ 17.7% and 12.6%, respectively）, and the metal industry （ 10.6% and 7.0%, respectively）. Anthropogenic sources clearly contributed most to PM2.5 but natural sources contributed most to PM2.5-10.

关键词： Trombay PM2.5 PM2.5-10 Black carbon Metals Positive matrix factorization

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THE EFFECT OF MAGNETIC FIELDS ON LOW FREQUENCY OSCILLATING NATURAL CONVECTION WITH PRESSURE GRADIENT

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Applied Mathematics and Mechanics(English Edition) 2003年第3期24卷 274-283页

作者： G.C.Sharma Madhu Jain mahesh chandra School of Mathematical Sciences Institute of Basic ScienceSchool of Mathematical SciencesInstitute of Basic ScienceSchool of Mathematical SciencesInstitute of Basic Science KhandariAgra-282002IndiaKhandariAgra-282002IndiaKhandariAgra-282002India

The oscillating natural convection in the presence of transverse magnetic field with time depending pressure gradient is studied. The analysis of the problem is carried out by assuming that the fluid is flowing in a parallel plate configuration. The emphasis is on low frequency oscillating convective flows induced by g-jitter associated with micro gravity because of their importance to the space processing materials. A general solution for an oscillating flow in the presence of transverse magnetic field is carried out. Some special cases of the oscillating flow and its response to an applied magnetic field are performed. It was observed that the behavior of oscillating free convective flows depends on frequency, amplitude of the driving buoyancy forces, temperature gradient,magnetic field and the electric conditions of the channel walls. In the absence of magnetic field, buoyancy force plays a predominant role in driving the oscillatory flow pattern, and velocity magnitude is also affected by temperature gradients. To suppress the oscillating flow external magnetic field can be used. It is also found that the reduction of the velocity is inversely proportional to the square of the applied magnetic field with conducting wall but directly proportional to the inverse of the magnetic field with insulating wall. Detailed calculations and computational results are also carried out to depict the real situation.

关键词： convection g- jitter acceleration buoyancy force magnetic field pressure gradient

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A Review on the Evaporation Dynamics of Sessile Drops of Binary Mixtures:Challenges and Opportunities

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Fluid Dynamics & Materials Processing 2021年第2期17卷 253-284页

作者： Pradeep Gurrala Saravanan Balusamy Sayak Banerjee Kirti chandra sahu Department of Mechanical and Aerospace Engineering Indian Institute of Technology HyderabadSangareddyTelanganaIndia Department of Chemical Engineering Indian Institute of Technology HyderabadSangareddyTelanganaIndia

The wetting and evaporation dynamics of sessile droplets have gained considerable attention over the last few years due to their relevance to many practical applications,ranging from a variety of industrial problems to several biological *** made of binary mixtures typically undergo complex dynamics due to the differential volatility of the considered components and the ensuing presence of thermocapillary *** these reasons,many research groups have focused on the evaporation of binary droplets using a variegated set of experimental,numerical,and purely theoretical *** from reviewing the state-of-the-art about the existing experimental,analytical,and computational techniques used to study the evaporation dynamics of binary sessile droplets,we also provide some indications about possible future research directions in this specific area.

关键词： Wetting dynamics evaporation sessile droplet binary mixture thermocapillary flow

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Differences in Tree Species Diversity and Soil Nutrient Status in a Tropical Sacred Forest Ecosystem on Niyamgiri Hill Range,Eastern Ghats,India

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Journal of Mountain Science 2012年第4期9卷 492-500页

作者： Sudam Charan sahu Nabin Kumar DHAL Brij LAL Rama chandra MOHANTY Environment and Sustainability Department CSIR-IMMTBhubaneswar-751013India Biodiversity Division CSIR-IHBTPalampurIndia Department of Botany Utkal UniversityBhubaneswar-751004India

We have quantitatively analyzed the tree species diversity with respect to soil nutrient status in three sites of a sacred forest ecosystem of Niyamgiri hill range, Eastern Ghats, India. Extensive field surveys and sampling were conducted in 3 sites of the hill range： Site 1 Pterocarpus dominated forest （PTF）（19°40＇02.2＇＇ N and 83°21＇23.1＇＇ E）, Site 2 Mangifera dominated forest （MAF）（19°40＇02.8＇＇ N and 83°21＇40.8＇＇ E） and Site 3 Mixed forest （MIF）（19°36＇47.1＂ N and 83°21＇02.7＇＇ E）. A total of 28 families, 42 genera, 46 tree species, and 286 individual trees were recorded on an area of0.6 ha. Tree density varied between 470 and 49o individuals ha and average basal area between 3.16 and l0.04 m2 ha-1. Shannon Index （H＇） ranged from 2.34 to 4.53, Simpson＇s Index ranged from 0.07 to o.09, and equitability Index ranged from 0.7 to 1.34. The number of individuals was highest in the girth at breast height （GBH） class of 50-7o cm. The soil nutrient status of the three forest types was related to tree species diversity. The soil pH value of the three sites reflected the slightly acidic nature of the area. Species diversity was positively correlated with organic carbon and phosphorus and negatively with nitrogen, EC and pH. The results of the current study may be helpful to further develop a conservation planfor tree species in tropical sacred forest ecosystems.

