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Transactions of Nonferrous Metals Society of China 2012年第3期22卷 700-710页

作者： A.venugopal Rajiv PANDA Sushant MANWATKAR K.SREEKUMAR L.RAMA KRISHNA G.SUNDARARAJAN Material Characterization Division Materials and Metallurgy GroupVikram Sarabhai Space CentreThiruvananthapuram-695022India International Advanced Research Centre for Powder Metallurgy and New Materials Hyderabad-500005India

Alumina coating was formed on AA7075 aluminum alloy by micro arc oxidation（MAO） method and its corrosion and stress corrosion cracking（SCC） behaviors were examined in 3.5%（mass fraction） NaCl *** impedance spectroscopy（EIS） was used to evaluate the degradation of the coating as a function of immersion time and was modeled with appropriate equivalent *** load stress corrosion cracking（SCC） results followed by post-test metallographic observations demonstrated the usefulness of MAO coating to avoid the premature failure of the alloy due to severe localized corrosion initiated by Cu-and Fe-rich intermetallic phases.

关键词： aluminum alloy micro arc oxidation impedance spectroscopy stress corrosion

Carcinoma of the Ovary Presenting as Cutaneous Metastases

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Case Reports in Clinical Medicine 2016年第11期5卷 500-504页

作者： Monisha venugopal Naresh Duthaluri Prabhu Purushothamanan Anukiran Ravichandran Arcot Rekha Sri Ramachandra Medical College and Research Institute Sri Ramachandra University Chennai India

Introduction: Cutaneous metastasis is common from malignancies of the genitourinary system and occasionally from the digestive system. Cutaneous metastases, due to ovarian carcinoma as a presenting feature, being diagnosed on cytology, are uncommonly reported. Case Report: A 70-year-old lady presented with a cutaneous nodule and progressive abdominal distension. Investigations for metastatic nodule showed it to be a lesion from the ovary. Discussion: Carcinoma ovary is often diagnosed when patients present with ascites and the association with a parietal wall deposit is uncommon. The occurrence of a parietal wall nodule when the ascites is negative for malignant cells is not previously documented. Conclusion: We discuss literature of the malignancies that present with a parietal wall metastases and the management of ovarian carcinoma.

关键词： Carcinoma Ovary Cutaneous Nodule Cytology

Environmentally assisted cracking resistance of Al-Cu-Li alloy AA2195 using slow strain rate test in 3.5% NaCl solution

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Transactions of Nonferrous Metals Society of China 2017年第2期27卷 241-249页

作者： R.GHOSH A.venugopal P.RAMESH NARAYANAN S.C.SHARMA P.V.VENKITAKRISHNAN Materials and Metallurgy Group Materials and Mechanical EntityVikram Sarabhai Space CentreThiruvananthapuram-695022KeralaIndia

The general corrosion and environmental cracking resistances of Al-Cu-Li alloy AA2195 were investigated in 3.5% NaCl environment and compared with those of another high strength alloy AA2219. The general corrosion resistance of these alloys was examined using immersion corrosion and potentiodynamic polarization tests, while the stress corrosion cracking （SCC） resistance was evaluated by slow strain rate test （SSRT） method. The tested samples were further characterized by SEM-EDS and optical profilometry to study the change in corrosion morphology, elemental content and depth of corrosion attack. The reduction in ductility was used as a parameter to evaluate the SCC susceptibility of the alloys. The results indicated that the corrosion resistance of AA2195 alloy was better than that of AA2219 alloy as it exhibited lower corrosion rate, along with lower pit depth and density. However, the SCC index （εNaCl/εair） measured was greater than 0.90, indicating good environmental cracking resistance of both the alloys. Detailed fractography of the failed samples under SEM？EDS, in general, revealed a typical ductile cracking morphology for both the alloys.