关键词： Tree species diversity Sacred forestecosystem Soil nutrient status Eastern Ghats

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Ameliorative effect of Pergularia daemia(Forssk.) Chiov. leaves extract against anti-tuberculosis drugs induced liver injury in rats

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Asian Pacific Journal of Tropical Medicine 2018年第9期11卷 518-525页

作者： Gita Mishra Hemeshwer Kumar chandra Nisha sahu Satendra Kumar Nirala Monika Bhadauria Toxicology and Pharmacology Laboratory Department of ZoologyGuru Ghasidas University Laboratory of Natural Products Department of Rural Technology and Social DevelopmentGuru Ghasidas University

Objective:To evaluate therapeutic potential of hydroethanolic extract of Pergularia daemia(***) against anti-tuberculosis drugs(ATDs) induced liver ***:Wistar albino rats were divided into seven groups of six animal in *** ATDs and *** extract(100,200 and 400 mg/kg,p.o.) were conjointly administered for 8 weeks and various biochemical,histoarchitectural,ultrastructural studies were ***:Administration of ATDs significantly increased aspartate aminotransferase,alanine aminotransferase,alkaline phosphatase,triglycerides,cholesterol,bilirubin and decreased glucose and albumin *** lipid peroxidation and reduction in glutathione,superoxide dismutase,catalase,glutathione peroxidase,glutathione reductase and glucose-6-phosphate dehydrogenase were found after ATDs *** of *** extract maintained serum biochemical indices as well as antioxidant status similar to control and diminished oxidative stress in dose dependent *** and ultra-structural observations substantiated biochemical ***:*** has therapeutic potential against ATDs induced liver injury and may be of clinical significance after extensive studies.

关键词： Antituberculosis drugs Hepatic injury Pergularia daemia Antioxidant activity

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Propolis modulates cellular biochemistry, antioxidants, cytokine profile, histological and ultra-morphological status against antituberculosis drugs induced hepatic injury

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Asian Pacific Journal of Tropical Medicine 2018年第11期11卷 609-620页

作者： Nisha sahu Gita Mishra Hemeshwer Kumar chandra Satendra Kumar Nirala Monika Bhadauria Toxicology and Pharmacology Laboratory Department of Zoology Guru Ghasidas University Laboratory of Natural Products Department of Rural Technology and Social development Guru Ghasidas University

To evaluate hepatic injury induced by antituberculosis drugs(ATDs) when administered orally for 2, 4, 6 and 8 weeks and the therapeutic potential of propolis(bee hive product) against ATDs induced hepatic injury. Methods: The ATDs were administered for 8 weeks as well as propolis extract at three different doses(100, 200, 400 mg/kg) conjointly for 8 weeks in rats. Silymarin(50 mg/kg) was given as positive control. Animals were euthanized after 8 weeks; blood and liver samples were collected to perform various biochemicals, serological and histopathological and ultramorphological studies. Results: Significant increase(P < 0.05) in aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, triglyceride and cholesterol along with reduction in glucose and albumin level were noted after ATDs induced hepatic injury. Significant increase(P < 0.05) in lipid peroxidation, triglyceride, cholesterol and CYP2E1 activity; decline in reduced glutathione, catalase, superoxide dismutase, glutathione reductase, glutathione peroxidase, glucose-6-phosphatase dehydrogenase activity were observed after ATDs intoxication. Due to presence of a wide range of flavonoids and polyphenols in propolis extract, its administration reduced hepatic injury and maintained biochemical indices towards control. Histopathological and electron microscopic observations indicated hepatoprotective potential of propolis at cellular level whereas, TNF-α, IL-6 and IGF-1 confirmed therapeutic potential of propolis at molecular level. Conclusions: It can be concluded that propolis possess hepatoprotective potential against ATDs induced hepatic injury that may prove itself as a clinically useful natural product in management of drug induced liver injury.

关键词： Antituberculosis drugs Propolis Biochemical Hepatic injury

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