关键词： Al-Cu-Li alloy stress corrosion cracking fractography potentiodynamic polarization

纤维蛋白胶与无缝无胶自体球结膜瓣固定术治疗翼状胬肉的疗效比较（英文）

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国际眼科杂志 2019年第11期19卷 1819-1827页

作者： Manipur Raviraj Sahana Chikkanayakanahalli venugopal Kavitha Acharya Pavana Bomalapura Ramamurthy Lakshmi 哈桑眼科医学研究所

目的:比较两种大小纤维蛋白胶与无缝无胶自体球结膜瓣固定术在原发性翼状胬肉手术中的患者舒适度、移植物稳定性、移植物炎症、复发等术后并发症。方法:本研究对2014-12/2016-08共80例翼状胬肉患者(80眼)进行前瞻性介入对比研究。研究... 详细信息

目的:比较两种大小纤维蛋白胶与无缝无胶自体球结膜瓣固定术在原发性翼状胬肉手术中的患者舒适度、移植物稳定性、移植物炎症、复发等术后并发症。方法:本研究对2014-12/2016-08共80例翼状胬肉患者(80眼)进行前瞻性介入对比研究。研究组随机抽取并分为两组,组1接受纤维蛋白胶疗法,组2采用无缝合无胶结膜自体移植固定术。每组再将等量的受试者随机平均分为两组(组1:组A+组B,组2:组C+组D)。组A(自体移植物的大小与裸眼巩膜相同)和组B(比裸巩膜大1 mm)实施纤维蛋白胶疗法;组C(自体移植物的大小与裸眼巩膜相同)和组D(比裸巩膜大1 mm)采用无缝线无胶结膜自体移植固定术。每一位患者都接受翼状胬肉切除术,并根据组别使用不同大小的自体球结膜瓣。结果:组1平均年龄为43.525,组2平均年龄为42.2。男性20例,女性60例。37例患者右眼有翼状胬肉。四组间平均手术时长相似。在术后随访期间,除结膜下出血(纤维蛋白胶组在术后1wk内明显增多)外,4组间患者的舒适度、移植物回缩、移植物炎症和移植物水肿等术后参数均相似(P<0.0001)。组2仅3例患者出现4级移植物回缩/移位。术后1wk,组A和组D各出现1例移植囊肿患者。随访6mo后,组D中2例患者复发。结论:两种方法均安全有效,术后不适及并发症少。与纤维蛋白胶疗法相比,无缝无胶疗法更加经济且效果相当。由于该手术成本低,且具有纤维蛋白胶疗法的所有优点,无缝无胶法可被认为是治疗患者非常有效的方法。

关键词：原发性翼状胬肉自体结膜瓣移植纤维蛋白胶无胶缝合法

Crystal and Molecular Structure of 2-Amino-3-Ethyl Carboxamido-4-Metyl-5-Carboxy Ethyl Thiophene

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Crystal Structure Theory and Applications 2012年第3期1卷 92-96页

作者： Dhananjay Dey venugopal Prakash Vasu Janardhanan Saravanan Deepak Chopra Department of Chemistry Indian Institute of Science Education and Research Bhopal India PES College of Pharmacy Bangalore India Shirdi Sai Engineering College Bangalore India Vivekananda Degree College Bangalore India

The crystal and molecular structure of 2-Amino-3-ethyl carboxamido-4-methyl-5-carboxy ethyl thiophene (C11H16N2O3S) has been investigated from single crystal X-ray diffraction data. The primary focus is to investigate the molecular geometry of this compound in the solid state along with the associated inter and intra-molecular hydrogen bonding and related weak interactions present in this molecule. This compound crystallizes in the monoclinic space group P21/c with cell parameters, a = 8.1344(3) , b = 13.7392(4) , c = 11.4704(4) , β = 100.769(2), V = 1259.36 (7) 3, D = 1.352 g·cm–3, Z = 4. The molecular geometry is stabilized by intra-molecular N-H…O=C and C-H…O interactions along with intramolecular C-H…N and C-H…O interactions which contribute towards the stability of the crystal packing.

关键词： Crystal Molecular Conformation Intermolecular Interactions Spectroscopy Diffraction

Caffeic acid and protocatechuic acid modulate Nrf2 and inhibit Ehrlich ascites carcinomas in mice

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Asian Pacific Journal of Tropical Biomedicine 2021年第6期11卷 244-253页

作者： venugopal R.Bovilla Preethi G.Anantharaju Sireesh Dornadula Prashanthkumar M.Veeresh Mahadevaswamy G.Kuruburu Vidya G.Bettada Kunka Mohanram Ramkumar SubbaRao V.Madhunapantula Center of Excellence in Molecular Biology and Regenerative Medicine Department of BiochemistryJSS Medical CollegeJSS Academy of Higher Education&ResearchMysore-570015KarnatakaIndia SRM Research Institute Department of BiotechnologySchool of BioengineeringSRM Institute of Science and TechnologyKattankulathur-603203Tamil NaduIndia

Objective:To assess the nuclear factor-erythroid 2-related factor-2(Nrf2)modulatory effect of caffeic acid and protocatechuic acid and determine the anti-tumor activity of these phenolic compounds against Ehrlich ascites carcinoma growth in ***:Antioxidant activity of protocatechuic acid and caffeic acid was assessed using ferric reducing antioxidant power(FRAP)and 2,2-diphenyl-1-picrylhydrazyl(DPPH).Nrf2 activation potential of phenolic compounds was tested by quantitative realtime polymerase chain reaction,and luciferase complementation reporter *** vivo efficacy was tested using the Ehrlich ascites carcinoma ***:FRAP and DPPH radical scavenging assays showed that caffeic acid and protocatechuic acid were more potent compared with cinnamic acid and benzoic *** complementation reporter assays identified caffeic acid and protocatechuic acid as the activators of *** caffeic acid and protocatechuic acid upregulated the expression of Nrf2 target genes heme oxygenase-1(HO-1),glutamate-cysteine ligase catalytic subunit(GCLC),and glutamate-cysteine ligase modifier subunit(GCLM)and the activity of NAD(P)H:quinone oxidoreductase 1(NQO1)when tested on HCT-116 cells using a cell-based assay system at 9 *** addition,intraperitoneal administration of caffeic acid and protocatechuic acid to Ehrlich ascites carcinoma bearing mice suppressed tumor growth and ***:Caffeic acid and protocatechuic acid can modulate Nrf2 and inhibit Ehrlich ascites carcinoma cells.

关键词： Ehrlich ascites carcinomas Nrf2 Protocatechuic acid Caffeic acid NQO1 activity

X-Ray Diffraction Studies of Rice Husk Ash—An Ecofriendly Concrete at Different Temperatures

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American Journal of Analytical Chemistry 2013年第8期4卷 368-372页

作者： Patnaikuni Chandan Kumar Nutulapati V. S. venugopal Department of Civil Engineering &Chemistry GITAM University Visakhapatnam India

In the majority of rice producing countries, much of the husk produced from the processing of rice is either burnt or dumped as waste. Rice husks are one of the largest readily available but most under-utilized biomass resources, being an ideal fuel for electricity generation. In this communication the author reported the X-ray diffraction studies on rice husk ash (RHA) concrete samples heated at 300℃ and 1000℃ which were compared and observed that at 300℃ the inner surface of the specimen shows an extra compound. Copper Iron Lead Telluride Cu3FePbTe4 along with SiO2, Al5Fe2ZnO4 was present on the surface which also and might be responsible for imparting additional strength to 7.5% RHA concrete at 300℃. The X-ray diffraction studies of samples exposed to 1000℃ on temperature showed that the additional chemical compounds formed at lower temperatures were not found at 1000℃ at outer and inner surfaces of the sample indicating its possible reason for exhibiting poor strengths for all specimens. The outer surface of the 1000℃ heated specimen showed a compound named dichloroglyoxime C2H2Cl2N2O2 along with SiO2 but the inner surface of the same sample showed SiO2 alone.

关键词： Rice Husk Ash Concrete X-Ray Diffraction Studies Different Temperature Environment

Multi-compartmental transdermal patch for simultaneous delivery of multiple drugs:formulation and evaluation of newly developed novel dosage form

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Journal of Coastal Life Medicine 2015年第7期 534-538页

作者： Vijayan venugopal Jayaraja Kumar Selvadurai Muralidharan P.Vasanth Raj Unit of Pharmaceutical Technology Faculty of PharmacyAIMST UniversityBedong-08100Malaysia

Objective:To evaluate the formulation of multi-compartmental transdermal patches for simultaneous delivery of multiple drugs:aceclofenac and ***:The patch was prepared by simple solvent casting method using hydroxy propyl methyl celluloseK100Mas matrix forming agent and dimethyl sulphoxide as permeation *** prepared transdermal patch was evaluated by physiochemical parameters andin-vitro diffusion ***:The multi-compartmental transdermal patch showed sustained drug release over the period of 12 ***:Multicompartmental transdermal patches shows better bioavailability,therapeutic efficacy and very economic as compared with other dosage forms.

关键词： Multi-compartmental Transdermal patch Aceclofenac Serratiopeptidase

Cardiogenic differentiation of mesenchymal stem cells on elastomeric poly (glycerol sebacate)/collagen core/shell fibers

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World Journal of Cardiology 2013年第3期5卷 28-41页

作者： Rajeswari Ravichandran Jayarama Reddy venugopal Subramanian Sundarrajan Shayanti Mukherjee Seeram Ramakrishna Faculty of Engineering Nanoscience and Nanotechnology Initiative National University of Singapore Department of Mechanical Engineering National University of Singapore

AIM: To facilitate engineering of suitable biomaterials to meet the challenges associated with myocardial infarction. METHODS: Poly (glycerol sebacate)/collagen (PGS/ collagen) core/shell fibers were fabricated by core/ shell electrospinning technique, with core as PGS and shell as collagen polymer; and the scaffolds were characterized by scanning electron microscope (SEM), fourier transform infrared spectroscopy (FTIR), contact angle and tensile testing for cardiac tissue engineering. Collagen nanofibers were also fabricated by electrospinning for comparison with core/shell fibers. Studies on cell-scaffold interaction were carriedout using cardiac cells and mesenchymal stem cells (MSCs) co-culture system with cardiac cells and MSCs separately serving as positive and negative controls respectively. The co-culture system was characterized for cell proliferation and differentiation of MSCs into cardiomyogenic lineage in the co-culture environment using dual immunocytochemistry. The co-culture cells were stained with cardiac specific marker proteins like actinin and troponin and MSC specific marker protein CD 105 for proving the cardiogenic differentiation of MSCs. Further the morphology of cells was analyzed using ***: PGS/collagen core/shell fibers, core is PGS polymer having an elastic modulus related to that of cardiac fibers and shell as collagen, providing natural environment for cellular activities like cell adhesion, proliferation and differentiation. SEM micrographs of electrospun fibrous scaffolds revealed porous, beadless, uniform fibers with a fiber diameter in the range of 380 ± 77 nm and 1192 ± 277 nm for collagen fibers and PGS/collagen core/shell fibers respectively. The obtained PGS/collagen core/shell fibrous scaffolds were hydrophilic having a water contact angle of 17.9 ± 4.6° compared to collagen nanofibers which had a contact angle value of 30 ± 3.2°. The PGS/collagen core/shell fibers had mechanical properties comparable to that of native

关键词： Mesenchymal stem cells Cardiac cells Coculture Cardiac patch Poly (glycerol sebacate) Core/ shell fibers.

Isolation and Characterization of R-Enantiomer in Ezetimibe

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American Journal of Analytical Chemistry 2013年第9期4卷 488-495页

作者： Kameswararao Chimalakonda venugopal Kamani Madhusudhan Gutta Srinivasulu Polisetty Sai Venkata Srinivas Koduri Inogent laboratories Pvt Ltd. IDA-Nacharam Jawaharlal Nehru Technological University Hyderabad Hyderabad India

A simple and rapid Supercritical Fluid Chromatography (SFC) method has been developed to isolate and characterize R-Isomer of Ezetimi be by using normal phase Chiral Cel OD-H with 250 mm × 30 mm, 5 microns column using a mobile phase system containing super critical fluid carbondi oxide (Co2) and the percentage of 2-Propanol as a mobile phase (85:15) and detection at 230 nm. The isolated R-Isomer is characterized by using UV-vis, FT-IR, ESI-MS, HPLC1H and 13C NMR. The purity of isolated R-Isomer is about 98%.

关键词： Isolation Characterization (R)-Isomer Ezetimibe Supercritical Fluid Hromatography (SFC)